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Oral cavity carcinoma

MedGen UID:
57468
•Concept ID:
C0151546
•
Neoplastic Process
Synonyms: Carcinoma of Mouth; carcinoma of mouth; Carcinoma of Oral Cavity; carcinoma of oral cavity; Carcinoma of the Oral Cavity; carcinoma of the oral cavity; Mouth Carcinoma; mouth carcinoma; Oral Cavity Carcinoma; oral cavity carcinoma
 
Monarch Initiative: MONDO:0044925

Definition

A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral cavity carcinoma

Professional guidelines

PubMed

Oligometastases in head and neck carcinoma and their impact on management.
Mat Lazim N, Elliott M, Wykes J, Clark J
ANZ J Surg 2021 Dec;91(12):2617-2623. Epub 2021 Feb 26 doi: 10.1111/ans.16622. PMID: 33634950
Oral Cavity Carcinoma: Current Management, Controversies, and Future Directions.
Chinn SB, Myers JN
J Clin Oncol 2015 Oct 10;33(29):3269-76. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.61.2929. PMID: 26351335Free PMC Article
Oral cancer treatment.
Day TA, Davis BK, Gillespie MB, Joe JK, Kibbey M, Martin-Harris B, Neville B, Reed SG, Richardson MS, Rosenzweig S, Sharma AK, Smith MM, Stewart S, Stuart RK
Curr Treat Options Oncol 2003 Feb;4(1):27-41. doi: 10.1007/s11864-003-0029-4. PMID: 12525277

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Oral cavity carcinoma in patients with and without a history of lichen planus: A comparative analysis.
Iocca O, Copelli C, Rubattino S, Sedran L, Di Maio P, Arduino PG, Ramieri G, Garzino-Demo P
Head Neck 2023 Jun;45(6):1367-1375. Epub 2023 Mar 31 doi: 10.1002/hed.27350. PMID: 37002194
Lymph node ratio-dependent prognosis stratification and postoperative radiotherapy utilization in T1-2N1 oral cavity carcinoma.
Wang J, Liu Y, Shayan G, Ma Y, Yi J
Radiother Oncol 2022 Jul;172:83-90. Epub 2022 May 12 doi: 10.1016/j.radonc.2022.05.009. PMID: 35568286
Salvage surgery for recurrent carcinoma of the oral cavity: assessment of prognostic factors.
Nandy K, Rai S, Bhatt S, Puj K, Rathod P, Gangopadhyay A
Int J Oral Maxillofac Surg 2022 May;51(5):602-611. Epub 2021 Aug 19 doi: 10.1016/j.ijom.2021.07.020. PMID: 34419287
p53 mutations in oral cavity carcinoma.
Ragos V, S Mastronikolis N, Tsiambas E, Baliou E, N Mastronikolis S, Tsoukalas N, E Patsouri E, P Fotiades P
J BUON 2018 Nov-Dec;23(6):1569-1572. PMID: 30610778
Epidemiology of Oral Cancer in Iran: a Systematic Review.
Maleki D, Ghojazadeh M, Mahmoudi SS, Mahmoudi SM, Pournaghi-Azar F, Torab A, Piri R, Azami-Aghdash S, Naghavi-Behzad M
Asian Pac J Cancer Prev 2015;16(13):5427-32. doi: 10.7314/apjcp.2015.16.13.5427. PMID: 26225689

Diagnosis

Oral cavity carcinoma in patients with and without a history of lichen planus: A comparative analysis.
Iocca O, Copelli C, Rubattino S, Sedran L, Di Maio P, Arduino PG, Ramieri G, Garzino-Demo P
Head Neck 2023 Jun;45(6):1367-1375. Epub 2023 Mar 31 doi: 10.1002/hed.27350. PMID: 37002194
Autofluorescence Image-Guided Endoscopy in the Management of Upper Aerodigestive Tract Tumors.
Mat Lazim N, Kandhro AH, Menegaldo A, Spinato G, Verro B, Abdullah B
Int J Environ Res Public Health 2022 Dec 22;20(1) doi: 10.3390/ijerph20010159. PMID: 36612479Free PMC Article
Systematic classification of confocal laser endomicroscopy for the diagnosis of oral cavity carcinoma.
Sievert M, Oetter N, Mantsopoulos K, Gostian AO, Mueller SK, Koch M, Balk M, Thimsen V, Stelzle F, Eckstein M, Iro H, Goncalves M
Oral Oncol 2022 Sep;132:105978. Epub 2022 Jun 21 doi: 10.1016/j.oraloncology.2022.105978. PMID: 35749803
What is the role of sentinel lymph node biopsy in early-stage oral cavity carcinoma?
Mehta V, Nathan CA
Laryngoscope 2016 Jan;126(1):9-10. Epub 2015 Aug 8 doi: 10.1002/lary.25541. PMID: 26257245
An oral cavity carcinoma nomogram to predict benefit of adjuvant radiotherapy.
Wang SJ, Patel SG, Shah JP, Goldstein DP, Irish JC, Carvalho AL, Kowalski LP, Lockhart JL, Holland JM, Gross ND
JAMA Otolaryngol Head Neck Surg 2013 Jun;139(6):554-9. doi: 10.1001/jamaoto.2013.3001. PMID: 23680917

