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White dot syndrome

MedGen UID:
735629
•Concept ID:
C1532959
•
Disease or Syndrome
Synonyms: White Dot Syndrome; White Dot Syndromes
SNOMED CT: White dot syndrome (415843000)

Definition

A group of idiopathic multifocal posterior uveitis syndromes involving the CHOROID; RETINAL PIGMENT EPITHELIUM; and RETINA. They are characterized by multiple lesions of hypoautofluorescent dots in the FUNDUS OCULI and reduced VISUAL ACUITY. Several entities including BIRDSHOT CHORIORETINOPATHY are HLA-A ANTIGENS serotype A29 positive. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWhite dot syndrome

Professional guidelines

PubMed

Differential diagnosis of myopic choroidal neovascularization (mCNV): insights from multimodal imaging and treatment implications.
Feo A, De Simone L, Cimino L, Angi M, Romano MR
Graefes Arch Clin Exp Ophthalmol 2024 Jul;262(7):2005-2026. Epub 2023 Dec 7 doi: 10.1007/s00417-023-06320-w. PMID: 38060000
The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis.
Agarwal A, Invernizzi A
Ocul Immunol Inflamm 2022 Apr 3;30(3):682-689. Epub 2022 May 20 doi: 10.1080/09273948.2022.2071743. PMID: 35593586
Classification Criteria For Multiple Evanescent White Dot Syndrome.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:198-204. Epub 2021 Apr 15 doi: 10.1016/j.ajo.2021.03.050. PMID: 33845025Free PMC Article

Recent clinical studies

Etiology

Latest advances in white spot syndromes: New findings and interpretations.
Cicinelli MV, Ramtohul P, Marchese A, Bandello F, Bailey Freund K, Miserocchi E, Jampol LM
Prog Retin Eye Res 2023 Nov;97:101207. Epub 2023 Aug 12 doi: 10.1016/j.preteyeres.2023.101207. PMID: 37574123
INTRARETINAL HYPERREFLECTIVE LINES.
Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A, Cohen SY
Retina 2021 Jan 1;41(1):82-92. doi: 10.1097/IAE.0000000000002806. PMID: 32251237
Similarities and differences between three different types of white dot syndrome and the therapeutic possibilities.
Cozubas R, Ungureanu E, Instrate SL, Alexandrescu C, Nanu RV, Carstocea L, Voinea LM, Ciuluvica R
Rom J Ophthalmol 2018 Jul-Sep;62(3):183-187. PMID: 30505986Free PMC Article
The white dot syndromes.
Matsumoto Y, Haen SP, Spaide RF
Compr Ophthalmol Update 2007 Jul-Aug;8(4):179-200; discussion 203-4. PMID: 17999832
The white dot syndromes.
Quillen DA, Davis JB, Gottlieb JL, Blodi BA, Callanan DG, Chang TS, Equi RA
Am J Ophthalmol 2004 Mar;137(3):538-50. doi: 10.1016/j.ajo.2004.01.053. PMID: 15013878

Diagnosis

Latest advances in white spot syndromes: New findings and interpretations.
Cicinelli MV, Ramtohul P, Marchese A, Bandello F, Bailey Freund K, Miserocchi E, Jampol LM
Prog Retin Eye Res 2023 Nov;97:101207. Epub 2023 Aug 12 doi: 10.1016/j.preteyeres.2023.101207. PMID: 37574123
MULTIPLE EVANESCENT WHITE DOT SYNDROME MASQUERADER.
Moraes RT, Peixoto AL, Moraes LS, Lima LH, Balaratnasingam C, Sarraf D, Vianna RNG
Retin Cases Brief Rep 2021 Sep 1;15(Suppl 1):S45-S48. doi: 10.1097/ICB.0000000000001156. PMID: 34171902
INTRARETINAL HYPERREFLECTIVE LINES.
Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A, Cohen SY
Retina 2021 Jan 1;41(1):82-92. doi: 10.1097/IAE.0000000000002806. PMID: 32251237
Multiple evanescent white dot syndrome (MEWDS).
dell'Omo R, Pavesio CE
Int Ophthalmol Clin 2012 Fall;52(4):221-8. doi: 10.1097/IIO.0b013e31826647ed. PMID: 22954944
White spots syndromes.
Verougstraete C
Bull Soc Belge Ophtalmol 2001;(279):67-78. PMID: 11344717

