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Mild Cardiac Valve Regurgitation

MedGen UID:
476744
•Concept ID:
C3275111
•
Disease or Syndrome

Definition

Evidence of mild retrograde blood flow through the valve(s) of the heart. (ACC) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMild Cardiac Valve Regurgitation

Professional guidelines

PubMed

New Perspective on Pathophysiology and Management of Functional Mitral Regurgitation.
Kumar M, Thompson PD, Chen K
Trends Cardiovasc Med 2023 Aug;33(6):386-392. Epub 2022 Mar 5 doi: 10.1016/j.tcm.2022.03.001. PMID: 35259483
Management of patients with mitral regurgitation ineligible for standard therapy undergoing TMVI screening.
Ludwig S, Sedighian R, Weimann J, Koell B, Waldschmidt L, Schäfer A, Seiffert M, Westermann D, Reichenspurner H, Blankenberg S, Schofer N, Lubos E, Conradi L, Kalbacher D
EuroIntervention 2022 Jun 24;18(3):213-223. doi: 10.4244/EIJ-D-21-00708. PMID: 34992049Free PMC Article
Tricuspid regurgitation diagnosis and treatment.
Arsalan M, Walther T, Smith RL 2nd, Grayburn PA
Eur Heart J 2017 Mar 1;38(9):634-638. doi: 10.1093/eurheartj/ehv487. PMID: 26358570

Recent clinical studies

Etiology

Balloon- vs Self-Expanding Transcatheter Valves for Failed Small Surgical Aortic Bioprostheses: 1-Year Results of the LYTEN Trial.
Nuche J, Abbas AE, Serra V, Vilalta V, Nombela-Franco L, Regueiro A, Al-Azizi KM, Iskander A, Conradi L, Forcillo J, Lilly S, Calabuig A, Fernandez-Nofrerias E, Mohammadi S, Giuliani C, Pelletier-Beaumont E, Pibarot P, Rodés-Cabau J
JACC Cardiovasc Interv 2023 Dec 25;16(24):2999-3012. Epub 2023 Oct 23 doi: 10.1016/j.jcin.2023.10.028. PMID: 37902146
Incidence of Prosthesis-Patient Mismatch in Valve-in-Valve with a Supra-Annular Valve.
Alwan L, Ruge H, Krane M, Prinzing A, Noebauer C, Lange R, Erlebach M
Thorac Cardiovasc Surg 2023 Dec;71(8):632-640. Epub 2022 Mar 7 doi: 10.1055/s-0042-1742755. PMID: 35255516
TAVI in 2022: Remaining issues and future direction.
Webb JG, Blanke P, Meier D, Sathananthan J, Lauck S, Chatfield AG, Jelisejevas J, Wood DA, Akodad M
Arch Cardiovasc Dis 2022 Apr;115(4):235-242. Epub 2022 Apr 20 doi: 10.1016/j.acvd.2022.04.001. PMID: 35527211
Transfemoral Tricuspid Valve Replacement in Patients With Tricuspid Regurgitation: TRISCEND Study 30-Day Results.
Kodali S, Hahn RT, George I, Davidson CJ, Narang A, Zahr F, Chadderdon S, Smith R, Grayburn PA, O'Neill WW, Wang DD, Herrmann H, Silvestry F, Elmariah S, Inglessis I, Passeri J, Lim DS, Salerno M, Makar M, Mack MJ, Leon MB, Makkar R; TRISCEND Investigators
JACC Cardiovasc Interv 2022 Mar 14;15(5):471-480. doi: 10.1016/j.jcin.2022.01.016. PMID: 35272771
Transcatheter Therapies for Treating Tricuspid Regurgitation.
Rodés-Cabau J, Hahn RT, Latib A, Laule M, Lauten A, Maisano F, Schofer J, Campelo-Parada F, Puri R, Vahanian A
J Am Coll Cardiol 2016 Apr 19;67(15):1829-1845. doi: 10.1016/j.jacc.2016.01.063. PMID: 27081024

Diagnosis

Acute mitral regurgitation with and without acute heart failure.
Boudoulas KD, Triposkiadis F, Koenig S, Marmagkiolis K, Iliescu C, Pitsis A, Boudoulas H
Heart Fail Rev 2023 Sep;28(5):1201-1209. Epub 2023 Jul 6 doi: 10.1007/s10741-023-10322-5. PMID: 37414917
Impact of Tricuspid Regurgitation Severity and Repair on Aortic Valve Replacement.
Bustamante-Munguira J, Alvarez P, Romero B, Muñoz-Guijosa C, Camara M, Vallejo N, Lopez-Ayerbe J, Coca A, Figuerola-Tejerina A
Ann Thorac Surg 2022 Sep;114(3):767-775. Epub 2021 Apr 25 doi: 10.1016/j.athoracsur.2021.03.102. PMID: 33910051
Echocardiographic examination of mitral valve abnormalities in the paediatric population: current practices.
Cantinotti M, Giordano R, Koestenberger M, Voges I, Santoro G, Franchi E, Assanta N, Valverde I, Simpson J, Kutty S
Cardiol Young 2020 Jan;30(1):1-11. Epub 2020 Jan 8 doi: 10.1017/S1047951119003196. PMID: 31910934
Transcatheter Therapies for Treating Tricuspid Regurgitation.
Rodés-Cabau J, Hahn RT, Latib A, Laule M, Lauten A, Maisano F, Schofer J, Campelo-Parada F, Puri R, Vahanian A
J Am Coll Cardiol 2016 Apr 19;67(15):1829-1845. doi: 10.1016/j.jacc.2016.01.063. PMID: 27081024
Quantitation of mitral regurgitation.
Topilsky Y, Grigioni F, Enriquez-Sarano M
Semin Thorac Cardiovasc Surg 2011 Summer;23(2):106-14. doi: 10.1053/j.semtcvs.2011.07.004. PMID: 22041039

