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Benign melanocytic skin nevus

MedGen UID:
264151
•Concept ID:
C1456781
•
Neoplastic Process
Synonyms: Benign Melanocytic Nevus; benign melanocytic nevus; Benign melanocytic nevus of skin; Benign Melanocytic Nevus of Skin; benign melanocytic nevus of skin; Benign Melanocytic Nevus of the Skin; benign melanocytic nevus of the skin; benign melanocytic skin nevus; Benign melanoma; Benign Mole; benign mole; Benign Nevus of Skin; benign nevus of skin; Benign Nevus of the Skin; benign nevus of the skin; Benign Skin Melanocytic Nevus; Benign Skin Nevus; benign skin nevus; Hairy nevus; Melanocytic nevus; Nevus; Pigmented nevus
SNOMED CT: Benign melanocytic nevus of skin (400010006); Pigmented nevus (1163403006); Melanocytic nevus (1163403006); Hairy nevus (1163403006); Benign melanoma (1163403006); Nevus (1163403006)
 
Monarch Initiative: MONDO:0044794

Definition

A circumscribed proliferation of melanocytes in the skin. It is characterized by the absence of atypical or malignant cytological features, and absence of invasive features or metastatic potential. Variants include the Spitz nevus, halo nevus, blue nevus, and balloon cell nevus. [from NCI]

Professional guidelines

PubMed

Diagnosis and Management of Acral Pigmented Lesions.
Ingrassia JP, Stein JA, Levine A, Liebman TN
Dermatol Surg 2023 Oct 1;49(10):926-931. Epub 2023 Aug 8 doi: 10.1097/DSS.0000000000003891. PMID: 37556446
S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Laser treatment of benign melanocytic lesion: a review.
Araghi F, Ohadi L, Moravvej H, Amani M, Allameh F, Dadkhahfar S
Lasers Med Sci 2022 Dec;37(9):3353-3362. Epub 2022 Sep 12 doi: 10.1007/s10103-022-03642-9. PMID: 36097230

Recent clinical studies

Etiology

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Melanocytic naevi, melanocytomas and emerging concepts.
Yeh I
Pathology 2023 Mar;55(2):178-186. Epub 2022 Dec 27 doi: 10.1016/j.pathol.2022.12.341. PMID: 36642570
Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Trends in pediatric skin cancer.
Moustafa D, Neale H, Hawryluk EB
Curr Opin Pediatr 2020 Aug;32(4):516-523. doi: 10.1097/MOP.0000000000000917. PMID: 32618791
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article

Diagnosis

Review: Are moles senescent?
Bennett DC
Pigment Cell Melanoma Res 2024 May;37(3):391-402. Epub 2024 Feb 15 doi: 10.1111/pcmr.13163. PMID: 38361107
Melanocytic naevi, melanocytomas and emerging concepts.
Yeh I
Pathology 2023 Mar;55(2):178-186. Epub 2022 Dec 27 doi: 10.1016/j.pathol.2022.12.341. PMID: 36642570
Spitz melanocytic tumours - a review.
Yeh I, Busam KJ
Histopathology 2022 Jan;80(1):122-134. doi: 10.1111/his.14583. PMID: 34958498
PRAME Expression in Melanocytic Tumors.
Lezcano C, Jungbluth AA, Nehal KS, Hollmann TJ, Busam KJ
Am J Surg Pathol 2018 Nov;42(11):1456-1465. doi: 10.1097/PAS.0000000000001134. PMID: 30045064Free PMC Article
Blue lesions.
Longo C, Scope A, Lallas A, Zalaudek I, Moscarella E, Gardini S, Argenziano G, Pellacani G
Dermatol Clin 2013 Oct;31(4):637-47, ix. Epub 2013 Aug 23 doi: 10.1016/j.det.2013.07.001. PMID: 24075551

Therapy

Trajectories of premalignancy during the journey from melanocyte to melanoma.
Colebatch AJ, Scolyer RA
Pathology 2018 Jan;50(1):16-23. Epub 2017 Nov 10 doi: 10.1016/j.pathol.2017.09.002. PMID: 29132722
The Genetic Evolution of Melanoma from Precursor Lesions.
Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC
N Engl J Med 2015 Nov 12;373(20):1926-36. doi: 10.1056/NEJMoa1502583. PMID: 26559571
Angioadnexocentric nevus.
Hashimoto K, Amano M, Setoyama M
J Dermatol 2012 Nov;39(11):909-15. Epub 2012 Jul 4 doi: 10.1111/j.1346-8138.2012.01599.x. PMID: 22762690
Dermoscopy.
Tanaka M
J Dermatol 2006 Aug;33(8):513-7. doi: 10.1111/j.1346-8138.2006.00126.x. PMID: 16923131
Cutaneous desmoplastic melanoma.
Busam KJ
Adv Anat Pathol 2005 Mar;12(2):92-102. doi: 10.1097/01.pap.0000155071.86944.a6. PMID: 15731577

Prognosis

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Clinical prediction guides

Blue naevi and the blue tumour spectrum.
de la Fouchardiere A
Pathology 2023 Mar;55(2):187-195. Epub 2022 Dec 28 doi: 10.1016/j.pathol.2022.12.342. PMID: 36641378
Interpretation of the Complex Melanoma Pathology Report.
Crompton JG, Busam KJ, Bartlett EK
Surg Oncol Clin N Am 2020 Jul;29(3):327-338. doi: 10.1016/j.soc.2020.02.013. PMID: 32482311
Noninvasive diagnosis in dermatology.
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Onychoscopy.
Lencastre A, Lamas A, Sá D, Tosti A
Clin Dermatol 2013 Sep-Oct;31(5):587-93. doi: 10.1016/j.clindermatol.2013.06.016. PMID: 24079588
Pointillist nevi.
Huynh PM, Glusac EJ, Bolognia JL
J Am Acad Dermatol 2001 Sep;45(3):397-400. doi: 10.1067/mjd.2001.116343. PMID: 11511837

Recent systematic reviews

Risk of melanoma in congenital melanocytic nevi of all sizes: A systematic review.
Scard C, Aubert H, Wargny M, Martin L, Barbarot S
J Eur Acad Dermatol Venereol 2023 Jan;37(1):32-39. Epub 2022 Oct 5 doi: 10.1111/jdv.18581. PMID: 36149403
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Genome-wide copy number variations as molecular diagnostic tool for cutaneous intermediate melanocytic lesions: a systematic review and individual patient data meta-analysis.
Ebbelaar CF, Jansen AML, Bloem LT, Blokx WAM
Virchows Arch 2021 Oct;479(4):773-783. Epub 2021 Apr 13 doi: 10.1007/s00428-021-03095-5. PMID: 33851238Free PMC Article

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