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Periapical periodontitis

MedGen UID:
45396
•Concept ID:
C0031030
•
Disease or Syndrome
Synonyms: Apical Periodontitides; Apical Periodontitis; Periapical Periodontitides; Periapical Periodontitis; Periodontitides, Apical; Periodontitides, Periapical; Periodontitis, Apical; Periodontitis, Periapical
SNOMED CT: Apical periodontitis (39273001)
 
Monarch Initiative: MONDO:0004508

Definition

Inflammation of the periapical tissue. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is periapical granuloma. Suppurative inflammation is periapical abscess. [from MONDO]

Professional guidelines

PubMed

Management of Endodontic Disease for Odontogenic Sinusitis.
Pannkuk TF, Craig JR, Tušas P, Simuntis R
Otolaryngol Clin North Am 2024 Dec;57(6):1119-1138. Epub 2024 Aug 30 doi: 10.1016/j.otc.2024.07.002. PMID: 39214736
Effect of endodontic treatment on endothelial dysfunction and subclinical atherosclerosis-a prospective intervention study.
Chauhan N, Mittal S, Tewari S, Sen J, Laller K
Clin Oral Investig 2023 Sep;27(9):5617-5625. Epub 2023 Jul 31 doi: 10.1007/s00784-023-05183-z. PMID: 37522992
European Society of Endodontology position statement: the use of antibiotics in endodontics.
Segura-Egea JJ, Gould K, Şen BH, Jonasson P, Cotti E, Mazzoni A, Sunay H, Tjäderhane L, Dummer PMH
Int Endod J 2018 Jan;51(1):20-25. Epub 2017 Jun 14 doi: 10.1111/iej.12781. PMID: 28436043

Recent clinical studies

Etiology

Interaction between apical periodontitis and systemic disease (Review).
Ye L, Cao L, Song W, Yang C, Tang Q, Yuan Z
Int J Mol Med 2023 Jul;52(1) Epub 2023 Jun 2 doi: 10.3892/ijmm.2023.5263. PMID: 37264964Free PMC Article
Non-surgical root canal treatment and retreatment versus apical surgery in treating apical periodontitis: A systematic review.
Bucchi C, Rosen E, Taschieri S
Int Endod J 2023 Oct;56 Suppl 3:475-486. Epub 2022 Jul 9 doi: 10.1111/iej.13793. PMID: 35762859
Present status and future directions: Microbiology of endodontic infections.
Siqueira JF Jr, Rôças IN
Int Endod J 2022 May;55 Suppl 3:512-530. Epub 2022 Jan 13 doi: 10.1111/iej.13677. PMID: 34958494
Endodontic medicine: connections between apical periodontitis and systemic diseases.
Segura-Egea JJ, Martín-González J, Castellanos-Cosano L
Int Endod J 2015 Oct;48(10):933-51. Epub 2015 Aug 3 doi: 10.1111/iej.12507. PMID: 26174809
Causes and management of post-treatment apical periodontitis.
Siqueira JF Jr, Rôças IN, Ricucci D, Hülsmann M
Br Dent J 2014 Mar;216(6):305-12. doi: 10.1038/sj.bdj.2014.200. PMID: 24651336

Diagnosis

Artificial intelligence for caries and periapical periodontitis detection.
Li S, Liu J, Zhou Z, Zhou Z, Wu X, Li Y, Wang S, Liao W, Ying S, Zhao Z
J Dent 2022 Jul;122:104107. Epub 2022 Mar 24 doi: 10.1016/j.jdent.2022.104107. PMID: 35341892
Apical periodontitis after intense bruxism.
Gund MP, Wrbas KT, Hannig M, Rupf S
BMC Oral Health 2022 Mar 24;22(1):91. doi: 10.1186/s12903-022-02123-3. PMID: 35331220Free PMC Article
Present status and future directions: Managing endodontic emergencies.
Abbott PV
Int Endod J 2022 May;55 Suppl 3:778-803. Epub 2022 Jan 13 doi: 10.1111/iej.13678. PMID: 34958512
The global prevalence of apical periodontitis: a systematic review and meta-analysis.
Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA
Int Endod J 2021 May;54(5):712-735. Epub 2021 Jan 22 doi: 10.1111/iej.13467. PMID: 33378579
Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.
Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513Free PMC Article