Therapy

The multimodal imaging features and outcomes of multifocal choroiditis/punctate inner choroidopathy lesion with multiple evanescent white dot syndrome-like features: a retrospective study.
Chen C, Cheng Y, Zhang Z, Zhang Y, Hou S, Wang G, Peng X
BMC Ophthalmol 2024 Jan 2;24(1):3. doi: 10.1186/s12886-023-03277-6. PMID: 38166867Free PMC Article
Multiple Evanescent White Dot Syndrome Following Adenovirus Vector-Based COVID-19 Vaccine (Covishield).
Baharani A, Reddy RR
Ocul Immunol Inflamm 2023 Aug;31(6):1299-1304. Epub 2023 Apr 12 doi: 10.1080/09273948.2023.2192271. PMID: 37043615
Ocular Adverse Events After COVID-19 Vaccination.
Ng XL, Betzler BK, Testi I, Ho SL, Tien M, Ngo WK, Zierhut M, Chee SP, Gupta V, Pavesio CE, de Smet MD, Agrawal R
Ocul Immunol Inflamm 2021 Aug 18;29(6):1216-1224. Epub 2021 Sep 24 doi: 10.1080/09273948.2021.1976221. PMID: 34559576Free PMC Article
A Multiple Evanescent White Dot Syndrome-like Reaction to Concurrent Retinal Insults.
Cicinelli MV, Hassan OM, Gill MK, Goldstein D, Parodi MB, Jampol LM
Ophthalmol Retina 2021 Oct;5(10):1017-1026. Epub 2020 Dec 22 doi: 10.1016/j.oret.2020.12.007. PMID: 33348087
The white dot syndromes.
Matsumoto Y, Haen SP, Spaide RF
Compr Ophthalmol Update 2007 Jul-Aug;8(4):179-200; discussion 203-4. PMID: 17999832

Prognosis

Fundus autofluorescence in uveitis: from pathogenesis to imaging interpretation.
Saturno MC, Neri P, Pichi F
Int Ophthalmol 2023 Nov;43(11):4359-4371. Epub 2023 Jul 7 doi: 10.1007/s10792-023-02803-1. PMID: 37418226
INTRARETINAL HYPERREFLECTIVE LINES.
Amoroso F, Mrejen S, Pedinielli A, Tabary S, Souied EH, Gaudric A, Cohen SY
Retina 2021 Jan 1;41(1):82-92. doi: 10.1097/IAE.0000000000002806. PMID: 32251237
Similarities and differences between three different types of white dot syndrome and the therapeutic possibilities.
Cozubas R, Ungureanu E, Instrate SL, Alexandrescu C, Nanu RV, Carstocea L, Voinea LM, Ciuluvica R
Rom J Ophthalmol 2018 Jul-Sep;62(3):183-187. PMID: 30505986Free PMC Article
The white dot syndromes.
Matsumoto Y, Haen SP, Spaide RF
Compr Ophthalmol Update 2007 Jul-Aug;8(4):179-200; discussion 203-4. PMID: 17999832
The white dot syndromes.
Vianna RN, Socci D, Nehemy MB, Deschênes J, Burnier MN Jr
Arq Bras Oftalmol 2007 May-Jun;70(3):554-62. doi: 10.1590/s0004-27492007000300031. PMID: 17768571

