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Ventricular Dysfunction

MedGen UID:
69305
•Concept ID:
C0242973
•
Pathologic Function
Synonyms: Dysfunction, Ventricular; Dysfunctions, Ventricular; Ventricular Dysfunctions

Definition

Impairment of the ventricle to either fill or eject adequately. [from NCI]

Professional guidelines

PubMed

2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Writing Committee Members, Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, Bittl JA, Cohen MG, DiMaio JM, Don CW, Fremes SE, Gaudino MF, Goldberger ZD, Grant MC, Jaswal JB, Kurlansky PA, Mehran R, Metkus TS Jr, Nnacheta LC, Rao SV, Sellke FW, Sharma G, Yong CM, Zwischenberger BA
J Am Coll Cardiol 2022 Jan 18;79(2):e21-e129. Epub 2021 Dec 9 doi: 10.1016/j.jacc.2021.09.006. PMID: 34895950
2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, Bittl JA, Cohen MG, DiMaio JM, Don CW, Fremes SE, Gaudino MF, Goldberger ZD, Grant MC, Jaswal JB, Kurlansky PA, Mehran R, Metkus TS Jr, Nnacheta LC, Rao SV, Sellke FW, Sharma G, Yong CM, Zwischenberger BA
Circulation 2022 Jan 18;145(3):e4-e17. Epub 2021 Dec 9 doi: 10.1161/CIR.0000000000001039. PMID: 34882436
Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy: An Expert Consensus Document.
Ammirati E, Frigerio M, Adler ED, Basso C, Birnie DH, Brambatti M, Friedrich MG, Klingel K, Lehtonen J, Moslehi JJ, Pedrotti P, Rimoldi OE, Schultheiss HP, Tschöpe C, Cooper LT Jr, Camici PG
Circ Heart Fail 2020 Nov;13(11):e007405. Epub 2020 Nov 12 doi: 10.1161/CIRCHEARTFAILURE.120.007405. PMID: 33176455Free PMC Article

Recent clinical studies

Etiology

Aortic Stenosis: Guidelines and Evidence Gaps.
Harris AW, Pibarot P, Otto CM
Cardiol Clin 2020 Feb;38(1):55-63. Epub 2019 Nov 1 doi: 10.1016/j.ccl.2019.09.003. PMID: 31753177
Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography.
Nagueh SF
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):228-244. Epub 2019 Apr 12 doi: 10.1016/j.jcmg.2018.10.038. PMID: 30982669
Pulmonary Hypertension.
Kim D, George MP
Med Clin North Am 2019 May;103(3):413-423. doi: 10.1016/j.mcna.2018.12.002. PMID: 30955510
Pulmonary Embolism.
Rali P, Gandhi V, Malik K
Crit Care Nurs Q 2016 Apr-Jun;39(2):131-8. doi: 10.1097/CNQ.0000000000000106. PMID: 26919674
The pathophysiology of heart failure with preserved ejection fraction.
Borlaug BA
Nat Rev Cardiol 2014 Sep;11(9):507-15. Epub 2014 Jun 24 doi: 10.1038/nrcardio.2014.83. PMID: 24958077

Diagnosis

Subclinical right ventricular dysfunction diagnosis in systemic sclerosis.
Floria M, Mihailov L, Iov DE
Echocardiography 2024 Jul;41(7):e15885. doi: 10.1111/echo.15885. PMID: 38973770
Management of Acute Right Ventricular Failure.
Asakage A, Bækgaard J, Mebazaa A, Deniau B
Curr Heart Fail Rep 2023 Jun;20(3):218-229. Epub 2023 May 8 doi: 10.1007/s11897-023-00601-5. PMID: 37155123
Right Ventricular Failure.
Leeper B
AACN Adv Crit Care 2020 Mar 15;31(1):49-56. doi: 10.4037/aacnacc2020172. PMID: 32168515
Case-Based Imaging Curriculum.
Nagueh SF, Chandrashekhar Y
JACC Cardiovasc Imaging 2020 Jan;13(1 Pt 2):343-344. doi: 10.1016/j.jcmg.2019.12.003. PMID: 31918905
Right ventricular failure management.
Bakar SN, Jia S, Smith SJ
Curr Opin Cardiol 2019 Mar;34(2):213-217. doi: 10.1097/HCO.0000000000000595. PMID: 30575646

Therapy

STICH3C: Rationale and Study Protocol.
Fremes SE, Marquis-Gravel G, Gaudino MFL, Jolicoeur EM, Bédard S, Masterson Creber R, Ruel M, Vervoort D, Wijeysundera HC, Farkouh ME, Rouleau JL; STICH3C Study Investigators
Circ Cardiovasc Interv 2023 Aug;16(8):e012527. Epub 2023 Aug 15 doi: 10.1161/CIRCINTERVENTIONS.122.012527. PMID: 37582169
SGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials.
Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, McMurray JJV, Solomon SD
Lancet 2022 Sep 3;400(10354):757-767. Epub 2022 Aug 27 doi: 10.1016/S0140-6736(22)01429-5. PMID: 36041474
Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials.
Grayburn PA, Sannino A, Packer M
JACC Cardiovasc Imaging 2019 Feb;12(2):353-362. Epub 2018 Dec 12 doi: 10.1016/j.jcmg.2018.11.006. PMID: 30553663
Pulmonary hypertension due to left heart disease.
Vachiéry JL, Tedford RJ, Rosenkranz S, Palazzini M, Lang I, Guazzi M, Coghlan G, Chazova I, De Marco T
Eur Respir J 2019 Jan;53(1) Epub 2019 Jan 24 doi: 10.1183/13993003.01897-2018. PMID: 30545974Free PMC Article
Clinical course and predictive value of congestion during hospitalization in patients admitted for worsening signs and symptoms of heart failure with reduced ejection fraction: findings from the EVEREST trial.
Ambrosy AP, Pang PS, Khan S, Konstam MA, Fonarow GC, Traver B, Maggioni AP, Cook T, Swedberg K, Burnett JC Jr, Grinfeld L, Udelson JE, Zannad F, Gheorghiade M; EVEREST Trial Investigators
Eur Heart J 2013 Mar;34(11):835-43. Epub 2013 Jan 4 doi: 10.1093/eurheartj/ehs444. PMID: 23293303

