U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Disorder of periapical tissues of tooth

MedGen UID:
14679
•Concept ID:
C0031028
•
Disease or Syndrome
Synonyms: Disease, Periapical; Diseases, Periapical; Periapical Disease; Periapical Diseases
SNOMED CT: Periradicular disease (34282009); Disorder of periapical tissues of tooth (34282009)

Definition

Diseases of the PERIAPICAL TISSUE surrounding the root of the tooth, which is distinguished from DENTAL PULP DISEASES inside the TOOTH ROOT. [from MeSH]

Professional guidelines

PubMed

Tooth survival after endodontic treatment.
Fransson H, Dawson V
Int Endod J 2023 Mar;56 Suppl 2:140-153. Epub 2022 Oct 2 doi: 10.1111/iej.13835. PMID: 36149887
Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.
Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513Free PMC Article
European Society of Endodontology position statement: Management of deep caries and the exposed pulp.
European Society of Endodontology (ESE) developed by:, Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, Krastl G, Dammaschke T, Fransson H, Markvart M, Zehnder M, Bjørndal L
Int Endod J 2019 Jul;52(7):923-934. doi: 10.1111/iej.13080. PMID: 30664240

Recent clinical studies

Etiology

A literature review of local and systemic considerations for endodontic treatments in older adults.
Kytridou V, Gkikas I, Garcia MN, Cepeda O, Hildebolt CF
Gerodontology 2023 Dec;40(4):410-421. Epub 2023 Mar 27 doi: 10.1111/ger.12679. PMID: 36971290
Pain and flare-up after endodontic treatment procedures.
Sipavičiūtė E, Manelienė R
Stomatologija 2014;16(1):25-30. PMID: 24824057
A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health.
Ng YL, Mann V, Gulabivala K
Int Endod J 2011 Jul;44(7):583-609. Epub 2011 Mar 2 doi: 10.1111/j.1365-2591.2011.01872.x. PMID: 21366626
Outcome of secondary root canal treatment: a systematic review of the literature.
Ng YL, Mann V, Gulabivala K
Int Endod J 2008 Dec;41(12):1026-46. doi: 10.1111/j.1365-2591.2008.01484.x. PMID: 19133093
Factors affecting the long-term results of endodontic treatment.
Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

Diagnosis

Retrospective Evaluation of Periradicular Biopsies: An 18-Year Study.
Krongbaramee T, Wongpattaraworakul W, Lanzel EA, Hellstein JW, Teixeira FB
J Endod 2023 Nov;49(11):1457-1463. Epub 2023 Aug 4 doi: 10.1016/j.joen.2023.07.023. PMID: 37543187
Pharmacological Management of Acute Endodontic Pain.
Khan AA, Diogenes A
Drugs 2021 Sep;81(14):1627-1643. Epub 2021 Oct 7 doi: 10.1007/s40265-021-01564-4. PMID: 34618315
Craniofacial and oral alterations in patients with Neurofibromatosis 1.
Visnapuu V, Peltonen S, Alivuotila L, Happonen RP, Peltonen J
Orphanet J Rare Dis 2018 Aug 9;13(1):131. doi: 10.1186/s13023-018-0881-8. PMID: 30092804Free PMC Article
AAE Consensus Conference on Diagnostic Terminology: background and perspectives.
Glickman GN
J Endod 2009 Dec;35(12):1619-20. doi: 10.1016/j.joen.2009.09.029. PMID: 19932336
One-visit endodontics.
Ashkenaz PJ
Dent Clin North Am 1984 Oct;28(4):853-63. PMID: 6594282

Therapy

Pharmacological Management of Acute Endodontic Pain.
Khan AA, Diogenes A
Drugs 2021 Sep;81(14):1627-1643. Epub 2021 Oct 7 doi: 10.1007/s40265-021-01564-4. PMID: 34618315
Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.
Cope AL, Francis N, Wood F, Chestnutt IG
Cochrane Database Syst Rev 2018 Sep 27;9(9):CD010136. doi: 10.1002/14651858.CD010136.pub3. PMID: 30259968Free PMC Article
Regenerative endodontics: a comprehensive review.
Kim SG, Malek M, Sigurdsson A, Lin LM, Kahler B
Int Endod J 2018 Dec;51(12):1367-1388. Epub 2018 Jun 11 doi: 10.1111/iej.12954. PMID: 29777616
Aetiology of root canal treatment failure: why well-treated teeth can fail.
Siqueira JF Jr
Int Endod J 2001 Jan;34(1):1-10. doi: 10.1046/j.1365-2591.2001.00396.x. PMID: 11307374

