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Childhood testicular germ cell tumor

MedGen UID:
208758
•Concept ID:
C0796663
•
Neoplastic Process
Synonyms: Childhood Testicular Germ Cell Neoplasm; childhood testicular germ cell neoplasm; Childhood Testicular Germ Cell Tumor; childhood testicular germ cell tumor; paediatric testicular germ cell neoplasm; paediatric testicular germ cell tumour; Pediatric Testicular Germ Cell Neoplasm; pediatric testicular germ cell neoplasm; Pediatric Testicular Germ Cell Tumor; pediatric testicular germ cell tumor; testicular germ cell tumor of childhood; testicular germ cell tumour of childhood
 
Monarch Initiative: MONDO:0003758

Definition

A germ cell tumor that arises from the testis during childhood. [from NCI]

Professional guidelines

PubMed

Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.
Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C
Nat Rev Urol 2016 Jul;13(7):409-19. Epub 2016 Jun 14 doi: 10.1038/nrurol.2016.107. PMID: 27296647
Fertility outcome of patients with testicular tumor: before and after treatment.
Ping P, Gu BH, Li P, Huang YR, Li Z
Asian J Androl 2014 Jan-Feb;16(1):107-11. doi: 10.4103/1008-682X.122194. PMID: 24369141Free PMC Article

Recent clinical studies

Etiology

The fate of germ cells in cryptorchid testis.
Thorup J, Hildorf S, Hildorf AE, Baastrup JM, Mamsen LS, Andersen CY, Olsen TE, Cortes D
Front Endocrinol (Lausanne) 2023;14:1305428. Epub 2024 Jan 3 doi: 10.3389/fendo.2023.1305428. PMID: 38234428Free PMC Article
Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors.
Lengert AVH, Pereira LDNB, Cabral ERM, Gomes INF, Jesus LM, Gonçalves MFS, Rocha AOD, Tassinari TA, Silva LSD, Laus AC, Vidal DO, Pinto MT, Reis RM, Lopes LF
Front Biosci (Landmark Ed) 2022 Aug 16;27(8):245. doi: 10.31083/j.fbl2708245. PMID: 36042160
Update on pediatric testicular germ cell tumors.
Aldrink JH, Glick RD, Baertschiger RM, Kulaylat AN, Lautz TB, Christison-Lagay E, Grant CN, Tracy E, Dasgupta R, Brown EG, Mattei P, Rothstein DH, Rodeberg DA, Ehrlich PF
J Pediatr Surg 2022 Apr;57(4):690-699. Epub 2021 Apr 15 doi: 10.1016/j.jpedsurg.2021.04.001. PMID: 33975708
Childhood height and risk of testicular germ cell tumors in adulthood.
McGlynn KA, Petrick JL, Gamborg M, Aarestrup J, Baker JL
Int J Cancer 2018 Aug 15;143(4):767-772. Epub 2018 Mar 26 doi: 10.1002/ijc.31354. PMID: 29508384Free PMC Article
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.
Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C
Nat Rev Urol 2016 Jul;13(7):409-19. Epub 2016 Jun 14 doi: 10.1038/nrurol.2016.107. PMID: 27296647

Diagnosis

Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors.
Lengert AVH, Pereira LDNB, Cabral ERM, Gomes INF, Jesus LM, Gonçalves MFS, Rocha AOD, Tassinari TA, Silva LSD, Laus AC, Vidal DO, Pinto MT, Reis RM, Lopes LF
Front Biosci (Landmark Ed) 2022 Aug 16;27(8):245. doi: 10.31083/j.fbl2708245. PMID: 36042160
Update on pediatric testicular germ cell tumors.
Aldrink JH, Glick RD, Baertschiger RM, Kulaylat AN, Lautz TB, Christison-Lagay E, Grant CN, Tracy E, Dasgupta R, Brown EG, Mattei P, Rothstein DH, Rodeberg DA, Ehrlich PF
J Pediatr Surg 2022 Apr;57(4):690-699. Epub 2021 Apr 15 doi: 10.1016/j.jpedsurg.2021.04.001. PMID: 33975708
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
Childhood height and risk of testicular germ cell tumors in adulthood.
McGlynn KA, Petrick JL, Gamborg M, Aarestrup J, Baker JL
Int J Cancer 2018 Aug 15;143(4):767-772. Epub 2018 Mar 26 doi: 10.1002/ijc.31354. PMID: 29508384Free PMC Article
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.
Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C
Nat Rev Urol 2016 Jul;13(7):409-19. Epub 2016 Jun 14 doi: 10.1038/nrurol.2016.107. PMID: 27296647

