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Paramesangial deposits

MedGen UID:
1788955
•Concept ID:
C5539442
•
Finding
HPO: HP:0033233

Definition

Mesangial immune deposit located adjacent to the paramesangial glomerular basement membrane. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParamesangial deposits

Recent clinical studies

Etiology

Significance of broad distribution of electron-dense deposits in patients with IgA nephropathy.
Kusaba G, Ohsawa I, Ishii M, Inoshita H, Takagi M, Tanifuji C, Takahashi K, Nakamoto J, Yoshida M, Ohi H, Horikoshi S, Kurihara H, Tomino Y
Med Mol Morphol 2012 Dec;45(1):29-34. Epub 2012 Mar 20 doi: 10.1007/s00795-011-0538-3. PMID: 22431181
Glomerular deposits and hypoalbuminemia in acute post-streptococcal glomerulonephritis.
West CD, McAdams AJ
Pediatr Nephrol 1998 Aug;12(6):471-4. doi: 10.1007/s004670050490. PMID: 9745871

Diagnosis

Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
Nail-patella syndrome and IgA nephropathy in a Chinese woman.
Chuah KL, Tan PH, Choong HL, Lai D, Chiang G
Pathology 1999 Nov;31(4):345-9. doi: 10.1080/003130299104701. PMID: 10643004
Membranoproliferative glomerulonephritis type III: association of glomerular deposits with circulating nephritic factor-stabilized convertase.
West CD, McAdams AJ
Am J Kidney Dis 1998 Jul;32(1):56-63. doi: 10.1053/ajkd.1998.v32.pm9669425. PMID: 9669425
Fabry-like laminated myelin body associated with IgA nephropathy.
Yoshida A, Morozumi K, Takeda A, Koyama K, Oikawa T
Nihon Jinzo Gakkai Shi 1994 Nov;36(11):1303-7. PMID: 7853764
Glomerulonephritis and IgA deficiency.
French MA, Shortland JR, Coward RA, Brown CB
Clin Nephrol 1987 Apr;27(4):199-205. PMID: 3581527

Therapy

Immunoglobulin A nephropathy with massive paramesangial deposits caused by anti-vascular endothelial growth factor therapy for metastatic rectal cancer: a case report and review of the literature.
Yahata M, Nakaya I, Sakuma T, Sato H, Aoki S, Soma J
BMC Res Notes 2013 Nov 9;6:450. doi: 10.1186/1756-0500-6-450. PMID: 24207130Free PMC Article
Glomerular deposits and hypoalbuminemia in acute post-streptococcal glomerulonephritis.
West CD, McAdams AJ
Pediatr Nephrol 1998 Aug;12(6):471-4. doi: 10.1007/s004670050490. PMID: 9745871
Glomerulonephritis with predominant paramesangial IgG deposition.
Kano K, Ueda Y, Iidaka K, Ichimura T
Pathol Int 1996 Apr;46(4):306-9. doi: 10.1111/j.1440-1827.1996.tb03616.x. PMID: 8726857

Prognosis

Glomerular deposits and hypoalbuminemia in acute post-streptococcal glomerulonephritis.
West CD, McAdams AJ
Pediatr Nephrol 1998 Aug;12(6):471-4. doi: 10.1007/s004670050490. PMID: 9745871
Glomerulonephritis with predominant paramesangial IgG deposition.
Kano K, Ueda Y, Iidaka K, Ichimura T
Pathol Int 1996 Apr;46(4):306-9. doi: 10.1111/j.1440-1827.1996.tb03616.x. PMID: 8726857

Clinical prediction guides

Direct observation of epoxy resin blocks for renal biopsy by low-vacuum scanning electron microscopy.
Tojo A, Abe M, Matsuyama KI
Med Mol Morphol 2023 Sep;56(3):206-216. Epub 2023 May 10 doi: 10.1007/s00795-023-00356-x. PMID: 37165248Free PMC Article
Significance of broad distribution of electron-dense deposits in patients with IgA nephropathy.
Kusaba G, Ohsawa I, Ishii M, Inoshita H, Takagi M, Tanifuji C, Takahashi K, Nakamoto J, Yoshida M, Ohi H, Horikoshi S, Kurihara H, Tomino Y
Med Mol Morphol 2012 Dec;45(1):29-34. Epub 2012 Mar 20 doi: 10.1007/s00795-011-0538-3. PMID: 22431181
The alternative pathway C3 convertase and glomerular deposits.
West CD, McAdams AJ
Pediatr Nephrol 1999 Jun;13(5):448-53. doi: 10.1007/s004670050638. PMID: 10412868
Glomerular paramesangial deposits: association with hypocomplementemia in membranoproliferative glomerulonephritis types I and III.
West CD, McAdams AJ
Am J Kidney Dis 1998 Mar;31(3):427-34. doi: 10.1053/ajkd.1998.v31.pm9506679. PMID: 9506679
Membranoproliferative glomerulonephritis associated with hepatitis B and C viral infections: from viruslike particles in the cryoprecipitate to viral localization in paramesangial deposits, problematic investigations prone to artifacts.
Pucillo LP, Agnello V
Curr Opin Nephrol Hypertens 1994 Jul;3(4):465-70. doi: 10.1097/00041552-199407000-00014. PMID: 8076152

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