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Refractory Chronic Myeloid Leukemia, BCR-ABL1 Positive

MedGen UID:
234587
•Concept ID:
C1370868
•
Neoplastic Process
Synonyms: Refractory CGL; Refractory Chronic Granulocytic Leukemia; Refractory Chronic Myelocytic Leukemia; Refractory Chronic Myelogenous Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Refractory Chronic Myeloid Leukemia; Refractory Chronic Myeloid Leukemia, BCR::ABL1 Positive

Definition

Chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Chronic Myeloid Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

Asciminib for third-line treatment of chronic myeloid leukemia: Cost-effectiveness analysis based on treatment-free remission approach.
García Molina A
Farm Hosp 2024 Sep-Oct;48(5):T222-T229. Epub 2024 Jul 15 doi: 10.1016/j.farma.2024.06.004. PMID: 39013681
Asciminib for third-line treatment of chronic myeloid leukemia: Cost-effectiveness analysis based on treatment-free remission approach.
Garcia Molina A
Farm Hosp 2024 Sep-Oct;48(5):222-229. Epub 2024 Apr 27 doi: 10.1016/j.farma.2024.03.008. PMID: 38679535
Olverembatinib Treatment in Pediatric Patients With Relapsed Philadelphia-Chromosome-Positive Acute Lymphoblastic Leukemia.
Li X, Zhang J, Liu F, Liu T, Zhang R, Chen Y, Guo Y, Fang Y, Xu X, Pui CH, Zhu X
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):660-666. Epub 2023 May 11 doi: 10.1016/j.clml.2023.04.012. PMID: 37301632

Recent clinical studies

Etiology

Combination of venetoclax with BCR-ABL tyrosine kinase inhibitor as a therapeutic strategy for Philadelphia chromosome-positive leukemias.
Zou JY, Huang SM, Zhoub HX, Xu MZ, Sun AN, Wu DP, Xue SL, Zhang TT
Hematology 2023 Dec;28(1):2237790. doi: 10.1080/16078454.2023.2237790. PMID: 37477259
Application of precision medicine in clinical routine in haematology-Challenges and opportunities.
Wästerlid T, Cavelier L, Haferlach C, Konopleva M, Fröhling S, Östling P, Bullinger L, Fioretos T, Smedby KE
J Intern Med 2022 Aug;292(2):243-261. Epub 2022 Jun 4 doi: 10.1111/joim.13508. PMID: 35599019Free PMC Article
A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review.
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Expression of Hippo signaling pathway and Aurora kinase genes in chronic myeloid leukemia.
Marsola APZC, Simões BP, Palma LC, Berzoti-Coelho MG, Burin SM, de Castro FA
Med Oncol 2018 Jan 31;35(3):26. doi: 10.1007/s12032-018-1079-6. PMID: 29387948
Ponatinib in chronic myeloid leukemia (CML): Consensus on patient treatment and management from a European expert panel.
Müller MC, Cervantes F, Hjorth-Hansen H, Janssen JJWM, Milojkovic D, Rea D, Rosti G
Crit Rev Oncol Hematol 2017 Dec;120:52-59. Epub 2017 Oct 8 doi: 10.1016/j.critrevonc.2017.10.002. PMID: 29198338

Diagnosis

Ponatinib and blinatumomab for Philadelphia chromosome-positive acute lymphoblastic leukaemia: a US, single-centre, single-arm, phase 2 trial.
Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Application of precision medicine in clinical routine in haematology-Challenges and opportunities.
Wästerlid T, Cavelier L, Haferlach C, Konopleva M, Fröhling S, Östling P, Bullinger L, Fioretos T, Smedby KE
J Intern Med 2022 Aug;292(2):243-261. Epub 2022 Jun 4 doi: 10.1111/joim.13508. PMID: 35599019Free PMC Article
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Omacetaxine Mepesuccinate for Chronic Myeloid Leukemia.
Rosshandler Y, Shen AQ, Cortes J, Khoury HJ
Expert Rev Hematol 2016 May;9(5):419-24. Epub 2016 Apr 21 doi: 10.1586/17474086.2016.1151351. PMID: 26853281
Myelodysplastic/myeloproliferative neoplasms.
Cazzola M, Malcovati L, Invernizzi R
Hematology Am Soc Hematol Educ Program 2011;2011:264-72. doi: 10.1182/asheducation-2011.1.264. PMID: 22160044

