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Central Nervous System Mesenchymal Chondrosarcoma

MedGen UID:
1381789
•Concept ID:
C4329636
•
Neoplastic Process

Definition

A mesenchymal chondrosarcoma that arises from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Mesenchymal Chondrosarcoma

Recent clinical studies

Etiology

Extraskeletal Mesenchymal Chondrosarcoma of Central Nervous System - A Rare but Aggressive Tumor: Analysis of Five Cases.
Chatterjee D, Radotra BD, Madan R, Gupta SK
Neurol India 2022 Jan-Feb;70(1):285-288. doi: 10.4103/0028-3886.338726. PMID: 35263897
Primary central nervous system sarcomas in adults: A systematic review.
Haider AS, Palmisciano P, Sagoo NS, Bin Alamer O, El Ahmadieh TY, Pan E, Garzon-Muvdi T
Clin Neurol Neurosurg 2022 Mar;214:107127. Epub 2022 Jan 12 doi: 10.1016/j.clineuro.2022.107127. PMID: 35151057
Distinguishing Falcine Chondrosarcomas from Their Mimics and Management.
Omezine S, Bouali S, Taallah M, Zehani A, Kallel J, Jemel H
World Neurosurg 2018 Oct;118:279-283. Epub 2018 Jul 3 doi: 10.1016/j.wneu.2018.06.164. PMID: 30257291
Intracranial Extraskeletal Mesenchymal Chondrosarcoma.
Sadashiva N, Sharma A, Shukla D, Rajalakshmi P, Mahadevan A, Devi BI
World Neurosurg 2016 Nov;95:618.e1-618.e6. Epub 2016 Aug 23 doi: 10.1016/j.wneu.2016.08.049. PMID: 27565470
Mesenchymal chondrosarcoma: a clinicopathologic and flow cytometric study of 13 cases presenting in the central nervous system.
Rushing EJ, Armonda RA, Ansari Q, Mena H
Cancer 1996 May 1;77(9):1884-91. doi: 10.1002/(SICI)1097-0142(19960501)77:9<1884::AID-CNCR19>3.0.CO;2-W. PMID: 8646689

Diagnosis

Extraskeletal Mesenchymal Chondrosarcoma of Central Nervous System - A Rare but Aggressive Tumor: Analysis of Five Cases.
Chatterjee D, Radotra BD, Madan R, Gupta SK
Neurol India 2022 Jan-Feb;70(1):285-288. doi: 10.4103/0028-3886.338726. PMID: 35263897
Primary intradural extramedullary spinal mesenchymal chondrosarcoma: case report and literature review.
Chen CW, Chen IH, Hu MH, Lee JC, Huang HY, Hong RL, Yang SH
BMC Musculoskelet Disord 2019 Sep 4;20(1):408. doi: 10.1186/s12891-019-2799-2. PMID: 31484514Free PMC Article
Distinguishing Falcine Chondrosarcomas from Their Mimics and Management.
Omezine S, Bouali S, Taallah M, Zehani A, Kallel J, Jemel H
World Neurosurg 2018 Oct;118:279-283. Epub 2018 Jul 3 doi: 10.1016/j.wneu.2018.06.164. PMID: 30257291
Intracranial Extraskeletal Mesenchymal Chondrosarcoma.
Sadashiva N, Sharma A, Shukla D, Rajalakshmi P, Mahadevan A, Devi BI
World Neurosurg 2016 Nov;95:618.e1-618.e6. Epub 2016 Aug 23 doi: 10.1016/j.wneu.2016.08.049. PMID: 27565470
Primary falcine chondrosarcoma.
Kathiravel Y, Finnis ND
J Clin Neurosci 2008 Dec;15(12):1406-9. Epub 2008 Oct 7 doi: 10.1016/j.jocn.2007.08.005. PMID: 18842412

