U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Borrelia infectious disease

MedGen UID:
2325
•Concept ID:
C0006035
•
Disease or Syndrome
Synonyms: Borrelia Infection; Borrelia Infections; Infection, Borrelia; Infections, Borrelia
SNOMED CT: Borreliosis (240668005)
 
Monarch Initiative: MONDO:0006681

Definition

Infections with bacteria of the genus borrelia. [from MONDO]

Professional guidelines

PubMed

Septic Arthritis: Diagnosis and Treatment.
Earwood JS, Walker TR, Sue GJC
Am Fam Physician 2021 Dec 1;104(6):589-597. PMID: 34913662
Lyme borreliosis: diagnosis and management.
Kullberg BJ, Vrijmoeth HD, van de Schoor F, Hovius JW
BMJ 2020 May 26;369:m1041. doi: 10.1136/bmj.m1041. PMID: 32457042
Guidelines for diagnosis and treatment in neurology - Lyme neuroborreliosis.
Rauer S, Kastenbauer S, Hofmann H, Fingerle V, Huppertz HI, Hunfeld KP, Krause A, Ruf B, Dersch R; Consensus group
Ger Med Sci 2020;18:Doc03. Epub 2020 Feb 27 doi: 10.3205/000279. PMID: 32341686Free PMC Article

Recent clinical studies

Etiology

Septic Arthritis: Diagnosis and Treatment.
Earwood JS, Walker TR, Sue GJC
Am Fam Physician 2021 Dec 1;104(6):589-597. PMID: 34913662
Human babesiosis.
Krause PJ
Int J Parasitol 2019 Feb;49(2):165-174. Epub 2019 Jan 26 doi: 10.1016/j.ijpara.2018.11.007. PMID: 30690090
Diagnosing Borreliosis.
Cutler SJ, Rudenko N, Golovchenko M, Cramaro WJ, Kirpach J, Savic S, Christova I, Amaro A
Vector Borne Zoonotic Dis 2017 Jan;17(1):2-11. doi: 10.1089/vbz.2016.1962. PMID: 28055580
Lyme borreliosis.
Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS
Nat Rev Dis Primers 2016 Dec 15;2:16090. doi: 10.1038/nrdp.2016.90. PMID: 27976670Free PMC Article
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article

Diagnosis

Septic Arthritis: Diagnosis and Treatment.
Earwood JS, Walker TR, Sue GJC
Am Fam Physician 2021 Dec 1;104(6):589-597. PMID: 34913662
Lyme Disease in Humans.
Radolf JD, Strle K, Lemieux JE, Strle F
Curr Issues Mol Biol 2021;42:333-384. Epub 2020 Dec 11 doi: 10.21775/cimb.042.333. PMID: 33303701Free PMC Article
Lyme borreliosis: diagnosis and management.
Kullberg BJ, Vrijmoeth HD, van de Schoor F, Hovius JW
BMJ 2020 May 26;369:m1041. doi: 10.1136/bmj.m1041. PMID: 32457042
Lyme borreliosis.
Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS
Nat Rev Dis Primers 2016 Dec 15;2:16090. doi: 10.1038/nrdp.2016.90. PMID: 27976670Free PMC Article
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article

Therapy

Septic Arthritis: Diagnosis and Treatment.
Earwood JS, Walker TR, Sue GJC
Am Fam Physician 2021 Dec 1;104(6):589-597. PMID: 34913662
A selective antibiotic for Lyme disease.
Leimer N, Wu X, Imai Y, Morrissette M, Pitt N, Favre-Godal Q, Iinishi A, Jain S, Caboni M, Leus IV, Bonifay V, Niles S, Bargabos R, Ghiglieri M, Corsetti R, Krumpoch M, Fox G, Son S, Klepacki D, Polikanov YS, Freliech CA, McCarthy JE, Edmondson DG, Norris SJ, D'Onofrio A, Hu LT, Zgurskaya HI, Lewis K
Cell 2021 Oct 14;184(21):5405-5418.e16. Epub 2021 Oct 6 doi: 10.1016/j.cell.2021.09.011. PMID: 34619078Free PMC Article
Lyme borreliosis: diagnosis and management.
Kullberg BJ, Vrijmoeth HD, van de Schoor F, Hovius JW
BMJ 2020 May 26;369:m1041. doi: 10.1136/bmj.m1041. PMID: 32457042
Lyme borreliosis.
Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS
Nat Rev Dis Primers 2016 Dec 15;2:16090. doi: 10.1038/nrdp.2016.90. PMID: 27976670Free PMC Article
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article