Therapy

Apical periodontitis after intense bruxism.
Gund MP, Wrbas KT, Hannig M, Rupf S
BMC Oral Health 2022 Mar 24;22(1):91. doi: 10.1186/s12903-022-02123-3. PMID: 35331220Free PMC Article
Present status and future directions of intracanal medicaments.
Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J
Int Endod J 2022 May;55 Suppl 3(Suppl 3):613-636. Epub 2022 Apr 19 doi: 10.1111/iej.13731. PMID: 35322427Free PMC Article
Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981
Endodontic procedures for retreatment of periapical lesions.
Del Fabbro M, Corbella S, Sequeira-Byron P, Tsesis I, Rosen E, Lolato A, Taschieri S
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005511. doi: 10.1002/14651858.CD005511.pub3. PMID: 27759881Free PMC Article
Causes and management of post-treatment apical periodontitis.
Siqueira JF Jr, Rôças IN, Ricucci D, Hülsmann M
Br Dent J 2014 Mar;216(6):305-12. doi: 10.1038/sj.bdj.2014.200. PMID: 24651336

Prognosis

Interaction between apical periodontitis and systemic disease (Review).
Ye L, Cao L, Song W, Yang C, Tang Q, Yuan Z
Int J Mol Med 2023 Jul;52(1) Epub 2023 Jun 2 doi: 10.3892/ijmm.2023.5263. PMID: 37264964Free PMC Article
Tooth survival after endodontic treatment.
Fransson H, Dawson V
Int Endod J 2023 Mar;56 Suppl 2:140-153. Epub 2022 Oct 2 doi: 10.1111/iej.13835. PMID: 36149887
Present status and future directions of intracanal medicaments.
Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J
Int Endod J 2022 May;55 Suppl 3(Suppl 3):613-636. Epub 2022 Apr 19 doi: 10.1111/iej.13731. PMID: 35322427Free PMC Article
Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.
Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513Free PMC Article
Aetiology, classification and pathogenesis of pulp and periapical disease.
López-Marcos JF
Med Oral Patol Oral Cir Bucal 2004;9 Suppl:58-62; 52-7. PMID: 15580137

Clinical prediction guides

Artificial intelligence for caries and periapical periodontitis detection.
Li S, Liu J, Zhou Z, Zhou Z, Wu X, Li Y, Wang S, Liao W, Ying S, Zhao Z
J Dent 2022 Jul;122:104107. Epub 2022 Mar 24 doi: 10.1016/j.jdent.2022.104107. PMID: 35341892
Present status and future directions of intracanal medicaments.
Ordinola-Zapata R, Noblett WC, Perez-Ron A, Ye Z, Vera J
Int Endod J 2022 May;55 Suppl 3(Suppl 3):613-636. Epub 2022 Apr 19 doi: 10.1111/iej.13731. PMID: 35322427Free PMC Article
Present status and future directions: Microbiology of endodontic infections.
Siqueira JF Jr, Rôças IN
Int Endod J 2022 May;55 Suppl 3:512-530. Epub 2022 Jan 13 doi: 10.1111/iej.13677. PMID: 34958494
Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.
Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513Free PMC Article
Assessment of treatment failure in endodontic therapy.
Bergenholtz G
J Oral Rehabil 2016 Oct;43(10):753-8. Epub 2016 Aug 13 doi: 10.1111/joor.12423. PMID: 27519460

Recent systematic reviews

Effectiveness of adjunct therapy for the treatment of apical periodontitis: A systematic review and meta-analysis.
Meire MA, Bronzato JD, Bomfim RA, Gomes BPFA
Int Endod J 2023 Oct;56 Suppl 3:455-474. Epub 2022 Oct 8 doi: 10.1111/iej.13838. PMID: 36156804
Non-surgical root canal treatment and retreatment versus apical surgery in treating apical periodontitis: A systematic review.
Bucchi C, Rosen E, Taschieri S
Int Endod J 2023 Oct;56 Suppl 3:475-486. Epub 2022 Jul 9 doi: 10.1111/iej.13793. PMID: 35762859
Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981
The global prevalence of apical periodontitis: a systematic review and meta-analysis.
Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA
Int Endod J 2021 May;54(5):712-735. Epub 2021 Jan 22 doi: 10.1111/iej.13467. PMID: 33378579
Endodontic procedures for retreatment of periapical lesions.
Del Fabbro M, Corbella S, Sequeira-Byron P, Tsesis I, Rosen E, Lolato A, Taschieri S
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005511. doi: 10.1002/14651858.CD005511.pub3. PMID: 27759881Free PMC Article

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