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Locally Advanced Oral Cavity Carcinoma

MedGen UID:
1734218
•Concept ID:
C5419068
•
Neoplastic Process

Definition

Oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Oral Cavity Carcinoma

Professional guidelines

PubMed

Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies.
Asarkar AA, Chang BA, de Bree R, Kowalski LP, Guntinas-Lichius O, Bradley PJ, de Graaf P, Strojan P, Rao KN, Mäkitie AA, López F, Rinaldo A, Palme C, Genden EM, Sanabria A, Rodrigo JP, Ferlito A
Adv Ther 2024 Jun;41(6):2133-2150. Epub 2024 Apr 20 doi: 10.1007/s12325-024-02861-6. PMID: 38642199

Recent clinical studies

Etiology

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas.
Wang K, Gui L, Lu H, He X, Li D, Liu C, Liu S, Wang X
Front Immunol 2023;14:1189752. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1189752. PMID: 37583698Free PMC Article
Neoadjuvant immunochemotherapy for locally advanced resectable oral squamous cell carcinoma: a prospective single-arm trial (Illuminate Trial).
Huang Y, Sun J, Li J, Zhu D, Dong M, Dou S, Tang Y, Shi W, Sun Q, Zhao T, Zhou Z, Zhou X, Liu Y, Li J, Zhu G, Zhang D, Chen Y, Zhu Q, Ju W, Zhong L
Int J Surg 2023 Aug 1;109(8):2220-2227. doi: 10.1097/JS9.0000000000000489. PMID: 37288582Free PMC Article
Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma.
Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS
Cell Rep Med 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. PMID: 34755131Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Diagnosis

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Adenoid Cystic Carcinoma.
Castelnuovo P, Turri-Zanoni M
Adv Otorhinolaryngol 2020;84:197-209. Epub 2020 Jul 30 doi: 10.1159/000457939. PMID: 32731238
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Therapy

A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma.
Ju WT, Xia RH, Zhu DW, Dou SJ, Zhu GP, Dong MJ, Wang LZ, Sun Q, Zhao TC, Zhou ZH, Liang SY, Huang YY, Tang Y, Wu SC, Xia J, Chen SQ, Bai YZ, Li J, Zhu Q, Zhong LP
Nat Commun 2022 Sep 14;13(1):5378. doi: 10.1038/s41467-022-33080-8. PMID: 36104359Free PMC Article
Phase II Clinical Trial of Neoadjuvant and Adjuvant Pembrolizumab in Resectable Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma.
Wise-Draper TM, Gulati S, Palackdharry S, Hinrichs BH, Worden FP, Old MO, Dunlap NE, Kaczmar JM, Patil Y, Riaz MK, Tang A, Mark J, Zender C, Gillenwater AM, Bell D, Kurtzweil N, Mathews M, Allen CL, Mierzwa ML, Casper K, Jandarov R, Medvedovic M, Lee JJ, Harun N, Takiar V, Gillison M
Clin Cancer Res 2022 Apr 1;28(7):1345-1352. doi: 10.1158/1078-0432.CCR-21-3351. PMID: 35338369Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma.
Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS
Cell Rep Med 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. PMID: 34755131Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Prognosis

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas.
Wang K, Gui L, Lu H, He X, Li D, Liu C, Liu S, Wang X
Front Immunol 2023;14:1189752. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1189752. PMID: 37583698Free PMC Article
Induction Chemotherapy for Advanced Oral Cavity Cancer.
de Oliveira TB, Marta GN, de Castro Junior G, Kowalski LP
Curr Oncol Rep 2021 Aug 27;23(11):129. doi: 10.1007/s11912-021-01119-6. PMID: 34453267
Contemporary Treatment of Locally Advanced Oral Cancer.
Kim D, Li R
Curr Treat Options Oncol 2019 Mar 14;20(4):32. doi: 10.1007/s11864-019-0631-8. PMID: 30874958
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678

Clinical prediction guides

Neoadjuvant immunochemotherapy for locally advanced resectable oral squamous cell carcinoma: a prospective single-arm trial (Illuminate Trial).
Huang Y, Sun J, Li J, Zhu D, Dong M, Dou S, Tang Y, Shi W, Sun Q, Zhao T, Zhou Z, Zhou X, Liu Y, Li J, Zhu G, Zhang D, Chen Y, Zhu Q, Ju W, Zhong L
Int J Surg 2023 Aug 1;109(8):2220-2227. doi: 10.1097/JS9.0000000000000489. PMID: 37288582Free PMC Article
A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma.
Ju WT, Xia RH, Zhu DW, Dou SJ, Zhu GP, Dong MJ, Wang LZ, Sun Q, Zhao TC, Zhou ZH, Liang SY, Huang YY, Tang Y, Wu SC, Xia J, Chen SQ, Bai YZ, Li J, Zhu Q, Zhong LP
Nat Commun 2022 Sep 14;13(1):5378. doi: 10.1038/s41467-022-33080-8. PMID: 36104359Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Response and recurrence correlates in individuals treated with neoadjuvant anti-PD-1 therapy for resectable oral cavity squamous cell carcinoma.
Liu S, Knochelmann HM, Lomeli SH, Hong A, Richardson M, Yang Z, Lim RJ, Wang Y, Dumitras C, Krysan K, Timmers C, Romeo MJ, Krieg C, O'Quinn EC, Horton JD, Dubinett SM, Paulos CM, Neskey DM, Lo RS
Cell Rep Med 2021 Oct 19;2(10):100411. doi: 10.1016/j.xcrm.2021.100411. PMID: 34755131Free PMC Article
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205

Recent systematic reviews

Methods, Detection Rates, and Survival Outcomes of Screening for Head and Neck Cancers: A Systematic Review.
Sykes EA, Weisbrod N, Rival E, Haque A, Fu R, Eskander A
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1047-1056. doi: 10.1001/jamaoto.2023.3010. PMID: 37796524
Prognostic significance of CircRNAs expression in oral squamous cell carcinoma.
Zhang L, Wang M, Ren W, Li S, Zhi K, Gao L, Zheng J
Oral Dis 2023 May;29(4):1439-1453. Epub 2022 Mar 27 doi: 10.1111/odi.14188. PMID: 35286741
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
A systematic review of proteomic biomarkers in oral squamous cell cancer.
Pillai J, Chincholkar T, Dixit R, Pandey M
World J Surg Oncol 2021 Oct 28;19(1):315. doi: 10.1186/s12957-021-02423-y. PMID: 34711249Free PMC Article
Prognostic value of c-MET in head and neck cancer: A systematic review and meta-analysis of aggregate data.
Szturz P, Budíková M, Vermorken JB, Horová I, Gál B, Raymond E, de Gramont A, Faivre S
Oral Oncol 2017 Nov;74:68-76. Epub 2017 Sep 27 doi: 10.1016/j.oraloncology.2017.09.009. PMID: 29103754

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