Therapy

Individualized risk assessment of distant metastases in oral cavity carcinoma: a validated predictive-score model.
Id Said B, Alfaraj FA, Marta GN, Kowalski LP, Kohler HF, Huang SH, Su J, Xu W, Eng L, de Moraes FY, Hahn E, Kim JJ, O'Sullivan B, Ringash J, Waldron J, Matos LL, Prisman E, Irish JC, Yao CMKL, de Almeida JR, Goldstein DP, Hope A, Hosni A
J Natl Cancer Inst 2023 Dec 6;115(12):1555-1562. doi: 10.1093/jnci/djad144. PMID: 37498564
Non-operative management for oral cavity carcinoma: Definitive radiation therapy as a potential alternative treatment approach.
Hosni A, Chiu K, Huang SH, Xu W, Huang J, Bayley A, Bratman SV, Cho J, Giuliani M, Kim J, O'Sullivan B, Ringash J, Waldron J, Spreafico A, de Almeida JR, Monteiro E, Witterick I, Chepeha DB, Gilbert RW, Irish JC, Goldstein DP, Hope A
Radiother Oncol 2021 Jan;154:70-75. Epub 2020 Aug 28 doi: 10.1016/j.radonc.2020.08.013. PMID: 32861702Free PMC Article
Oral Cavity Cancer Outcomes in Remote, Betel Nut-Endemic Pacific Islands.
Narayanan AM, Finegersh AF, Chang MP, Orosco RK, Moss WJ
Ann Otol Rhinol Laryngol 2020 Dec;129(12):1215-1220. Epub 2020 Jun 16 doi: 10.1177/0003489420934846. PMID: 32546006
Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience.
Scher ED, Romesser PB, Chen C, Ho F, Wuu Y, Sherman EJ, Fury MG, Wong RJ, McBride S, Lee NY, Riaz N
Oral Oncol 2015 Jul;51(7):709-15. Epub 2015 May 7 doi: 10.1016/j.oraloncology.2015.04.007. PMID: 25958830Free PMC Article
Oral cancer treatment.
Day TA, Davis BK, Gillespie MB, Joe JK, Kibbey M, Martin-Harris B, Neville B, Reed SG, Richardson MS, Rosenzweig S, Sharma AK, Smith MM, Stewart S, Stuart RK
Curr Treat Options Oncol 2003 Feb;4(1):27-41. doi: 10.1007/s11864-003-0029-4. PMID: 12525277

Prognosis

Oral cavity carcinoma in patients with and without a history of lichen planus: A comparative analysis.
Iocca O, Copelli C, Rubattino S, Sedran L, Di Maio P, Arduino PG, Ramieri G, Garzino-Demo P
Head Neck 2023 Jun;45(6):1367-1375. Epub 2023 Mar 31 doi: 10.1002/hed.27350. PMID: 37002194
Autofluorescence Image-Guided Endoscopy in the Management of Upper Aerodigestive Tract Tumors.
Mat Lazim N, Kandhro AH, Menegaldo A, Spinato G, Verro B, Abdullah B
Int J Environ Res Public Health 2022 Dec 22;20(1) doi: 10.3390/ijerph20010159. PMID: 36612479Free PMC Article
Salvage surgery for recurrent carcinoma of the oral cavity: assessment of prognostic factors.
Nandy K, Rai S, Bhatt S, Puj K, Rathod P, Gangopadhyay A
Int J Oral Maxillofac Surg 2022 May;51(5):602-611. Epub 2021 Aug 19 doi: 10.1016/j.ijom.2021.07.020. PMID: 34419287
p53 mutations in oral cavity carcinoma.
Ragos V, S Mastronikolis N, Tsiambas E, Baliou E, N Mastronikolis S, Tsoukalas N, E Patsouri E, P Fotiades P
J BUON 2018 Nov-Dec;23(6):1569-1572. PMID: 30610778
Epidemiology of Oral Cancer in Iran: a Systematic Review.
Maleki D, Ghojazadeh M, Mahmoudi SS, Mahmoudi SM, Pournaghi-Azar F, Torab A, Piri R, Azami-Aghdash S, Naghavi-Behzad M
Asian Pac J Cancer Prev 2015;16(13):5427-32. doi: 10.7314/apjcp.2015.16.13.5427. PMID: 26225689

