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Infarct

MedGen UID:
9461
•Concept ID:
C0021308
•
Pathologic Function
Synonyms: Infarction; Infarctions; Infarcts
SNOMED CT: Infarct (55641003); Infarction (55641003)

Definition

A localized pathological necrosis of tissue resulting from obstruction of the blood supply usually by a thrombus, an embolus, or vascular torsion. [from NCI]

Professional guidelines

PubMed

Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.
Tay J, Morris RG, Markus HS
Int J Stroke 2021 Jul;16(5):510-518. Epub 2021 Feb 4 doi: 10.1177/1747493021990906. PMID: 33527880Free PMC Article
Management of acute ischemic stroke.
Phipps MS, Cronin CA
BMJ 2020 Feb 13;368:l6983. doi: 10.1136/bmj.l6983. PMID: 32054610
Management of Intracranial Pressure.
Freeman WD
Continuum (Minneap Minn) 2015 Oct;21(5 Neurocritical Care):1299-323. doi: 10.1212/CON.0000000000000235. PMID: 26426232

Recent clinical studies

Etiology

Vascular dementia.
Quinn J
J Am Med Dir Assoc 2003 Nov-Dec;4(6 Suppl):S155-61. doi: 10.1097/01.JAM.0000095365.40379.04. PMID: 14613592
Pathophysiology of vascular dementia and white matter changes.
Parnetti L
Rev Neurol (Paris) 1999;155(9):754-8. PMID: 10528362
Ischemic preconditioning: exploring the paradox.
Przyklenk K, Kloner RA
Prog Cardiovasc Dis 1998 May-Jun;40(6):517-47. doi: 10.1016/s0033-0620(98)80002-9. PMID: 9647608
Multi-infarct dementia (MID).
Malone MJ
J S C Med Assoc 1994 Nov;90(11):539-42. PMID: 7853857
Bone infarct-associated osteosarcoma.
Torres FX, Kyriakos M
Cancer 1992 Nov 15;70(10):2418-30. doi: 10.1002/1097-0142(19921115)70:10<2418::aid-cncr2820701007>3.0.co;2-e. PMID: 1423172

Diagnosis

Diagnosis and management of spinal cord emergencies.
Flanagan EP, Pittock SJ
Handb Clin Neurol 2017;140:319-335. doi: 10.1016/B978-0-444-63600-3.00017-9. PMID: 28187806
The clinical diagnosis of vascular dementia.
Wallin A, Blennow K
Dementia 1994 May-Aug;5(3-4):181-4. doi: 10.1159/000106719. PMID: 8087176
Multi-infarct dementia, subcortical dementia, and hydrocephalus.
Nadeau SE
South Med J 1991 May;84(5 Suppl 1):S41-52. PMID: 2035108
Post-stroke depression.
Chalmers GL
Int Clin Psychopharmacol 1990 Jul;5 Suppl 3:21-31. PMID: 2230070
Bladder infarct.
Nino-Murcia M, Friedland GW
Urol Radiol 1988;9(4):234-6. doi: 10.1007/BF02932674. PMID: 3394185

Therapy

Preventing Covert Brain Infarct-Related Cognitive Impairment and Dementia.
Durrani R, Hill MD, Smith EE
Can J Neurol Sci 2020 Jul;47(4):456-463. Epub 2020 Mar 3 doi: 10.1017/cjn.2020.45. PMID: 32122431
Evolving therapies for myocardial ischemia/reperfusion injury.
Ibáñez B, Heusch G, Ovize M, Van de Werf F
J Am Coll Cardiol 2015 Apr 14;65(14):1454-71. doi: 10.1016/j.jacc.2015.02.032. PMID: 25857912
Ischaemic conditioning: pitfalls on the path to clinical translation.
Przyklenk K
Br J Pharmacol 2015 Apr;172(8):1961-73. Epub 2015 Feb 27 doi: 10.1111/bph.13064. PMID: 25560903Free PMC Article
Magnesium and myocardial infarction.
Shechter M, Shechter A
Clin Calcium 2005 Nov;15(11):111-5. PMID: 16272621
Citicoline. Ferrer Internacional.
Alexandrov AV
Curr Opin Investig Drugs 2001 Dec;2(12):1757-62. PMID: 11892942

