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Meningococcal infection

MedGen UID:
7537
•Concept ID:
C0025303
•
Disease or Syndrome
Synonyms: Infection, Meningococcal; Infections, Meningococcal; Meningococcal Disease; Meningococcal Diseases; Meningococcal Infection; Meningococcal Infections
SNOMED CT: Meningococcal disease (23511006); Meningococcal infectious disease (23511006); Infection due to Neisseria meningitidis (23511006); Meningococcal infection (23511006)
 
Monarch Initiative: MONDO:0005373

Definition

Infections with bacteria of the species neisseria meningitidis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningococcal infection

Professional guidelines

PubMed

An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Severe meningococcal infection: a review of epidemiology, diagnosis, and management.
Campsall PA, Laupland KB, Niven DJ
Crit Care Clin 2013 Jul;29(3):393-409. doi: 10.1016/j.ccc.2013.03.001. PMID: 23830646
Management of meningococcal infections.
Klein NJ, Heyderman RS, Levin M
Br J Hosp Med 1993 Jun 16-Jul 13;50(1):42-9. PMID: 8364705

Recent clinical studies

Etiology

Atypical hemolytic uremic syndrome in the era of terminal complement inhibition: an observational cohort study.
Brocklebank V, Walsh PR, Smith-Jackson K, Hallam TM, Marchbank KJ, Wilson V, Bigirumurame T, Dutt T, Montgomery EK, Malina M, Wong EKS, Johnson S, Sheerin NS, Kavanagh D
Blood 2023 Oct 19;142(16):1371-1386. doi: 10.1182/blood.2022018833. PMID: 37369098Free PMC Article
Complement-driven hemolytic uremic syndrome.
Leon J, LeStang MB, Sberro-Soussan R, Servais A, Anglicheau D, Frémeaux-Bacchi V, Zuber J
Am J Hematol 2023 May;98 Suppl 4:S44-S56. doi: 10.1002/ajh.26854. PMID: 36683290
Recognizing Vaccine-Preventable Diseases and Managing Outbreaks.
Hamilton JL
Prim Care 2020 Sep;47(3):467-481. Epub 2020 May 22 doi: 10.1016/j.pop.2020.05.003. PMID: 32718444
Long-term safety and efficacy of eculizumab in generalized myasthenia gravis.
Muppidi S, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Nowak RJ, Andersen H, Casasnovas C, de Bleecker JL, Vu TH, Mantegazza R, O'Brien FL, Wang JJ, Fujita KP, Howard JF Jr; Regain Study Group
Muscle Nerve 2019 Jul;60(1):14-24. Epub 2019 Mar 8 doi: 10.1002/mus.26447. PMID: 30767274Free PMC Article
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752

Diagnosis

Recognizing Vaccine-Preventable Diseases and Managing Outbreaks.
Hamilton JL
Prim Care 2020 Sep;47(3):467-481. Epub 2020 May 22 doi: 10.1016/j.pop.2020.05.003. PMID: 32718444
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Treatment of meningococcal infection.
Welch SB, Nadel S
Arch Dis Child 2003 Jul;88(7):608-14. doi: 10.1136/adc.88.7.608. PMID: 12818909Free PMC Article
Meningococcal infection.
Boyne L
Nurs Stand 2001 Oct 31-Nov 6;16(7):47-53; quiz 54-5. doi: 10.7748/ns2001.10.16.7.47.c3110. PMID: 11974830
Meningococcemia.
Salzman MB, Rubin LG
Infect Dis Clin North Am 1996 Dec;10(4):709-25. doi: 10.1016/s0891-5520(05)70323-8. PMID: 8958165

Therapy

Long-term safety and efficacy of eculizumab in generalized myasthenia gravis.
Muppidi S, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Nowak RJ, Andersen H, Casasnovas C, de Bleecker JL, Vu TH, Mantegazza R, O'Brien FL, Wang JJ, Fujita KP, Howard JF Jr; Regain Study Group
Muscle Nerve 2019 Jul;60(1):14-24. Epub 2019 Mar 8 doi: 10.1002/mus.26447. PMID: 30767274Free PMC Article
Investigational drugs in development to prevent neuromyelitis optica relapses.
Paul F, Murphy O, Pardo S, Levy M
Expert Opin Investig Drugs 2018 Mar;27(3):265-271. Epub 2018 Feb 28 doi: 10.1080/13543784.2018.1443077. PMID: 29465257
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study.
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
Management of meningococcal infections.
Klein NJ, Heyderman RS, Levin M
Br J Hosp Med 1993 Jun 16-Jul 13;50(1):42-9. PMID: 8364705
Preventing meningococcal infection.
Drug Ther Bull 1990 Apr 30;28(9):34-6. PMID: 2131249

