U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult lymphocyte depleted classical Hodgkin lymphoma

MedGen UID:
79003
•Concept ID:
C0279540
•
Neoplastic Process
Synonyms: Adult Lymphocyte Depleted Classical Hodgkin Lymphoma; Adult Lymphocyte Depleted Hodgkin Lymphoma; Adult Lymphocyte Depleted Hodgkin's Lymphoma; Adult Lymphocyte-Depleted Classic Hodgkin Lymphoma; Adult Lymphocyte-Depleted Classical Hodgkin Lymphoma

Definition

Lymphocyte-depleted classic Hodgkin lymphoma occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult lymphocyte depleted classical Hodgkin lymphoma

Professional guidelines

PubMed

Management of limited-stage Hodgkin lymphoma.
Al-Juhaishi T, Ahmed S
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):500-509. doi: 10.1182/hematology.2023000511. PMID: 38066938Free PMC Article
Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Lymphoma: Diagnosis and Treatment.
Lewis WD, Lilly S, Jones KL
Am Fam Physician 2020 Jan 1;101(1):34-41. PMID: 31894937

Recent clinical studies

Etiology

Classic Hodgkin lymphoma in young people.
Gupta S, Craig JW
Semin Diagn Pathol 2023 Nov;40(6):379-391. Epub 2023 Jun 30 doi: 10.1053/j.semdp.2023.06.005. PMID: 37451943
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396
Hodgkin's lymphoma.
Yung L, Linch D
Lancet 2003 Mar 15;361(9361):943-51. doi: 10.1016/S0140-6736(03)12777-8. PMID: 12648984

Diagnosis

Classic Hodgkin lymphoma in young people.
Gupta S, Craig JW
Semin Diagn Pathol 2023 Nov;40(6):379-391. Epub 2023 Jun 30 doi: 10.1053/j.semdp.2023.06.005. PMID: 37451943
How I treat nodular lymphocyte-predominant Hodgkin lymphoma.
Eichenauer DA, Engert A
Blood 2020 Dec 24;136(26):2987-2993. doi: 10.1182/blood.2019004044. PMID: 32877522
Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396
Hodgkin's lymphoma.
Yung L, Linch D
Lancet 2003 Mar 15;361(9361):943-51. doi: 10.1016/S0140-6736(03)12777-8. PMID: 12648984

Therapy

Brentuximab Vedotin Plus AVD for First-Line Treatment of Early-Stage Unfavorable Hodgkin Lymphoma (BREACH): A Multicenter, Open-Label, Randomized, Phase II Trial.
Fornecker LM, Lazarovici J, Aurer I, Casasnovas RO, Gac AC, Bonnet C, Bouabdallah K, Feugier P, Specht L, Molina L, Touati M, Borel C, Stamatoullas A, Nicolas-Virelizier E, Pascal L, Lugtenburg P, Di Renzo N, Vander Borght T, Traverse-Glehen A, Dartigues P, Hutchings M, Versari A, Meignan M, Federico M, André M; LYSA-FIL-EORTC Intergroup
J Clin Oncol 2023 Jan 10;41(2):327-335. Epub 2022 Jul 22 doi: 10.1200/JCO.21.01281. PMID: 35867960
Hodgkin lymphoma: A 2020 update on diagnosis, risk-stratification, and management.
Ansell SM
Am J Hematol 2020 Aug;95(8):978-989. Epub 2020 Jun 8 doi: 10.1002/ajh.25856. PMID: 32384177
Treatment of classical Hodgkin's lymphoma in children and adolescents.
Gómez-Almaguer D, González-Llano O, Jiménez-Antolinez V, Gómez-De León A
Expert Opin Pharmacother 2019 Jul;20(10):1227-1234. Epub 2019 Apr 25 doi: 10.1080/14656566.2019.1606212. PMID: 31021660
Hodgkin lymphoma in elderly patients.
Borchmann S, Engert A, Böll B
Curr Opin Oncol 2018 Sep;30(5):308-316. doi: 10.1097/CCO.0000000000000464. PMID: 29994901
Hodgkin's lymphoma.
Yung L, Linch D
Lancet 2003 Mar 15;361(9361):943-51. doi: 10.1016/S0140-6736(03)12777-8. PMID: 12648984

