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Therapy related acute myeloid leukemia and myelodysplastic syndrome

MedGen UID:
220954
•Concept ID:
C1292776
•
Neoplastic Process
Synonyms: Acute Myeloid Leukaemias and Myelodysplastic Syndromes, Therapy-Related; Myeloid neoplasm post cytotoxic therapy; Myeloid Neoplasm Post Cytotoxic Therapy; Secondary Acute granulocytic Leukaemia; Secondary Acute granulocytic Leukemia; Secondary Acute myeloblastic Leukaemia; Secondary Acute myeloblastic Leukemia; Secondary Acute myelocytic Leukaemia; Secondary Acute myelocytic Leukemia; Secondary Acute myelogenous Leukaemia; Secondary Acute myelogenous Leukemia; secondary acute myeloid leukaemia; Secondary Acute myeloid Leukaemia (AML); Secondary acute myeloid leukemia; secondary acute myeloid leukemia; Secondary Acute myeloid Leukemia (AML); Secondary AGL; Secondary AML; secondary AML; therapy related acute myeloid leukemia and myelodysplastic syndrome; Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome; Therapy-Related AML and MDS; Therapy-related AML and myelodysplastic syndrome; therapy-related AML and myelodysplastic syndrome; Therapy-Related Myeloid Neoplasm
SNOMED CT: Therapy related acute myeloid leukemia and myelodysplastic syndrome (721306009); Myeloid neoplasm post cytotoxic therapy (1251599007)
 
Monarch Initiative: MONDO:0019457
Orphanet: ORPHA86846

Definition

Acute myeloid leukemias, myelodysplastic syndromes, and myelodysplastic/myeloproliferative neoplasms arising as a result of the mutagenic effect of chemotherapy agents and/or radiation that are used for the treatment of neoplastic or non-neoplastic disorders. [from NCI]

Professional guidelines

PubMed

Clonal selection in therapy-related myelodysplastic syndromes and acute myeloid leukemia under azacitidine treatment.
Calleja A, Yun S, Moreilhon C, Karsenti JM, Gastaud L, Mannone L, Komrokji R, Al Ali N, Dadone-Montaudie B, Robert G, Auberger P, Raynaud S, Sallman DA, Cluzeau T
Eur J Haematol 2020 May;104(5):488-498. Epub 2020 Mar 9 doi: 10.1111/ejh.13390. PMID: 31990086
Therapy-related myelodysplastic syndrome and acute myeloid leukemia following treatment of acute myeloid leukemia: possible role of cytarabine.
Arana-Yi C, Block AW, Sait SN, Ford LA, Barcos M, Baer MR
Leuk Res 2008 Jul;32(7):1043-8. Epub 2008 Feb 21 doi: 10.1016/j.leukres.2007.11.006. PMID: 18093651

Recent clinical studies

Etiology

Characteristics and Outcomes of Patients With Multiple Myeloma Who Developed Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome After Autologous Cell Transplantation.
Yalniz FF, Greenbaum U, Pasvolsky O, Milton DR, Kanagal-Shamanna R, Ramdial J, Srour S, Mehta R, Alousi A, Popat UR, Nieto Y, Kebriaei P, Al-Atrash G, Oran B, Hosing C, Ahmed S, Champlin RE, Shpall EJ, Qazilbash MH, Bashir Q
Transplant Cell Ther 2024 Feb;30(2):205.e1-205.e12. Epub 2023 Jul 10 doi: 10.1016/j.jtct.2023.06.015. PMID: 37437764
Clinicopathological aspects of therapy-related acute myeloid leukemia and myelodysplastic syndrome.
Chua CC, Fleming S, Wei AH
Best Pract Res Clin Haematol 2019 Mar;32(1):3-12. Epub 2019 Feb 27 doi: 10.1016/j.beha.2019.02.007. PMID: 30927972
Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients.
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Therapy-related acute myeloid leukemia and myelodysplastic syndrome after hematopoietic cell transplantation for lymphoma.
Yamasaki S, Suzuki R, Hatano K, Fukushima K, Iida H, Morishima S, Suehiro Y, Fukuda T, Uchida N, Uchiyama H, Ikeda H, Yokota A, Tsukasaki K, Yamaguchi H, Kuroda J, Nakamae H, Adachi Y, Matsuoka KI, Nakamura Y, Atsuta Y, Suzumiya J
Bone Marrow Transplant 2017 Jul;52(7):969-976. Epub 2017 Apr 3 doi: 10.1038/bmt.2017.52. PMID: 28368379
Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome.
Kröger N, Brand R, van Biezen A, Cahn JY, Slavin S, Blaise D, Sierra J, Zander A, Niederwieser D, de Witte T; Myelodysplastic Syndromes Subcommittee of The Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Bone Marrow Transplant 2006 Jan;37(2):183-9. doi: 10.1038/sj.bmt.1705226. PMID: 16299545

