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High Grade Sarcoma

MedGen UID:
234347
Concept ID:
C1334008
Neoplastic Process
Synonyms: High-Grade Sarcoma; Poorly Differentiated or Undifferentiated Sarcoma

Definition

A sarcoma with the morphologic features of a high grade tumor and lack of differentiation. [from NCI]

Professional guidelines

PubMed

Stacchiotti S, Tap W, Leonard H, Zaffaroni N, Baldi GG
Curr Treat Options Oncol 2023 Jun;24(6):667-679. Epub 2023 Apr 14 doi: 10.1007/s11864-023-01076-1. PMID: 37058275
Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299

Recent clinical studies

Etiology

Bernardes Antunes P, Gonçalves B
Rev Esp Enferm Dig 2023 Sep;115(9):517-518. doi: 10.17235/reed.2022.9093/2022. PMID: 36043549
Chan EY, Ali A, Zubair MM, Nguyen DT, Ibarra-Cortez SH, Graviss EA, Shapira OM, Ravi V, MacGillivray TE, Reardon MJ
J Thorac Cardiovasc Surg 2023 Sep;166(3):828-838.e2. Epub 2022 Feb 1 doi: 10.1016/j.jtcvs.2021.10.070. PMID: 35219517
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Stacchiotti S, Miah AB, Frezza AM, Messiou C, Morosi C, Caraceni A, Antonescu CR, Bajpai J, Baldini E, Bauer S, Biagini R, Bielack S, Blay JY, Bonvalot S, Boukovinas I, Bovee JVMG, Boye K, Brodowicz T, Callegaro D, De Alava E, Deoras-Sutliff M, Dufresne A, Eriksson M, Errani C, Fedenko A, Ferraresi V, Ferrari A, Fletcher CDM, Garcia Del Muro X, Gelderblom H, Gladdy RA, Gouin F, Grignani G, Gutkovich J, Haas R, Hindi N, Hohenberger P, Huang P, Joensuu H, Jones RL, Jungels C, Kasper B, Kawai A, Le Cesne A, Le Grange F, Leithner A, Leonard H, Lopez Pousa A, Martin Broto J, Merimsky O, Merriam P, Miceli R, Mir O, Molinari M, Montemurro M, Oldani G, Palmerini E, Pantaleo MA, Patel S, Piperno-Neumann S, Raut CP, Ravi V, Razak ARA, Reichardt P, Rubin BP, Rutkowski P, Safwat AA, Sangalli C, Sapisochin G, Sbaraglia M, Scheipl S, Schöffski P, Strauss D, Strauss SJ, Sundby Hall K, Tap WD, Trama A, Tweddle A, van der Graaf WTA, Van De Sande MAJ, Van Houdt W, van Oortmerssen G, Wagner AJ, Wartenberg M, Wood J, Zaffaroni N, Zimmermann C, Casali PG, Dei Tos AP, Gronchi A
ESMO Open 2021 Jun;6(3):100170. Epub 2021 Jun 2 doi: 10.1016/j.esmoop.2021.100170. PMID: 34090171Free PMC Article
Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

Stacchiotti S, Tap W, Leonard H, Zaffaroni N, Baldi GG
Curr Treat Options Oncol 2023 Jun;24(6):667-679. Epub 2023 Apr 14 doi: 10.1007/s11864-023-01076-1. PMID: 37058275
Lee YL, Bai YS, Chang CC, Huang CY, Kung FT, Yin CS
Taiwan J Obstet Gynecol 2022 Mar;61(2):388-390. doi: 10.1016/j.tjog.2022.02.036. PMID: 35361409
Yamamoto H, Ishihara S, Toda Y, Oda Y
Med Mol Morphol 2020 Mar;53(1):1-6. Epub 2019 Nov 20 doi: 10.1007/s00795-019-00238-1. PMID: 31748824
Marwan H, Green JM 3rd, Tursun R, Marx RE
J Oral Maxillofac Surg 2016 Nov;74(11):2312-2316. Epub 2016 May 3 doi: 10.1016/j.joms.2016.04.028. PMID: 27235177
Mir O, Berrada N, Domont J, Cioffi A, Boulet B, Terrier P, Bonvalot S, Trichot C, Lokiec F, Le Cesne A
Cancer Chemother Pharmacol 2012 Feb;69(2):357-67. Epub 2011 Jul 19 doi: 10.1007/s00280-011-1707-8. PMID: 21769666

Prognosis

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467
Lou S, Balluff B, de Graaff MA, Cleven AH, Briaire-de Bruijn I, Bovée JV, McDonnell LA
Proteomics 2016 Jun;16(11-12):1802-13. doi: 10.1002/pmic.201500514. PMID: 27174013
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Clinical prediction guides

Stacchiotti S, Tap W, Leonard H, Zaffaroni N, Baldi GG
Curr Treat Options Oncol 2023 Jun;24(6):667-679. Epub 2023 Apr 14 doi: 10.1007/s11864-023-01076-1. PMID: 37058275
Le MK, Omori M, Oishi N, Oi M, Fukasawa H, Hirata S, Kondo T
Pathol Int 2021 Mar;71(3):199-203. Epub 2021 Jan 14 doi: 10.1111/pin.13065. PMID: 33444473
Kachare SD, Brinkley J, Vohra NA, Zervos EE, Wong JH, Fitzgerald TL
J Surg Oncol 2015 Sep;112(4):338-43. Epub 2015 Aug 7 doi: 10.1002/jso.23989. PMID: 26250782
Mir O, Berrada N, Domont J, Cioffi A, Boulet B, Terrier P, Bonvalot S, Trichot C, Lokiec F, Le Cesne A
Cancer Chemother Pharmacol 2012 Feb;69(2):357-67. Epub 2011 Jul 19 doi: 10.1007/s00280-011-1707-8. PMID: 21769666
Wilkins RM, Camozzi AB, Gitelis SB
J Knee Surg 2005 Oct;18(4):305-9. doi: 10.1055/s-0030-1248197. PMID: 16262014

Recent systematic reviews

Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366

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