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Contact dermatitis

MedGen UID:
8329
Concept ID:
C0011616
Disease or Syndrome
Synonyms: Contact Dermatitides; Contact Dermatitis; Contact Eczema; Contact Sensitivities; Contact Sensitivity; Dermatitides, Contact; Dermatitis Venenata; Dermatitis, Contact; Eczema, Contact; Sensitivities, Contact; Sensitivity, Contact
SNOMED CT: CD - Contact dermatitis (40275004); Contact eczema (40275004); Contact dermatitis (40275004); Dermatitis venenata (40275004)
 
HPO: HP:0032282
Monarch Initiative: MONDO:0005480

Definition

An inflammatory process in skin caused by an exogenous agent that directly or indirectly injure the skin. If the offending agent is identified and removed, the eruption will resolve. An unusual or patterned eruption may be a clue to the presence of a contact dermatitis. Patch testing may be helpful in the differential diagnosis. [from HPO]

Professional guidelines

PubMed

Thyssen JP, Schuttelaar MLA, Alfonso JH, Andersen KE, Angelova-Fischer I, Arents BWM, Bauer A, Brans R, Cannavo A, Christoffers WA, Crépy MN, Elsner P, Fartasch M, Filon FL, Giménez-Arnau AM, Gonçalo M, Guzmán-Perera MG, Hamann CR, Hoetzenecker W, Johansen JD, John SM, Kunkeler ACM, Hadzavdic SL, Molin S, Nixon R, Oosterhaven JAF, Rustemeyer T, Serra-Baldrich E, Shah M, Simon D, Skudlik C, Spiewak R, Valiukevičienė S, Voorberg AN, Weisshaar E, Agner T
Contact Dermatitis 2022 May;86(5):357-378. Epub 2022 Mar 3 doi: 10.1111/cod.14035. PMID: 34971008
Li Y, Li L
Clin Rev Allergy Immunol 2021 Dec;61(3):245-281. Epub 2021 Jul 15 doi: 10.1007/s12016-021-08875-0. PMID: 34264448
Lugović-Mihić L, Pilipović K, Crnarić I, Šitum M, Duvančić T
Acta Clin Croat 2018 Jun;57(2):342-351. doi: 10.20471/acc.2018.57.02.16. PMID: 30431729Free PMC Article

Recent clinical studies

Etiology

Yamaguchi HL, Yamaguchi Y, Peeva E
Int J Mol Sci 2023 Aug 19;24(16) doi: 10.3390/ijms241612975. PMID: 37629154Free PMC Article
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Uyesugi BA, Sheehan MP
Clin Rev Allergy Immunol 2019 Feb;56(1):110-118. doi: 10.1007/s12016-018-8715-y. PMID: 30269296
Gru AA, Salavaggione AL
Semin Diagn Pathol 2017 May;34(3):226-236. Epub 2017 Feb 10 doi: 10.1053/j.semdp.2017.02.002. PMID: 28237387
Alfalah M, Loranger C, Sasseville D
Dermatitis 2017 Jan/Feb;28(1):3-4. doi: 10.1097/DER.0000000000000234. PMID: 27775973

Diagnosis

Johansen JD, Bonefeld CM, Schwensen JFB, Thyssen JP, Uter W
J Allergy Clin Immunol 2022 Apr;149(4):1162-1171. Epub 2022 Feb 18 doi: 10.1016/j.jaci.2022.02.002. PMID: 35183605
Li Y, Li L
Clin Rev Allergy Immunol 2021 Dec;61(3):245-281. Epub 2021 Jul 15 doi: 10.1007/s12016-021-08875-0. PMID: 34264448
Nassau S, Fonacier L
Med Clin North Am 2020 Jan;104(1):61-76. Epub 2019 Oct 28 doi: 10.1016/j.mcna.2019.08.012. PMID: 31757238
Bains SN, Nash P, Fonacier L
Clin Rev Allergy Immunol 2019 Feb;56(1):99-109. doi: 10.1007/s12016-018-8713-0. PMID: 30293200
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788

