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Leprosy

MedGen UID:
6049
Concept ID:
C0023343
Disease or Syndrome
Synonym: Hansen's disease
SNOMED CT: Leprosy (81004002); Hansen's disease (81004002); Infection due to Mycobacterium leprae (81004002); Mycobacterium leprae infection (81004002)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0005124
Orphanet: ORPHA548

Definition

A chronic infectious disease affecting primarily the skin and peripheral nervous system. [from ORDO]

Professional guidelines

PubMed

Maymone MBC, Venkatesh S, Laughter M, Abdat R, Hugh J, Dacso MM, Rao PN, Stryjewska BM, Dunnick CA, Dellavalle RP
J Am Acad Dermatol 2020 Jul;83(1):17-30. Epub 2020 Mar 31 doi: 10.1016/j.jaad.2019.10.138. PMID: 32244016
Alemu Belachew W, Naafs B
J Eur Acad Dermatol Venereol 2019 Jul;33(7):1205-1213. Epub 2019 Apr 3 doi: 10.1111/jdv.15569. PMID: 30945360
Trayes KP, Savage K, Studdiford JS
Am Fam Physician 2018 Sep 1;98(5):283-291. PMID: 30216021

Recent clinical studies

Etiology

Froes LAR Junior, Sotto MN, Trindade MAB
An Bras Dermatol 2022 May-Jun;97(3):338-347. Epub 2022 Apr 2 doi: 10.1016/j.abd.2021.08.006. PMID: 35379512Free PMC Article
Froes LAR Jr, Trindade MAB, Sotto MN
Int Rev Immunol 2022;41(2):72-83. Epub 2020 Nov 26 doi: 10.1080/08830185.2020.1851370. PMID: 33241709
Fava VM, Dallmann-Sauer M, Schurr E
Hum Genet 2020 Jun;139(6-7):835-846. Epub 2019 Nov 11 doi: 10.1007/s00439-019-02087-5. PMID: 31713021
Saunderson PR
Clin Dermatol 2016 Jan-Feb;34(1):79-81. Epub 2015 Oct 31 doi: 10.1016/j.clindermatol.2015.10.019. PMID: 26773627
Virmond M, Grzybowski A
Clin Dermatol 2015 Jan-Feb;33(1):1-2. doi: 10.1016/j.clindermatol.2014.10.002. PMID: 25432804

Diagnosis

Marques W
Curr Opin Neurol 2024 Oct 1;37(5):487-492. Epub 2024 Jul 25 doi: 10.1097/WCO.0000000000001304. PMID: 39051539
Neema S, Battula S
N Engl J Med 2022 Sep 29;387(13):1217. doi: 10.1056/NEJMicm2202533. PMID: 36170503
Gómez-Cerquera JM, Herrera-Darias S, Domingo-Amela A, Graells-Estrada J
Med Clin (Barc) 2022 Dec 9;159(11):556. Epub 2022 Sep 16 doi: 10.1016/j.medcli.2022.07.015. PMID: 36116975
Makhakhe L
S Afr Fam Pract (2004) 2021 Oct 29;63(1):e1-e6. doi: 10.4102/safp.v63i1.5311. PMID: 34797098Free PMC Article
Khadilkar SV, Patil SB, Shetty VP
J Neurol Sci 2021 Jan 15;420:117288. Epub 2020 Dec 25 doi: 10.1016/j.jns.2020.117288. PMID: 33360424

Therapy

Saini I, Joshi J, Kaur S
Cell Immunol 2024 May-Jun;399-400:104826. Epub 2024 Apr 23 doi: 10.1016/j.cellimm.2024.104826. PMID: 38669897
Wang L, Wang H, Yan L, Yu M, Yang J, Li J, Li J, Ning Y, Jiang H, Shi Y, Zhang W, Xiong L, Liu J, Kuang Y, Wang H, He J, Wang D, Li B, Liu Y, Shui T, Wang Y, Chen H, Sha X, Long H, Yu X, Shen C, Shen J, Yang X, Gu H, Zhang G, Wang B
N Engl J Med 2023 May 18;388(20):1843-1852. doi: 10.1056/NEJMoa2205487. PMID: 37195940
Sardana K, Sachdeva S
J Cosmet Dermatol 2022 Jan;21(1):85-98. Epub 2021 Sep 26 doi: 10.1111/jocd.14436. PMID: 34564936
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Palit A, Kar HK
Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):115-123. doi: 10.4103/ijdvl.IJDVL_326_19. PMID: 31975697

