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Benign Supratentorial Neoplasm

MedGen UID:
155588
•Concept ID:
C0751588
•
Neoplastic Process
Synonyms: Benign Supratentorial Neoplasms; Neoplasm, Benign Supratentorial; Neoplasms, Benign Supratentorial; Supratentorial Neoplasm, Benign; Supratentorial Neoplasms, Benign

Definition

A neoplasm that arises from above the cerebellar tentorium and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Diagnosis and Treatment of Pituitary Adenomas: A Review.
Molitch ME
JAMA 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699. PMID: 28170483
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2011 Feb;96(2):273-88. doi: 10.1210/jc.2010-1692. PMID: 21296991

Recent clinical studies

Etiology

Supratentorial ependymoma in childhood: more than just RELA or YAP.
Zschernack V, Jünger ST, Mynarek M, Rutkowski S, Garre ML, Ebinger M, Neu M, Faber J, Erdlenbruch B, Claviez A, Bielack S, Brozou T, Frühwald MC, Dörner E, Dreschmann V, Stock A, Solymosi L, Hench J, Frank S, Vokuhl C, Waha A, Andreiuolo F, Pietsch T
Acta Neuropathol 2021 Mar;141(3):455-466. Epub 2021 Jan 22 doi: 10.1007/s00401-020-02260-5. PMID: 33481105Free PMC Article
Supratentorial pediatric cortical ependymomas: a comprehensive retrospective study.
Wang Q, Cheng J, Zhang S, Li Q, Hui X, Ju Y
Neurosurg Rev 2021 Jun;44(3):1543-1551. Epub 2020 Jun 30 doi: 10.1007/s10143-020-01336-w. PMID: 32607870
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Treatment and survival of supratentorial and posterior fossa ependymomas in adults.
Nuño M, Yu JJ, Varshneya K, Alexander J, Mukherjee D, Black KL, Patil CG
J Clin Neurosci 2016 Jun;28:24-30. Epub 2016 Jan 19 doi: 10.1016/j.jocn.2015.11.014. PMID: 26810473
Surgical management of supratentorial ependymomas.
Chakraborty A, Harkness W, Phipps K
Childs Nerv Syst 2009 Oct;25(10):1215-20. Epub 2009 Apr 9 doi: 10.1007/s00381-009-0881-z. PMID: 19357853

Diagnosis

Supratentorial and Infratentorial Ependymoma.
Myseros JS
Adv Tech Stand Neurosurg 2024;53:93-118. doi: 10.1007/978-3-031-67077-0_7. PMID: 39287805
Approaches to supratentorial brain tumours in children.
Sepulveda F, Scotto Opipari R, Coppola F, Ramaglia A, Mankad K, Alves CAP, Bison B, Löbel U
Neuroradiology 2024 Sep;66(9):1495-1512. Epub 2024 Jul 2 doi: 10.1007/s00234-024-03398-9. PMID: 38953989
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Supratentorial Tumors in Pediatric Patients.
Zamora C, Huisman TA, Izbudak I
Neuroimaging Clin N Am 2017 Feb;27(1):39-67. doi: 10.1016/j.nic.2016.08.003. PMID: 27889023
Supratentorial paraventricular schwannoma.
Glikstein R, Biswas A, Mohr G, Albrecht S
Neuroradiol J 2015 Feb;28(1):46-50. doi: 10.15274/NRJ-2014-10104. PMID: 25924172Free PMC Article

Therapy

Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Stereotactic Cryodestruction of Gliomas.
Martynov BV, Kholyavin AI, Nizkovolos VB, Parfenov VE, Trufanov GE, Svistov DV
Prog Neurol Surg 2018;32:27-38. Epub 2018 Jul 10 doi: 10.1159/000469677. PMID: 29990971
Diagnosis and management of craniopharyngiomas in the era of genomics and targeted therapy.
Martinez-Gutierrez JC, D'Andrea MR, Cahill DP, Santagata S, Barker FG 2nd, Brastianos PK
Neurosurg Focus 2016 Dec;41(6):E2. doi: 10.3171/2016.9.FOCUS16325. PMID: 27903124
Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802.
Shaw EG, Wang M, Coons SW, Brachman DG, Buckner JC, Stelzer KJ, Barger GR, Brown PD, Gilbert MR, Mehta MP
J Clin Oncol 2012 Sep 1;30(25):3065-70. Epub 2012 Jul 30 doi: 10.1200/JCO.2011.35.8598. PMID: 22851558Free PMC Article
Treatment of prolactinomas.
Colao A, Annunziato L, Lombardi G
Ann Med 1998 Oct;30(5):452-9. doi: 10.3109/07853899809002486. PMID: 9814831

