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Salivary gland mucoepidermoid carcinoma

MedGen UID:
277630
•Concept ID:
C1335903
•
Neoplastic Process
Synonyms: Mucoepidermoid carcinoma of salivary gland; Mucoepidermoid Carcinoma of Salivary Gland; mucoepidermoid carcinoma of salivary gland; Mucoepidermoid Carcinoma of the Salivary Gland; mucoepidermoid carcinoma of the salivary gland; saliva-secreting gland mucoepidermoid carcinoma; Salivary Gland Mucoepidermoid Carcinoma; salivary gland mucoepidermoid carcinoma
SNOMED CT: Mucoepidermoid carcinoma of salivary gland (423708008)
 
Monarch Initiative: MONDO:0021009

Definition

A carcinoma that arises from the salivary glands. It is the most common primary carcinoma of the salivary glands and usually presents as a firm and painless mass. It is characterized by the presence of squamous cells, mucus producing cells, and cells of intermediate type. The majority of cases have a favorable outcome. [from NCI]

Professional guidelines

PubMed

Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria.
Goode RK, Auclair PL, Ellis GL
Cancer 1998 Apr 1;82(7):1217-24. doi: 10.1002/(sici)1097-0142(19980401)82:7<1217::aid-cncr2>3.0.co;2-c. PMID: 9529011

Recent clinical studies

Etiology

Epidemiological and clinical characteristics of synchronous lung metastasis in major salivary gland mucoepidermoid carcinoma.
Li Y, Hu C
Eur Arch Otorhinolaryngol 2023 Aug;280(8):3835-3841. Epub 2023 Apr 26 doi: 10.1007/s00405-023-07963-5. PMID: 37100896
Prognostic impact of MUC1 and potential regulatory miR-145 and miR-21 expression in salivary mucoepidermoid carcinoma.
Abdolrahmani A, Kardouni Khoozestani N, Azmoudeh-Ardalan F, Shamshiri AR
Head Neck Pathol 2022 Dec;16(4):1134-1145. Epub 2022 Aug 18 doi: 10.1007/s12105-022-01475-0. PMID: 35980523Free PMC Article
Prognostic impact of CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma: A multiinstitutional retrospective study.
Okumura Y, Nakano S, Murase T, Ueda K, Kawakita D, Nagao T, Kusafuka K, Urano M, Yamamoto H, Kano S, Tsukahara K, Okami K, Nagao T, Hanai N, Iwai H, Kawata R, Tada Y, Nibu KI, Inagaki H
Cancer Sci 2020 Nov;111(11):4195-4204. Epub 2020 Sep 14 doi: 10.1111/cas.14632. PMID: 32860299Free PMC Article
A comparative analysis of sinonasal and salivary gland mucoepidermoid carcinoma using population-based data.
Patel TD, Vázquez A, Patel DM, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2015 Jan;5(1):78-84. Epub 2014 Oct 20 doi: 10.1002/alr.21422. PMID: 25332187
Clinicopathological features of mucoepidermoid carcinoma.
Yamazaki K, Ohta H, Shodo R, Matsuyama H, Takahashi S
J Laryngol Otol 2014 Jan;128(1):91-5. Epub 2014 Jan 22 doi: 10.1017/S0022215113003459. PMID: 24451647

Diagnosis

Identifying potential immuno-oncology targets in salivary gland mucoepidermoid carcinoma based on inflammatory status and treatment response.
Urumarudappa SKJ, Tran VNT, Oo HM, Suntiparpluacha M, Sampattavanich S, Rosa V, Ruangritchankul K, Ferreira JN, Chaisuparat R
J Oral Pathol Med 2023 Nov;52(10):939-950. Epub 2023 Sep 27 doi: 10.1111/jop.13488. PMID: 37756121
Epidemiological and clinical characteristics of synchronous lung metastasis in major salivary gland mucoepidermoid carcinoma.
Li Y, Hu C
Eur Arch Otorhinolaryngol 2023 Aug;280(8):3835-3841. Epub 2023 Apr 26 doi: 10.1007/s00405-023-07963-5. PMID: 37100896
Survival of salivary gland cancer stem cells requires mTOR signaling.
Andrade NP, Warner KA, Zhang Z, Pearson AT, Mantesso A, Guimaraēs DM, Altemani A, Mariano FV, Nunes FD, Nör JE
Cell Death Dis 2021 Jan 21;12(1):108. doi: 10.1038/s41419-021-03391-7. PMID: 33479203Free PMC Article
Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.
Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP
Head Neck Pathol 2021 Jun;15(2):491-502. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01226-z. PMID: 32959209Free PMC Article
Clinicopathologic and genetic features of primary bronchopulmonary mucoepidermoid carcinoma: the MD Anderson Cancer Center experience and comprehensive review of the literature.
Salem A, Bell D, Sepesi B, Papadimitrakopoulou V, El-Naggar A, Moran CA, Kalhor N
Virchows Arch 2017 Jun;470(6):619-626. Epub 2017 Mar 25 doi: 10.1007/s00428-017-2104-4. PMID: 28343305