Clinical prediction guides

Submandibular gland involvement in oral cavity squamous cell carcinoma: a retrospective multicenter study.
Iocca O, Copelli C, Garzino-Demo P, Ramieri G, Rubattino S, Sedran L, Volpe F, Manfuso A, Longo F, Sanchez-Aniceto G, Rivero-Calle Á, García-Sánchez A, Pellini R, Petruzzi G, Moretto S, Al-Qamachi L, Aga H, Ridley S, Di Maio P
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4205-4214. Epub 2023 Jun 6 doi: 10.1007/s00405-023-08007-8. PMID: 37280380Free PMC Article
Systematic classification of confocal laser endomicroscopy for the diagnosis of oral cavity carcinoma.
Sievert M, Oetter N, Mantsopoulos K, Gostian AO, Mueller SK, Koch M, Balk M, Thimsen V, Stelzle F, Eckstein M, Iro H, Goncalves M
Oral Oncol 2022 Sep;132:105978. Epub 2022 Jun 21 doi: 10.1016/j.oraloncology.2022.105978. PMID: 35749803
Salvage surgery for recurrent carcinoma of the oral cavity: assessment of prognostic factors.
Nandy K, Rai S, Bhatt S, Puj K, Rathod P, Gangopadhyay A
Int J Oral Maxillofac Surg 2022 May;51(5):602-611. Epub 2021 Aug 19 doi: 10.1016/j.ijom.2021.07.020. PMID: 34419287
Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers.
Tang KD, Menezes L, Baeten K, Walsh LJ, Whitfield BCS, Batstone MD, Kenny L, Frazer IH, Scheper GC, Punyadeera C
Biomolecules 2020 Feb 3;10(2) doi: 10.3390/biom10020223. PMID: 32028653Free PMC Article
p53 mutations in oral cavity carcinoma.
Ragos V, S Mastronikolis N, Tsiambas E, Baliou E, N Mastronikolis S, Tsoukalas N, E Patsouri E, P Fotiades P
J BUON 2018 Nov-Dec;23(6):1569-1572. PMID: 30610778

Recent systematic reviews

Submandibular gland involvement in oral cavity squamous cell carcinoma: a retrospective multicenter study.
Iocca O, Copelli C, Garzino-Demo P, Ramieri G, Rubattino S, Sedran L, Volpe F, Manfuso A, Longo F, Sanchez-Aniceto G, Rivero-Calle Á, García-Sánchez A, Pellini R, Petruzzi G, Moretto S, Al-Qamachi L, Aga H, Ridley S, Di Maio P
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4205-4214. Epub 2023 Jun 6 doi: 10.1007/s00405-023-08007-8. PMID: 37280380Free PMC Article
Selective neck dissection in surgically treated head and neck squamous cell carcinoma patients with a clinically positive neck: Systematic review.
Rodrigo JP, Grilli G, Shah JP, Medina JE, Robbins KT, Takes RP, Hamoir M, Kowalski LP, Suárez C, López F, Quer M, Boedeker CC, de Bree R, Coskun H, Rinaldo A, Silver CE, Ferlito A
Eur J Surg Oncol 2018 Apr;44(4):395-403. Epub 2018 Jan 11 doi: 10.1016/j.ejso.2018.01.003. PMID: 29395434
Epidemiology of Oral Cancer in Iran: a Systematic Review.
Maleki D, Ghojazadeh M, Mahmoudi SS, Mahmoudi SM, Pournaghi-Azar F, Torab A, Piri R, Azami-Aghdash S, Naghavi-Behzad M
Asian Pac J Cancer Prev 2015;16(13):5427-32. doi: 10.7314/apjcp.2015.16.13.5427. PMID: 26225689
Exploring the link between microorganisms and oral cancer: a systematic review of the literature.
Hooper SJ, Wilson MJ, Crean SJ
Head Neck 2009 Sep;31(9):1228-39. doi: 10.1002/hed.21140. PMID: 19475550

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    Clinical resources

    Practice guidelines

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

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    Reviews

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