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Skin papilloma

MedGen UID:
91127
•Concept ID:
C0347390
•
Neoplastic Process
Synonyms: basosquamous tumor, benign; Cutaneous Papilloma; cutaneous papilloma; Papilloma of skin; Papilloma of Skin; papilloma of skin; Papilloma of the Skin; papilloma of the skin; Skin Papilloma; skin papilloma; zone of skin papilloma
SNOMED CT: Papilloma of skin (255184001)
 
Monarch Initiative: MONDO:0002536

Definition

A benign papillary neoplastic growth on the skin composed of epithelial cells and a fibrous stalk. It usually develops in the eyelid, axilla, neck, upper chest, and groin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin papilloma

Professional guidelines

PubMed

FDA Approval Summary: Vemurafenib for the Treatment of Patients with Erdheim-Chester Disease with the BRAFV600 Mutation.
Oneal PA, Kwitkowski V, Luo L, Shen YL, Subramaniam S, Shord S, Goldberg KB, McKee AE, Kaminskas E, Farrell A, Pazdur R
Oncologist 2018 Dec;23(12):1520-1524. Epub 2018 Aug 17 doi: 10.1634/theoncologist.2018-0295. PMID: 30120160Free PMC Article

Recent clinical studies

Etiology

Phytocompounds from essential oil of Mentha aquatica L. cv. Lime prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRAS(Q61L) keratinocytes and reprogramming macrophage activities.
Chang CT, Chen YH, Shyur LF
Phytomedicine 2024 Jan;122:155161. Epub 2023 Oct 22 doi: 10.1016/j.phymed.2023.155161. PMID: 37939409
Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis.
Davies SC, Hussein IM, Nguyen TM, Parker CE, Khanna R, Jairath V
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD012381. doi: 10.1002/14651858.CD012381.pub2. PMID: 31984480Free PMC Article
The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis.
Chen P, Chen F, Zhou B
Cutan Ocul Toxicol 2019 Jun;38(2):105-111. Epub 2019 Jan 28 doi: 10.1080/15569527.2018.1553180. PMID: 30501438
PTEN positively regulates UVB-induced DNA damage repair.
Ming M, Feng L, Shea CR, Soltani K, Zhao B, Han W, Smart RC, Trempus CS, He YY
Cancer Res 2011 Aug 1;71(15):5287-95. Epub 2011 Jul 19 doi: 10.1158/0008-5472.CAN-10-4614. PMID: 21771908Free PMC Article

Diagnosis

An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy.
Wang H, Xu Q, Zhao C, Zhu Z, Zhu X, Zhou J, Zhang S, Yang T, Zhang B, Li J, Yan M, Liu R, Ma C, Quan Y, Zhang Y, Zhang W, Geng Y, Chen C, Chen S, Liu D, Chen Y, Tian D, Su M, Chen X, Gu J
J Immunother Cancer 2020 Aug;8(2) doi: 10.1136/jitc-2020-000661. PMID: 32819973Free PMC Article
Discovering pH triggered charge rebound surface modulated topical nanotherapy against aggressive skin papilloma.
Sahu P, Kashaw SK, Sau S, Kushwah V, Jain S, Iyer AK
Mater Sci Eng C Mater Biol Appl 2020 Feb;107:110263. Epub 2019 Oct 12 doi: 10.1016/j.msec.2019.110263. PMID: 31761163
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Unbekandt M, Belshaw S, Bower J, Clarke M, Cordes J, Crighton D, Croft DR, Drysdale MJ, Garnett MJ, Gill K, Gray C, Greenhalgh DA, Hall JAM, Konczal J, Lilla S, McArthur D, McConnell P, McDonald L, McGarry L, McKinnon H, McMenemy C, Mezna M, Morrice NA, Munro J, Naylor G, Rath N, Schüttelkopf AW, Sime M, Olson MF
Cancer Res 2018 Apr 15;78(8):2096-2114. Epub 2018 Jan 30 doi: 10.1158/0008-5472.CAN-17-2870. PMID: 29382705Free PMC Article
Vemurafenib for BRAF V600-Mutant Erdheim-Chester Disease and Langerhans Cell Histiocytosis: Analysis of Data From the Histology-Independent, Phase 2, Open-label VE-BASKET Study.
Diamond EL, Subbiah V, Lockhart AC, Blay JY, Puzanov I, Chau I, Raje NS, Wolf J, Erinjeri JP, Torrisi J, Lacouture M, Elez E, Martínez-Valle F, Durham B, Arcila ME, Ulaner G, Abdel-Wahab O, Pitcher B, Makrutzki M, Riehl T, Baselga J, Hyman DM
JAMA Oncol 2018 Mar 1;4(3):384-388. doi: 10.1001/jamaoncol.2017.5029. PMID: 29188284Free PMC Article
Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro.
Nass N, Streit S, Wybranski C, Jürgens J, Brauner J, Schulz N, Powerski M, Ricke J, Kalinski T, Dudeck O, Seidensticker M
Anticancer Res 2017 Jan;37(1):87-93. doi: 10.21873/anticanres.11293. PMID: 28011478

