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Panuveitis

MedGen UID:
45303
Concept ID:
C0030343
Disease or Syndrome
Synonym: Inflammation of the whole uveal tract
SNOMED CT: Panuveitis (75614007); Diffuse uveitis (75614007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0012121
Monarch Initiative: MONDO:0017255
Orphanet: ORPHA280898

Definition

Inflammation of the uveal tract in which inflammation affects the anterior chamber, vitreous, retina or choroid. [from HPO]

Conditions with this feature

Autoinflammatory disease, X-linked
MedGen UID:
1811268
Concept ID:
C5676885
Disease or Syndrome
X-linked systemic autoinflammatory disease (SAIDX) is characterized by the onset of systemic autoinflammation in the first months of life. Features include lymphadenopathy, hepatosplenomegaly, fever, panniculitis, and nodular skin rash. Additional manifestations may include inflammation of the optic nerve, intracranial hemorrhage, and lipodystrophy. Laboratory studies show hypogammaglobulinemia, increased or decreased white blood cell count, autoimmune cytopenias, elevated serum inflammatory markers, and a type I interferon signature (de Jesus et al., 2020 and Lee et al., 2022).

Professional guidelines

PubMed

Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:80-88. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.058. PMID: 33845008Free PMC Article
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726

Recent clinical studies

Etiology

Gentile P, Ragusa E, Bolletta E, De Simone L, Gozzi F, Cappella M, Fastiggi M, De Fanti A, Cimino L
Ocul Immunol Inflamm 2023 Dec;31(10):2050-2059. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2271988. PMID: 37922466
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Chan NS, Choi J, Cheung CMG
Asia Pac J Ophthalmol (Phila) 2018 May-Jun;7(3):192-199. Epub 2018 Apr 23 doi: 10.22608/APO.2018116. PMID: 29682916
Tsirouki T, Dastiridou A, Symeonidis C, Tounakaki O, Brazitikou I, Kalogeropoulos C, Androudi S
Ocul Immunol Inflamm 2018;26(1):2-16. Epub 2016 Jul 28 doi: 10.1080/09273948.2016.1196713. PMID: 27467180
Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057. PMID: 16196117Free PMC Article

Diagnosis

Agarwal M, Radosavljevic A, Tyagi M, Pichi F, Al Dhanhani AA, Agarwal A, Cunningham ET Jr
Ocul Immunol Inflamm 2023 May;31(4):793-809. Epub 2022 May 17 doi: 10.1080/09273948.2022.2058554. PMID: 35579612
Parchand S, Agrawal D, Ayyadurai N, Agarwal A, Gangwe A, Behera S, Bhatia P, Mulkutkar S, Barwar G, Singh R, Sen A, Agarwal M
Indian J Ophthalmol 2022 Jun;70(6):1931-1944. doi: 10.4103/ijo.IJO_2363_21. PMID: 35647958Free PMC Article
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Abdelwareth Mohammed A, Soliman MM, Osman AA, El-Zanaty RT
Ocul Immunol Inflamm 2021 Jul 4;29(5):1007-1016. Epub 2020 Feb 18 doi: 10.1080/09273948.2020.1714060. PMID: 32068471
Tsirouki T, Dastiridou A, Symeonidis C, Tounakaki O, Brazitikou I, Kalogeropoulos C, Androudi S
Ocul Immunol Inflamm 2018;26(1):2-16. Epub 2016 Jul 28 doi: 10.1080/09273948.2016.1196713. PMID: 27467180

Therapy

Parchand S, Agrawal D, Ayyadurai N, Agarwal A, Gangwe A, Behera S, Bhatia P, Mulkutkar S, Barwar G, Singh R, Sen A, Agarwal M
Indian J Ophthalmol 2022 Jun;70(6):1931-1944. doi: 10.4103/ijo.IJO_2363_21. PMID: 35647958Free PMC Article
Agrawal R, Testi I, Bodaghi B, Barisani-Asenbauer T, McCluskey P, Agarwal A, Kempen JH, Gupta A, Smith JR, de Smet MD, Yuen YS, Mahajan S, Kon OM, Nguyen QD, Pavesio C, Gupta V; Collaborative Ocular Tuberculosis Study Consensus Group
Ophthalmology 2021 Feb;128(2):277-287. Epub 2020 Jun 27 doi: 10.1016/j.ophtha.2020.06.052. PMID: 32603726
Dutta Majumder P, Chen EJ, Shah J, Ching Wen Ho D, Biswas J, See Yin L, Gupta V, Pavesio C, Agrawal R
Ocul Immunol Inflamm 2019;27(1):117-125. Epub 2017 Oct 11 doi: 10.1080/09273948.2017.1371765. PMID: 29020491
LaMattina KC, Goldstein DA
Expert Rev Clin Immunol 2017 Mar;13(3):181-188. doi: 10.1080/1744666X.2017.1288097. PMID: 28140700
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665

