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Aggressive NK-cell leukemia

MedGen UID:
266235
Concept ID:
C1292777
Neoplastic Process
Synonym: Aggressive natural killer cell leukemia
SNOMED CT: Aggressive NK-cell leukemia (128833001); Aggressive NK cell leukemia (128833001); Aggressive natural killer-cell leukemia (128833001); Aggressive natural killer-cell leukemia (721310007)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019470
Orphanet: ORPHA86873

Definition

An extremely rare and highly aggressive neoplasm, usually manifesting in the third to fourth decade of life, affecting males and females equally, and characterized by the onset of high fever, weight loss, jaundice, skin infiltration, lymphadenopathy, hepatosplenomegaly, and severe anemia. It has a fulminant and rapidly fatal disease course with the progressive appearance of multiorgan failure and disseminated intravascular coagulation. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggressive NK-cell leukemia
Follow this link to review classifications for Aggressive NK-cell leukemia in Orphanet.

Professional guidelines

PubMed

Tse E, Au-Yeung R, Kwong YL
Expert Rev Hematol 2019 Nov;12(11):927-935. Epub 2019 Sep 5 doi: 10.1080/17474086.2019.1660640. PMID: 31487202
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476

Recent clinical studies

Etiology

Liu DL, Wang YJ, Qian SY, Ma SS, Ding MJ, Dong M, Zhang JM, Zhang MZ, Chen QJ, Zhang XD
Hematology 2024 Dec;29(1):2307817. Epub 2024 Feb 6 doi: 10.1080/16078454.2024.2307817. PMID: 38319083
Boo YL, Koh LP
Transplant Cell Ther 2021 Jul;27(7):571-588. Epub 2021 Apr 20 doi: 10.1016/j.jtct.2021.04.002. PMID: 33857661
El Hussein S, Patel KP, Fang H, Thakral B, Loghavi S, Kanagal-Shamanna R, Konoplev S, Jabbour EJ, Medeiros LJ, Khoury JD
Am J Surg Pathol 2020 Sep;44(9):1235-1243. doi: 10.1097/PAS.0000000000001518. PMID: 32590457
Montes-Mojarro IA, Kim WY, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2020 Jan;37(1):32-46. Epub 2019 Dec 17 doi: 10.1053/j.semdp.2019.12.004. PMID: 31889602
Liang X, Graham DK
Cancer 2008 Apr 1;112(7):1425-36. doi: 10.1002/cncr.23316. PMID: 18286525

Diagnosis

Liu DL, Wang YJ, Qian SY, Ma SS, Ding MJ, Dong M, Zhang JM, Zhang MZ, Chen QJ, Zhang XD
Hematology 2024 Dec;29(1):2307817. Epub 2024 Feb 6 doi: 10.1080/16078454.2024.2307817. PMID: 38319083
Shafiee A, Shamsi S, Kohandel Gargari O, Beiky M, Allahkarami MM, Miyanaji AB, Aghajanian S, Mozhgani SH
Rev Med Virol 2022 Jul;32(4):e2328. Epub 2022 Feb 4 doi: 10.1002/rmv.2328. PMID: 35122349
El Hussein S, Patel KP, Fang H, Thakral B, Loghavi S, Kanagal-Shamanna R, Konoplev S, Jabbour EJ, Medeiros LJ, Khoury JD
Am J Surg Pathol 2020 Sep;44(9):1235-1243. doi: 10.1097/PAS.0000000000001518. PMID: 32590457
Tse E, Au-Yeung R, Kwong YL
Expert Rev Hematol 2019 Nov;12(11):927-935. Epub 2019 Sep 5 doi: 10.1080/17474086.2019.1660640. PMID: 31487202
Choi WT, Gill RM
Surg Pathol Clin 2018 Jun;11(2):389-402. Epub 2018 Mar 21 doi: 10.1016/j.path.2018.02.003. PMID: 29751882

Therapy

Tse E, Au-Yeung R, Kwong YL
Expert Rev Hematol 2019 Nov;12(11):927-935. Epub 2019 Sep 5 doi: 10.1080/17474086.2019.1660640. PMID: 31487202
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106
Suzuki R
Int J Hematol 2010 Dec;92(5):697-701. Epub 2010 Dec 1 doi: 10.1007/s12185-010-0726-2. PMID: 21116747
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476
Greer JP, Mosse CA
Curr Hematol Malig Rep 2009 Oct;4(4):245-52. doi: 10.1007/s11899-009-0032-3. PMID: 20425414

Prognosis

Liu DL, Wang YJ, Qian SY, Ma SS, Ding MJ, Dong M, Zhang JM, Zhang MZ, Chen QJ, Zhang XD
Hematology 2024 Dec;29(1):2307817. Epub 2024 Feb 6 doi: 10.1080/16078454.2024.2307817. PMID: 38319083
Montes-Mojarro IA, Kim WY, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2020 Jan;37(1):32-46. Epub 2019 Dec 17 doi: 10.1053/j.semdp.2019.12.004. PMID: 31889602
Kimura H
Adv Exp Med Biol 2018;1045:459-475. doi: 10.1007/978-981-10-7230-7_21. PMID: 29896680
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106
Greer JP, Mosse CA
Curr Hematol Malig Rep 2009 Oct;4(4):245-52. doi: 10.1007/s11899-009-0032-3. PMID: 20425414

Clinical prediction guides

Liu DL, Wang YJ, Qian SY, Ma SS, Ding MJ, Dong M, Zhang JM, Zhang MZ, Chen QJ, Zhang XD
Hematology 2024 Dec;29(1):2307817. Epub 2024 Feb 6 doi: 10.1080/16078454.2024.2307817. PMID: 38319083
Hong M, Lee T, Young Kang S, Kim SJ, Kim W, Ko YH
Mod Pathol 2016 May;29(5):430-43. Epub 2016 Mar 25 doi: 10.1038/modpathol.2016.47. PMID: 27015135
Sekiguchi N, Asano N, Ito T, Momose K, Momose M, Ishida F
Int J Hematol 2012 Oct;96(4):461-8. Epub 2012 Aug 14 doi: 10.1007/s12185-012-1159-x. PMID: 22890551
Makishima H, Ito T, Momose K, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Ichikawa N, Ueno M, Kobayashi H, Kitano K, Saito H, Kiyosawa K, Ishida F
Leuk Res 2007 Sep;31(9):1237-45. Epub 2006 Nov 22 doi: 10.1016/j.leukres.2006.10.020. PMID: 17123604
Chan JK
Semin Diagn Pathol 2003 May;20(2):105-20. doi: 10.1016/s0740-2570(03)00013-3. PMID: 12945934

Recent systematic reviews

Alekshun TJ, Sokol L
Cancer Control 2007 Apr;14(2):141-50. doi: 10.1177/107327480701400207. PMID: 17387299

Supplemental Content

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