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Postmenopausal osteoporosis

MedGen UID:
10498
Concept ID:
C0029458
Disease or Syndrome
Synonyms: BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS; OSTEOPOROSIS, INVOLUTIONAL
SNOMED CT: Postmenopausal osteoporosis (102447009); Type I osteoporosis (32369003); Type 1 osteoporosis (32369003); Menopausal osteoporosis (32369003)
 
Monarch Initiative: MONDO:0008159
OMIM®: 120160; 166710

Definition

Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency. [from MONDO]

Professional guidelines

PubMed

Brown JP
Endocrinol Metab (Seoul) 2021 Jun;36(3):544-552. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.301. PMID: 34154042Free PMC Article
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB
Endocr Pract 2020 May;26(Suppl 1):1-46. doi: 10.4158/GL-2020-0524SUPPL. PMID: 32427503

Recent clinical studies

Etiology

Fischer V, Haffner-Luntzer M
Semin Cell Dev Biol 2022 Mar;123:14-21. Epub 2021 May 20 doi: 10.1016/j.semcdb.2021.05.014. PMID: 34024716
Brown JP
Endocrinol Metab (Seoul) 2021 Jun;36(3):544-552. Epub 2021 Jun 22 doi: 10.3803/EnM.2021.301. PMID: 34154042Free PMC Article
Arceo-Mendoza RM, Camacho PM
Endocrinol Metab Clin North Am 2021 Jun;50(2):167-178. doi: 10.1016/j.ecl.2021.03.009. PMID: 34023036
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
Johnston CB, Dagar M
Med Clin North Am 2020 Sep;104(5):873-884. Epub 2020 Jul 15 doi: 10.1016/j.mcna.2020.06.004. PMID: 32773051

Diagnosis

ACOG Committee on Clinical Practice Guidelines–Gynecology
Obstet Gynecol 2022 Apr 1;139(4):698-717. doi: 10.1097/AOG.0000000000004730. PMID: 35594133
Menopause 2021 Sep 1;28(9):973-997. doi: 10.1097/GME.0000000000001831. PMID: 34448749
Arceo-Mendoza RM, Camacho PM
Endocrinol Metab Clin North Am 2021 Jun;50(2):167-178. doi: 10.1016/j.ecl.2021.03.009. PMID: 34023036
Muñoz M, Robinson K, Shibli-Rahhal A
Clin Obstet Gynecol 2020 Dec;63(4):770-787. doi: 10.1097/GRF.0000000000000572. PMID: 33017332
Eastell R, Szulc P
Lancet Diabetes Endocrinol 2017 Nov;5(11):908-923. Epub 2017 Jul 7 doi: 10.1016/S2213-8587(17)30184-5. PMID: 28689768

Therapy

Wang WY, Chen LH, Ma WJ, You RX
Eur Rev Med Pharmacol Sci 2023 Sep;27(17):8253-8268. doi: 10.26355/eurrev_202309_33586. PMID: 37750653
Ma ML, Ma ZJ, He YL, Sun H, Yang B, Ruan BJ, Zhan WD, Li SX, Dong H, Wang YX
Front Public Health 2022;10:979649. Epub 2022 Aug 11 doi: 10.3389/fpubh.2022.979649. PMID: 36033779Free PMC Article
Hejazi K, Askari R, Hofmeister M
Arch Osteoporos 2022 Jul 27;17(1):102. doi: 10.1007/s11657-022-01140-7. PMID: 35896850
Rizzoli R
Best Pract Res Clin Endocrinol Metab 2018 Oct;32(5):739-757. Epub 2018 Sep 22 doi: 10.1016/j.beem.2018.09.005. PMID: 30449552
Howe TE, Shea B, Dawson LJ, Downie F, Murray A, Ross C, Harbour RT, Caldwell LM, Creed G
Cochrane Database Syst Rev 2011 Jul 6;(7):CD000333. doi: 10.1002/14651858.CD000333.pub2. PMID: 21735380

