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Cerebral infarction

MedGen UID:
3321
•Concept ID:
C0007785
•
Disease or Syndrome
Synonym: Cerebral infarct
SNOMED CT: Cerebral infarction (432504007)
 
HPO: HP:0025722
Monarch Initiative: MONDO:0002679
OMIM®: 601367

Definition

A necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors. [from HPO]

Professional guidelines

PubMed

Pathophysiology and Optimal Treatment of Intracranial Branch Atheromatous Disease.
Deguchi I, Takahashi S
J Atheroscler Thromb 2023 Jul 1;30(7):701-709. Epub 2023 May 13 doi: 10.5551/jat.RV22003. PMID: 37183021Free PMC Article
Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review).
Zhao Y, Zhang X, Chen X, Wei Y
Int J Mol Med 2022 Feb;49(2) Epub 2021 Dec 8 doi: 10.3892/ijmm.2021.5070. PMID: 34878154Free PMC Article
Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.
Demaerschalk BM, Kleindorfer DO, Adeoye OM, Demchuk AM, Fugate JE, Grotta JC, Khalessi AA, Levy EI, Palesch YY, Prabhakaran S, Saposnik G, Saver JL, Smith EE; American Heart Association Stroke Council and Council on Epidemiology and Prevention
Stroke 2016 Feb;47(2):581-641. Epub 2015 Dec 22 doi: 10.1161/STR.0000000000000086. PMID: 26696642

Recent clinical studies

Etiology

HMGB1, angel or devil, in ischemic stroke.
Gao B, Wang S, Li J, Han N, Ge H, Zhang G, Chang M
Brain Behav 2023 May;13(5):e2987. Epub 2023 Apr 16 doi: 10.1002/brb3.2987. PMID: 37062906Free PMC Article
Postprandial cerebral infarction.
Ikenouchi H, Yoshimoto T, Ihara M
J Clin Neurosci 2021 Dec;94:38-40. Epub 2021 Oct 6 doi: 10.1016/j.jocn.2021.09.034. PMID: 34863460
Chlamydia pneumoniae infection and cerebral infarction risk: a meta-analysis.
Su X, Chen HL
Int J Stroke 2014 Apr;9(3):356-64. Epub 2014 Mar 5 doi: 10.1111/ijs.12248. PMID: 24597545
Neonatal cerebral infarction.
Miller V
Semin Pediatr Neurol 2000 Dec;7(4):278-88. doi: 10.1053/spen.2000.20076. PMID: 11205717
Classification and natural history of clinically identifiable subtypes of cerebral infarction.
Bamford J, Sandercock P, Dennis M, Burn J, Warlow C
Lancet 1991 Jun 22;337(8756):1521-6. doi: 10.1016/0140-6736(91)93206-o. PMID: 1675378

Diagnosis

Pulmonary Vein Stump Thrombosis and Cerebral Infarction after Left Upper Lobectomy.
Yasuura Y, Kayata H, Konno H, Kojima H, Mizuno T, Isaka M, Ohde Y
Thorac Cardiovasc Surg 2023 Oct;71(7):589-594. Epub 2023 Feb 3 doi: 10.1055/s-0043-1761274. PMID: 36736369
Homonymous Hemianopsia Detected during a Meal.
Noda K, Hattori Y, Ihara M
Intern Med 2022 Sep 15;61(18):2823-2824. Epub 2022 Feb 19 doi: 10.2169/internalmedicine.9147-21. PMID: 35185055Free PMC Article
Chlamydia pneumoniae infection and cerebral infarction risk: a meta-analysis.
Su X, Chen HL
Int J Stroke 2014 Apr;9(3):356-64. Epub 2014 Mar 5 doi: 10.1111/ijs.12248. PMID: 24597545
Neonatal cerebral infarction.
Miller V
Semin Pediatr Neurol 2000 Dec;7(4):278-88. doi: 10.1053/spen.2000.20076. PMID: 11205717
Computed tomography.
Zappoli F, Lavaroni A, Leonardi M
Eur Neurol 1989;29 Suppl 2:30-2. doi: 10.1159/000116463. PMID: 2693098

Therapy

Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial.
Wolf S, Mielke D, Barner C, Malinova V, Kerz T, Wostrack M, Czorlich P, Salih F, Engel DC, Ehlert A, Staykov D, Alturki AY, Sure U, Bardutzky J, Schroeder HWS, Schürer L, Beck J, Juratli TA, Fritsch M, Lemcke J, Pohrt A, Meyer B, Schwab S, Rohde V, Vajkoczy P; EARLYDRAIN Study Group
JAMA Neurol 2023 Aug 1;80(8):833-842. doi: 10.1001/jamaneurol.2023.1792. PMID: 37330974Free PMC Article
Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial.
Jiang JL, Zhang L, He LL, Yu H, Li XF, Dai SH, Yu H
Anesth Analg 2023 Jan 1;136(1):60-69. Epub 2022 Oct 27 doi: 10.1213/ANE.0000000000006257. PMID: 36301724
A Comparison Between Enteral and Intravenous Nimodipine in Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis.
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.
JAMA 1995 May 10;273(18):1421-8. PMID: 7723155
Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.
Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd
Stroke 1993 Jan;24(1):35-41. doi: 10.1161/01.str.24.1.35. PMID: 7678184

