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Liposarcoma

MedGen UID:
44177
•Concept ID:
C0023827
•
Neoplastic Process
Synonym: Liposarcomas
SNOMED CT: Liposarcoma (254829001); Fibroliposarcoma (1162815008); Liposarcoma (1162815008); Malignant lipomatous tumor (1162815008); Malignant lipomatous tumor (254829001)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
HPO: HP:0012034
Monarch Initiative: MONDO:0005060
Orphanet: ORPHA69078

Definition

Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiposarcoma
Follow this link to review classifications for Liposarcoma in Orphanet.

Professional guidelines

PubMed

Myxoid Liposarcomas: Systemic Treatment Options.
Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Retroperitoneal Dedifferentiated Liposarcoma.
Dehner CA, Hagemann IS, Chrisinger JSA
Am J Clin Pathol 2021 Oct 13;156(5):920-925. doi: 10.1093/ajcp/aqab051. PMID: 34125170
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial.
Lansu J, Bovée JVMG, Braam P, van Boven H, Flucke U, Bonenkamp JJ, Miah AB, Zaidi SH, Thway K, Bruland ØS, Baldini EH, Jebsen NL, Scholten AN, van den Ende PLA, Krol ADG, Ubbels JF, van der Hage JA, van Werkhoven E, Klomp HM, van der Graaf WTA, van Coevorden F, Schrage Y, van Houdt WJ, Haas RL
JAMA Oncol 2021 Jan 1;7(1):e205865. Epub 2021 Jan 21 doi: 10.1001/jamaoncol.2020.5865. PMID: 33180100Free PMC Article
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Myxoid pleomorphic liposarcoma.
Fadaei S, Cordier F, Ferdinande L, Van Dorpe J, Creytens D
Histol Histopathol 2024 Sep;39(9):1101-1108. Epub 2024 Feb 26 doi: 10.14670/HH-18-724. PMID: 38450446
Myxoid Pleomorphic Liposarcoma.
Dermawan JK
Surg Pathol Clin 2024 Mar;17(1):25-29. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.005. PMID: 38278605
Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.
Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693
Dedifferentiated Liposarcoma: Systemic Therapy Options.
Gahvari Z, Parkes A
Curr Treat Options Oncol 2020 Feb 5;21(2):15. doi: 10.1007/s11864-020-0705-7. PMID: 32026050
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045

Therapy

The MDM2-p53 Antagonist Brigimadlin (BI 907828) in Patients with Advanced or Metastatic Solid Tumors: Results of a Phase Ia, First-in-Human, Dose-Escalation Study.
LoRusso P, Yamamoto N, Patel MR, Laurie SA, Bauer TM, Geng J, Davenport T, Teufel M, Li J, Lahmar M, Gounder MM
Cancer Discov 2023 Aug 4;13(8):1802-1813. doi: 10.1158/2159-8290.CD-23-0153. PMID: 37269344Free PMC Article
Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Dedifferentiated Liposarcoma: Systemic Therapy Options.
Gahvari Z, Parkes A
Curr Treat Options Oncol 2020 Feb 5;21(2):15. doi: 10.1007/s11864-020-0705-7. PMID: 32026050
Options for treating different soft tissue sarcoma subtypes.
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Prognosis

Eribulin in advanced liposarcoma and leiomyosarcoma.
Setola E, Noujaim J, Benson C, Chawla S, Palmerini E, Jones RL
Expert Rev Anticancer Ther 2017 Aug;17(8):717-723. Epub 2017 Jun 28 doi: 10.1080/14737140.2017.1344098. PMID: 28621163
Pleomorphic liposarcoma.
Oliveira AM, Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):274-85. PMID: 11757868
Dedifferentiated liposarcoma.
Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):263-6. PMID: 11757866
Nodular fasciitis.
Zuber TJ, Finley JL
South Med J 1994 Aug;87(8):842-4. doi: 10.1097/00007611-199408000-00020. PMID: 8052900
Liposarcoma.
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432

Clinical prediction guides

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial.
Lansu J, Bovée JVMG, Braam P, van Boven H, Flucke U, Bonenkamp JJ, Miah AB, Zaidi SH, Thway K, Bruland ØS, Baldini EH, Jebsen NL, Scholten AN, van den Ende PLA, Krol ADG, Ubbels JF, van der Hage JA, van Werkhoven E, Klomp HM, van der Graaf WTA, van Coevorden F, Schrage Y, van Houdt WJ, Haas RL
JAMA Oncol 2021 Jan 1;7(1):e205865. Epub 2021 Jan 21 doi: 10.1001/jamaoncol.2020.5865. PMID: 33180100Free PMC Article
Pharmacological therapies for Liposarcoma.
Saponara M, Stacchiotti S, Gronchi A
Expert Rev Clin Pharmacol 2017 Apr;10(4):361-377. Epub 2017 Feb 13 doi: 10.1080/17512433.2017.1289086. PMID: 28135854
Dedifferentiated liposarcoma.
Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):263-6. PMID: 11757866

Recent systematic reviews

Special features of sarcomas developed in patients with Lynch syndrome: A systematic review.
Poumeaud F, Valentin T, Vande Perre P, Jaffrelot M, Bonnet D, Chibon F, Chevreau C, Selves J, Guimbaud R, Fares N
Crit Rev Oncol Hematol 2023 Aug;188:104055. Epub 2023 Jun 8 doi: 10.1016/j.critrevonc.2023.104055. PMID: 37301271
Esophageal Lipoma and Liposarcoma: A Systematic Review.
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081
Primary Thyroid Sarcoma: A Systematic Review.
Surov A, Gottschling S, Wienke A, Meyer HJ, Spielmann RP, Dralle H
Anticancer Res 2015 Oct;35(10):5185-91. PMID: 26408676

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
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