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Leaflet Disruption Due To Calcification

MedGen UID:
317823
•Concept ID:
C1708667
•
Disease or Syndrome

Definition

The disturbance of a cusp of a heart valve secondary to the accumulation of calcium on the valve tissue. This most often results in stenosis of the valve. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeaflet Disruption Due To Calcification

Recent clinical studies

Etiology

The pathomechanism of human myxomatous valvular degeneration at the mechanical and cellular level.
Hu C, Wang Q, Xue H, Hong H, Shi J, Dong N, Zhang M
Rev Cardiovasc Med 2021 Jun 30;22(2):513-519. doi: 10.31083/j.rcm2202059. PMID: 34258920
Novel Surgical Technique to Prevent Left Ventricular Rupture After Mitral Valve Replacement.
Fadel M, Varghese S, Awad G, Wippermann J
Ann Thorac Surg 2021 Dec;112(6):e463-e466. Epub 2021 Mar 29 doi: 10.1016/j.athoracsur.2021.03.046. PMID: 33794159
Use of Transcatheter Valves for Open Surgical Mitral Valve Replacement. Australian Experience.
Ahmad T, Ludhani PM, Gurvitch R, Larobina M, Goldblatt J, Tatoulis J
Heart Lung Circ 2019 Mar;28(3):464-470. Epub 2018 Feb 21 doi: 10.1016/j.hlc.2018.02.008. PMID: 30170916
Progress in developing a living human tissue-engineered tri-leaflet heart valve assembled from tissue produced by the self-assembly approach.
Dubé J, Bourget JM, Gauvin R, Lafrance H, Roberge CJ, Auger FA, Germain L
Acta Biomater 2014 Aug;10(8):3563-70. Epub 2014 May 6 doi: 10.1016/j.actbio.2014.04.033. PMID: 24813743
Early stenosis and calcification of glutaraldehyde-preserved porcine xenografts in children.
Hellberg K, Ruschewski W, de Vivie ER
Thorac Cardiovasc Surg 1981 Dec;29(6):369-74. doi: 10.1055/s-2007-1023515. PMID: 6179219

Diagnosis

Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 1: Pluridisciplinary perspective on their hemodynamics and morphomechanics.
Pasipoularides A
J Mol Cell Cardiol 2019 Aug;133:223-232. Epub 2019 May 28 doi: 10.1016/j.yjmcc.2019.05.017. PMID: 31150733Free PMC Article
Use of Transcatheter Valves for Open Surgical Mitral Valve Replacement. Australian Experience.
Ahmad T, Ludhani PM, Gurvitch R, Larobina M, Goldblatt J, Tatoulis J
Heart Lung Circ 2019 Mar;28(3):464-470. Epub 2018 Feb 21 doi: 10.1016/j.hlc.2018.02.008. PMID: 30170916
Spontaneous rupture of atrioventricular valve tensor apparatus as late manifestation of anti-Ro/SSA antibody-mediated cardiac disease.
Cuneo BF, Fruitman D, Benson DW, Ngan BY, Liske MR, Wahren-Herlineus M, Ho SY, Jaeggi E
Am J Cardiol 2011 Mar 1;107(5):761-6. Epub 2011 Jan 19 doi: 10.1016/j.amjcard.2010.10.059. PMID: 21247531
Clinical and morphologic expression of hypertrophic cardiomyopathy in patients > or = 65 years of age.
Lewis JF, Maron BJ
Am J Cardiol 1994 Jun 1;73(15):1105-11. doi: 10.1016/0002-9149(94)90291-7. PMID: 8198038
Nonrheumatic mitral incompetence.
Yahini JH, Deutsch V, Miller HI, Shem-Tov A, Atlas P, Neufeld HN
Isr J Med Sci 1975 Sep;11(9):928-67. PMID: 1184367