Prognosis

Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review.
Niazi SA, Bakhsh A
Medicina (Kaunas) 2022 Jul 14;58(7) doi: 10.3390/medicina58070931. PMID: 35888650Free PMC Article
Endodontic medicine: connections between apical periodontitis and systemic diseases.
Segura-Egea JJ, Martín-González J, Castellanos-Cosano L
Int Endod J 2015 Oct;48(10):933-51. Epub 2015 Aug 3 doi: 10.1111/iej.12507. PMID: 26174809
A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health.
Ng YL, Mann V, Gulabivala K
Int Endod J 2011 Jul;44(7):583-609. Epub 2011 Mar 2 doi: 10.1111/j.1365-2591.2011.01872.x. PMID: 21366626
Modern endodontic surgery concepts and practice: a review.
Kim S, Kratchman S
J Endod 2006 Jul;32(7):601-23. Epub 2006 May 6 doi: 10.1016/j.joen.2005.12.010. PMID: 16793466
Factors affecting the long-term results of endodontic treatment.
Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

Clinical prediction guides

Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway.
Yang M, Shen Z, Zhang X, Song Z, Zhang Y, Lin Z, Chen L
Free Radic Biol Med 2023 Nov 1;208:334-347. Epub 2023 Aug 22 doi: 10.1016/j.freeradbiomed.2023.08.020. PMID: 37619958
Present status and future directions: Microbiology of endodontic infections.
Siqueira JF Jr, Rôças IN
Int Endod J 2022 May;55 Suppl 3:512-530. Epub 2022 Jan 13 doi: 10.1111/iej.13677. PMID: 34958494
Endodontic Periapical Lesion: An Overview on the Etiology, Diagnosis and Current Treatment Modalities.
Karamifar K, Tondari A, Saghiri MA
Eur Endod J 2020;5(2):54-67. Epub 2020 Jul 14 doi: 10.14744/eej.2020.42714. PMID: 32766513Free PMC Article
Modern endodontic surgery concepts and practice: a review.
Kim S, Kratchman S
J Endod 2006 Jul;32(7):601-23. Epub 2006 May 6 doi: 10.1016/j.joen.2005.12.010. PMID: 16793466
Factors affecting the long-term results of endodontic treatment.
Sjogren U, Hagglund B, Sundqvist G, Wing K
J Endod 1990 Oct;16(10):498-504. doi: 10.1016/S0099-2399(07)80180-4. PMID: 2084204

Recent systematic reviews

Effectiveness of adjunct therapy for the treatment of apical periodontitis: A systematic review and meta-analysis.
Meire MA, Bronzato JD, Bomfim RA, Gomes BPFA
Int Endod J 2023 Oct;56 Suppl 3:455-474. Epub 2022 Oct 8 doi: 10.1111/iej.13838. PMID: 36156804
Deep learning for caries detection: A systematic review.
Mohammad-Rahimi H, Motamedian SR, Rohban MH, Krois J, Uribe SE, Mahmoudinia E, Rokhshad R, Nadimi M, Schwendicke F
J Dent 2022 Jul;122:104115. Epub 2022 Mar 30 doi: 10.1016/j.jdent.2022.104115. PMID: 35367318
Regenerative Endodontic Procedures for the Treatment of Necrotic Mature Teeth with Apical Periodontitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Glynis A, Foschi F, Kefalou I, Koletsi D, Tzanetakis GN
J Endod 2021 Jun;47(6):873-882. Epub 2021 Mar 31 doi: 10.1016/j.joen.2021.03.015. PMID: 33811981
The global prevalence of apical periodontitis: a systematic review and meta-analysis.
Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA
Int Endod J 2021 May;54(5):712-735. Epub 2021 Jan 22 doi: 10.1111/iej.13467. PMID: 33378579
Endodontic procedures for retreatment of periapical lesions.
Del Fabbro M, Corbella S, Sequeira-Byron P, Tsesis I, Rosen E, Lolato A, Taschieri S
Cochrane Database Syst Rev 2016 Oct 19;10(10):CD005511. doi: 10.1002/14651858.CD005511.pub3. PMID: 27759881Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...