Therapy

Olbrich H, Sadik CD, Ludwig RJ, Thaçi D, Boch K
Biomolecules 2023 Mar 31;13(4) doi: 10.3390/biom13040634. PMID: 37189381Free PMC Article
Gupta AK, Talukder M
J Cosmet Dermatol 2022 May;21(5):1841-1848. Epub 2022 Mar 14 doi: 10.1111/jocd.14895. PMID: 35238144
Lebwohl MG, Stein Gold L, Strober B, Papp KA, Armstrong AW, Bagel J, Kircik L, Ehst B, Hong HC, Soung J, Fromowitz J, Guenthner S, Piscitelli SC, Rubenstein DS, Brown PM, Tallman AM, Bissonnette R
N Engl J Med 2021 Dec 9;385(24):2219-2229. doi: 10.1056/NEJMoa2103629. PMID: 34879448
Alavi A, Sibbald RG, Ladizinski B, Saraiya A, Lee KC, Skotnicki-Grant S, Maibach H
Adv Skin Wound Care 2016 Jun;29(6):278-86. doi: 10.1097/01.ASW.0000482834.94375.1e. PMID: 27171256
Singh M, Alavi A, Wong R, Akita S
Am J Clin Dermatol 2016 Jun;17(3):277-92. doi: 10.1007/s40257-016-0186-4. PMID: 27021652

Prognosis

Herman A, Aerts O, de Montjoye L, Tromme I, Goossens A, Baeck M
J Eur Acad Dermatol Venereol 2019 Feb;33(2):267-276. doi: 10.1111/jdv.15267. PMID: 30284765
Hermida MD, Cabrera HN
Skinmed 2017;15(1):37-42. Epub 2017 Feb 1 PMID: 28270308
Mowad CM, Anderson B, Scheinman P, Pootongkam S, Nedorost S, Brod B
J Am Acad Dermatol 2016 Jun;74(6):1029-40. doi: 10.1016/j.jaad.2015.02.1139. PMID: 27185421
Usatine RP, Riojas M
Am Fam Physician 2010 Aug 1;82(3):249-55. PMID: 20672788
Beltrani VS
Curr Opin Allergy Clin Immunol 2003 Apr;3(2):115-23. doi: 10.1097/00130832-200304000-00005. PMID: 12750608

Clinical prediction guides

Shah S, Baskaran N, Vinay K, Bishnoi A, Parsad D, Kumaran MS
Int J Dermatol 2023 Dec;62(12):1447-1457. Epub 2023 Sep 28 doi: 10.1111/ijd.16859. PMID: 37767951
de Boer FL, van der Molen HF, Kezic S
Contact Dermatitis 2023 Oct;89(4):221-229. Epub 2023 Aug 12 doi: 10.1111/cod.14391. PMID: 37571977
Nogueira S, Rodrigues MA, Vender R, Torres T
Dermatol Ther 2022 Dec;35(12):e15931. Epub 2022 Oct 21 doi: 10.1111/dth.15931. PMID: 36226669Free PMC Article
Bailey E, Kroshinsky D
Dermatol Ther 2011 Mar-Apr;24(2):229-39. doi: 10.1111/j.1529-8019.2011.01398.x. PMID: 21410612
Trattner A, David M
J Am Acad Dermatol 2005 May;52(5):831-3. doi: 10.1016/j.jaad.2004.12.042. PMID: 15858473

Recent systematic reviews

Olbrich H, Sadik CD, Ludwig RJ, Thaçi D, Boch K
Biomolecules 2023 Mar 31;13(4) doi: 10.3390/biom13040634. PMID: 37189381Free PMC Article
Reynaert V, Gutermuth J, Wollenberg A
J Eur Acad Dermatol Venereol 2023 Jun;37(6):1149-1159. Epub 2023 Feb 16 doi: 10.1111/jdv.18920. PMID: 36695082
Contini M, Hollander MHJ, Vissink A, Schepers RH, Jansma J, Schortinghuis J
Int J Environ Res Public Health 2023 Jan 13;20(2) doi: 10.3390/ijerph20021522. PMID: 36674277Free PMC Article
Puyana C, Chandan N, Tsoukas M
J Cosmet Dermatol 2022 Dec;21(12):6636-6643. Epub 2022 Oct 31 doi: 10.1111/jocd.15420. PMID: 36176207
Loh EW, Yew YW
Contact Dermatitis 2022 Oct;87(4):303-314. Epub 2022 May 2 doi: 10.1111/cod.14133. PMID: 35460528Free PMC Article

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