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Sarcomatoid carcinoma of the tongue

MedGen UID:
834096
•Concept ID:
C2018408
•
Neoplastic Process
Synonym: Spindle cell carcinoma of the tongue
 
HPO: HP:0030415

Definition

Sarcomatoid (spindle cell) carcinomas of the tongue is a variant of squamous carcinoma of tongue that is monoclonal, having evolved from a conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcomatoid carcinoma of the tongue

Professional guidelines

PubMed

AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406
White lesions in the oral cavity: clinical presentation, diagnosis, and treatment.
Jones KB, Jordan R
Semin Cutan Med Surg 2015 Dec;34(4):161-70. doi: 10.12788/j.sder.2015.0180. PMID: 26650693

Recent clinical studies

Etiology

High-Performance Photodynamic Therapy of Tongue Squamous Cell Carcinoma with Multifunctional Nano-Verteporfin.
Yu L, Xu Z, Zhu G, Zeng L, Zhang Z, Yu Y, Wang S, Zhang X, Zhou N, Liang L
Int J Nanomedicine 2024;19:2611-2623. Epub 2024 Mar 13 doi: 10.2147/IJN.S452060. PMID: 38505166Free PMC Article
Prediction of Prognosis of Tongue Squamous Cell Carcinoma Based on Clinical MR Imaging Data Modeling.
Liu J, Song L, Zhou J, Yu M, Hu Y, Zhang J, Song P, Ye Y, Wang J, Feng G, Guo H, An P
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207006. doi: 10.1177/15330338231207006. PMID: 37872687Free PMC Article
Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study.
Calabrese L, Tagliabue M, Grammatica A, De Berardinis R, Corso F, Gazzini L, Abousiam M, Fazio E, Mattavelli D, Fontanella W, Giannini L, Bresciani L, Bruschini R, Gandini S, Piazza C, Ansarin M
Head Neck 2023 Nov;45(11):2862-2873. Epub 2023 Sep 20 doi: 10.1002/hed.27517. PMID: 37727894
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546

Diagnosis

Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Case of squamous cell carcinoma of the tongue in a pregnant woman, with literature review.
Alramadhan SA, Fitzpatrick SG, Kim K, Cohen DM, Bhattacharyya I, Islam MN
Quintessence Int 2021 Mar 3;52(4):340-346. doi: 10.3290/j.qi.b912637. PMID: 33491384
Transoral Robotic Surgery and the Unknown Primary.
Ofo E, Spiers H, Kim D, Duvvuri U
ORL J Otorhinolaryngol Relat Spec 2018;80(3-4):148-155. Epub 2018 Nov 12 doi: 10.1159/000490596. PMID: 30419564
Newly described salivary gland tumors.
Skalova A, Michal M, Simpson RH
Mod Pathol 2017 Jan;30(s1):S27-S43. doi: 10.1038/modpathol.2016.167. PMID: 28060365
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Therapy

High-Performance Photodynamic Therapy of Tongue Squamous Cell Carcinoma with Multifunctional Nano-Verteporfin.
Yu L, Xu Z, Zhu G, Zeng L, Zhang Z, Yu Y, Wang S, Zhang X, Zhou N, Liang L
Int J Nanomedicine 2024;19:2611-2623. Epub 2024 Mar 13 doi: 10.2147/IJN.S452060. PMID: 38505166Free PMC Article
Subgemmal neurogenous plaques of the tongue: a systematic autopsy study.
Val-Bernal JF, Garijo MF, Fontanil N
Rom J Morphol Embryol 2022 Jul-Sep;63(3):545-553. doi: 10.47162/RJME.63.3.09. PMID: 36588493Free PMC Article
The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma.
Campbell BR, Chen Z, Faden DL, Agrawal N, Li RJ, Hanna GJ, Iyer NG, Boot A, Rozen SG, Vettore AL, Panda B, Krishnan NM, Pickering CR, Myers JN, Guo X, Lang Kuhs KA
Cancer 2021 Feb 15;127(4):544-553. Epub 2020 Nov 4 doi: 10.1002/cncr.33309. PMID: 33146897Free PMC Article
Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma: A Phase 2 Open-Label Randomized Clinical Trial.
Schoenfeld JD, Hanna GJ, Jo VY, Rawal B, Chen YH, Catalano PS, Lako A, Ciantra Z, Weirather JL, Criscitiello S, Luoma A, Chau N, Lorch J, Kass JI, Annino D, Goguen L, Desai A, Ross B, Shah HJ, Jacene HA, Margalit DN, Tishler RB, Wucherpfennig KW, Rodig SJ, Uppaluri R, Haddad RI
JAMA Oncol 2020 Oct 1;6(10):1563-1570. doi: 10.1001/jamaoncol.2020.2955. PMID: 32852531Free PMC Article
Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial.
Nichols AC, Theurer J, Prisman E, Read N, Berthelet E, Tran E, Fung K, de Almeida JR, Bayley A, Goldstein DP, Hier M, Sultanem K, Richardson K, Mlynarek A, Krishnan S, Le H, Yoo J, MacNeil SD, Winquist E, Hammond JA, Venkatesan V, Kuruvilla S, Warner A, Mitchell S, Chen J, Corsten M, Johnson-Obaseki S, Eapen L, Odell M, Parker C, Wehrli B, Kwan K, Palma DA
Lancet Oncol 2019 Oct;20(10):1349-1359. Epub 2019 Aug 12 doi: 10.1016/S1470-2045(19)30410-3. PMID: 31416685