Prognosis

Lewiecki EM, Dinavahi RV, Lazaretti-Castro M, Ebeling PR, Adachi JD, Miyauchi A, Gielen E, Milmont CE, Libanati C, Grauer A
J Bone Miner Res 2019 Mar;34(3):419-428. Epub 2018 Dec 3 doi: 10.1002/jbmr.3622. PMID: 30508316
Vellanki K, Hou S
Am J Kidney Dis 2018 May;71(5):710-719. Epub 2018 Mar 9 doi: 10.1053/j.ajkd.2017.12.019. PMID: 29530509
Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S
Lancet Diabetes Endocrinol 2017 Jul;5(7):513-523. Epub 2017 May 22 doi: 10.1016/S2213-8587(17)30138-9. PMID: 28546097
Marshall D, Johnell O, Wedel H
BMJ 1996 May 18;312(7041):1254-9. doi: 10.1136/bmj.312.7041.1254. PMID: 8634613Free PMC Article
Genant HK, Wu CY, van Kuijk C, Nevitt MC
J Bone Miner Res 1993 Sep;8(9):1137-48. doi: 10.1002/jbmr.5650080915. PMID: 8237484

Clinical prediction guides

Kobayakawa T, Miyazaki A, Saito M, Suzuki T, Takahashi J, Nakamura Y
Sci Rep 2021 Jun 3;11(1):11801. doi: 10.1038/s41598-021-91248-6. PMID: 34083636Free PMC Article
Ebina K, Tsuboi H, Nagayama Y, Kashii M, Kaneshiro S, Miyama A, Nakaya H, Kunugiza Y, Hirao M, Okamura G, Etani Y, Takami K, Goshima A, Miura T, Nakata K, Okada S
Joint Bone Spine 2021 Oct;88(5):105219. Epub 2021 May 19 doi: 10.1016/j.jbspin.2021.105219. PMID: 34020048
Barron RL, Oster G, Grauer A, Crittenden DB, Weycker D
Osteoporos Int 2020 Nov;31(11):2103-2111. Epub 2020 Jul 1 doi: 10.1007/s00198-020-05294-3. PMID: 32613410Free PMC Article
Black DM, Rosen CJ
N Engl J Med 2016 Jan 21;374(3):254-62. doi: 10.1056/NEJMcp1513724. PMID: 26789873
Genant HK, Wu CY, van Kuijk C, Nevitt MC
J Bone Miner Res 1993 Sep;8(9):1137-48. doi: 10.1002/jbmr.5650080915. PMID: 8237484

Recent systematic reviews

Händel MN, Cardoso I, von Bülow C, Rohde JF, Ussing A, Nielsen SM, Christensen R, Body JJ, Brandi ML, Diez-Perez A, Hadji P, Javaid MK, Lems WF, Nogues X, Roux C, Minisola S, Kurth A, Thomas T, Prieto-Alhambra D, Ferrari SL, Langdahl B, Abrahamsen B
BMJ 2023 May 2;381:e068033. doi: 10.1136/bmj-2021-068033. PMID: 37130601Free PMC Article
Ayers C, Kansagara D, Lazur B, Fu R, Kwon A, Harrod C
Ann Intern Med 2023 Feb;176(2):182-195. Epub 2023 Jan 3 doi: 10.7326/M22-0684. PMID: 36592455
Singh S, Dutta S, Khasbage S, Kumar T, Sachin J, Sharma J, Varthya SB
Osteoporos Int 2022 Jan;33(1):1-12. Epub 2021 Aug 25 doi: 10.1007/s00198-021-06095-y. PMID: 34432115Free PMC Article
Su Y, Chen Z, Xie W
Biomed Res Int 2020;2020:6210201. Epub 2020 May 15 doi: 10.1155/2020/6210201. PMID: 32509864Free PMC Article
Howe TE, Shea B, Dawson LJ, Downie F, Murray A, Ross C, Harbour RT, Caldwell LM, Creed G
Cochrane Database Syst Rev 2011 Jul 6;(7):CD000333. doi: 10.1002/14651858.CD000333.pub2. PMID: 21735380

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