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Mesenchymal chondrosarcoma

MedGen UID:
104904
Concept ID:
C0206637
Neoplastic Process
Synonyms: Chondrosarcoma, Mesenchymal; Chondrosarcomas, Mesenchymal; Mesenchymal Chondrosarcoma; Mesenchymal Chondrosarcomas
SNOMED CT: Mesenchymal chondrosarcoma (1290898006); Mesenchymal chondrosarcoma (56565002)
 
Monarch Initiative: MONDO:0006853

Definition

A morphologic variant of chondrosarcoma arising from bone and soft tissue. It is characterized by the presence of malignant small round cells, biphasic growth pattern, and well differentiated hyaline cartilage. Clinical presentation includes pain and swelling. The clinical course is aggressive, with local recurrences and distant metastases. [from NCI]

Professional guidelines

PubMed

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Rekhi B, Mridha A, Kattoor J
Indian J Pathol Microbiol 2019 Apr-Jun;62(2):199-205. doi: 10.4103/IJPM.IJPM_675_18. PMID: 30971540
Thompson LD
Mod Pathol 2017 Jan;30(s1):S1-S26. doi: 10.1038/modpathol.2016.119. PMID: 28060373

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Strach MC, Grimison PS, Hong A, Boyle R, Stalley P, Karim R, Connolly EA, Bae S, Desai J, Crowe P, Singhal N, Bhadri VA
Cancer Med 2023 Jan;12(1):368-378. Epub 2022 May 23 doi: 10.1002/cam4.4849. PMID: 35603739Free PMC Article
Beena D, Kattoor J, Mathews A, P Nair S, M V, T P, N G
Gulf J Oncolog 2021 Jan;1(35):54-58. PMID: 33716213
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
Ghafoor S, Hameed MR, Tap WD, Hwang S
Skeletal Radiol 2021 Feb;50(2):333-341. Epub 2020 Jul 30 doi: 10.1007/s00256-020-03558-x. PMID: 32734374Free PMC Article
Tsuchiya M, Masui T, Otsuki Y, Sakahara H
Br J Radiol 2018 Oct;91(1090):20170579. Epub 2018 Jul 25 doi: 10.1259/bjr.20170579. PMID: 29975155Free PMC Article

Diagnosis

Beena D, Kattoor J, Mathews A, P Nair S, M V, T P, N G
Gulf J Oncolog 2021 Jan;1(35):54-58. PMID: 33716213
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP
Virchows Arch 2020 Jan;476(1):109-119. Epub 2019 Dec 4 doi: 10.1007/s00428-019-02720-8. PMID: 31802230
Peker D, Wei S, Siegal GP
Surg Pathol Clin 2019 Sep;12(3):831-847. Epub 2019 May 22 doi: 10.1016/j.path.2019.03.007. PMID: 31352990
Arora K, Riddle ND
Arch Pathol Lab Med 2018 Nov;142(11):1421-1424. doi: 10.5858/arpa.2017-0109-RS. PMID: 30407856
Simon B, Chandramohan A, Eapen A, Nayak S, Jeyaraj V
J Vasc Interv Radiol 2014 Dec;25(12):1937. Epub 2014 Nov 20 doi: 10.1016/j.jvir.2014.07.030. PMID: 25457141

Therapy

Eder JP, Doroshow DB, Do KT, Keedy VL, Sklar JS, Glazer P, Bindra R, Shapiro GI
JCO Precis Oncol 2021 Nov;5:466-472. doi: 10.1200/PO.20.00247. PMID: 34994649Free PMC Article
Tsuda Y, Ogura K, Hakozaki M, Kikuta K, Ae K, Tsuchiya H, Iwata S, Ueda T, Kawano H, Kawai A
J Surg Oncol 2017 May;115(6):760-767. doi: 10.1002/jso.24567. PMID: 29044531
Jones RL, Katz D, Loggers ET, Davidson D, Rodler ET, Pollack SM
Med Oncol 2017 Aug 29;34(10):167. doi: 10.1007/s12032-017-1030-2. PMID: 28852958Free PMC Article
Gordon EM, Sankhala KK, Chawla N, Chawla SP
Adv Ther 2016 Jul;33(7):1055-71. Epub 2016 May 27 doi: 10.1007/s12325-016-0344-3. PMID: 27234989Free PMC Article
Sevel D
Br J Ophthalmol 1974 Oct;58(10):882-7. doi: 10.1136/bjo.58.10.882. PMID: 4451652Free PMC Article

Prognosis

Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP
Virchows Arch 2020 Jan;476(1):109-119. Epub 2019 Dec 4 doi: 10.1007/s00428-019-02720-8. PMID: 31802230
Peker D, Wei S, Siegal GP
Surg Pathol Clin 2019 Sep;12(3):831-847. Epub 2019 May 22 doi: 10.1016/j.path.2019.03.007. PMID: 31352990
Arora K, Riddle ND
Arch Pathol Lab Med 2018 Nov;142(11):1421-1424. doi: 10.5858/arpa.2017-0109-RS. PMID: 30407856
Simon B, Chandramohan A, Eapen A, Nayak S, Jeyaraj V
J Vasc Interv Radiol 2014 Dec;25(12):1937. Epub 2014 Nov 20 doi: 10.1016/j.jvir.2014.07.030. PMID: 25457141

Clinical prediction guides

Eder JP, Doroshow DB, Do KT, Keedy VL, Sklar JS, Glazer P, Bindra R, Shapiro GI
JCO Precis Oncol 2021 Nov;5:466-472. doi: 10.1200/PO.20.00247. PMID: 34994649Free PMC Article
Chen W, Hornick JL, Fletcher CDM
Histopathology 2021 Jan;78(2):334-337. Epub 2020 Oct 19 doi: 10.1111/his.14231. PMID: 32779239
Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP
Virchows Arch 2020 Jan;476(1):109-119. Epub 2019 Dec 4 doi: 10.1007/s00428-019-02720-8. PMID: 31802230
Ma X, Meng G, Wang K, Li D, Wang L, Li H, Zhang J, Zhang L, Wu Z
World Neurosurg 2019 Feb;122:e1078-e1082. Epub 2018 Nov 9 doi: 10.1016/j.wneu.2018.10.230. PMID: 30415056
Kilpatrick SE, Reith JD, Rubin B
Adv Anat Pathol 2018 Sep;25(5):314-326. doi: 10.1097/PAP.0000000000000203. PMID: 29911999

Recent systematic reviews

Kumarasamy S, Garg K, Garg A, Sharma MC, Singh M, Chandra PS, Kale SS
Childs Nerv Syst 2024 Sep;40(9):2723-2733. Epub 2024 May 19 doi: 10.1007/s00381-024-06452-2. PMID: 38762839
Haider AS, Palmisciano P, Sagoo NS, Bin Alamer O, El Ahmadieh TY, Pan E, Garzon-Muvdi T
Clin Neurol Neurosurg 2022 Mar;214:107127. Epub 2022 Jan 12 doi: 10.1016/j.clineuro.2022.107127. PMID: 35151057
Xu J, Li D, Xie L, Tang S, Guo W
PLoS One 2015;10(4):e0122216. Epub 2015 Apr 7 doi: 10.1371/journal.pone.0122216. PMID: 25849226Free PMC Article

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

    Consumer resources

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