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Intraocular lymphoma

MedGen UID:
79344
•Concept ID:
C0281658
•
Neoplastic Process
Synonyms: Intraocular Lymphoma; Intraocular Lymphomas; Lymphoma, Intraocular; Lymphomas, Intraocular
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0004351
Orphanet: ORPHA279904

Definition

A non-Hodgkin lymphoma that arises within the eyeball. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598
Present and future treatment options for primary CNS lymphoma.
Citterio G, Reni M, Ferreri AJ
Expert Opin Pharmacother 2015;16(17):2569-79. Epub 2015 Sep 15 doi: 10.1517/14656566.2015.1088828. PMID: 26371872

Recent clinical studies

Etiology

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma.
Carbonell D, Mahajan S, Chee SP, Sobolewska B, Agrawal R, Bülow T, Gupta V, Jones NP, Accorinti M, Agarwal M, Batchelor T, Biswas J, Cimino L, tenDam-van Loon NH, de-la-Torre A, Frenkel S, Pe'er J, Kramer M, Miserocchi E, Mochizuki M, Ness T, Rosenbaum JT, Sen HN, Simion M (VRL patient), Sitter H, Vasconcelos-Santos DV, Habot-Wilner Z, Coupland SE, Pulido JS, Smith J, Thorne JE, Zierhut M; Study Group for Vitreoretinal Lymphoma Diagnostics
Ocul Immunol Inflamm 2021 Apr 3;29(3):507-520. Epub 2021 May 19 doi: 10.1080/09273948.2021.1878233. PMID: 34009095
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Primary Vitreoretinal Lymphoma -- A Review.
Araujo I, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 May-Jun;6(3):283-289. doi: 10.22608/APO.2017150. PMID: 28558176
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696

Diagnosis

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Intraocular Lymphoma.
Cunningham ET, Miserocchi E, Smith JR, Gonzales JA, Zierhut M
Ocul Immunol Inflamm 2021 Apr 3;29(3):425-429. doi: 10.1080/09273948.2021.1941684. PMID: 34296968
Primary intraocular lymphoma.
Garcia-Saenz MC, Pessanha FI, de la Puente Azpitarte V, Crespo-Carballes MJ, Arias-Puente A
Arch Soc Esp Oftalmol (Engl Ed) 2020 Apr;95(4):e27. Epub 2019 Dec 30 doi: 10.1016/j.oftal.2019.11.007. PMID: 31899059
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary intraocular lymphoma.
Sagoo MS, Mehta H, Swampillai AJ, Cohen VM, Amin SZ, Plowman PN, Lightman S
Surv Ophthalmol 2014 Sep-Oct;59(5):503-16. Epub 2013 Dec 31 doi: 10.1016/j.survophthal.2013.12.001. PMID: 24560125

Therapy

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary intraocular lymphoma.
Sagoo MS, Mehta H, Swampillai AJ, Cohen VM, Amin SZ, Plowman PN, Lightman S
Surv Ophthalmol 2014 Sep-Oct;59(5):503-16. Epub 2013 Dec 31 doi: 10.1016/j.survophthal.2013.12.001. PMID: 24560125
Rituximab for intraocular lymphoma.
Itty S, Pulido JS
Retina 2009 Feb;29(2):129-32. doi: 10.1097/IAE.0b013e318192f574. PMID: 19202422

Prognosis

Diagnosis and management of vitreoretinal lymphoma: present and future treatment perspectives.
Kaburaki T, Taoka K
Jpn J Ophthalmol 2023 Jul;67(4):363-381. Epub 2023 May 20 doi: 10.1007/s10384-023-00997-6. PMID: 37209195
Ocular Oncology-Primary and Metastatic Malignancies.
Williams BK Jr, Di Nicola M
Med Clin North Am 2021 May;105(3):531-550. Epub 2021 Apr 2 doi: 10.1016/j.mcna.2021.02.005. PMID: 33926645
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696
Primary intraocular lymphoma.
Sagoo MS, Mehta H, Swampillai AJ, Cohen VM, Amin SZ, Plowman PN, Lightman S
Surv Ophthalmol 2014 Sep-Oct;59(5):503-16. Epub 2013 Dec 31 doi: 10.1016/j.survophthal.2013.12.001. PMID: 24560125

Clinical prediction guides

Presentation, Diagnostic Testing and Initial Treatment of Vitreoretinal Lymphoma.
International Vitreoretinal B-Cell Lymphoma Registry Investigator Group
Ophthalmol Retina 2024 Jan;8(1):72-80. Epub 2023 Aug 28 doi: 10.1016/j.oret.2023.08.012. PMID: 37648063
Neuro-Ophthalmic Manifestations of Intracranial Malignancies.
Dermarkarian CR, Kini AT, Al Othman BA, Lee AG
J Neuroophthalmol 2020 Sep;40(3):e31-e48. doi: 10.1097/WNO.0000000000000950. PMID: 32282510
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome.
Chaput F, Amer R, Baglivo E, Touitou V, Kozyreff A, Bron D, Bodaghi B, LeHoang P, Bergstrom C, Grossniklaus HE, Chan CC, Pe'er J, Caspers LE
Ocul Immunol Inflamm 2017 Oct;25(5):639-648. Epub 2016 Mar 22 doi: 10.3109/09273948.2016.1139733. PMID: 27002464
Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
Ferreri AJ, Cwynarski K, Pulczynski E, Ponzoni M, Deckert M, Politi LS, Torri V, Fox CP, Rosée PL, Schorb E, Ambrosetti A, Roth A, Hemmaway C, Ferrari A, Linton KM, Rudà R, Binder M, Pukrop T, Balzarotti M, Fabbri A, Johnson P, Gørløv JS, Hess G, Panse J, Pisani F, Tucci A, Stilgenbauer S, Hertenstein B, Keller U, Krause SW, Levis A, Schmoll HJ, Cavalli F, Finke J, Reni M, Zucca E, Illerhaus G; International Extranodal Lymphoma Study Group (IELSG)
Lancet Haematol 2016 May;3(5):e217-27. Epub 2016 Apr 6 doi: 10.1016/S2352-3026(16)00036-3. PMID: 27132696

Recent systematic reviews

Diagnostic methods for primary vitreoretinal lymphoma: A systematic review.
Huang RS, Mihalache A, Popovic MM, Cruz-Pimentel M, Pandya BU, Muni RH, Kertes PJ
Surv Ophthalmol 2024 May-Jun;69(3):456-464. Epub 2023 Dec 30 doi: 10.1016/j.survophthal.2023.12.001. PMID: 38163550
Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review.
Rafizadeh SM, Ghahvehchian H, Rajabi MT, Heidari M, Rahmanikhah E
Ophthalmic Plast Reconstr Surg 2024 May-Jun 01;40(3):235-244. Epub 2023 Sep 18 doi: 10.1097/IOP.0000000000002520. PMID: 37721309
Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma.
Fox CP, Phillips EH, Smith J, Linton K, Gallop-Evans E, Hemmaway C, Auer DP, Fuller C, Davies AJ, McKay P, Cwynarski K; British Society for Haematology
Br J Haematol 2019 Feb;184(3):348-363. Epub 2018 Nov 23 doi: 10.1111/bjh.15661. PMID: 30467845

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