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Abnormal glomerular mesangial matrix morphology

MedGen UID:
1778151
•Concept ID:
C5539441
•
Anatomical Abnormality
HPO: HP:0033232

Definition

Any structural anomaly of the glomerular matrix. Mesangial cells generate and embed in their own extracellular matrix. The mesangial matrix is different in composition from the glomerular basement membrane. Its constituents are type IV collagen (but only the alpha1 and alpha2 chains); type V collagen; laminin A, B1, and B2; and considerable amounts of fibronectin, heparan sulfate and chondroitin sulfate proteoglycans, entactin, and nidogen. Furthermore, small amounts of the proteoglycans decorin and biglycan are found in the mesangial matrix. [from HPO]

Professional guidelines

PubMed

Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease.
Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA
Curr Opin Nephrol Hypertens 2004 Jul;13(4):417-22. doi: 10.1097/01.mnh.0000133974.24935.fe. PMID: 15199292

Recent clinical studies

Etiology

Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy.
He J, Liu B, Du X, Wei Y, Kong D, Feng B, Guo R, Asiamah EA, Griffin MD, Hynes SO, Shen S, Liu Y, Cui H, Ma J, O'Brien T
Stem Cell Res Ther 2024 Mar 5;15(1):66. doi: 10.1186/s13287-024-03647-x. PMID: 38443965Free PMC Article
HIV-associated nephropathy: experimental models.
Avila-Casado C, Fortoul TI, Chugh SS
Contrib Nephrol 2011;169:270-285. Epub 2011 Jan 20 doi: 10.1159/000320212. PMID: 21252526
Differential glomerular immunoexpression of matrix metalloproteinases MMP-2 and MMP-9 in idiopathic IgA nephropathy and Schoenlein-Henoch nephritis.
Danilewicz M, Wagrowska-Danilewicz M
Folia Histochem Cytobiol 2010 Jan 1;48(1):63-7. doi: 10.2478/v10042-008-0086-4. PMID: 20529817
Morphological features in IgA nephropathy.
Ferrario F, Rastaldi MP, Napodano P
Ann Med Interne (Paris) 1999 Feb;150(2):108-16. PMID: 10392259
Mesangial cells and their adhesive properties.
Pröls F, Hartner A, Schöcklmann HO, Sterzel RB
Exp Nephrol 1999 Mar-Apr;7(2):137-46. doi: 10.1159/000020594. PMID: 10213867

Diagnosis

Histopathology of MPGN and C3 glomerulopathies.
Cook HT, Pickering MC
Nat Rev Nephrol 2015 Jan;11(1):14-22. Epub 2014 Dec 2 doi: 10.1038/nrneph.2014.217. PMID: 25447133
Collagen Type III Glomerulopathies.
Cohen AH
Adv Chronic Kidney Dis 2012 Mar;19(2):101-6. doi: 10.1053/j.ackd.2012.02.017. PMID: 22449347
Pathology of human diabetic nephropathy.
Najafian B, Alpers CE, Fogo AB
Contrib Nephrol 2011;170:36-47. Epub 2011 Jun 9 doi: 10.1159/000324942. PMID: 21659756
Collagen type III glomerulopathy: a new type of hereditary nephropathy.
Gubler MC, Dommergues JP, Foulard M, Bensman A, Leroy JP, Broyer M, Habib R
Pediatr Nephrol 1993 Aug;7(4):354-60. doi: 10.1007/BF00857536. PMID: 8398640
Membranoproliferative glomerulonephritis and persistent hypocomplementaemia.
Cameron JS, Glasgow EF, Ogg CS, White RH
Br Med J 1970 Oct 3;4(5726):7-14. doi: 10.1136/bmj.4.5726.7. PMID: 4097129Free PMC Article