Diagnosis

Characteristics and Outcomes of Patients With Multiple Myeloma Who Developed Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome After Autologous Cell Transplantation.
Yalniz FF, Greenbaum U, Pasvolsky O, Milton DR, Kanagal-Shamanna R, Ramdial J, Srour S, Mehta R, Alousi A, Popat UR, Nieto Y, Kebriaei P, Al-Atrash G, Oran B, Hosing C, Ahmed S, Champlin RE, Shpall EJ, Qazilbash MH, Bashir Q
Transplant Cell Ther 2024 Feb;30(2):205.e1-205.e12. Epub 2023 Jul 10 doi: 10.1016/j.jtct.2023.06.015. PMID: 37437764
Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients.
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome.
Kröger N, Brand R, van Biezen A, Cahn JY, Slavin S, Blaise D, Sierra J, Zander A, Niederwieser D, de Witte T; Myelodysplastic Syndromes Subcommittee of The Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Bone Marrow Transplant 2006 Jan;37(2):183-9. doi: 10.1038/sj.bmt.1705226. PMID: 16299545

Therapy

Characteristics and Outcomes of Patients With Multiple Myeloma Who Developed Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome After Autologous Cell Transplantation.
Yalniz FF, Greenbaum U, Pasvolsky O, Milton DR, Kanagal-Shamanna R, Ramdial J, Srour S, Mehta R, Alousi A, Popat UR, Nieto Y, Kebriaei P, Al-Atrash G, Oran B, Hosing C, Ahmed S, Champlin RE, Shpall EJ, Qazilbash MH, Bashir Q
Transplant Cell Ther 2024 Feb;30(2):205.e1-205.e12. Epub 2023 Jul 10 doi: 10.1016/j.jtct.2023.06.015. PMID: 37437764
Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients.
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Therapy-related acute myeloid leukemia and myelodysplastic syndrome after hematopoietic cell transplantation for lymphoma.
Yamasaki S, Suzuki R, Hatano K, Fukushima K, Iida H, Morishima S, Suehiro Y, Fukuda T, Uchida N, Uchiyama H, Ikeda H, Yokota A, Tsukasaki K, Yamaguchi H, Kuroda J, Nakamae H, Adachi Y, Matsuoka KI, Nakamura Y, Atsuta Y, Suzumiya J
Bone Marrow Transplant 2017 Jul;52(7):969-976. Epub 2017 Apr 3 doi: 10.1038/bmt.2017.52. PMID: 28368379
Therapy-related leukemia and myelodysplasia following oral administration of etoposide for recurrent breast cancer.
Yagita M, Ieki Y, Onishi R, Huang CL, Adachi M, Horiike S, Konaka Y, Taki T, Miyake M
Int J Oncol 1998 Jul;13(1):91-6. doi: 10.3892/ijo.13.1.91. PMID: 9625808
Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases.
Michels SD, McKenna RW, Arthur DC, Brunning RD
Blood 1985 Jun;65(6):1364-72. PMID: 3857944