Therapy

Phytocompounds from essential oil of Mentha aquatica L. cv. Lime prevent vemurafenib-promoted skin carcinogenesis via inhibiting HRAS(Q61L) keratinocytes and reprogramming macrophage activities.
Chang CT, Chen YH, Shyur LF
Phytomedicine 2024 Jan;122:155161. Epub 2023 Oct 22 doi: 10.1016/j.phymed.2023.155161. PMID: 37939409
Discovering pH triggered charge rebound surface modulated topical nanotherapy against aggressive skin papilloma.
Sahu P, Kashaw SK, Sau S, Kushwah V, Jain S, Iyer AK
Mater Sci Eng C Mater Biol Appl 2020 Feb;107:110263. Epub 2019 Oct 12 doi: 10.1016/j.msec.2019.110263. PMID: 31761163
Vemurafenib for BRAF V600-Mutant Erdheim-Chester Disease and Langerhans Cell Histiocytosis: Analysis of Data From the Histology-Independent, Phase 2, Open-label VE-BASKET Study.
Diamond EL, Subbiah V, Lockhart AC, Blay JY, Puzanov I, Chau I, Raje NS, Wolf J, Erinjeri JP, Torrisi J, Lacouture M, Elez E, Martínez-Valle F, Durham B, Arcila ME, Ulaner G, Abdel-Wahab O, Pitcher B, Makrutzki M, Riehl T, Baselga J, Hyman DM
JAMA Oncol 2018 Mar 1;4(3):384-388. doi: 10.1001/jamaoncol.2017.5029. PMID: 29188284Free PMC Article
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis.
Deshmukh J, Pofahl R, Pfister H, Haase I
Oncotarget 2016 Sep 6;7(36):57841-57850. doi: 10.18632/oncotarget.11069. PMID: 27506937Free PMC Article
Tacrolimus in dermatology.
Dé Tran QH, Guay E, Chartier S, Tousignant J
J Cutan Med Surg 2001 Jul-Aug;5(4):329-35. Epub 2001 May 2 doi: 10.1007/s102270000022. PMID: 11907845

Prognosis

An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy.
Wang H, Xu Q, Zhao C, Zhu Z, Zhu X, Zhou J, Zhang S, Yang T, Zhang B, Li J, Yan M, Liu R, Ma C, Quan Y, Zhang Y, Zhang W, Geng Y, Chen C, Chen S, Liu D, Chen Y, Tian D, Su M, Chen X, Gu J
J Immunother Cancer 2020 Aug;8(2) doi: 10.1136/jitc-2020-000661. PMID: 32819973Free PMC Article
Vemurafenib for BRAF V600-Mutant Erdheim-Chester Disease and Langerhans Cell Histiocytosis: Analysis of Data From the Histology-Independent, Phase 2, Open-label VE-BASKET Study.
Diamond EL, Subbiah V, Lockhart AC, Blay JY, Puzanov I, Chau I, Raje NS, Wolf J, Erinjeri JP, Torrisi J, Lacouture M, Elez E, Martínez-Valle F, Durham B, Arcila ME, Ulaner G, Abdel-Wahab O, Pitcher B, Makrutzki M, Riehl T, Baselga J, Hyman DM
JAMA Oncol 2018 Mar 1;4(3):384-388. doi: 10.1001/jamaoncol.2017.5029. PMID: 29188284Free PMC Article
Free radical scavenging, antitumor and anticarcinogenic activity of gossypin.
Babu BH, Jayram HN, Nair MG, Ajaikumar KB, Padikkala J
J Exp Clin Cancer Res 2003 Dec;22(4):581-9. PMID: 15053300

Clinical prediction guides

An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy.
Wang H, Xu Q, Zhao C, Zhu Z, Zhu X, Zhou J, Zhang S, Yang T, Zhang B, Li J, Yan M, Liu R, Ma C, Quan Y, Zhang Y, Zhang W, Geng Y, Chen C, Chen S, Liu D, Chen Y, Tian D, Su M, Chen X, Gu J
J Immunother Cancer 2020 Aug;8(2) doi: 10.1136/jitc-2020-000661. PMID: 32819973Free PMC Article
Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis.
Davies SC, Hussein IM, Nguyen TM, Parker CE, Khanna R, Jairath V
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD012381. doi: 10.1002/14651858.CD012381.pub2. PMID: 31984480Free PMC Article
Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis.
Deshmukh J, Pofahl R, Haase I
Cell Death Dis 2017 Mar 9;8(3):e2664. doi: 10.1038/cddis.2017.63. PMID: 28277539Free PMC Article
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis.
Deshmukh J, Pofahl R, Pfister H, Haase I
Oncotarget 2016 Sep 6;7(36):57841-57850. doi: 10.18632/oncotarget.11069. PMID: 27506937Free PMC Article
Mutagenicity and carcinogenicity of smoked meat from Nagaland, a region of India prone to a high incidence of nasopharyngeal cancer.
Sarkar S, Nagabhushan M, Soman CS, Tricker AR, Bhide SV
Carcinogenesis 1989 Apr;10(4):733-6. doi: 10.1093/carcin/10.4.733. PMID: 2649267

Recent systematic reviews

Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis.
Davies SC, Hussein IM, Nguyen TM, Parker CE, Khanna R, Jairath V
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD012381. doi: 10.1002/14651858.CD012381.pub2. PMID: 31984480Free PMC Article
The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis.
Chen P, Chen F, Zhou B
Cutan Ocul Toxicol 2019 Jun;38(2):105-111. Epub 2019 Jan 28 doi: 10.1080/15569527.2018.1553180. PMID: 30501438

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