Clinical prediction guides

The characteristics of white dot syndromes following COVID-19 Vaccines: a systematic review.
Abu Serhan H, Abu Suilik H, Hassan AK, AlSamhori JF, Hassan AR, Siddiq A, Ahmed N, Elnahry AG
Int Ophthalmol 2024 Apr 23;44(1):189. doi: 10.1007/s10792-024-03119-4. PMID: 38652153Free PMC Article
Presumed Müller Cell Activation in Multiple Evanescent White Dot Syndrome.
Cicinelli MV, Menean M, Apuzzo A, Scandale P, Marchese A, Introini U, Battaglia Parodi M, Bandello F, Miserocchi E
Invest Ophthalmol Vis Sci 2023 Oct 3;64(13):20. doi: 10.1167/iovs.64.13.20. PMID: 37824135Free PMC Article
COMPARISON OF PRIMARY AND SECONDARY FORMS OF MULTIPLE EVANESCENT WHITE DOT SYNDROME.
Serrar Y, Cahuzac A, Gascon P, Langlois-Jacques C, Mauget-Faÿsse M, Wolff B, Sève P, Kodjikian L, Mathis T
Retina 2022 Dec 1;42(12):2368-2378. doi: 10.1097/IAE.0000000000003609. PMID: 36394891
Multifocal Evanescent White Dot Syndrome-like Phenotypes Associated with Inflammatory and Myopic Choroidal Neovascularization.
Burke TR, Addison PKF, Pavesio CE
Ocul Immunol Inflamm 2022 Oct-Nov;30(7-8):1707-1714. Epub 2021 Jun 14 doi: 10.1080/09273948.2021.1936563. PMID: 34124984
Multiple evanescent white dot syndrome: clinical course and factors influencing visual acuity recovery.
Bosello F, Westcott M, Casalino G, Agorogiannis G, Micciolo R, Rees A, Pavesio C
Br J Ophthalmol 2022 Jan;106(1):121-127. Epub 2020 Oct 21 doi: 10.1136/bjophthalmol-2020-317357. PMID: 33087315

Recent systematic reviews

Comprehensive insights into COVID-19 vaccine-associated multiple evanescent white dot syndrome (MEWDS): A systematic analysis of reported cases.
Zeng Y, Du Z, Shao C, Zhao M
Hum Vaccin Immunother 2024 Dec 31;20(1):2350812. Epub 2024 May 16 doi: 10.1080/21645515.2024.2350812. PMID: 38752704
The characteristics of white dot syndromes following COVID-19 Vaccines: a systematic review.
Abu Serhan H, Abu Suilik H, Hassan AK, AlSamhori JF, Hassan AR, Siddiq A, Ahmed N, Elnahry AG
Int Ophthalmol 2024 Apr 23;44(1):189. doi: 10.1007/s10792-024-03119-4. PMID: 38652153Free PMC Article
Differential diagnosis of myopic choroidal neovascularization (mCNV): insights from multimodal imaging and treatment implications.
Feo A, De Simone L, Cimino L, Angi M, Romano MR
Graefes Arch Clin Exp Ophthalmol 2024 Jul;262(7):2005-2026. Epub 2023 Dec 7 doi: 10.1007/s00417-023-06320-w. PMID: 38060000
Outcomes in PIC-Related CNV: Pooled Analysis of Individual Participant Data.
Zaslavsky K, Park T, Lang Mcinnis R, Mandell M, Lee J, Lee C, Gilbert R, Derzko-Dzulynsky L
Ocul Immunol Inflamm 2023 Nov;31(9):1825-1836. Epub 2022 Sep 30 doi: 10.1080/09273948.2022.2124176. PMID: 36179037
Indocyanine green angiography in chorioretinal diseases: indications and interpretation: an evidence-based update.
Stanga PE, Lim JI, Hamilton P
Ophthalmology 2003 Jan;110(1):15-21; quiz 22-3. doi: 10.1016/s0161-6420(02)01563-4. PMID: 12511340

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