Prognosis

Supratentorial pediatric cortical ependymomas: a comprehensive retrospective study.
Wang Q, Cheng J, Zhang S, Li Q, Hui X, Ju Y
Neurosurg Rev 2021 Jun;44(3):1543-1551. Epub 2020 Jun 30 doi: 10.1007/s10143-020-01336-w. PMID: 32607870
Seizures in supratentorial meningioma: a systematic review and meta-analysis.
Englot DJ, Magill ST, Han SJ, Chang EF, Berger MS, McDermott MW
J Neurosurg 2016 Jun;124(6):1552-61. Epub 2015 Dec 4 doi: 10.3171/2015.4.JNS142742. PMID: 26636386Free PMC Article
Supratentorial paraventricular schwannoma.
Glikstein R, Biswas A, Mohr G, Albrecht S
Neuroradiol J 2015 Feb;28(1):46-50. doi: 10.15274/NRJ-2014-10104. PMID: 25924172Free PMC Article
Surgical management of supratentorial ependymomas.
Chakraborty A, Harkness W, Phipps K
Childs Nerv Syst 2009 Oct;25(10):1215-20. Epub 2009 Apr 9 doi: 10.1007/s00381-009-0881-z. PMID: 19357853
Low-grade gliomas in adults.
Rees JH
Curr Opin Neurol 2002 Dec;15(6):657-61. doi: 10.1097/01.wco.0000044760.39452.71. PMID: 12447102

Clinical prediction guides

Clinical and imaging characteristics of supratentorial glioma with IDH2 mutation.
Ikeda S, Sakata A, Arakawa Y, Mineharu Y, Makino Y, Takeuchi Y, Fushimi Y, Okuchi S, Nakajima S, Otani S, Nakamoto Y
Neuroradiology 2024 Jun;66(6):973-981. Epub 2024 Apr 24 doi: 10.1007/s00234-024-03361-8. PMID: 38653782
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Supratentorial ependymoma in childhood: more than just RELA or YAP.
Zschernack V, Jünger ST, Mynarek M, Rutkowski S, Garre ML, Ebinger M, Neu M, Faber J, Erdlenbruch B, Claviez A, Bielack S, Brozou T, Frühwald MC, Dörner E, Dreschmann V, Stock A, Solymosi L, Hench J, Frank S, Vokuhl C, Waha A, Andreiuolo F, Pietsch T
Acta Neuropathol 2021 Mar;141(3):455-466. Epub 2021 Jan 22 doi: 10.1007/s00401-020-02260-5. PMID: 33481105Free PMC Article
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Seizures in supratentorial meningioma: a systematic review and meta-analysis.
Englot DJ, Magill ST, Han SJ, Chang EF, Berger MS, McDermott MW
J Neurosurg 2016 Jun;124(6):1552-61. Epub 2015 Dec 4 doi: 10.3171/2015.4.JNS142742. PMID: 26636386Free PMC Article

Recent systematic reviews

Giant prolactinomas, a detailed analysis of 196 adult cases.
Lisa B, Arno V, Christophe B, Heyning Paul V, Carlien H
Pituitary 2023 Oct;26(5):529-537. Epub 2023 Aug 7 doi: 10.1007/s11102-023-01337-0. PMID: 37544978
Diagnostic challenges in cyclic Cushing's syndrome: a systematic review.
Nowak E, Vogel F, Albani A, Braun L, Rubinstein G, Zopp S, Ritzel K, Beuschlein F, Theodoropoulou M, Reincke M
Lancet Diabetes Endocrinol 2023 Aug;11(8):593-606. Epub 2023 Jul 7 doi: 10.1016/S2213-8587(23)00150-X. PMID: 37429301
Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis.
Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M
JAMA Oncol 2016 Nov 1;2(11):1460-1469. doi: 10.1001/jamaoncol.2016.1373. PMID: 27310651Free PMC Article
Seizures in supratentorial meningioma: a systematic review and meta-analysis.
Englot DJ, Magill ST, Han SJ, Chang EF, Berger MS, McDermott MW
J Neurosurg 2016 Jun;124(6):1552-61. Epub 2015 Dec 4 doi: 10.3171/2015.4.JNS142742. PMID: 26636386Free PMC Article
Pituitary incidentalomas.
Scangas GA, Laws ER Jr
Pituitary 2014 Oct;17(5):486-91. doi: 10.1007/s11102-013-0517-x. PMID: 24052242

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