Therapy

Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair: A Randomized Clinical Trial.
Akowuah EF, Maier RH, Hancock HC, Kharatikoopaei E, Vale L, Fernandez-Garcia C, Ogundimu E, Wagnild J, Mathias A, Walmsley Z, Howe N, Kasim A, Graham R, Murphy GJ, Zacharias J; UK Mini Mitral Trial Investigators
JAMA 2023 Jun 13;329(22):1957-1966. doi: 10.1001/jama.2023.7800. PMID: 37314276Free PMC Article
TAVI in 2022: Remaining issues and future direction.
Webb JG, Blanke P, Meier D, Sathananthan J, Lauck S, Chatfield AG, Jelisejevas J, Wood DA, Akodad M
Arch Cardiovasc Dis 2022 Apr;115(4):235-242. Epub 2022 Apr 20 doi: 10.1016/j.acvd.2022.04.001. PMID: 35527211
Transfemoral Tricuspid Valve Replacement in Patients With Tricuspid Regurgitation: TRISCEND Study 30-Day Results.
Kodali S, Hahn RT, George I, Davidson CJ, Narang A, Zahr F, Chadderdon S, Smith R, Grayburn PA, O'Neill WW, Wang DD, Herrmann H, Silvestry F, Elmariah S, Inglessis I, Passeri J, Lim DS, Salerno M, Makar M, Mack MJ, Leon MB, Makkar R; TRISCEND Investigators
JACC Cardiovasc Interv 2022 Mar 14;15(5):471-480. doi: 10.1016/j.jcin.2022.01.016. PMID: 35272771
Impact of Tricuspid Regurgitation Severity and Repair on Aortic Valve Replacement.
Bustamante-Munguira J, Alvarez P, Romero B, Muñoz-Guijosa C, Camara M, Vallejo N, Lopez-Ayerbe J, Coca A, Figuerola-Tejerina A
Ann Thorac Surg 2022 Sep;114(3):767-775. Epub 2021 Apr 25 doi: 10.1016/j.athoracsur.2021.03.102. PMID: 33910051
5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial.
Mack MJ, Leon MB, Smith CR, Miller DC, Moses JW, Tuzcu EM, Webb JG, Douglas PS, Anderson WN, Blackstone EH, Kodali SK, Makkar RR, Fontana GP, Kapadia S, Bavaria J, Hahn RT, Thourani VH, Babaliaros V, Pichard A, Herrmann HC, Brown DL, Williams M, Akin J, Davidson MJ, Svensson LG; PARTNER 1 trial investigators
Lancet 2015 Jun 20;385(9986):2477-84. Epub 2015 Mar 15 doi: 10.1016/S0140-6736(15)60308-7. PMID: 25788234

Prognosis

Incidence of Prosthesis-Patient Mismatch in Valve-in-Valve with a Supra-Annular Valve.
Alwan L, Ruge H, Krane M, Prinzing A, Noebauer C, Lange R, Erlebach M
Thorac Cardiovasc Surg 2023 Dec;71(8):632-640. Epub 2022 Mar 7 doi: 10.1055/s-0042-1742755. PMID: 35255516
Surgical management of traumatic tricuspid insufficiency.
Zhang Z, Yin K, Dong L, Sun Y, Guo C, Lin Y, Wang C
J Card Surg 2017 Jun;32(6):342-346. Epub 2017 May 24 doi: 10.1111/jocs.13156. PMID: 28543789
Transcatheter Therapies for Treating Tricuspid Regurgitation.
Rodés-Cabau J, Hahn RT, Latib A, Laule M, Lauten A, Maisano F, Schofer J, Campelo-Parada F, Puri R, Vahanian A
J Am Coll Cardiol 2016 Apr 19;67(15):1829-1845. doi: 10.1016/j.jacc.2016.01.063. PMID: 27081024
5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial.
Mack MJ, Leon MB, Smith CR, Miller DC, Moses JW, Tuzcu EM, Webb JG, Douglas PS, Anderson WN, Blackstone EH, Kodali SK, Makkar RR, Fontana GP, Kapadia S, Bavaria J, Hahn RT, Thourani VH, Babaliaros V, Pichard A, Herrmann HC, Brown DL, Williams M, Akin J, Davidson MJ, Svensson LG; PARTNER 1 trial investigators
Lancet 2015 Jun 20;385(9986):2477-84. Epub 2015 Mar 15 doi: 10.1016/S0140-6736(15)60308-7. PMID: 25788234
Quantitation of mitral regurgitation.
Topilsky Y, Grigioni F, Enriquez-Sarano M
Semin Thorac Cardiovasc Surg 2011 Summer;23(2):106-14. doi: 10.1053/j.semtcvs.2011.07.004. PMID: 22041039

