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cardiac valvular disease

MedGen UID:: 5463
•Concept ID:: C0018824
•: Disease or Syndrome

Synonyms:	Disease, Heart Valvular; Heart Disease, Valvular; Heart Valve Disease; Heart Valve Diseases; Heart Valvular Disease; Heart Valvular Diseases; Valve Disease, Heart; Valvular Disease, Heart; Valvular Heart Disease; Valvular Heart Diseases
SNOMED CT:	Heart valve disorder (368009); Valvular heart disease (368009); Heart valve disease (368009); Disorder of heart valve (368009)

Monarch Initiative:	MONDO:0002869

Definition

Any heart disorder characterized by a defect in valve structure or function. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVcardiac valvular disease

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of cardiovascular system
        Heart disease
        cardiac valvular disease
        Aortic valve disorder
        Aortic regurgitation
        Congenital aortic valve insufficiency
        Aortic valve atresia
        Aortic valve calcification
        Aortic annulus calcification
        Aortic valve leaflet calcification
        Aortic valve disease 1
        Aortic valve disease 2
        Aortic valve disease 3
        Aortic valve prolapse
        Aortic valve stenosis
        Subvalvular aortic stenosis
        Supravalvar aortic stenosis
        Bicuspid aortic valve
        Purely bicuspid aortic valve
        Single raphe bicuspid aortic valve
        Two-raphe bicuspid aortic valve
        Familial bicuspid aortic valve
        Quadricuspid aortic valve
        Cardiac valve prolapse
        Mitral valve prolapse
        Myxomatous mitral valve degeneration
        Tricuspid valve prolapse
        Cusp Tear
        Heart valve regurgitation
        Mild Cardiac Valve Regurgitation
        Mitral regurgitation
        Moderate Cardiac Valve Regurgitation
        No Cardiac Valve Regurgitation
        Pulmonary valve insufficiency
        Congenital pulmonary insufficiency
        Severe Cardiac Valve Regurgitation
        Tricuspid regurgitation
        Leaflet Disruption
        Leaflet Disruption Due To Calcification
        Leaflet Disruption Due To Host Tissue Overgrowth
        Leaflet Disruption Due To Infection
        Leaflet Disruption Due To Suture Abrasion
        Leaflet Disruption Due To Unknown Cause
        Mitral stenosis
        Congenital mitral stenosis
        Mitral valve disorder
        Mitral atresia disorder
        Primary Valvular Disorder
        Prosthetic Valve Thrombosis
        Pulmonary valve atresia
        Pulmonary atresia with intact ventricular septum
        Pulmonary atresia with ventricular septal defect
        Pulmonary valve disorder
        Pulmonary valve stenosis
        Noonan syndrome with multiple lentigines
        LEOPARD syndrome 1
        LEOPARD syndrome 2
        LEOPARD syndrome 3
        Pulmonary subvalvular stenosis
        Tricuspid atresia
        Unguarded tricuspid valve
        Tricuspid stenosis
        Tricuspid valve disorder

Professional guidelines

PubMed

Guidelines for the Evaluation of Prosthetic Valve Function With Cardiovascular Imaging: A Report From the American Society of Echocardiography Developed in Collaboration With the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography.

Zoghbi WA, Jone PN, Chamsi-Pasha MA, Chen T, Collins KA, Desai MY, Grayburn P, Groves DW, Hahn RT, Little SH, Kruse E, Sanborn D, Shah SB, Sugeng L, Swaminathan M, Thaden J, Thavendiranathan P, Tsang W, Weir-McCall JR, Gill E
J Am Soc Echocardiogr 2024 Jan;37(1):2-63. doi: 10.1016/j.echo.2023.10.004. PMID: 38182282

Best practice policy statement on urodynamic antibiotic prophylaxis in the non-index patient.

Cameron AP, Campeau L, Brucker BM, Clemens JQ, Bales GT, Albo ME, Kennelly MJ
Neurourol Urodyn 2017 Apr;36(4):915-926. Epub 2017 Mar 27 doi: 10.1002/nau.23253. PMID: 28345769

Classification criteria for antiphospholipid syndrome: the case for cardiac valvular disease.

Petri MA
J Rheumatol 2004 Dec;31(12):2329-30. PMID: 15570630

See all (8)

Curated

UK NICE Guideline NG208, Heart valve disease presenting in adults: investigation and management, 2021

Recent clinical studies

Etiology

Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial.

Ordi-Ros J, Sáez-Comet L, Pérez-Conesa M, Vidal X, Riera-Mestre A, Castro-Salomó A, Cuquet-Pedragosa J, Ortiz-Santamaria V, Mauri-Plana M, Solé C, Cortés-Hernández J
Ann Intern Med 2019 Nov 19;171(10):685-694. Epub 2019 Oct 15 doi: 10.7326/M19-0291. PMID: 31610549

Autosomal dominant polycystic kidney disease.

Cornec-Le Gall E, Alam A, Perrone RD
Lancet 2019 Mar 2;393(10174):919-935. Epub 2019 Feb 25 doi: 10.1016/S0140-6736(18)32782-X. PMID: 30819518

Percutaneous mitral heart valve repair--MitraClip.

Doshi JV, Agrawal S, Garg J, Paudel R, Palaniswamy C, Doshi TV, Gotsis W, Frishman WH
Cardiol Rev 2014 Nov-Dec;22(6):289-96. doi: 10.1097/CRD.0000000000000036. PMID: 25098200

Acquired disorders of platelet function.