Prognosis

Complement-driven hemolytic uremic syndrome.
Leon J, LeStang MB, Sberro-Soussan R, Servais A, Anglicheau D, Frémeaux-Bacchi V, Zuber J
Am J Hematol 2023 May;98 Suppl 4:S44-S56. doi: 10.1002/ajh.26854. PMID: 36683290
Investigational drugs in development to prevent neuromyelitis optica relapses.
Paul F, Murphy O, Pardo S, Levy M
Expert Opin Investig Drugs 2018 Mar;27(3):265-271. Epub 2018 Feb 28 doi: 10.1080/13543784.2018.1443077. PMID: 29465257
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Meningococcal infection.
Boyne L
Nurs Stand 2001 Oct 31-Nov 6;16(7):47-53; quiz 54-5. doi: 10.7748/ns2001.10.16.7.47.c3110. PMID: 11974830
Meningococcemia.
Salzman MB, Rubin LG
Infect Dis Clin North Am 1996 Dec;10(4):709-25. doi: 10.1016/s0891-5520(05)70323-8. PMID: 8958165

Clinical prediction guides

Atypical hemolytic uremic syndrome in the era of terminal complement inhibition: an observational cohort study.
Brocklebank V, Walsh PR, Smith-Jackson K, Hallam TM, Marchbank KJ, Wilson V, Bigirumurame T, Dutt T, Montgomery EK, Malina M, Wong EKS, Johnson S, Sheerin NS, Kavanagh D
Blood 2023 Oct 19;142(16):1371-1386. doi: 10.1182/blood.2022018833. PMID: 37369098Free PMC Article
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study.
Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowak RJ, O'Brien F, Wang JJ, Mantegazza R; REGAIN Study Group
Lancet Neurol 2017 Dec;16(12):976-986. Epub 2017 Oct 20 doi: 10.1016/S1474-4422(17)30369-1. PMID: 29066163
An international consensus approach to the management of atypical hemolytic uremic syndrome in children.
Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Frémeaux-Bacchi V; HUS International
Pediatr Nephrol 2016 Jan;31(1):15-39. Epub 2015 Apr 11 doi: 10.1007/s00467-015-3076-8. PMID: 25859752
Pathogenesis of meningococcemia.
Coureuil M, Join-Lambert O, Lécuyer H, Bourdoulous S, Marullo S, Nassif X
Cold Spring Harb Perspect Med 2013 Jun 1;3(6) doi: 10.1101/cshperspect.a012393. PMID: 23732856Free PMC Article
Molecular epidemiology of meningococci: application of DNA sequence typing.
Vogel U
Int J Med Microbiol 2010 Nov;300(7):415-20. Epub 2010 May 26 doi: 10.1016/j.ijmm.2010.04.017. PMID: 20537945

Recent systematic reviews

Range of invasive meningococcal disease sequelae and health economic application - a systematic and clinical review.
Shen J, Begum N, Ruiz-Garcia Y, Martinon-Torres F, Bekkat-Berkani R, Meszaros K
BMC Public Health 2022 May 31;22(1):1078. doi: 10.1186/s12889-022-13342-2. PMID: 35641955Free PMC Article
Interventions for atypical haemolytic uraemic syndrome.
Pugh D, O'Sullivan ED, Duthie FA, Masson P, Kavanagh D
Cochrane Database Syst Rev 2021 Mar 23;3(3):CD012862. doi: 10.1002/14651858.CD012862.pub2. PMID: 33783815Free PMC Article
Pre-admission antibiotics for suspected cases of meningococcal disease.
Sudarsanam TD, Rupali P, Tharyan P, Abraham OC, Thomas K
Cochrane Database Syst Rev 2017 Jun 14;6(6):CD005437. doi: 10.1002/14651858.CD005437.pub4. PMID: 28613408Free PMC Article
Antibiotics for preventing meningococcal infections.
Zalmanovici Trestioreanu A, Fraser A, Gafter-Gvili A, Paul M, Leibovici L
Cochrane Database Syst Rev 2013 Oct 25;2013(10):CD004785. doi: 10.1002/14651858.CD004785.pub5. PMID: 24163051Free PMC Article
Antibiotics for preventing meningococcal infections.
Zalmanovici Trestioreanu A, Fraser A, Gafter-Gvili A, Paul M, Leibovici L
Cochrane Database Syst Rev 2011 Aug 10;(8):CD004785. doi: 10.1002/14651858.CD004785.pub4. PMID: 21833949

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