Prognosis

Chakaya J, Petersen E, Nantanda R, Mungai BN, Migliori GB, Amanullah F, Lungu P, Ntoumi F, Kumarasamy N, Maeurer M, Zumla A
Int J Infect Dis 2022 Nov;124 Suppl 1:S26-S29. Epub 2022 Mar 20 doi: 10.1016/j.ijid.2022.03.011. PMID: 35321845Free PMC Article
Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T
PLoS Negl Trop Dis 2020 Apr;14(4):e0008276. Epub 2020 Apr 27 doi: 10.1371/journal.pntd.0008276. PMID: 32339201Free PMC Article
Maymone MBC, Laughter M, Venkatesh S, Dacso MM, Rao PN, Stryjewska BM, Hugh J, Dellavalle RP, Dunnick CA
J Am Acad Dermatol 2020 Jul;83(1):1-14. Epub 2020 Mar 27 doi: 10.1016/j.jaad.2019.12.080. PMID: 32229279
White C, Franco-Paredes C
Clin Microbiol Rev 2015 Jan;28(1):80-94. doi: 10.1128/CMR.00079-13. PMID: 25567223Free PMC Article
Jacobson RR, Krahenbuhl JL
Lancet 1999 Feb 20;353(9153):655-60. doi: 10.1016/S0140-6736(98)06322-3. PMID: 10030346

Clinical prediction guides

Somensi DN, de Sousa EJS, Lopes GL, de Sousa GC, Xavier MB
Indian J Dermatol Venereol Leprol 2022 Sep-Oct;88(5):641-644. doi: 10.25259/IJDVL_917_19. PMID: 34951937
Makhakhe L
S Afr Fam Pract (2004) 2021 Oct 29;63(1):e1-e6. doi: 10.4102/safp.v63i1.5311. PMID: 34797098Free PMC Article
Ayatollahi A, Gholami J, Saberi M, Hosseini H, Firooz A
Lasers Med Sci 2020 Jul;35(5):1007-1024. Epub 2020 Feb 5 doi: 10.1007/s10103-020-02957-9. PMID: 32026164
Robertson J
Bull Hist Med 2018;92(2):261-286. doi: 10.1353/bhm.2018.0027. PMID: 29961715
Ankad BS, Sakhare PS
Int J Dermatol 2018 Jan;57(1):74-76. Epub 2017 Aug 22 doi: 10.1111/ijd.13731. PMID: 28833001

Recent systematic reviews

Li X, Li G, Yang J, Jin G, Shao Y, Li Y, Wei P, Zhang L
Int J Mol Sci 2022 Oct 18;23(20) doi: 10.3390/ijms232012443. PMID: 36293307Free PMC Article
Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T
PLoS Negl Trop Dis 2020 Apr;14(4):e0008276. Epub 2020 Apr 27 doi: 10.1371/journal.pntd.0008276. PMID: 32339201Free PMC Article
Ayatollahi A, Gholami J, Saberi M, Hosseini H, Firooz A
Lasers Med Sci 2020 Jul;35(5):1007-1024. Epub 2020 Feb 5 doi: 10.1007/s10103-020-02957-9. PMID: 32026164
Hesseler MJ, Shyam N
J Am Acad Dermatol 2019 Sep;81(3):834-846. Epub 2019 Apr 19 doi: 10.1016/j.jaad.2019.04.037. PMID: 31009668
Smith WC, Saunderson P
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418690Free PMC Article

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