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Refractory Neutropenia

MedGen UID:
414877
•Concept ID:
C2826320
•
Neoplastic Process

Definition

A myelodysplastic syndrome characterized by the presence of at least 10% dysplastic neutrophils in the bone marrow or the peripheral blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Neutropenia

Professional guidelines

PubMed

SOHO State of the Art Updates and Next Questions: Treatment of Lower Risk Myelodysplastic Syndromes.
Volpe VO, Garcia-Manero G, Komrokji RS
Clin Lymphoma Myeloma Leuk 2023 Mar;23(3):168-177. Epub 2023 Jan 13 doi: 10.1016/j.clml.2023.01.001. PMID: 36682988
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
Del Vecchio A, Christensen RD
Early Hum Dev 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5. PMID: 22633505

Recent clinical studies

Etiology

Risk factors and clinical outcomes of breakthrough yeast bloodstream infections in patients with hematological malignancies in the era of newer antifungal agents.
Kim SH, Choi JK, Cho SY, Lee HJ, Park SH, Choi SM, Lee DG, Choi JH, Yoo JH, Lee JW
Med Mycol 2018 Feb 1;56(2):197-206. doi: 10.1093/mmy/myx038. PMID: 28525644Free PMC Article
Changes in the Updated 2016: WHO Classification of the Myelodysplastic Syndromes and Related Myeloid Neoplasms.
Bennett JM
Clin Lymphoma Myeloma Leuk 2016 Nov;16(11):607-609. Epub 2016 Aug 12 doi: 10.1016/j.clml.2016.08.005. PMID: 27693133
Abrupt evolution of Philadelphia chromosome-positive acute myeloid leukemia in myelodysplastic syndrome.
Fukunaga A, Sakoda H, Iwamoto Y, Inano S, Sueki Y, Yanagida S, Arima N
Eur J Haematol 2013 Mar;90(3):245-9. Epub 2013 Jan 9 doi: 10.1111/ejh.12056. PMID: 23240925
Refractory cytopenia with unilineage dysplasia: analysis of prognostic factors and survival in 126 patients.
Breccia M, Latagliata R, Cannella L, Carmosino I, Santopietro M, Loglisci G, Federico V, Alimena G
Leuk Lymphoma 2010 May;51(5):783-8. doi: 10.3109/10428191003682759. PMID: 20302387
Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusions.
Safdar A, Rodriguez GH, Lichtiger B, Dickey BF, Kontoyiannis DP, Freireich EJ, Shpall EJ, Raad II, Kantarjian HM, Champlin RE
Cancer 2006 Jun 15;106(12):2664-71. doi: 10.1002/cncr.21929. PMID: 16691620

Diagnosis

Specific Granule Deficiency Due To Novel Homozygote SMARCD2 Variant.
Kihtir Z, Çelik K, Tayfun Küpesiz F, Küpesiz OA, Kocacik Uygun DF, Arayici S, Ongun H, Acarbulut İ, Sağlam C, Ceylaner G, Bingöl A
Pediatr Allergy Immunol Pulmonol 2022 Mar;35(1):43-46. doi: 10.1089/ped.2021.0070. PMID: 35320004
Immunotherapy-induced severe neutropenia with neurotoxicity: A case of a 75-year-old woman with ulcerative colitis diagnosed with melanoma.
Patel R, Pai L
J Oncol Pharm Pract 2020 Apr;26(3):730-734. Epub 2019 Jul 18 doi: 10.1177/1078155219862341. PMID: 31315551
Changes in the Updated 2016: WHO Classification of the Myelodysplastic Syndromes and Related Myeloid Neoplasms.
Bennett JM
Clin Lymphoma Myeloma Leuk 2016 Nov;16(11):607-609. Epub 2016 Aug 12 doi: 10.1016/j.clml.2016.08.005. PMID: 27693133
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
Del Vecchio A, Christensen RD
Early Hum Dev 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5. PMID: 22633505
Refractory cytopenia with unilineage dysplasia: analysis of prognostic factors and survival in 126 patients.
Breccia M, Latagliata R, Cannella L, Carmosino I, Santopietro M, Loglisci G, Federico V, Alimena G
Leuk Lymphoma 2010 May;51(5):783-8. doi: 10.3109/10428191003682759. PMID: 20302387