Therapy

Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies.
Florou M, Tsilidis KK, Siomou E, Koletsa T, Syrnioti A, Spyridakis I, Kaselas C, Ntzani EE
Eur J Pediatr 2023 Jun;182(6):2499-2507. Epub 2023 Mar 29 doi: 10.1007/s00431-023-04947-9. PMID: 36988678
Potential New Therapeutic Approaches for Cisplatin-Resistant Testicular Germ Cell Tumors.
Lengert AVH, Pereira LDNB, Cabral ERM, Gomes INF, Jesus LM, Gonçalves MFS, Rocha AOD, Tassinari TA, Silva LSD, Laus AC, Vidal DO, Pinto MT, Reis RM, Lopes LF
Front Biosci (Landmark Ed) 2022 Aug 16;27(8):245. doi: 10.31083/j.fbl2708245. PMID: 36042160
Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
Mendelian randomisation analysis provides no evidence for a relationship between adult height and testicular cancer risk.
Levy M, Hall D, Sud A, Law P, Litchfield K, Dudakia D, Haugen TB, Karlsson R, Reid A, Huddart RA, Grotmol T, Wiklund F, Houlston RS, Turnbull C
Andrology 2017 Sep;5(5):914-922. Epub 2017 Aug 13 doi: 10.1111/andr.12388. PMID: 28804972
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.
Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C
Nat Rev Urol 2016 Jul;13(7):409-19. Epub 2016 Jun 14 doi: 10.1038/nrurol.2016.107. PMID: 27296647

Prognosis

Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS).
Lanciotti L, Cofini M, Leonardi A, Bertozzi M, Penta L, Esposito S
Int J Environ Res Public Health 2019 Apr 9;16(7) doi: 10.3390/ijerph16071268. PMID: 30970592Free PMC Article
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.
Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C
Nat Rev Urol 2016 Jul;13(7):409-19. Epub 2016 Jun 14 doi: 10.1038/nrurol.2016.107. PMID: 27296647
Germ cell tumors in children and adolescents in Finland: trends over 1969-2008.
Pauniaho SL, Salonen J, Helminen M, Heikinheimo O, Vettenranta K, Heikinheimo M
Cancer Causes Control 2014 Oct;25(10):1337-41. Epub 2014 Jul 25 doi: 10.1007/s10552-014-0439-6. PMID: 25060481
Lifetime growth and risk of testicular cancer.
Richiardi L, Vizzini L, Pastore G, Segnan N, Gillio-Tos A, Fiano V, Grasso C, Ciuffreda L, Lista P, Pearce N, Merletti F
Int J Cancer 2014 Aug 1;135(3):695-701. Epub 2014 Jan 10 doi: 10.1002/ijc.28688. PMID: 24375202
Testicular microlithiasis: the importance of self-examination.
Price NR, Charlton A, Simango I, Smith GH
J Paediatr Child Health 2014 Oct;50(10):E102-5. Epub 2011 Mar 10 doi: 10.1111/j.1440-1754.2011.02021.x. PMID: 21392148

Clinical prediction guides

Risk for testicular germ cell tumors and spermatogenesis failure in post-pubertal undescended testes.
Ergül RB, Bayramoğlu Z, Keçeli AM, Dönmez Mİ
Int Urol Nephrol 2024 Jul;56(7):2269-2274. Epub 2024 Feb 13 doi: 10.1007/s11255-024-03963-4. PMID: 38349599
Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies.
Florou M, Tsilidis KK, Siomou E, Koletsa T, Syrnioti A, Spyridakis I, Kaselas C, Ntzani EE
Eur J Pediatr 2023 Jun;182(6):2499-2507. Epub 2023 Mar 29 doi: 10.1007/s00431-023-04947-9. PMID: 36988678
Childhood height and risk of testicular germ cell tumors in adulthood.
McGlynn KA, Petrick JL, Gamborg M, Aarestrup J, Baker JL
Int J Cancer 2018 Aug 15;143(4):767-772. Epub 2018 Mar 26 doi: 10.1002/ijc.31354. PMID: 29508384Free PMC Article
The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.
Litchfield K, Levy M, Huddart RA, Shipley J, Turnbull C
Nat Rev Urol 2016 Jul;13(7):409-19. Epub 2016 Jun 14 doi: 10.1038/nrurol.2016.107. PMID: 27296647
Pediatric germ cell tumors presenting beyond childhood?
Oosterhuis JW, Stoop JA, Rijlaarsdam MA, Biermann K, Smit VT, Hersmus R, Looijenga LH
Andrology 2015 Jan;3(1):70-7. Epub 2014 Nov 27 doi: 10.1111/andr.305. PMID: 25427839

Recent systematic reviews

Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies.
Florou M, Tsilidis KK, Siomou E, Koletsa T, Syrnioti A, Spyridakis I, Kaselas C, Ntzani EE
Eur J Pediatr 2023 Jun;182(6):2499-2507. Epub 2023 Mar 29 doi: 10.1007/s00431-023-04947-9. PMID: 36988678

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