Prognosis

Characteristics and Outcomes of Patients With Multiple Myeloma Who Developed Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome After Autologous Cell Transplantation.
Yalniz FF, Greenbaum U, Pasvolsky O, Milton DR, Kanagal-Shamanna R, Ramdial J, Srour S, Mehta R, Alousi A, Popat UR, Nieto Y, Kebriaei P, Al-Atrash G, Oran B, Hosing C, Ahmed S, Champlin RE, Shpall EJ, Qazilbash MH, Bashir Q
Transplant Cell Ther 2024 Feb;30(2):205.e1-205.e12. Epub 2023 Jul 10 doi: 10.1016/j.jtct.2023.06.015. PMID: 37437764
Therapy-related acute myeloid leukemia and myelodysplastic syndrome among refractory germ cell tumor patients.
Inoue Y, Nakamura T, Nakanishi H, Oishi M, Hongo F, Okihara K, Mizutani S, Kuroda J, Ukimura O
Int J Urol 2018 Jul;25(7):678-683. Epub 2018 May 11 doi: 10.1111/iju.13597. PMID: 29752743
Therapy-related acute myeloid leukemia and myelodysplastic syndrome after hematopoietic cell transplantation for lymphoma.
Yamasaki S, Suzuki R, Hatano K, Fukushima K, Iida H, Morishima S, Suehiro Y, Fukuda T, Uchida N, Uchiyama H, Ikeda H, Yokota A, Tsukasaki K, Yamaguchi H, Kuroda J, Nakamae H, Adachi Y, Matsuoka KI, Nakamura Y, Atsuta Y, Suzumiya J
Bone Marrow Transplant 2017 Jul;52(7):969-976. Epub 2017 Apr 3 doi: 10.1038/bmt.2017.52. PMID: 28368379
High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome.
Cleven AH, Nardi V, Ok CY, Goswami M, Dal Cin P, Zheng Z, Iafrate AJ, Abdul Hamid MA, Wang SA, Hasserjian RP
Mod Pathol 2015 Apr;28(4):552-63. Epub 2014 Nov 21 doi: 10.1038/modpathol.2014.153. PMID: 25412846
Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome.
Kröger N, Brand R, van Biezen A, Cahn JY, Slavin S, Blaise D, Sierra J, Zander A, Niederwieser D, de Witte T; Myelodysplastic Syndromes Subcommittee of The Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Bone Marrow Transplant 2006 Jan;37(2):183-9. doi: 10.1038/sj.bmt.1705226. PMID: 16299545

Clinical prediction guides

Characteristics and Outcomes of Patients With Multiple Myeloma Who Developed Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome After Autologous Cell Transplantation.
Yalniz FF, Greenbaum U, Pasvolsky O, Milton DR, Kanagal-Shamanna R, Ramdial J, Srour S, Mehta R, Alousi A, Popat UR, Nieto Y, Kebriaei P, Al-Atrash G, Oran B, Hosing C, Ahmed S, Champlin RE, Shpall EJ, Qazilbash MH, Bashir Q
Transplant Cell Ther 2024 Feb;30(2):205.e1-205.e12. Epub 2023 Jul 10 doi: 10.1016/j.jtct.2023.06.015. PMID: 37437764
High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome.
Cleven AH, Nardi V, Ok CY, Goswami M, Dal Cin P, Zheng Z, Iafrate AJ, Abdul Hamid MA, Wang SA, Hasserjian RP
Mod Pathol 2015 Apr;28(4):552-63. Epub 2014 Nov 21 doi: 10.1038/modpathol.2014.153. PMID: 25412846
Therapy-related leukemia and myelodysplasia following oral administration of etoposide for recurrent breast cancer.
Yagita M, Ieki Y, Onishi R, Huang CL, Adachi M, Horiike S, Konaka Y, Taki T, Miyake M
Int J Oncol 1998 Jul;13(1):91-6. doi: 10.3892/ijo.13.1.91. PMID: 9625808

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