Therapy

Granulocyte-colony-stimulating Factor-resistant Neutropenia and Polyneuropathy Presenting as Severe Complications of Sjögren's Syndrome.
Tomita K, Tokugawa S, Inui G, Moriyasu S, Ikeuchi T, Touge H, Tajima F
Intern Med 2022 Nov 1;61(21):3287-3291. Epub 2022 Mar 26 doi: 10.2169/internalmedicine.9092-21. PMID: 35342136Free PMC Article
Refractory Neutropenia Secondary to Dual Immune Checkpoint Inhibitors That Required Second-Line Immunosuppression.
Meti N, Petrogiannis-Haliotis T, Esfahani K
J Oncol Pract 2018 Aug;14(8):514-516. Epub 2018 Jul 13 doi: 10.1200/JOP.18.00177. PMID: 30004823
Risk factors and clinical outcomes of breakthrough yeast bloodstream infections in patients with hematological malignancies in the era of newer antifungal agents.
Kim SH, Choi JK, Cho SY, Lee HJ, Park SH, Choi SM, Lee DG, Choi JH, Yoo JH, Lee JW
Med Mycol 2018 Feb 1;56(2):197-206. doi: 10.1093/mmy/myx038. PMID: 28525644Free PMC Article
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
Del Vecchio A, Christensen RD
Early Hum Dev 2012 May;88 Suppl 2:S19-24. doi: 10.1016/S0378-3782(12)70007-5. PMID: 22633505
Central venous catheter infection in a child: case report and review of Kluyvera infection in children.
Brooks T, Feldman S
South Med J 2003 Feb;96(2):214-7. doi: 10.1097/01.SMJ.0000051273.09417.6B. PMID: 12630654

Prognosis

Risk factors and clinical outcomes of breakthrough yeast bloodstream infections in patients with hematological malignancies in the era of newer antifungal agents.
Kim SH, Choi JK, Cho SY, Lee HJ, Park SH, Choi SM, Lee DG, Choi JH, Yoo JH, Lee JW
Med Mycol 2018 Feb 1;56(2):197-206. doi: 10.1093/mmy/myx038. PMID: 28525644Free PMC Article
Abrupt evolution of Philadelphia chromosome-positive acute myeloid leukemia in myelodysplastic syndrome.
Fukunaga A, Sakoda H, Iwamoto Y, Inano S, Sueki Y, Yanagida S, Arima N
Eur J Haematol 2013 Mar;90(3):245-9. Epub 2013 Jan 9 doi: 10.1111/ejh.12056. PMID: 23240925
Refractory cytopenia with unilineage dysplasia: analysis of prognostic factors and survival in 126 patients.
Breccia M, Latagliata R, Cannella L, Carmosino I, Santopietro M, Loglisci G, Federico V, Alimena G
Leuk Lymphoma 2010 May;51(5):783-8. doi: 10.3109/10428191003682759. PMID: 20302387
Rhizomucor variabilis var. regularior and Hormographiella aspergillata infections in a leukemic bone marrow transplant recipient with refractory neutropenia.
Abuali MM, Posada R, Del Toro G, Roman E, Ramani R, Chaturvedi S, Chaturvedi V, LaBombardi VJ
J Clin Microbiol 2009 Dec;47(12):4176-9. Epub 2009 Oct 21 doi: 10.1128/JCM.00305-09. PMID: 19846651Free PMC Article
Refractory anaemia according to the FAB classification: a report on 69 cases.
Fenaux P, Estienne MH, Lepelley P, Zandecki M, Lai JL, Beuscart R, Jouet JP, Cosson A, Bauters F
Eur J Haematol 1988 Apr;40(4):318-25. doi: 10.1111/j.1600-0609.1988.tb00185.x. PMID: 3366222

Clinical prediction guides

Risk factors and clinical outcomes of breakthrough yeast bloodstream infections in patients with hematological malignancies in the era of newer antifungal agents.
Kim SH, Choi JK, Cho SY, Lee HJ, Park SH, Choi SM, Lee DG, Choi JH, Yoo JH, Lee JW
Med Mycol 2018 Feb 1;56(2):197-206. doi: 10.1093/mmy/myx038. PMID: 28525644Free PMC Article
Refractory cytopenia with unilineage dysplasia: analysis of prognostic factors and survival in 126 patients.
Breccia M, Latagliata R, Cannella L, Carmosino I, Santopietro M, Loglisci G, Federico V, Alimena G
Leuk Lymphoma 2010 May;51(5):783-8. doi: 10.3109/10428191003682759. PMID: 20302387
Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusions.
Safdar A, Rodriguez GH, Lichtiger B, Dickey BF, Kontoyiannis DP, Freireich EJ, Shpall EJ, Raad II, Kantarjian HM, Champlin RE
Cancer 2006 Jun 15;106(12):2664-71. doi: 10.1002/cncr.21929. PMID: 16691620

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