Prognosis

Prediction of Prognosis of Tongue Squamous Cell Carcinoma Based on Clinical MR Imaging Data Modeling.
Liu J, Song L, Zhou J, Yu M, Hu Y, Zhang J, Song P, Ye Y, Wang J, Feng G, Guo H, An P
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207006. doi: 10.1177/15330338231207006. PMID: 37872687Free PMC Article
Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study.
Calabrese L, Tagliabue M, Grammatica A, De Berardinis R, Corso F, Gazzini L, Abousiam M, Fazio E, Mattavelli D, Fontanella W, Giannini L, Bresciani L, Bruschini R, Gandini S, Piazza C, Ansarin M
Head Neck 2023 Nov;45(11):2862-2873. Epub 2023 Sep 20 doi: 10.1002/hed.27517. PMID: 37727894
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG
Oral Oncol 2019 Mar;90:115-121. Epub 2019 Feb 15 doi: 10.1016/j.oraloncology.2019.02.001. PMID: 30846169Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546

Clinical prediction guides

Efficacy of MUC1-targeted CAR-NK cells against human tongue squamous cell carcinoma.
Lin X, Guan T, Li Y, Lin Y, Huang G, Lin Y, Sun P, Li C, Gu J, Zeng H, Ma C
Front Immunol 2024;15:1337557. Epub 2024 Feb 7 doi: 10.3389/fimmu.2024.1337557. PMID: 38390321Free PMC Article
Prediction of Prognosis of Tongue Squamous Cell Carcinoma Based on Clinical MR Imaging Data Modeling.
Liu J, Song L, Zhou J, Yu M, Hu Y, Zhang J, Song P, Ye Y, Wang J, Feng G, Guo H, An P
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207006. doi: 10.1177/15330338231207006. PMID: 37872687Free PMC Article
Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study.
Calabrese L, Tagliabue M, Grammatica A, De Berardinis R, Corso F, Gazzini L, Abousiam M, Fazio E, Mattavelli D, Fontanella W, Giannini L, Bresciani L, Bruschini R, Gandini S, Piazza C, Ansarin M
Head Neck 2023 Nov;45(11):2862-2873. Epub 2023 Sep 20 doi: 10.1002/hed.27517. PMID: 37727894
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Margin distance in oral tongue cancer surgery: A systematic review of survival and recurrence outcomes.
Spence RN, Efthymiou V, Goss D, Varvares MA
Oral Oncol 2023 Dec;147:106609. Epub 2023 Nov 8 doi: 10.1016/j.oraloncology.2023.106609. PMID: 37948894
Systematic review of benefits and practical challenges for application of Mohs surgery for oral tumors.
Hussain A, Kim EY, Khachemoune A
Arch Dermatol Res 2023 Nov;315(9):2479-2484. Epub 2023 May 12 doi: 10.1007/s00403-023-02632-3. PMID: 37173597
Oral and Maxillofacial Neuroendocrine Carcinoma: A Systematic Review.
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Human papillomavirus infection and oral squamous cell carcinoma - a systematic review.
Melo BAC, Vilar LG, Oliveira NR, Lima PO, Pinheiro MB, Domingueti CP, Pereira MC
Braz J Otorhinolaryngol 2021 May-Jun;87(3):346-352. Epub 2020 Nov 29 doi: 10.1016/j.bjorl.2020.10.017. PMID: 33339760Free PMC Article
Age and risk of recurrence in oral tongue squamous cell carcinoma: Systematic review.
Lenze NR, Farquhar DR, Dorismond C, Sheth S, Zevallos JP, Blumberg J, Lumley C, Patel S, Hackman T, Weissler MC, Yarbrough WG, Olshan AF, Zanation AM
Head Neck 2020 Dec;42(12):3755-3768. Epub 2020 Sep 11 doi: 10.1002/hed.26464. PMID: 32914472

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