Prognosis

Septic Arthritis: Diagnosis and Treatment.
Earwood JS, Walker TR, Sue GJC
Am Fam Physician 2021 Dec 1;104(6):589-597. PMID: 34913662
Lyme Disease in Humans.
Radolf JD, Strle K, Lemieux JE, Strle F
Curr Issues Mol Biol 2021;42:333-384. Epub 2020 Dec 11 doi: 10.21775/cimb.042.333. PMID: 33303701Free PMC Article
Diagnosing Borreliosis.
Cutler SJ, Rudenko N, Golovchenko M, Cramaro WJ, Kirpach J, Savic S, Christova I, Amaro A
Vector Borne Zoonotic Dis 2017 Jan;17(1):2-11. doi: 10.1089/vbz.2016.1962. PMID: 28055580
Chronic Lyme disease.
Lantos PM
Infect Dis Clin North Am 2015 Jun;29(2):325-40. doi: 10.1016/j.idc.2015.02.006. PMID: 25999227Free PMC Article
Erythema migrans.
Nadelman RB
Infect Dis Clin North Am 2015 Jun;29(2):211-39. doi: 10.1016/j.idc.2015.02.001. PMID: 25999220

Clinical prediction guides

Persistent Symptoms After Lyme Disease: Clinical Characteristics, Predictors, and Classification.
Baarsma ME, Hovius JW
J Infect Dis 2024 Aug 14;230(Supplement_1):S62-S69. doi: 10.1093/infdis/jiae203. PMID: 39140720
A comprehensive genetic map of cytokine responses in Lyme borreliosis.
Botey-Bataller J, Vrijmoeth HD, Ursinus J, Kullberg BJ, van den Wijngaard CC, Ter Hofstede H, Alaswad A, Gupta MK, Roesner LM, Huehn J, Werfel T, Schulz TF, Xu CJ, Netea MG, Hovius JW, Joosten LAB, Li Y
Nat Commun 2024 May 7;15(1):3795. doi: 10.1038/s41467-024-47505-z. PMID: 38714679Free PMC Article
The structure of a hibernating ribosome in a Lyme disease pathogen.
Sharma MR, Manjari SR, Agrawal EK, Keshavan P, Koripella RK, Majumdar S, Marcinkiewicz AL, Lin YP, Agrawal RK, Banavali NK
Nat Commun 2023 Oct 31;14(1):6961. doi: 10.1038/s41467-023-42266-7. PMID: 37907464Free PMC Article
Evolutionary aspects of emerging Lyme disease in Canada.
Ogden NH, Feil EJ, Leighton PA, Lindsay LR, Margos G, Mechai S, Michel P, Moriarty TJ
Appl Environ Microbiol 2015 Nov;81(21):7350-9. Epub 2015 Aug 21 doi: 10.1128/AEM.01671-15. PMID: 26296723Free PMC Article
Lyme arthritis.
Kahan A, Amor B, Menkes CJ
Biomed Pharmacother 1989;43(6):401-3. doi: 10.1016/0753-3322(89)90236-9. PMID: 2686765

Recent systematic reviews

Discrepancy between IDSA and ESGBOR in Lyme disease: Individual participant meta-analysis in Türkiye.
Yıldız AB, Çetin E, Pınarlık F, Keske Ş, Can F, Ergönül Ö
Zoonoses Public Health 2024 Jun;71(4):337-348. Epub 2024 Feb 27 doi: 10.1111/zph.13119. PMID: 38413371
Prevalence and clinical manifestation of Borrelia miyamotoi in Ixodes ticks and humans in the northern hemisphere: a systematic review and meta-analysis.
Hoornstra D, Azagi T, van Eck JA, Wagemakers A, Koetsveld J, Spijker R, Platonov AE, Sprong H, Hovius JW
Lancet Microbe 2022 Oct;3(10):e772-e786. Epub 2022 Sep 13 doi: 10.1016/S2666-5247(22)00157-4. PMID: 36113496
Morgellons disease etiology and therapeutic approach: a systematic review.
Beuerlein KG, Balogh EA, Feldman SR
Dermatol Online J 2021 Aug 15;27(8) doi: 10.5070/D327854682. PMID: 34755952
Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis.
Zhou G, Xu X, Zhang Y, Yue P, Luo S, Fan Y, Chen J, Liu M, Dong Y, Li B, Kong J, Wen S, Liu A, Bao F
BMC Infect Dis 2021 Nov 8;21(1):1141. doi: 10.1186/s12879-021-06837-7. PMID: 34749665Free PMC Article
Systematic review of Lyme disease in Turkey.
Önal U, Aytaç Erdem H, Uyan Önal A, Reşat Sipahi O
Trop Doct 2019 Jul;49(3):165-170. Epub 2019 Apr 24 doi: 10.1177/0049475519843387. PMID: 31018773

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...