Prognosis

Identifying potential immuno-oncology targets in salivary gland mucoepidermoid carcinoma based on inflammatory status and treatment response.
Urumarudappa SKJ, Tran VNT, Oo HM, Suntiparpluacha M, Sampattavanich S, Rosa V, Ruangritchankul K, Ferreira JN, Chaisuparat R
J Oral Pathol Med 2023 Nov;52(10):939-950. Epub 2023 Sep 27 doi: 10.1111/jop.13488. PMID: 37756121
Epidemiological and clinical characteristics of synchronous lung metastasis in major salivary gland mucoepidermoid carcinoma.
Li Y, Hu C
Eur Arch Otorhinolaryngol 2023 Aug;280(8):3835-3841. Epub 2023 Apr 26 doi: 10.1007/s00405-023-07963-5. PMID: 37100896
Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.
Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP
Head Neck Pathol 2021 Jun;15(2):491-502. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01226-z. PMID: 32959209Free PMC Article
Clinicopathologic and genetic features of primary bronchopulmonary mucoepidermoid carcinoma: the MD Anderson Cancer Center experience and comprehensive review of the literature.
Salem A, Bell D, Sepesi B, Papadimitrakopoulou V, El-Naggar A, Moran CA, Kalhor N
Virchows Arch 2017 Jun;470(6):619-626. Epub 2017 Mar 25 doi: 10.1007/s00428-017-2104-4. PMID: 28343305
Clinicopathological features of mucoepidermoid carcinoma.
Yamazaki K, Ohta H, Shodo R, Matsuyama H, Takahashi S
J Laryngol Otol 2014 Jan;128(1):91-5. Epub 2014 Jan 22 doi: 10.1017/S0022215113003459. PMID: 24451647

Clinical prediction guides

Identifying potential immuno-oncology targets in salivary gland mucoepidermoid carcinoma based on inflammatory status and treatment response.
Urumarudappa SKJ, Tran VNT, Oo HM, Suntiparpluacha M, Sampattavanich S, Rosa V, Ruangritchankul K, Ferreira JN, Chaisuparat R
J Oral Pathol Med 2023 Nov;52(10):939-950. Epub 2023 Sep 27 doi: 10.1111/jop.13488. PMID: 37756121
Survival of salivary gland cancer stem cells requires mTOR signaling.
Andrade NP, Warner KA, Zhang Z, Pearson AT, Mantesso A, Guimaraēs DM, Altemani A, Mariano FV, Nunes FD, Nör JE
Cell Death Dis 2021 Jan 21;12(1):108. doi: 10.1038/s41419-021-03391-7. PMID: 33479203Free PMC Article
mTOR Inhibition Ablates Cisplatin-Resistant Salivary Gland Cancer Stem Cells.
Nakano T, Warner KA, Oklejas AE, Zhang Z, Rodriguez-Ramirez C, Shuman AG, Nör JE
J Dent Res 2021 Apr;100(4):377-386. Epub 2020 Oct 17 doi: 10.1177/0022034520965141. PMID: 33073679Free PMC Article
Expression of Mucins in Salivary Gland Mucoepidermoid Carcinoma.
Robinson L, van Heerden MB, Ker-Fox JG, Hunter KD, van Heerden WFP
Head Neck Pathol 2021 Jun;15(2):491-502. Epub 2020 Sep 21 doi: 10.1007/s12105-020-01226-z. PMID: 32959209Free PMC Article
Clinicopathological features of mucoepidermoid carcinoma.
Yamazaki K, Ohta H, Shodo R, Matsuyama H, Takahashi S
J Laryngol Otol 2014 Jan;128(1):91-5. Epub 2014 Jan 22 doi: 10.1017/S0022215113003459. PMID: 24451647

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