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Aseptic Necrosis of Head and Neck of Femur

MedGen UID:
420
•Concept ID:
C0003977
•
Disease or Syndrome

Definition

Aseptic necrosis involving the head and neck of the femur. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAseptic Necrosis of Head and Neck of Femur

Professional guidelines

PubMed

The height-to-width index for the assessment of femoral head deformity following osteonecrosis in the treatment of developmental dysplasia.
Casaletto JA, Perry DC, Foster A, Bass A, Bruce CE
J Bone Joint Surg Am 2009 Dec;91(12):2915-21. doi: 10.2106/JBJS.H.00954. PMID: 19952255
Alcoholism associated ischemic necrosis of the femoral head. Early diagnosis and treatment.
Hungerford DS, Zizic TM
Clin Orthop Relat Res 1978 Jan-Feb;(130):144-153. PMID: 639386
Damage to the capital femoral epiphysis due to Frejka pillow treatment.
Ilfeld FW, Makin M
J Bone Joint Surg Am 1977 Jul;59(5):654-8. PMID: 873959

Recent clinical studies

Etiology

Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction.
Ma Z, Sun J, Jiang Q, Zhao Y, Jiang H, Sun P, Feng W
Front Endocrinol (Lausanne) 2024;15:1341366. Epub 2024 Feb 7 doi: 10.3389/fendo.2024.1341366. PMID: 38384969Free PMC Article
Oral corticosteroid use and the risk of developing avascular necrosis: A large retrospective review.
Grond SE, Little RE, Campbell DA, Loehrl TA, Poetker DM
Int Forum Allergy Rhinol 2022 Jul;12(7):903-909. Epub 2022 Jan 5 doi: 10.1002/alr.22950. PMID: 34918464
A Modification of the Dunn Osteotomy With Preservation of the Ligamentum Teres.
Bali N, Harrison J, Laugharne E, Bache CE
J Pediatr Orthop 2017 Jun;37(4):279-284. doi: 10.1097/BPO.0000000000000626. PMID: 26445173
Femoral Head Avascular Necrosis Is Not Caused by Arthroscopic Posterolateral Femoroplasty.
Rupp RE, Rupp SN
Orthopedics 2016 May 1;39(3):177-80. Epub 2016 Apr 12 doi: 10.3928/01477447-20160404-01. PMID: 27064782
Fractures of the head and neck of the femur in children: an outcome study.
Hajdu S, Oberleitner G, Schwendenwein E, Ringl H, Vécsei V
Int Orthop 2011 Jun;35(6):883-8. Epub 2010 May 20 doi: 10.1007/s00264-010-1039-z. PMID: 20490791Free PMC Article

Diagnosis

Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction.
Ma Z, Sun J, Jiang Q, Zhao Y, Jiang H, Sun P, Feng W
Front Endocrinol (Lausanne) 2024;15:1341366. Epub 2024 Feb 7 doi: 10.3389/fendo.2024.1341366. PMID: 38384969Free PMC Article
Bone marrow edema of the hip: a narrative review.
Di Martino A, Brunello M, Villari E, Cataldi P, D'Agostino C, Faldini C
Arch Orthop Trauma Surg 2023 Nov;143(11):6901-6917. Epub 2023 Jun 28 doi: 10.1007/s00402-023-04961-4. PMID: 37378892
Quantitative dynamic contrast-enhanced MRI of bone marrow perfusion at the proximal femur: influence of femoral head osteonecrosis risk factor and overt osteonecrosis.
Gondim Teixeira PA, Dubois L, Hossu G, Gillet R, Badr S, Cotten A, Blum A
Eur Radiol 2023 Apr;33(4):2340-2349. Epub 2022 Nov 17 doi: 10.1007/s00330-022-09250-z. PMID: 36394602
Oral corticosteroid use and the risk of developing avascular necrosis: A large retrospective review.
Grond SE, Little RE, Campbell DA, Loehrl TA, Poetker DM
Int Forum Allergy Rhinol 2022 Jul;12(7):903-909. Epub 2022 Jan 5 doi: 10.1002/alr.22950. PMID: 34918464
Femoral Head Avascular Necrosis Is Not Caused by Arthroscopic Posterolateral Femoroplasty.
Rupp RE, Rupp SN
Orthopedics 2016 May 1;39(3):177-80. Epub 2016 Apr 12 doi: 10.3928/01477447-20160404-01. PMID: 27064782

