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Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive

MedGen UID:
124511
•Concept ID:
C0278787
•
Neoplastic Process
Synonyms: Recurrent Chronic Myelogenous Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Recurrent Chronic Myeloid Leukemia; Recurrent Chronic Myeloid Leukemia, BCR::ABL1 Positive; Relapsed CGL; Relapsed Chronic Myelogenous Leukemia; Relapsed CML

Definition

The reemergence of chronic myeloid leukemia, BCR-ABL1 positive after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

Prospects for achieving treatment-free remission in chronic myeloid leukaemia.
Saglio G, Gale RP
Br J Haematol 2020 Aug;190(3):318-327. Epub 2020 Feb 14 doi: 10.1111/bjh.16506. PMID: 32057102Free PMC Article
Treatment-free remission in chronic myeloid leukemia.
Molica M, Naqvi K, Cortes JE, Paul S, Kadia TM, Breccia M, Kantarjian H, Jabbour EJ
Clin Adv Hematol Oncol 2019 Dec;17(12):686-696. PMID: 31851157
Management of chronic myeloid leukemia in blast crisis.
Saußele S, Silver RT
Ann Hematol 2015 Apr;94 Suppl 2:S159-65. Epub 2015 Mar 27 doi: 10.1007/s00277-015-2324-0. PMID: 25814082

Recent clinical studies

Etiology

Lineage-specific detection of residual disease predicts relapse in patients with chronic myeloid leukemia stopping therapy.
Pagani IS, Shanmuganathan N, Dang P, Saunders VA, Grose R, Kok CH, James J, Tolland M, Braley JA, Altamura HK, Yeung DT, Branford S, Yong ASM, Hughes TP, Ross DM
Blood 2023 Dec 21;142(25):2192-2197. doi: 10.1182/blood.2023021119. PMID: 37616555
Treatment-Free Remission: the New Goal in CML Therapy.
Atallah E, Sweet K
Curr Hematol Malig Rep 2021 Oct;16(5):433-439. Epub 2021 Oct 7 doi: 10.1007/s11899-021-00653-1. PMID: 34618317Free PMC Article
Treatment-free remission in chronic myeloid leukemia.
Molica M, Naqvi K, Cortes JE, Paul S, Kadia TM, Breccia M, Kantarjian H, Jabbour EJ
Clin Adv Hematol Oncol 2019 Dec;17(12):686-696. PMID: 31851157
Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia.
Branford S, Kim DDH, Apperley JF, Eide CA, Mustjoki S, Ong ST, Nteliopoulos G, Ernst T, Chuah C, Gambacorti-Passerini C, Mauro MJ, Druker BJ, Kim DW, Mahon FX, Cortes J, Radich JP, Hochhaus A, Hughes TP; International CML Foundation Genomics Alliance
Leukemia 2019 Aug;33(8):1835-1850. Epub 2019 Jun 17 doi: 10.1038/s41375-019-0512-y. PMID: 31209280Free PMC Article
Analyzing molecular response in chronic myeloid leukemia clinical trials: pitfalls and golden rules.
Guilhot J, Preudhomme C, Mahon FX, Guilhot F
Cancer 2015 Feb 15;121(4):490-7. Epub 2014 Oct 24 doi: 10.1002/cncr.29053. PMID: 25346428

Diagnosis

Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia.
Shin JE, Kim SH, Kong M, Kim HR, Yoon S, Kee KM, Kim JA, Kim DH, Park SY, Park JH, Kim H, No KT, Lee HW, Gee HY, Hong S, Guan KL, Roe JS, Lee H, Kim DW, Park HW
Mol Cancer 2023 Nov 6;22(1):177. doi: 10.1186/s12943-023-01837-4. PMID: 37932786Free PMC Article
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Declaration of Bcr-Abl1 independence.
Zhao H, Deininger MW
Leukemia 2020 Nov;34(11):2827-2836. Epub 2020 Sep 10 doi: 10.1038/s41375-020-01037-9. PMID: 32908250
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Do we need more drugs for chronic myeloid leukemia?
Holyoake TL, Helgason GV
Immunol Rev 2015 Jan;263(1):106-23. doi: 10.1111/imr.12234. PMID: 25510274

Therapy

Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Declaration of Bcr-Abl1 independence.
Zhao H, Deininger MW
Leukemia 2020 Nov;34(11):2827-2836. Epub 2020 Sep 10 doi: 10.1038/s41375-020-01037-9. PMID: 32908250
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
Do we need more drugs for chronic myeloid leukemia?
Holyoake TL, Helgason GV
Immunol Rev 2015 Jan;263(1):106-23. doi: 10.1111/imr.12234. PMID: 25510274

Prognosis

Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia.
Shin JE, Kim SH, Kong M, Kim HR, Yoon S, Kee KM, Kim JA, Kim DH, Park SY, Park JH, Kim H, No KT, Lee HW, Gee HY, Hong S, Guan KL, Roe JS, Lee H, Kim DW, Park HW
Mol Cancer 2023 Nov 6;22(1):177. doi: 10.1186/s12943-023-01837-4. PMID: 37932786Free PMC Article
Lineage-specific detection of residual disease predicts relapse in patients with chronic myeloid leukemia stopping therapy.
Pagani IS, Shanmuganathan N, Dang P, Saunders VA, Grose R, Kok CH, James J, Tolland M, Braley JA, Altamura HK, Yeung DT, Branford S, Yong ASM, Hughes TP, Ross DM
Blood 2023 Dec 21;142(25):2192-2197. doi: 10.1182/blood.2023021119. PMID: 37616555
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Treatment-free remission in chronic myeloid leukemia.
Molica M, Naqvi K, Cortes JE, Paul S, Kadia TM, Breccia M, Kantarjian H, Jabbour EJ
Clin Adv Hematol Oncol 2019 Dec;17(12):686-696. PMID: 31851157
Management of chronic myeloid leukemia in blast crisis.
Saußele S, Silver RT
Ann Hematol 2015 Apr;94 Suppl 2:S159-65. Epub 2015 Mar 27 doi: 10.1007/s00277-015-2324-0. PMID: 25814082

Clinical prediction guides

Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia.
Shin JE, Kim SH, Kong M, Kim HR, Yoon S, Kee KM, Kim JA, Kim DH, Park SY, Park JH, Kim H, No KT, Lee HW, Gee HY, Hong S, Guan KL, Roe JS, Lee H, Kim DW, Park HW
Mol Cancer 2023 Nov 6;22(1):177. doi: 10.1186/s12943-023-01837-4. PMID: 37932786Free PMC Article
Lineage-specific detection of residual disease predicts relapse in patients with chronic myeloid leukemia stopping therapy.
Pagani IS, Shanmuganathan N, Dang P, Saunders VA, Grose R, Kok CH, James J, Tolland M, Braley JA, Altamura HK, Yeung DT, Branford S, Yong ASM, Hughes TP, Ross DM
Blood 2023 Dec 21;142(25):2192-2197. doi: 10.1182/blood.2023021119. PMID: 37616555
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Treatment-free remission in chronic myeloid leukemia.
Molica M, Naqvi K, Cortes JE, Paul S, Kadia TM, Breccia M, Kantarjian H, Jabbour EJ
Clin Adv Hematol Oncol 2019 Dec;17(12):686-696. PMID: 31851157
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763

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