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Abnormal glomerular mesangium morphology

MedGen UID:
871248
•Concept ID:
C4025733
•
Anatomical Abnormality
Synonyms: Abnormality glomerular mesangium morphology; Abnormality of the glomerular mesangium; Mesangial abnormality
 
HPO: HP:0001966

Definition

An abnormality of the mesangium, i.e., of the central part of the renal glomerulus between capillaries. [from HPO]

Professional guidelines

PubMed

Tonsillectomy with methylprednisolone pulse therapy as rescue treatment for steroid-resistant IgA nephropathy in children.
Kawasaki Y, Suyama K, Abe Y, Ushijima Y, Sakai N, Takano K, Ito M, Hashimoto K, Hosoya M
Tohoku J Exp Med 2009 May;218(1):11-6. doi: 10.1620/tjem.218.11. PMID: 19398868
Prenatal diagnosis of nail-patella syndrome by intrauterine kidney biopsy.
Gubler MC, Levy M
Am J Med Genet 1993 Aug 1;47(1):122-4. doi: 10.1002/ajmg.1320470127. PMID: 8368242

Recent clinical studies

Etiology

Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy.
Noris M, Donadelli R, Remuzzi G
Pediatr Nephrol 2019 Aug;34(8):1311-1323. Epub 2018 Jun 9 doi: 10.1007/s00467-018-3989-0. PMID: 29948306
C3 glomerulopathy.
Servais A, Noël LH, Frémeaux-Bacchi V, Lesavre P
Contrib Nephrol 2013;181:185-93. Epub 2013 May 8 doi: 10.1159/000348654. PMID: 23689580
Henoch-Schönlein purpura nephritis: an update.
Davin JC, Weening JJ
Eur J Pediatr 2001 Dec;160(12):689-95. doi: 10.1007/s004310100841. PMID: 11795675
Mesangial cells and their adhesive properties.
Pröls F, Hartner A, Schöcklmann HO, Sterzel RB
Exp Nephrol 1999 Mar-Apr;7(2):137-46. doi: 10.1159/000020594. PMID: 10213867
Adult Henoch-Schönlein nephritis.
Faull RJ, Aarons I, Woodroffe AJ, Clarkson AR
Aust N Z J Med 1987 Aug;17(4):396-401. doi: 10.1111/j.1445-5994.1987.tb00072.x. PMID: 3435317

Diagnosis

Post-transplant immunoglobulin A deposition and nephropathy in allografts.
Sofue T, Suzuki H, Ueda N, Kushida Y, Minamino T
Nephrology (Carlton) 2018 Jul;23 Suppl 2:4-9. doi: 10.1111/nep.13281. PMID: 29968406
Collagenofibrotic glomerulopathy.
Patel S, Cimbaluk D
Kidney Int 2016 Jun;89(6):1406. doi: 10.1016/j.kint.2015.12.056. PMID: 27181787
C3 glomerulopathy.
Servais A, Noël LH, Frémeaux-Bacchi V, Lesavre P
Contrib Nephrol 2013;181:185-93. Epub 2013 May 8 doi: 10.1159/000348654. PMID: 23689580
Collagen Type III Glomerulopathies.
Cohen AH
Adv Chronic Kidney Dis 2012 Mar;19(2):101-6. doi: 10.1053/j.ackd.2012.02.017. PMID: 22449347
Nephrotic syndrome in the 1st year of life.
Habib R
Pediatr Nephrol 1993 Aug;7(4):347-53. doi: 10.1007/BF00857534. PMID: 8398639

Therapy

Post-transplant immunoglobulin A deposition and nephropathy in allografts.
Sofue T, Suzuki H, Ueda N, Kushida Y, Minamino T
Nephrology (Carlton) 2018 Jul;23 Suppl 2:4-9. doi: 10.1111/nep.13281. PMID: 29968406
Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice.
Cosgrove D, Dufek B, Meehan DT, Delimont D, Hartnett M, Samuelson G, Gratton MA, Phillips G, MacKenna DA, Bain G
Kidney Int 2018 Aug;94(2):303-314. Epub 2018 May 16 doi: 10.1016/j.kint.2018.02.024. PMID: 29759420Free PMC Article
Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study.
Kanai T, Akioka Y, Miura K, Hisano M, Koike J, Yamaguchi Y, Hattori M
BMC Nephrol 2018 Apr 6;19(1):82. doi: 10.1186/s12882-018-0874-9. PMID: 29625558Free PMC Article
C3 glomerulopathy.
Servais A, Noël LH, Frémeaux-Bacchi V, Lesavre P
Contrib Nephrol 2013;181:185-93. Epub 2013 May 8 doi: 10.1159/000348654. PMID: 23689580
Steroid-responsive idiopathic glomerular capillary endotheliosis: case report and literature review.
Subramanya A, Houghton D, Watnick S
Am J Kidney Dis 2005 Jun;45(6):1090-5. doi: 10.1053/j.ajkd.2005.03.010. PMID: 15957139

Prognosis

IgA Nephropathy Concomitant With Karyomegalic Interstitial Nephritis.
Wang Z, Ni X, Zhu S, Yue S
Am J Med Sci 2020 Sep;360(3):287-292. Epub 2020 Apr 17 doi: 10.1016/j.amjms.2020.04.010. PMID: 32387117
Post-transplant immunoglobulin A deposition and nephropathy in allografts.
Sofue T, Suzuki H, Ueda N, Kushida Y, Minamino T
Nephrology (Carlton) 2018 Jul;23 Suppl 2:4-9. doi: 10.1111/nep.13281. PMID: 29968406
Collagen Type III Glomerulopathies.
Cohen AH
Adv Chronic Kidney Dis 2012 Mar;19(2):101-6. doi: 10.1053/j.ackd.2012.02.017. PMID: 22449347
Molecular basis of IgA nephropathy.
Lai AS, Lai KN
Curr Mol Med 2005 Aug;5(5):475-87. doi: 10.2174/1566524054553450. PMID: 16101476
Henoch-Schönlein purpura nephritis: an update.
Davin JC, Weening JJ
Eur J Pediatr 2001 Dec;160(12):689-95. doi: 10.1007/s004310100841. PMID: 11795675

Clinical prediction guides

Post-transplant immunoglobulin A deposition and nephropathy in allografts.
Sofue T, Suzuki H, Ueda N, Kushida Y, Minamino T
Nephrology (Carlton) 2018 Jul;23 Suppl 2:4-9. doi: 10.1111/nep.13281. PMID: 29968406
Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice.
Cosgrove D, Dufek B, Meehan DT, Delimont D, Hartnett M, Samuelson G, Gratton MA, Phillips G, MacKenna DA, Bain G
Kidney Int 2018 Aug;94(2):303-314. Epub 2018 May 16 doi: 10.1016/j.kint.2018.02.024. PMID: 29759420Free PMC Article
WT1 and glomerular diseases.
Niaudet P, Gubler MC
Pediatr Nephrol 2006 Nov;21(11):1653-60. Epub 2006 Aug 23 doi: 10.1007/s00467-006-0208-1. PMID: 16927106
Molecular basis of IgA nephropathy.
Lai AS, Lai KN
Curr Mol Med 2005 Aug;5(5):475-87. doi: 10.2174/1566524054553450. PMID: 16101476
Cell cycle regulation in diabetic nephropathy.
Wolf G
Kidney Int Suppl 2000 Sep;77:S59-66. doi: 10.1046/j.1523-1755.2000.07710.x. PMID: 10997692

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