Therapy

Novel Surgical Technique to Prevent Left Ventricular Rupture After Mitral Valve Replacement.
Fadel M, Varghese S, Awad G, Wippermann J
Ann Thorac Surg 2021 Dec;112(6):e463-e466. Epub 2021 Mar 29 doi: 10.1016/j.athoracsur.2021.03.046. PMID: 33794159
Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls.
Poggio P, Grau JB, Field BC, Sainger R, Seefried WF, Rizzolio F, Ferrari G
J Cell Physiol 2011 Aug;226(8):2139-49. doi: 10.1002/jcp.22549. PMID: 21520066Free PMC Article
Mitral regurgitation following mitral balloon valvotomy. Differing mechanisms for severe versus mild-to-moderate lesions.
Essop MR, Wisenbaugh T, Skoularigis J, Middlemost S, Sareli P
Circulation 1991 Oct;84(4):1669-79. doi: 10.1161/01.cir.84.4.1669. PMID: 1914106
Valve failure with the Ionescu-Shiley bovine pericardial bioprosthesis: analysis of 2680 patients.
Reul GJ Jr, Cooley DA, Duncan JM, Frazier OH, Hallman GL, Livesay JJ, Ott DA, Walker WE
J Vasc Surg 1985 Jan;2(1):192-204. PMID: 3965752
The clinical life history of explanted prosthetic heart valves.
Marbarger JP Jr, Clark RE
Ann Thorac Surg 1982 Jul;34(1):22-33. doi: 10.1016/s0003-4975(10)60848-x. PMID: 7092396

Prognosis

Spontaneous rupture of atrioventricular valve tensor apparatus as late manifestation of anti-Ro/SSA antibody-mediated cardiac disease.
Cuneo BF, Fruitman D, Benson DW, Ngan BY, Liske MR, Wahren-Herlineus M, Ho SY, Jaeggi E
Am J Cardiol 2011 Mar 1;107(5):761-6. Epub 2011 Jan 19 doi: 10.1016/j.amjcard.2010.10.059. PMID: 21247531
Comparison of reoperation findings of the Carpentier-Edwards (standard) bioprosthesis and the St Jude bioimplant (formerly Liotta) in the mitral position.
Yamak B, Ozsöyler, Ulus AT, Kiziltepe U, Katircioğlu SF, Taşdemir O
Cardiovasc Surg 1999 Dec;7(7):730-4. doi: 10.1016/s0967-2109(99)00051-4. PMID: 10639048
Mitral regurgitation following mitral balloon valvotomy. Differing mechanisms for severe versus mild-to-moderate lesions.
Essop MR, Wisenbaugh T, Skoularigis J, Middlemost S, Sareli P
Circulation 1991 Oct;84(4):1669-79. doi: 10.1161/01.cir.84.4.1669. PMID: 1914106
Early stenosis and calcification of glutaraldehyde-preserved porcine xenografts in children.
Hellberg K, Ruschewski W, de Vivie ER
Thorac Cardiovasc Surg 1981 Dec;29(6):369-74. doi: 10.1055/s-2007-1023515. PMID: 6179219
Nonrheumatic mitral incompetence.
Yahini JH, Deutsch V, Miller HI, Shem-Tov A, Atlas P, Neufeld HN
Isr J Med Sci 1975 Sep;11(9):928-67. PMID: 1184367

Clinical prediction guides

Biomechanical Remodeling of Aortic Valve Interstitial Cells During Calcified Lesion Formation In Vitro.
Shih JY, Gee T, Scuderi G, Butcher J
Ann Biomed Eng 2024 May;52(5):1270-1279. Epub 2024 Feb 19 doi: 10.1007/s10439-024-03451-x. PMID: 38374519
Heart valve development, maintenance, and disease: the role of endothelial cells.
Tao G, Kotick JD, Lincoln J
Curr Top Dev Biol 2012;100:203-32. doi: 10.1016/B978-0-12-387786-4.00006-3. PMID: 22449845
Mitral regurgitation following mitral balloon valvotomy. Differing mechanisms for severe versus mild-to-moderate lesions.
Essop MR, Wisenbaugh T, Skoularigis J, Middlemost S, Sareli P
Circulation 1991 Oct;84(4):1669-79. doi: 10.1161/01.cir.84.4.1669. PMID: 1914106
Relation of calcification to torn leaflets of spontaneously degenerated porcine bioprosthetic valves.
Stein PD, Kemp SR, Riddle JM, Lee MW, Lewis JW Jr, Magilligan DJ Jr
Ann Thorac Surg 1985 Aug;40(2):175-80. doi: 10.1016/s0003-4975(10)60014-8. PMID: 4026449
Pathology of antibiotic-treated human heart valve allografts.
Gavin JB, Herdson PB, Monro JL, Barratt-Boyes BG
Thorax 1973 Jul;28(4):473-81. doi: 10.1136/thx.28.4.473. PMID: 4741451Free PMC Article

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