Therapy

Small cell osteosarcoma of the parietal region: a unique case at an unusual site.
Agarwal S, Gahlot GP, Bhalla A, Bakhshi S
BMJ Case Rep 2015 Dec 1;2015 doi: 10.1136/bcr-2015-210086. PMID: 26628304Free PMC Article
Central nervous system involvement in children with sarcoma.
Postovsky S, Ash S, Ramu IN, Yaniv Y, Zaizov R, Futerman B, Elhasid R, Ben Barak A, Halil A, Ben Arush MW
Oncology 2003;65(2):118-24. doi: 10.1159/000072336. PMID: 12931017

Prognosis

Distinguishing Falcine Chondrosarcomas from Their Mimics and Management.
Omezine S, Bouali S, Taallah M, Zehani A, Kallel J, Jemel H
World Neurosurg 2018 Oct;118:279-283. Epub 2018 Jul 3 doi: 10.1016/j.wneu.2018.06.164. PMID: 30257291
Intracranial Extraskeletal Mesenchymal Chondrosarcoma.
Sadashiva N, Sharma A, Shukla D, Rajalakshmi P, Mahadevan A, Devi BI
World Neurosurg 2016 Nov;95:618.e1-618.e6. Epub 2016 Aug 23 doi: 10.1016/j.wneu.2016.08.049. PMID: 27565470
Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases.
Fanburg-Smith JC, Auerbach A, Marwaha JS, Wang Z, Santi M, Judkins AR, Rushing EJ
Ann Diagn Pathol 2010 Feb;14(1):8-14. Epub 2009 Dec 8 doi: 10.1016/j.anndiagpath.2009.09.003. PMID: 20123451
Central nervous system mesenchymal chondrosarcoma.
Salvati M, Caroli E, Frati A, Piccirilli M, Agrillo A, Brogna C, Occhiogrosso G, Giangaspero F
J Exp Clin Cancer Res 2005 Jun;24(2):317-24. PMID: 16110767
Mesenchymal chondrosarcoma: a clinicopathologic and flow cytometric study of 13 cases presenting in the central nervous system.
Rushing EJ, Armonda RA, Ansari Q, Mena H
Cancer 1996 May 1;77(9):1884-91. doi: 10.1002/(SICI)1097-0142(19960501)77:9<1884::AID-CNCR19>3.0.CO;2-W. PMID: 8646689

Clinical prediction guides

Case report: A mesenchymal chondrosarcoma with alternative HEY1::NCOA2 fusions in the sella turcica.
Kishikawa S, Kondo A, Yao T, Saito T
Pathol Oncol Res 2024;30:1611730. Epub 2024 Aug 6 doi: 10.3389/pore.2024.1611730. PMID: 39165647Free PMC Article
Paediatric High-Grade Intracranial Mesenchymal Chondrosarcoma: A Case Report with 6 Years of Follow-Up without Recurrence.
Afşer KA, İştemen İ, Arslan A, Ökten AI
Pediatr Neurosurg 2020;55(5):299-303. Epub 2020 Nov 5 doi: 10.1159/000511021. PMID: 33152731
Spontaneous Intraventricular Hemorrhage: A Rare Presentation of a Skull Base Mesenchymal Chondrosarcoma.
Laghari AA, Javed G, Khan MF, Ahmed SI, Nathani KR, Ahmed R
World Neurosurg 2017 Mar;99:811.e1-811.e5. Epub 2016 Dec 29 doi: 10.1016/j.wneu.2016.12.086. PMID: 28042016
Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases.
Fanburg-Smith JC, Auerbach A, Marwaha JS, Wang Z, Rushing EJ
Hum Pathol 2010 May;41(5):653-62. doi: 10.1016/j.humpath.2009.11.006. PMID: 20138330
Central nervous system mesenchymal chondrosarcoma. Case report.
Harsh GR 4th, Wilson CB
J Neurosurg 1984 Aug;61(2):375-81. doi: 10.3171/jns.1984.61.2.0375. PMID: 6539815

Recent systematic reviews

Primary central nervous system sarcomas in adults: A systematic review.
Haider AS, Palmisciano P, Sagoo NS, Bin Alamer O, El Ahmadieh TY, Pan E, Garzon-Muvdi T
Clin Neurol Neurosurg 2022 Mar;214:107127. Epub 2022 Jan 12 doi: 10.1016/j.clineuro.2022.107127. PMID: 35151057

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