Therapy

The Efficacy and Mechanism of Chinese Herbal Medicine on Diabetic Kidney Disease.
Lu Z, Zhong Y, Liu W, Xiang L, Deng Y
J Diabetes Res 2019;2019:2697672. Epub 2019 Aug 25 doi: 10.1155/2019/2697672. PMID: 31534972Free PMC Article
Synergistic action of inflammation and lipid dysmetabolism on kidney damage in rats.
Wang Z, Huang W, Li H, Tang L, Sun H, Liu Q, Zhang L
Ren Fail 2018 Nov;40(1):175-182. doi: 10.1080/0886022X.2018.1450763. PMID: 29569980Free PMC Article
The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy.
Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A, Ziyadeh FN
Ren Fail 2001 May-Jul;23(3-4):471-81. doi: 10.1081/jdi-100104730. PMID: 11499562
Decrease of mesangial matrix after immunosuppressive therapy in children with reversible membranoproliferative glomerulonephritis type I.
Inaba S, Tanizawa T, Takahashi T, Ishihara S, Arai M, Sakai Y, Kurose KK, Matsukura H, Okada T
Clin Nephrol 1996 Apr;45(4):217-25. PMID: 8861795
Membranoproliferative glomerulonephritis and persistent hypocomplementaemia.
Cameron JS, Glasgow EF, Ogg CS, White RH
Br Med J 1970 Oct 3;4(5726):7-14. doi: 10.1136/bmj.4.5726.7. PMID: 4097129Free PMC Article

Prognosis

Collagen Type III Glomerulopathies.
Cohen AH
Adv Chronic Kidney Dis 2012 Mar;19(2):101-6. doi: 10.1053/j.ackd.2012.02.017. PMID: 22449347
Pathology of human diabetic nephropathy.
Najafian B, Alpers CE, Fogo AB
Contrib Nephrol 2011;170:36-47. Epub 2011 Jun 9 doi: 10.1159/000324942. PMID: 21659756
Molecular basis of IgA nephropathy.
Lai AS, Lai KN
Curr Mol Med 2005 Aug;5(5):475-87. doi: 10.2174/1566524054553450. PMID: 16101476
Collagen type III glomerulopathy: a new type of hereditary nephropathy.
Gubler MC, Dommergues JP, Foulard M, Bensman A, Leroy JP, Broyer M, Habib R
Pediatr Nephrol 1993 Aug;7(4):354-60. doi: 10.1007/BF00857536. PMID: 8398640
Membranoproliferative glomerulonephritis and persistent hypocomplementaemia.
Cameron JS, Glasgow EF, Ogg CS, White RH
Br Med J 1970 Oct 3;4(5726):7-14. doi: 10.1136/bmj.4.5726.7. PMID: 4097129Free PMC Article

Clinical prediction guides

DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways.
Li K, Zhang Y, Zhao W, Wang R, Li Y, Wei L, Wang L, Chen X, Chen Z, Liu P, Nie N, Tian X, Fu R
Toxicol Lett 2024 May 1;395:1-10. Epub 2024 Mar 6 doi: 10.1016/j.toxlet.2024.03.001. PMID: 38458339
Molecular basis of IgA nephropathy.
Lai AS, Lai KN
Curr Mol Med 2005 Aug;5(5):475-87. doi: 10.2174/1566524054553450. PMID: 16101476
Glomerular distribution and gelatinolytic activity of matrix metalloproteinases in human glomerulonephritis.
Urushihara M, Kagami S, Kuhara T, Tamaki T, Kuroda Y
Nephrol Dial Transplant 2002 Jul;17(7):1189-96. doi: 10.1093/ndt/17.7.1189. PMID: 12105240
Structural and functional changes in diabetic glomerulopathy.
Schleicher E, Kolm V, Ceol M, Nerlich A
Kidney Blood Press Res 1996;19(5):305-15. doi: 10.1159/000174091. PMID: 8956243
Nonimmunologic mechanisms of glomerular injury.
Olson JL, Heptinstall RH
Lab Invest 1988 Nov;59(5):564-78. PMID: 3054312

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