Prognosis

Brentuximab vedotin in combination with nivolumab in relapsed or refractory Hodgkin lymphoma: 3-year study results.
Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Hodgkin lymphoma.
Connors JM, Cozen W, Steidl C, Carbone A, Hoppe RT, Flechtner HH, Bartlett NL
Nat Rev Dis Primers 2020 Jul 23;6(1):61. doi: 10.1038/s41572-020-0189-6. PMID: 32703953
Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse.
Moskowitz CH, Walewski J, Nademanee A, Masszi T, Agura E, Holowiecki J, Abidi MH, Chen AI, Stiff P, Viviani S, Bachanova V, Sureda A, McClendon T, Lee C, Lisano J, Sweetenham J
Blood 2018 Dec 20;132(25):2639-2642. Epub 2018 Sep 28 doi: 10.1182/blood-2018-07-861641. PMID: 30266774
Hodgkin lymphoma in children and adolescents: improving the therapeutic index.
Kelly KM
Blood 2015 Nov 26;126(22):2452-8. Epub 2015 Nov 18 doi: 10.1182/blood-2015-07-641035. PMID: 26582374
Hodgkin's disease.
Medeiros LJ, Greiner TC
Cancer 1995 Jan 1;75(1 Suppl):357-69. doi: 10.1002/1097-0142(19950101)75:1+<357::aid-cncr2820751318>3.0.co;2-a. PMID: 8001007

Clinical prediction guides

International Prognostic Score for Nodular Lymphocyte-Predominant Hodgkin Lymphoma.
Binkley MS, Flerlage JE, Savage KJ, Akhtar S, Steiner R, Zhang XY, Dickinson M, Prica A, Major A, Hendrickson PG, Hopkins D, Ng A, Casulo C, Baron J, Roberts KB, Al Kendi J, Balogh A, Ricardi U, Torka P, Specht L, De Silva R, Pickard K, Blazin LJ, Henry M, Smith CM, Halperin D, Brady J, Brennan B, Senchenko MA, Reeves M, Hoppe BS, Terezakis S, Talaulikar D, Picardi M, Kirova Y, Fergusson P, Hawkes EA, Lee D, Doo NW, Barraclough A, Cheah CY, Ku M, Hamad N, Mutsando H, Gilbertson M, Marconi T, Viiala N, Maurer MJ, Eichenauer DA, Hoppe RT; GLOW Consortium
J Clin Oncol 2024 Jul 1;42(19):2271-2280. Epub 2024 Mar 26 doi: 10.1200/JCO.23.01655. PMID: 38531001
AYA Considerations for Aggressive Lymphomas.
Llaurador G, Giulino-Roth L
Curr Hematol Malig Rep 2021 Feb;16(1):61-71. Epub 2021 Mar 16 doi: 10.1007/s11899-021-00607-7. PMID: 33728589
Hodgkin's lymphoma in adults.
Townsend W, Linch D
Lancet 2012 Sep 1;380(9844):836-47. Epub 2012 Jul 25 doi: 10.1016/S0140-6736(12)60035-X. PMID: 22835602
Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome.
Carbone A, Spina M, Gloghini A, Tirelli U
Am J Hematol 2011 Feb;86(2):170-9. doi: 10.1002/ajh.21910. PMID: 21264899
Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation.
Fan Z, Natkunam Y, Bair E, Tibshirani R, Warnke RA
Am J Surg Pathol 2003 Oct;27(10):1346-56. doi: 10.1097/00000478-200310000-00007. PMID: 14508396

Recent systematic reviews

Chemotherapy for non-Hodgkin lymphoma in the hemodialysis patient: A comprehensive review.
Yasuda H, Yasuda M, Komatsu N
Cancer Sci 2021 Jul;112(7):2607-2624. Epub 2021 Jun 11 doi: 10.1111/cas.14933. PMID: 33938097Free PMC Article
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.
Hill HA, Qi X, Jain P, Nomie K, Wang Y, Zhou S, Wang ML
Blood Adv 2020 Jul 14;4(13):2927-2938. doi: 10.1182/bloodadvances.2019001350. PMID: 32598477Free PMC Article
Hodgkin Lymphoma in Adults.
Bröckelmann PJ, Eichenauer DA, Jakob T, Follmann M, Engert A, Skoetz N
Dtsch Arztebl Int 2018 Aug 6;115(31-32):535-540. doi: 10.3238/arztebl.2018.0535. PMID: 30149835Free PMC Article
Challenges and opportunities in primary CNS lymphoma: A systematic review.
Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J
Radiother Oncol 2017 Mar;122(3):352-361. Epub 2017 Jan 16 doi: 10.1016/j.radonc.2016.12.033. PMID: 28104300
Brentuximab vedotin in pretreated Hodgkin lymphoma patients: a systematic review and meta-analysis.
Dada R, Zekri J, Al Saadi R
Expert Opin Biol Ther 2016 Jun;16(6):739-45. Epub 2016 May 3 doi: 10.1080/14712598.2016.1180362. PMID: 27096887

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...