Clinical prediction guides

Transcatheter Mitral Valve Repair for Degenerative Mitral Regurgitation.
Makkar RR, Chikwe J, Chakravarty T, Chen Q, O'Gara PT, Gillinov M, Mack MJ, Vekstein A, Patel D, Stebbins AL, Gelijns AC, Makar M, Bhatt DL, Kapadia S, Vemulapalli S, Leon MB
JAMA 2023 May 23;329(20):1778-1788. doi: 10.1001/jama.2023.7089. PMID: 37219553Free PMC Article
Incidence of Prosthesis-Patient Mismatch in Valve-in-Valve with a Supra-Annular Valve.
Alwan L, Ruge H, Krane M, Prinzing A, Noebauer C, Lange R, Erlebach M
Thorac Cardiovasc Surg 2023 Dec;71(8):632-640. Epub 2022 Mar 7 doi: 10.1055/s-0042-1742755. PMID: 35255516
Artificial chordae for mitral valve repair.
Vendramin I, Milano AD, Pucci A, Lechiancole A, Sponga S, Bortolotti U, Livi U
J Card Surg 2022 Nov;37(11):3722-3728. Epub 2022 Sep 18 doi: 10.1111/jocs.16937. PMID: 36116053Free PMC Article
Transfemoral Tricuspid Valve Replacement in Patients With Tricuspid Regurgitation: TRISCEND Study 30-Day Results.
Kodali S, Hahn RT, George I, Davidson CJ, Narang A, Zahr F, Chadderdon S, Smith R, Grayburn PA, O'Neill WW, Wang DD, Herrmann H, Silvestry F, Elmariah S, Inglessis I, Passeri J, Lim DS, Salerno M, Makar M, Mack MJ, Leon MB, Makkar R; TRISCEND Investigators
JACC Cardiovasc Interv 2022 Mar 14;15(5):471-480. doi: 10.1016/j.jcin.2022.01.016. PMID: 35272771
Impact of Tricuspid Regurgitation Severity and Repair on Aortic Valve Replacement.
Bustamante-Munguira J, Alvarez P, Romero B, Muñoz-Guijosa C, Camara M, Vallejo N, Lopez-Ayerbe J, Coca A, Figuerola-Tejerina A
Ann Thorac Surg 2022 Sep;114(3):767-775. Epub 2021 Apr 25 doi: 10.1016/j.athoracsur.2021.03.102. PMID: 33910051

Recent systematic reviews

Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta-analysis.
Hameed I, Ahmed A, Kumar A, Li E, Candelario K, Khan S, Kannan A, Latif N, Amabile A, Geirsson A, Williams ML
Catheter Cardiovasc Interv 2023 Jul;102(1):166-175. Epub 2023 May 12 doi: 10.1002/ccd.30674. PMID: 37172208
Incidence, Risk Factors, and Prognosis of Tricuspid Regurgitation After Cardiac Implantable Electronic Device Implantation: A Systematic Review and Meta-analysis.
Zhang XX, Wei M, Xiang R, Lu YM, Zhang L, Li YD, Zhang JH, Xing Q, Tu-Erhong ZK, Tang BP, Zhou XH
J Cardiothorac Vasc Anesth 2022 Jun;36(6):1741-1755. Epub 2021 Jun 25 doi: 10.1053/j.jvca.2021.06.025. PMID: 34389210
Right ventricular dysfunction and tricuspid regurgitation in functional mitral regurgitation.
Truong VT, Ngo TNM, Mazur J, Nguyen HTM, Pham TTM, Palmer C, Pham KNP, Phan HT, Lee KS, Bannehr M, Butter C, Gyoten T, Chung ES
ESC Heart Fail 2021 Dec;8(6):4988-4996. Epub 2021 Sep 22 doi: 10.1002/ehf2.13558. PMID: 34551208Free PMC Article
Quantification of mitral valve regurgitation by 2D and 3D echocardiography compared with cardiac magnetic resonance a systematic review and meta-analysis.
Sköldborg V, Madsen PL, Dalsgaard M, Abdulla J
Int J Cardiovasc Imaging 2020 Feb;36(2):279-289. Epub 2019 Oct 29 doi: 10.1007/s10554-019-01713-7. PMID: 31664679
Transcatheter aortic valve replacement with new-generation devices: A systematic review and meta-analysis.
Barbanti M, Buccheri S, Rodés-Cabau J, Gulino S, Généreux P, Pilato G, Dvir D, Picci A, Costa G, Tamburino C, Leon MB, Webb JG
Int J Cardiol 2017 Oct 15;245:83-89. Epub 2017 Jul 25 doi: 10.1016/j.ijcard.2017.07.083. PMID: 28760396

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