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Disorder of periapical tissues of tooth

MedGen UID:: 14679
•Concept ID:: C0031028
•: Disease or Syndrome

Synonyms:	Disease, Periapical; Diseases, Periapical; Periapical Disease; Periapical Diseases
SNOMED CT:	Periradicular disease (34282009); Disorder of periapical tissues of tooth (34282009)

Definition

Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDisorder of periapical tissues of tooth

Pathological process
- Disease
  - Disorder by Site
    - Connective and Soft Tissue Disorder
      - Musculoskeletal system disorder
        Disorder of jaw
        Disorder of periapical tissues of tooth
        Periapical periodontitis
        Periapical granuloma
        Suppurative periapical periodontitis
        Periapical abscess with sinus tract
        Radicular cyst

Professional guidelines

PubMed

Tooth survival after endodontic treatment.

Fransson H, Dawson V
Int Endod J 2023 Mar;56 Suppl 2:140-153. Epub 2022 Oct 2 doi: 10.1111/iej.13835. PMID: 36149887

Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.

Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513 Free PMC Article

European Society of Endodontology position statement: Management of deep caries and the exposed pulp.

European Society of Endodontology (ESE) developed by:, Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, Krastl G, Dammaschke T, Fransson H, Markvart M, Zehnder M, Bjørndal L
Int Endod J 2019 Jul;52(7):923-934. doi: 10.1111/iej.13080. PMID: 30664240

See all (594)

Recent clinical studies

Etiology

Pain and flare-up after endodontic treatment procedures.

Sipavičiūtė E, Manelienė R
Stomatologija 2014;16(1):25-30. PMID: 24824057

A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health.

Ng YL, Mann V, Gulabivala K
Int Endod J 2011 Jul;44(7):583-609. Epub 2011 Mar 2 doi: 10.1111/j.1365-2591.2011.01872.x. PMID: 21366626

Outcome of secondary root canal treatment: a systematic review of the literature.

Ng YL, Mann V, Gulabivala K
Int Endod J 2008 Dec;41(12):1026-46. doi: 10.1111/j.1365-2591.2008.01484.x. PMID: 19133093

Factors affecting the long-term results of endodontic treatment.

Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

Periapical surgery.

Hirsch JM, Ahlström U, Henrikson PA, Heyden G, Peterson LE
Int J Oral Surg 1979 Jun;8(3):173-85. doi: 10.1016/s0300-9785(79)80016-2. PMID: 118123

See all (2414)

Diagnosis

Pharmacological Management of Acute Endodontic Pain.

Khan AA, Diogenes A
Drugs 2021 Sep;81(14):1627-1643. Epub 2021 Oct 7 doi: 10.1007/s40265-021-01564-4. PMID: 34618315

The many faces of periapical inflammation.

Boeddinghaus R, Whyte A
Clin Radiol 2020 Sep;75(9):675-687. Epub 2020 Jul 14 doi: 10.1016/j.crad.2020.06.009. PMID: 32680582

Interaction between endodontics and periodontics.

Rotstein I
Periodontol 2000 2017 Jun;74(1):11-39. doi: 10.1111/prd.12188. PMID: 28429484

Periapical actinomycosis.

Pasupathy SP, Chakravarthy D, Chanmougananda S, Nair PP
BMJ Case Rep 2012 Aug 1;2012 doi: 10.1136/bcr-2012-006218. PMID: 22854234 Free PMC Article

AAE Consensus Conference on Diagnostic Terminology: background and perspectives.

Glickman GN
J Endod 2009 Dec;35(12):1619-20. doi: 10.1016/j.joen.2009.09.029. PMID: 19932336

See all (2253)

Therapy

Pharmacological Management of Acute Endodontic Pain.

Khan AA, Diogenes A
Drugs 2021 Sep;81(14):1627-1643. Epub 2021 Oct 7 doi: 10.1007/s40265-021-01564-4. PMID: 34618315

Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981

Regenerative endodontics: a comprehensive review.

Kim SG, Malek M, Sigurdsson A, Lin LM, Kahler B
Int Endod J 2018 Dec;51(12):1367-1388. Epub 2018 Jun 11 doi: 10.1111/iej.12954. PMID: 29777616

Endodontic procedures for retreatment of periapical lesions.

Del Fabbro M, Corbella S, Sequeira-Byron P, Tsesis I, Rosen E, Lolato A, Taschieri S
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005511. doi: 10.1002/14651858.CD005511.pub3. PMID: 27759881 Free PMC Article

Pain and flare-up after endodontic treatment procedures.

Sipavičiūtė E, Manelienė R
Stomatologija 2014;16(1):25-30. PMID: 24824057

See all (1975)

Prognosis

Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review.

Niazi SA, Bakhsh A
Medicina (Kaunas) 2022 Jul 14;58(7) doi: 10.3390/medicina58070931. PMID: 35888650 Free PMC Article

Endodontic medicine: connections between apical periodontitis and systemic diseases.

Segura-Egea JJ, Martín-González J, Castellanos-Cosano L
Int Endod J 2015 Oct;48(10):933-51. Epub 2015 Aug 3 doi: 10.1111/iej.12507. PMID: 26174809

A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health.

Ng YL, Mann V, Gulabivala K
Int Endod J 2011 Jul;44(7):583-609. Epub 2011 Mar 2 doi: 10.1111/j.1365-2591.2011.01872.x. PMID: 21366626

Modern endodontic surgery concepts and practice: a review.

Kim S, Kratchman S
J Endod 2006 Jul;32(7):601-23. Epub 2006 May 6 doi: 10.1016/j.joen.2005.12.010. PMID: 16793466

Factors affecting the long-term results of endodontic treatment.

Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

See all (1378)

Clinical prediction guides

Artificial intelligence for caries and periapical periodontitis detection.

Li S, Liu J, Zhou Z, Zhou Z, Wu X, Li Y, Wang S, Liao W, Ying S, Zhao Z
J Dent 2022 Jul;122:104107. Epub 2022 Mar 24 doi: 10.1016/j.jdent.2022.104107. PMID: 35341892

Present status and future directions: Microbiology of endodontic infections.

Siqueira JF Jr, Rôças IN
Int Endod J 2022 May;55 Suppl 3:512-530. Epub 2022 Jan 13 doi: 10.1111/iej.13677. PMID: 34958494

Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.

Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513 Free PMC Article

Modern endodontic surgery concepts and practice: a review.

Kim S, Kratchman S
J Endod 2006 Jul;32(7):601-23. Epub 2006 May 6 doi: 10.1016/j.joen.2005.12.010. PMID: 16793466

Factors affecting the long-term results of endodontic treatment.

Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

See all (1563)

Recent systematic reviews

Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981

The global prevalence of apical periodontitis: a systematic review and meta-analysis.

Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA
Int Endod J 2021 May;54(5):712-735. Epub 2021 Jan 22 doi: 10.1111/iej.13467. PMID: 33378579

Oral manifestations of Diabetes Mellitus. A systematic review.

Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, Viñas M, López-López J
Med Oral Patol Oral Cir Bucal 2017 Sep 1;22(5):e586-e594. doi: 10.4317/medoral.21655. PMID: 28809366 Free PMC Article

Endodontic procedures for retreatment of periapical lesions.

Frequency of odontogenic cysts and tumors: a systematic review.

Johnson NR, Gannon OM, Savage NW, Batstone MD
J Investig Clin Dent 2014 Feb;5(1):9-14. Epub 2013 Jun 14 doi: 10.1111/jicd.12044. PMID: 23766099

See all (153)

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Disorder of periapical tissues of tooth

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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