Konkle BA
Hematology Am Soc Hematol Educ Program 2011;2011:391-6. doi: 10.1182/asheducation-2011.1.391. PMID: 22160063

Antiphospholipid syndrome.

Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

See all (68)

Diagnosis

Tricuspid valve diseases: Interventions on the forgotten heart valve.

Yoganathan A, Khan SNM, Khan H, Thirunavukarasu SA, Elghanam MA, Harky A
J Card Surg 2021 Jan;36(1):219-228. Epub 2020 Nov 1 doi: 10.1111/jocs.15159. PMID: 33135830

Autosomal dominant polycystic kidney disease.

Cornec-Le Gall E, Alam A, Perrone RD
Lancet 2019 Mar 2;393(10174):919-935. Epub 2019 Feb 25 doi: 10.1016/S0140-6736(18)32782-X. PMID: 30819518

Lyme Endocarditis.

Paim AC, Baddour LM, Pritt BS, Schuetz AN, Wilson JW
Am J Med 2018 Sep;131(9):1126-1129. Epub 2018 Mar 29 doi: 10.1016/j.amjmed.2018.02.032. PMID: 29605416

Antiphospholipid syndrome.

Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

See all (59)

Therapy

Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial.

Autosomal dominant polycystic kidney disease.

Cornec-Le Gall E, Alam A, Perrone RD
Lancet 2019 Mar 2;393(10174):919-935. Epub 2019 Feb 25 doi: 10.1016/S0140-6736(18)32782-X. PMID: 30819518

Best practice policy statement on urodynamic antibiotic prophylaxis in the non-index patient.

Cameron AP, Campeau L, Brucker BM, Clemens JQ, Bales GT, Albo ME, Kennelly MJ
Neurourol Urodyn 2017 Apr;36(4):915-926. Epub 2017 Mar 27 doi: 10.1002/nau.23253. PMID: 28345769

Acquired disorders of platelet function.

Konkle BA
Hematology Am Soc Hematol Educ Program 2011;2011:391-6. doi: 10.1182/asheducation-2011.1.391. PMID: 22160063

Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases.

Donnelly KB
Toxicol Pathol 2008 Feb;36(2):204-17. doi: 10.1177/0192623307312707. PMID: 18474943

See all (51)

Prognosis

Autosomal dominant polycystic kidney disease.

Cornec-Le Gall E, Alam A, Perrone RD
Lancet 2019 Mar 2;393(10174):919-935. Epub 2019 Feb 25 doi: 10.1016/S0140-6736(18)32782-X. PMID: 30819518

Patient-Specific Cardiovascular Computational Modeling: Diversity of Personalization and Challenges.

Gray RA, Pathmanathan P
J Cardiovasc Transl Res 2018 Apr;11(2):80-88. Epub 2018 Mar 6 doi: 10.1007/s12265-018-9792-2. PMID: 29512059 Free PMC Article

Manifestations of Lyme carditis.

Kostić T, Momčilović S, Perišić ZD, Apostolović SR, Cvetković J, Jovanović A, Barać A, Šalinger-Martinović S, Tasić-Otašević S
Int J Cardiol 2017 Apr 1;232:24-32. Epub 2016 Dec 27 doi: 10.1016/j.ijcard.2016.12.169. PMID: 28082088

Antiphospholipid syndrome.

Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Pulmonary capillary pressure: a review.

Cope DK, Grimbert F, Downey JM, Taylor AE
Crit Care Med 1992 Jul;20(7):1043-56. doi: 10.1097/00003246-199207000-00024. PMID: 1617975

See all (52)

Clinical prediction guides

A lightweight hybrid deep learning system for cardiac valvular disease classification.

Al-Issa Y, Alqudah AM
Sci Rep 2022 Aug 22;12(1):14297. doi: 10.1038/s41598-022-18293-7. PMID: 35995814 Free PMC Article

Patient-Specific Cardiovascular Computational Modeling: Diversity of Personalization and Challenges.

Gray RA, Pathmanathan P
J Cardiovasc Transl Res 2018 Apr;11(2):80-88. Epub 2018 Mar 6 doi: 10.1007/s12265-018-9792-2. PMID: 29512059 Free PMC Article

Concurrent aortic valvular disease and pulmonary sequestration: clinical implications.

Hui DS, Shavelle DM, Starnes VA, McFadden PM
Tex Heart Inst J 2014 Dec;41(6):649-52. Epub 2014 Dec 1 doi: 10.14503/THIJ-13-3907. PMID: 25593534 Free PMC Article

Antiphospholipid syndrome.

Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Pulmonary capillary pressure: a review.

Cope DK, Grimbert F, Downey JM, Taylor AE
Crit Care Med 1992 Jul;20(7):1043-56. doi: 10.1097/00003246-199207000-00024. PMID: 1617975

See all (42)

Recent systematic reviews

A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis.

Marrie RA, Reider N, Cohen J, Stuve O, Trojano M, Cutter G, Reingold S, Sorensen PS
Mult Scler 2015 Mar;21(3):318-31. Epub 2014 Dec 22 doi: 10.1177/1352458514564485. PMID: 25533300 Free PMC Article

See all (1)

MedGen

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Send to:

cardiac valvular disease

Definition

Term Hierarchy

Professional guidelines

PubMed

Curated

UK NICE Guideline NG208, Heart valve disease presenting in adults: investigation and management, 2021

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Curated

Consumer resources

Reviews

Related information

Recent activity