Prognosis

Association of glycemic variability with death and severe consciousness disturbance among critically ill patients with cerebrovascular disease: analysis of the MIMIC-IV database.
Cai W, Li Y, Guo K, Wu X, Chen C, Lin X
Cardiovasc Diabetol 2023 Nov 16;22(1):315. doi: 10.1186/s12933-023-02048-3. PMID: 37974159Free PMC Article
Triglyceride glucose index is a significant predictor of severe disturbance of consciousness and all-cause mortality in critical cerebrovascular disease patients.
Chen T, Qian Y, Deng X
Cardiovasc Diabetol 2023 Jun 29;22(1):156. doi: 10.1186/s12933-023-01893-6. PMID: 37386419Free PMC Article
High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial.
Grønberg BH, Killingberg KT, Fløtten Ø, Brustugun OT, Hornslien K, Madebo T, Langer SW, Schytte T, Nyman J, Risum S, Tsakonas G, Engleson J, Halvorsen TO
Lancet Oncol 2021 Mar;22(3):321-331. doi: 10.1016/S1470-2045(20)30742-7. PMID: 33662285
Pediatric Thromboembolism in Japan.
Tetsuhara K, Ishiguro A, Michihata N, Sensaki S, Nakadate H, Kimura Y, Tomizawa D, Matsumoto K
Indian J Pediatr 2016 Oct;83(10):1077-81. Epub 2016 Apr 7 doi: 10.1007/s12098-016-2094-2. PMID: 27053184
Classification and natural history of clinically identifiable subtypes of cerebral infarction.
Bamford J, Sandercock P, Dennis M, Burn J, Warlow C
Lancet 1991 Jun 22;337(8756):1521-6. doi: 10.1016/0140-6736(91)93206-o. PMID: 1675378

Clinical prediction guides

Longitudinal associations of cardiovascular health and vascular events with incident dementia.
Ou YN, Kuo K, Yang L, Zhang YR, Huang SY, Chen SD, Deng YT, Guo Y, Zhang RQ, Wu BS, Tan L, Dong Q, Feng JF, Cheng W, Yu JT
Stroke Vasc Neurol 2024 Aug 27;9(4):418-428. doi: 10.1136/svn-2023-002665. PMID: 37827852Free PMC Article
ERASER.
Fiehler J, Thomalla G, Bernhardt M, Kniep H, Berlis A, Dorn F, Eckert B, Kemmling A, Langner S, Remonda L, Reith W, Rohde S, Möhlenbruch M, Bendszus M, Forkert ND, Gellissen S
Stroke 2019 May;50(5):1275-1278. doi: 10.1161/STROKEAHA.119.024858. PMID: 31009356
Machine Learning-Based Model for Prediction of Outcomes in Acute Stroke.
Heo J, Yoon JG, Park H, Kim YD, Nam HS, Heo JH
Stroke 2019 May;50(5):1263-1265. doi: 10.1161/STROKEAHA.118.024293. PMID: 30890116
Prediction Factors of Recurrent Stroke among Chinese Adults Using Retinal Vasculature Characteristics.
Zhuo Y, Yu H, Yang Z, Zee B, Lee J, Kuang L
J Stroke Cerebrovasc Dis 2017 Apr;26(4):679-685. Epub 2017 Feb 21 doi: 10.1016/j.jstrokecerebrovasdis.2017.01.020. PMID: 28233623
Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke.
Pexman JH, Barber PA, Hill MD, Sevick RJ, Demchuk AM, Hudon ME, Hu WY, Buchan AM
AJNR Am J Neuroradiol 2001 Sep;22(8):1534-42. PMID: 11559501Free PMC Article

Recent systematic reviews

Comment on the 2023 Guidelines for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage.
Spears WE, Greer DM, Nguyen TN
Stroke 2023 Oct;54(10):2708-2712. Epub 2023 Aug 15 doi: 10.1161/STROKEAHA.123.043541. PMID: 37581267
Efficacy and Safety of Clazosentan After Aneurysmal Subarachnoid Hemorrhage: An Updated Meta-Analysis.
Pontes JPM, Santos MDC, Gibram FC, Rodrigues NMV, Cavalcante-Neto JF, Barros ADM, Solla DJF
Neurosurgery 2023 Dec 1;93(6):1208-1219. Epub 2023 Jul 18 doi: 10.1227/neu.0000000000002601. PMID: 37462365
Endovascular Therapy for Stroke Presenting Beyond 24 Hours: A Systematic Review and Meta-analysis.
Kobeissi H, Ghozy S, Adusumilli G, Kadirvel R, Brinjikji W, Rabinstein AA, Kallmes DF
JAMA Netw Open 2023 May 1;6(5):e2311768. doi: 10.1001/jamanetworkopen.2023.11768. PMID: 37140919Free PMC Article
A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury.
Yang K, Zeng L, Ge A, Wang S, Zeng J, Yuan X, Mei Z, Wang G, Ge J
Front Immunol 2022;13:930171. Epub 2022 Oct 7 doi: 10.3389/fimmu.2022.930171. PMID: 36275741Free PMC Article
A Comparison Between Enteral and Intravenous Nimodipine in Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis.
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702

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