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Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

MedGen UID:
1684136
•Concept ID:
C4763393
•
Neoplastic Process
Synonym: Recurrent PVRL DLBCL

Definition

The reemergence of primary vitreoretinal diffuse large B-cell lymphoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Vitreoretinal large B- cell lymphoma (VR- LBCL): Clinical and pathological features and treatment outcomes.
Fadlelseed H, Rhatigan M, Treacy M, Murphy C, O'Neill J, Kilmartin D, Kennedy S
Pathol Res Pract 2024 Sep;261:155500. Epub 2024 Jul 27 doi: 10.1016/j.prp.2024.155500. PMID: 39106590
Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
Saito T, Ohguro N, Iwahashi C, Hashida N
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2319-2326. Epub 2016 Jun 1 doi: 10.1007/s00417-016-3395-x. PMID: 27251192

Recent clinical studies

Etiology

Vitreoretinal large B- cell lymphoma (VR- LBCL): Clinical and pathological features and treatment outcomes.
Fadlelseed H, Rhatigan M, Treacy M, Murphy C, O'Neill J, Kilmartin D, Kennedy S
Pathol Res Pract 2024 Sep;261:155500. Epub 2024 Jul 27 doi: 10.1016/j.prp.2024.155500. PMID: 39106590
CYSTOID MACULAR EDEMA IN THE SETTING OF PRIMARY VITREORETINAL LYMPHOMA.
Deák GG, Sneed SR, Jampol LM
Retin Cases Brief Rep 2021 Mar 1;15(2):104-106. doi: 10.1097/ICB.0000000000000797. PMID: 30015778
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
Saito T, Ohguro N, Iwahashi C, Hashida N
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2319-2326. Epub 2016 Jun 1 doi: 10.1007/s00417-016-3395-x. PMID: 27251192

Diagnosis

Vitreoretinal large B- cell lymphoma (VR- LBCL): Clinical and pathological features and treatment outcomes.
Fadlelseed H, Rhatigan M, Treacy M, Murphy C, O'Neill J, Kilmartin D, Kennedy S
Pathol Res Pract 2024 Sep;261:155500. Epub 2024 Jul 27 doi: 10.1016/j.prp.2024.155500. PMID: 39106590
Vitreoretinal lymphoma: a diagnostic challenge.
Sáenz Decker E, García Fernández M, Gómez De la Torre R, Coto Hernández R, Santana García LI
Arch Soc Esp Oftalmol (Engl Ed) 2023 Dec;98(12):718-722. Epub 2023 Oct 7 doi: 10.1016/j.oftale.2023.10.002. PMID: 37813184
Steroid-induced delayed diagnosis of primary vitreoretinal lymphoma with ghost brain tumor: A case report.
Kau HC, Wang CJ, Tsai CC
Medicine (Baltimore) 2022 Jul 22;101(29):e29637. doi: 10.1097/MD.0000000000029637. PMID: 35866822Free PMC Article
Rapid Resolution of Presumed Vitreoretinal Lymphoma With Systemic Ibrutinib Therapy.
Mathai M, Fein JG
Ophthalmic Surg Lasers Imaging Retina 2021 Apr;52(4):227-230. Epub 2021 Apr 1 doi: 10.3928/23258160-20210330-07. PMID: 34039188
Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
Saito T, Ohguro N, Iwahashi C, Hashida N
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2319-2326. Epub 2016 Jun 1 doi: 10.1007/s00417-016-3395-x. PMID: 27251192

Therapy

Reduced frequency of Intravitreal methotrexate injection lowers the risk of Keratopathy in Vitreoretinal lymphoma patients.
Zhou X, Zhou X, Shi H, Lai J, Wang Q, Li Y, Chen K, Li Q, Zhou Q, Cao X, Chen B, Xiao J
BMC Ophthalmol 2020 May 12;20(1):189. doi: 10.1186/s12886-020-01464-3. PMID: 32397978Free PMC Article
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644

Prognosis

CYSTOID MACULAR EDEMA IN THE SETTING OF PRIMARY VITREORETINAL LYMPHOMA.
Deák GG, Sneed SR, Jampol LM
Retin Cases Brief Rep 2021 Mar 1;15(2):104-106. doi: 10.1097/ICB.0000000000000797. PMID: 30015778
Ibrutinib monotherapy for relapse or refractory primary CNS lymphoma and primary vitreoretinal lymphoma: Final analysis of the phase II 'proof-of-concept' iLOC study by the Lymphoma study association (LYSA) and the French oculo-cerebral lymphoma (LOC) network.
Soussain C, Choquet S, Blonski M, Leclercq D, Houillier C, Rezai K, Bijou F, Houot R, Boyle E, Gressin R, Nicolas-Virelizier E, Barrie M, Moluçon-Chabrot C, Lelez ML, Clavert A, Coisy S, Leruez S, Touitou V, Cassoux N, Daniau M, Ertault de la Bretonnière M, El Yamani A, Ghesquières H, Hoang-Xuan K
Eur J Cancer 2019 Aug;117:121-130. Epub 2019 Jul 3 doi: 10.1016/j.ejca.2019.05.024. PMID: 31279304
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Optical coherence tomography manifestations of primary vitreoretinal lymphoma.
Saito T, Ohguro N, Iwahashi C, Hashida N
Graefes Arch Clin Exp Ophthalmol 2016 Dec;254(12):2319-2326. Epub 2016 Jun 1 doi: 10.1007/s00417-016-3395-x. PMID: 27251192

Clinical prediction guides

Reduced frequency of Intravitreal methotrexate injection lowers the risk of Keratopathy in Vitreoretinal lymphoma patients.
Zhou X, Zhou X, Shi H, Lai J, Wang Q, Li Y, Chen K, Li Q, Zhou Q, Cao X, Chen B, Xiao J
BMC Ophthalmol 2020 May 12;20(1):189. doi: 10.1186/s12886-020-01464-3. PMID: 32397978Free PMC Article
Lenalidomide in combination with intravenous rituximab (REVRI) in relapsed/refractory primary CNS lymphoma or primary intraocular lymphoma: a multicenter prospective 'proof of concept' phase II study of the French Oculo-Cerebral lymphoma (LOC) Network and the Lymphoma Study Association (LYSA)†.
Ghesquieres H, Chevrier M, Laadhari M, Chinot O, Choquet S, Moluçon-Chabrot C, Beauchesne P, Gressin R, Morschhauser F, Schmitt A, Gyan E, Hoang-Xuan K, Nicolas-Virelizier E, Cassoux N, Touitou V, Le Garff-Tavernier M, Savignoni A, Turbiez I, Soumelis V, Houillier C, Soussain C
Ann Oncol 2019 Apr 1;30(4):621-628. doi: 10.1093/annonc/mdz032. PMID: 30698644
Recurrent pseudohypopyon in association with primary vitreoretinal lymphoma: a case report.
Kitao M, Hashida N, Nishida K
BMC Ophthalmol 2016 Jul 8;16:103. doi: 10.1186/s12886-016-0279-0. PMID: 27391815Free PMC Article

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