Therapy

Ponatinib and blinatumomab for Philadelphia chromosome-positive acute lymphoblastic leukaemia: a US, single-centre, single-arm, phase 2 trial.
Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay.
Perrotti D, Silvestri G, Stramucci L, Yu J, Trotta R
Curr Drug Targets 2017;18(4):377-388. doi: 10.2174/1389450117666160615074120. PMID: 27307150Free PMC Article
Omacetaxine Mepesuccinate for Chronic Myeloid Leukemia.
Rosshandler Y, Shen AQ, Cortes J, Khoury HJ
Expert Rev Hematol 2016 May;9(5):419-24. Epub 2016 Apr 21 doi: 10.1586/17474086.2016.1151351. PMID: 26853281
New Insights into the Molecular Resistance Mechanisms of Chronic Myeloid Leukemia.
Huang R, Kang Q, Liu H, Li Y
Curr Cancer Drug Targets 2016;16(4):323-45. doi: 10.2174/1568009615666150921141004. PMID: 26391311
Omacetaxine mepesuccinate in chronic myeloid leukemia.
Al Ustwani O, Griffiths EA, Wang ES, Wetzler M
Expert Opin Pharmacother 2014 Nov;15(16):2397-405. doi: 10.1517/14656566.2014.964642. PMID: 25301179

Prognosis

Application of precision medicine in clinical routine in haematology-Challenges and opportunities.
Wästerlid T, Cavelier L, Haferlach C, Konopleva M, Fröhling S, Östling P, Bullinger L, Fioretos T, Smedby KE
J Intern Med 2022 Aug;292(2):243-261. Epub 2022 Jun 4 doi: 10.1111/joim.13508. PMID: 35599019Free PMC Article
A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review.
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Expression of Hippo signaling pathway and Aurora kinase genes in chronic myeloid leukemia.
Marsola APZC, Simões BP, Palma LC, Berzoti-Coelho MG, Burin SM, de Castro FA
Med Oncol 2018 Jan 31;35(3):26. doi: 10.1007/s12032-018-1079-6. PMID: 29387948
Myelodysplastic/myeloproliferative neoplasms.
Cazzola M, Malcovati L, Invernizzi R
Hematology Am Soc Hematol Educ Program 2011;2011:264-72. doi: 10.1182/asheducation-2011.1.264. PMID: 22160044
Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele.
Virgili A, Koptyra M, Dasgupta Y, Glodkowska-Mrowka E, Stoklosa T, Nacheva EP, Skorski T
Cancer Res 2011 Aug 15;71(16):5381-6. Epub 2011 Jun 21 doi: 10.1158/0008-5472.CAN-11-0068. PMID: 21693657Free PMC Article

Clinical prediction guides

Ponatinib and blinatumomab for Philadelphia chromosome-positive acute lymphoblastic leukaemia: a US, single-centre, single-arm, phase 2 trial.
Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review.
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Expression of Hippo signaling pathway and Aurora kinase genes in chronic myeloid leukemia.
Marsola APZC, Simões BP, Palma LC, Berzoti-Coelho MG, Burin SM, de Castro FA
Med Oncol 2018 Jan 31;35(3):26. doi: 10.1007/s12032-018-1079-6. PMID: 29387948
The impact of multiple low-level BCR-ABL1 mutations on response to ponatinib.
Parker WT, Yeung DT, Yeoman AL, Altamura HK, Jamison BA, Field CR, Hodgson JG, Lustgarten S, Rivera VM, Hughes TP, Branford S
Blood 2016 Apr 14;127(15):1870-80. Epub 2016 Jan 14 doi: 10.1182/blood-2015-09-666214. PMID: 26773037Free PMC Article

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