Prognosis

Incidence, outcomes, and associated factors of isolated striatocapsular infarct after mechanical thrombectomy.
Sancho Saldaña A, Tejada Meza H, Serrano Ponz M, Aladrén Sangrós JÁ, Navasa Melado JM, Seral Moral P, Marta Moreno J
Neurologia (Engl Ed) 2022 May;37(4):250-256. Epub 2021 Apr 7 doi: 10.1016/j.nrleng.2019.01.015. PMID: 35595400
High Triglyceride-Glucose Index is Associated with Poor Cardiovascular Outcomes in Nondiabetic Patients with ACS with LDL-C below 1.8 mmol/L.
Zhang Y, Ding X, Hua B, Liu Q, Gao H, Chen H, Zhao XQ, Li W, Li H
J Atheroscler Thromb 2022 Feb 1;29(2):268-281. Epub 2021 Feb 3 doi: 10.5551/jat.61119. PMID: 33536384Free PMC Article
Value of echocardiography in predicting future cardiac events after acute myocardial infarction.
Pizzuto F, Voci P, Romeo F
Curr Opin Cardiol 2003 Sep;18(5):378-84. doi: 10.1097/00001573-200309000-00010. PMID: 12960471
Infarct anatomy, baroreflex sensitivity and sudden death.
Janse MJ
J Mol Cell Cardiol 1993 May;25(5):497-9. doi: 10.1006/jmcc.1993.1059. PMID: 8377210
Classification and natural history of clinically identifiable subtypes of cerebral infarction.
Bamford J, Sandercock P, Dennis M, Burn J, Warlow C
Lancet 1991 Jun 22;337(8756):1521-6. doi: 10.1016/0140-6736(91)93206-o. PMID: 1675378

Clinical prediction guides

Prognostic value of left ventricular blood stasis in patients with acute myocardial infarction: A cardiac magnetic resonance study.
Massussi M, Cipriani A, Meneghin S, De la Cruz N, Cecere A, D'Amico G, Cacciavillani L, De Conti G, Motta R, Tarantini G, Zorzi A, Iliceto S, De Lazzari M, Perazzolo Marra M
Int J Cardiol 2022 Jul 1;358:128-133. Epub 2022 Apr 6 doi: 10.1016/j.ijcard.2022.04.012. PMID: 35398235
Analysis of CT and MRI Combined Examination for the Diagnosis of Acute Cerebral Infarction.
Zhang W, Cheng J, Zhang Y, Wang K, Jin H
J Coll Physicians Surg Pak 2019 Sep;29(9):898-899. doi: 10.29271/jcpsp.2019.09.898. PMID: 31455492
Twenty years of ECG grading of the severity of ischemia.
Birnbaum GD, Birnbaum I, Birnbaum Y
J Electrocardiol 2014 Jul-Aug;47(4):546-55. Epub 2014 Feb 11 doi: 10.1016/j.jelectrocard.2014.02.003. PMID: 24630235
Noncontrast CT in acute stroke.
Vu D, Lev MH
Semin Ultrasound CT MR 2005 Dec;26(6):380-6. doi: 10.1053/j.sult.2005.07.008. PMID: 16392658
Myocardial contrast echocardiography in the evaluation of viable myocardium after acute myocardial infarction.
Galiuto L, Iliceto S
Am J Cardiol 1998 Jun 18;81(12A):29G-32G. doi: 10.1016/s0002-9149(98)00050-2. PMID: 9662224

Recent systematic reviews

Endovascular Thrombectomy in Patients With Very Low ASPECTS Scores: A Systematic Review and Meta-analysis.
Katsanos AH, Catanese L, Shoamanesh A
Neurology 2023 Nov 14;101(20):e2043-e2045. Epub 2023 Sep 29 doi: 10.1212/WNL.0000000000207869. PMID: 37775318Free PMC Article
The global prevalence of myocardial infarction: a systematic review and meta-analysis.
Salari N, Morddarvanjoghi F, Abdolmaleki A, Rasoulpoor S, Khaleghi AA, Hezarkhani LA, Shohaimi S, Mohammadi M
BMC Cardiovasc Disord 2023 Apr 22;23(1):206. doi: 10.1186/s12872-023-03231-w. PMID: 37087452Free PMC Article
Bone Infarcts and Tumorigenesis-Is There a Connection? A Mini-Mapping Review.
Konarski W, Poboży T, Hordowicz M, Śliwczyński A, Kotela I, Krakowiak J, Kotela A
Int J Environ Res Public Health 2022 Jul 29;19(15) doi: 10.3390/ijerph19159282. PMID: 35954639Free PMC Article
A systematic review and meta-analysis evaluating ischemic conditioning during percutaneous coronary intervention.
Blusztein DI, Brooks MJ, Andrews DT
Future Cardiol 2017 Nov;13(6):579-592. Epub 2017 Oct 27 doi: 10.2217/fca-2017-0042. PMID: 29076346
Magnesium in stroke treatment.
Muir KW
Postgrad Med J 2002 Nov;78(925):641-5. doi: 10.1136/pmj.78.925.641. PMID: 12496316Free PMC Article

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