Therapy

Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction.
Ma Z, Sun J, Jiang Q, Zhao Y, Jiang H, Sun P, Feng W
Front Endocrinol (Lausanne) 2024;15:1341366. Epub 2024 Feb 7 doi: 10.3389/fendo.2024.1341366. PMID: 38384969Free PMC Article
Should cannulated screws be removed after a femoral neck fracture has healed, and how? A finite element analysis of the femur before and after cannulated screw removal.
Wu L, Sun J, Fang N, Peng Q, Gao S, Liu L
Int Orthop 2022 Oct;46(10):2393-2403. Epub 2022 Jul 19 doi: 10.1007/s00264-022-05516-9. PMID: 35852654
Oral corticosteroid use and the risk of developing avascular necrosis: A large retrospective review.
Grond SE, Little RE, Campbell DA, Loehrl TA, Poetker DM
Int Forum Allergy Rhinol 2022 Jul;12(7):903-909. Epub 2022 Jan 5 doi: 10.1002/alr.22950. PMID: 34918464
Outcomes of Conversion Total Hip Arthroplasty From Free Vascularized Fibular Grafting.
Ryan SP, Wooster B, Jiranek W, Wellman S, Bolognesi M, Seyler T
J Arthroplasty 2019 Jan;34(1):88-92. Epub 2018 Sep 21 doi: 10.1016/j.arth.2018.09.041. PMID: 30322733
Correlation between baseline femoral neck marrow status and the development of femoral head osteonecrosis in corticosteroid-treated patients: a longitudinal study by MR imaging.
Vande Berg BC, Gilon R, Malghem J, Lecouvet F, Depresseux G, Houssiau FA
Eur J Radiol 2006 Jun;58(3):444-9. Epub 2006 Feb 28 doi: 10.1016/j.ejrad.2006.01.009. PMID: 16510260

Prognosis

Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction.
Ma Z, Sun J, Jiang Q, Zhao Y, Jiang H, Sun P, Feng W
Front Endocrinol (Lausanne) 2024;15:1341366. Epub 2024 Feb 7 doi: 10.3389/fendo.2024.1341366. PMID: 38384969Free PMC Article
Impingement-free hip range of motion after osteochondroplasty and relative neck lengthening in adults with healed Perthes disease.
Elmarghany M, Abd El-Ghaffar TM, Elgeushy A, Hasanin Y, Elzahed E, Abulsoud MI, Moawad M
J Orthop Surg Res 2020 Aug 26;15(1):358. doi: 10.1186/s13018-020-01899-w. PMID: 32847600Free PMC Article
Non-modifiable Risk Factors Associated with Avascular Necrosis in the US Military.
Gun BK, Frank RM, Gratton RW, Bader JO, Kusnezov N, Orr JD, Waterman BR
Mil Med 2020 Feb 12;185(1-2):e178-e182. doi: 10.1093/milmed/usz128. PMID: 31184698
Fractures of the head and neck of the femur in children: an outcome study.
Hajdu S, Oberleitner G, Schwendenwein E, Ringl H, Vécsei V
Int Orthop 2011 Jun;35(6):883-8. Epub 2010 May 20 doi: 10.1007/s00264-010-1039-z. PMID: 20490791Free PMC Article
Treatment of the unstable (acute) slipped capital femoral epiphysis.
Aronsson DD, Loder RT
Clin Orthop Relat Res 1996 Jan;(322):99-110. PMID: 8542719

Clinical prediction guides

Identification and analysis of mitochondria-related central genes in steroid-induced osteonecrosis of the femoral head, along with drug prediction.
Ma Z, Sun J, Jiang Q, Zhao Y, Jiang H, Sun P, Feng W
Front Endocrinol (Lausanne) 2024;15:1341366. Epub 2024 Feb 7 doi: 10.3389/fendo.2024.1341366. PMID: 38384969Free PMC Article
Outcomes of Conversion Total Hip Arthroplasty From Free Vascularized Fibular Grafting.
Ryan SP, Wooster B, Jiranek W, Wellman S, Bolognesi M, Seyler T
J Arthroplasty 2019 Jan;34(1):88-92. Epub 2018 Sep 21 doi: 10.1016/j.arth.2018.09.041. PMID: 30322733
The Effectiveness of Free Vascularized Fibular Flaps in Osteonecrosis of the Femoral Head and Neck: A Systematic Review.
Ligh CA, Nelson JA, Fischer JP, Kovach SJ, Levin LS
J Reconstr Microsurg 2017 Mar;33(3):163-172. Epub 2017 Jan 16 doi: 10.1055/s-0036-1594294. PMID: 28092922
A Modification of the Dunn Osteotomy With Preservation of the Ligamentum Teres.
Bali N, Harrison J, Laugharne E, Bache CE
J Pediatr Orthop 2017 Jun;37(4):279-284. doi: 10.1097/BPO.0000000000000626. PMID: 26445173
Study of malignant fibrous histiocytoma: clinical, statistic and histopatological interrelation.
Pobirci DD, Bogdan F, Pobirci O, Petcu CA, Roşca E
Rom J Morphol Embryol 2011;52(1 Suppl):385-8. PMID: 21424079

Recent systematic reviews

The Effectiveness of Free Vascularized Fibular Flaps in Osteonecrosis of the Femoral Head and Neck: A Systematic Review.
Ligh CA, Nelson JA, Fischer JP, Kovach SJ, Levin LS
J Reconstr Microsurg 2017 Mar;33(3):163-172. Epub 2017 Jan 16 doi: 10.1055/s-0036-1594294. PMID: 28092922

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