Prognosis

Finsterer J, Scorza FA, Scorza CA, Fiorini AC
J Neuroophthalmol 2021 Jun 1;41(2):166-169. doi: 10.1097/WNO.0000000000001273. PMID: 33999887
Dutta Majumder P, Chen EJ, Shah J, Ching Wen Ho D, Biswas J, See Yin L, Gupta V, Pavesio C, Agrawal R
Ocul Immunol Inflamm 2019;27(1):117-125. Epub 2017 Oct 11 doi: 10.1080/09273948.2017.1371765. PMID: 29020491
Tsirouki T, Dastiridou A, Symeonidis C, Tounakaki O, Brazitikou I, Kalogeropoulos C, Androudi S
Ocul Immunol Inflamm 2018;26(1):2-16. Epub 2016 Jul 28 doi: 10.1080/09273948.2016.1196713. PMID: 27467180
Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB
N Engl J Med 2016 Sep 8;375(10):932-43. doi: 10.1056/NEJMoa1509852. PMID: 27602665
Jabs DA, Nussenblatt RB, Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2005 Sep;140(3):509-16. doi: 10.1016/j.ajo.2005.03.057. PMID: 16196117Free PMC Article

Clinical prediction guides

Sotomayor Toribio M, Rueda Rueda T, Sánchez Vicente JL, López Herrero F, Cabanás Jiménez M, Mantrana Bermejo ME
Med Clin (Barc) 2023 Aug 11;161(3):107-109. Epub 2023 May 27 doi: 10.1016/j.medcli.2023.04.009. PMID: 37248128
Arora S, Surakiatchanukul T, Arora T, Errera MH, Agrawal H, Lupidi M, Chhablani J
Surv Ophthalmol 2022 Jan-Feb;67(1):97-148. Epub 2021 May 26 doi: 10.1016/j.survophthal.2021.05.007. PMID: 34048859
Ahnood D, Madhusudhan S, Tsaloumas MD, Waheed NK, Keane PA, Denniston AK
Surv Ophthalmol 2017 Mar-Apr;62(2):113-126. Epub 2016 Oct 15 doi: 10.1016/j.survophthal.2016.10.003. PMID: 27751823
Ostheimer TA, Burkholder BM, Leung TG, Butler NJ, Dunn JP, Thorne JE
Am J Ophthalmol 2014 Sep;158(3):637-43.e1. Epub 2014 May 27 doi: 10.1016/j.ajo.2014.05.019. PMID: 24875002
Fang W, Yang P
Curr Eye Res 2008 Jul;33(7):517-23. doi: 10.1080/02713680802233968. PMID: 18600484

Recent systematic reviews

Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010469. doi: 10.1002/14651858.CD010469.pub4. PMID: 37642198Free PMC Article
Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Jan 16;1(1):CD010469. doi: 10.1002/14651858.CD010469.pub3. PMID: 36645716Free PMC Article
Lobo-Chan AM, Joltikov K, Haseeb A, Mehta SD
Ophthalmic Epidemiol 2023 Oct;30(5):445-452. Epub 2022 Oct 6 doi: 10.1080/09286586.2022.2131837. PMID: 36204817Free PMC Article
He B, Tanya SM, Wang C, Kezouh A, Torun N, Ing E
Am J Ophthalmol 2022 Feb;234:117-125. Epub 2021 Jul 17 doi: 10.1016/j.ajo.2021.06.036. PMID: 34283983
Greco A, Fusconi M, Gallo A, Turchetta R, Marinelli C, Macri GF, De Virgilio A, de Vincentiis M
Autoimmun Rev 2013 Sep;12(11):1033-8. Epub 2013 Apr 6 doi: 10.1016/j.autrev.2013.01.004. PMID: 23567866

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