Prognosis

Impact of Right Ventricular Dysfunction on Short-term and Long-term Mortality in Sepsis: A Meta-analysis of 1,373 Patients.
Vallabhajosyula S, Shankar A, Vojjini R, Cheungpasitporn W, Sundaragiri PR, DuBrock HM, Sekiguchi H, Frantz RP, Cajigas HR, Kane GC, Oh JK
Chest 2021 Jun;159(6):2254-2263. Epub 2021 Feb 27 doi: 10.1016/j.chest.2020.12.016. PMID: 33359215Free PMC Article
Etiology and prognosis of patients with unexplained syncope and mid-range left ventricular dysfunction.
Francisco-Pascual J, Rodenas-Alesina E, Rivas-Gándara N, Belahnech Y, Olivella San Emeterio A, Pérez-Rodón J, Benito B, Santos-Ortega A, Moya-Mitjans À, Casas G, Cantalapiedra-Romero J, Maldonado J, Ferreira-González I
Heart Rhythm 2021 Apr;18(4):597-604. Epub 2020 Dec 14 doi: 10.1016/j.hrthm.2020.12.009. PMID: 33326869
Extracellular Myocardial Volume in Patients With Aortic Stenosis.
Everett RJ, Treibel TA, Fukui M, Lee H, Rigolli M, Singh A, Bijsterveld P, Tastet L, Musa TA, Dobson L, Chin C, Captur G, Om SY, Wiesemann S, Ferreira VM, Piechnik SK, Schulz-Menger J, Schelbert EB, Clavel MA, Newby DE, Myerson SG, Pibarot P, Lee S, Cavalcante JL, Lee SP, McCann GP, Greenwood JP, Moon JC, Dweck MR
J Am Coll Cardiol 2020 Jan 28;75(3):304-316. doi: 10.1016/j.jacc.2019.11.032. PMID: 31976869Free PMC Article
Right Ventricular Function and Prognosis in Patients with Low-Flow, Low-Gradient Severe Aortic Stenosis.
Cavalcante JL, Rijal S, Althouse AD, Delgado-Montero A, Katz WE, Schindler JT, Crock F, Harinstein ME, Navid F, Gleason TG, Lee JS
J Am Soc Echocardiogr 2016 Apr;29(4):325-33. Epub 2015 Dec 30 doi: 10.1016/j.echo.2015.12.001. PMID: 26743732
Acute left ventricular dysfunction in the critically ill.
Chockalingam A, Mehra A, Dorairajan S, Dellsperger KC
Chest 2010 Jul;138(1):198-207. doi: 10.1378/chest.09-1996. PMID: 20605820

Clinical prediction guides

Left Atrial Strain for Assessment of Left Ventricular Diastolic Function: Focus on Populations With Normal LVEF.
Nagueh SF, Khan SU
JACC Cardiovasc Imaging 2023 May;16(5):691-707. Epub 2023 Jan 11 doi: 10.1016/j.jcmg.2022.10.011. PMID: 36752445
Echocardiography derived intra-ventricular pressure gradients: a window to the temporal and spatial components of diastolic dysfunction.
Chalikias GK, Tziakas DN
Int J Cardiovasc Imaging 2021 Sep;37(9):2675-2678. Epub 2021 Jul 20 doi: 10.1007/s10554-021-02351-8. PMID: 34286446
Cardiac-MRI Predicts Clinical Worsening and Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.
Alabed S, Shahin Y, Garg P, Alandejani F, Johns CS, Lewis RA, Condliffe R, Wild JM, Kiely DG, Swift AJ
JACC Cardiovasc Imaging 2021 May;14(5):931-942. Epub 2020 Sep 30 doi: 10.1016/j.jcmg.2020.08.013. PMID: 33008758Free PMC Article
Vendor-Neutral Right Ventricular Strain Measurement.
Gao Z, Bortman J, Mahmood F, Mitchell J, Mahmood F, Matyal R
J Cardiothorac Vasc Anesth 2018 Aug;32(4):1759-1767. Epub 2018 Feb 9 doi: 10.1053/j.jvca.2018.02.014. PMID: 29555385
The Right Ventricle: Unforgettable With Imaging.
Marwick TH, Chandrashekhar Y
JACC Cardiovasc Imaging 2017 Oct;10(10 Pt B):1289-1290. doi: 10.1016/j.jcmg.2017.09.001. PMID: 29025580

Recent systematic reviews

Redefining the epidemiology of cardiac amyloidosis. A systematic review and meta-analysis of screening studies.
Aimo A, Merlo M, Porcari A, Georgiopoulos G, Pagura L, Vergaro G, Sinagra G, Emdin M, Rapezzi C
Eur J Heart Fail 2022 Dec;24(12):2342-2351. Epub 2022 May 16 doi: 10.1002/ejhf.2532. PMID: 35509173Free PMC Article
2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Writing Committee Members, Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM, Bittl JA, Cohen MG, DiMaio JM, Don CW, Fremes SE, Gaudino MF, Goldberger ZD, Grant MC, Jaswal JB, Kurlansky PA, Mehran R, Metkus TS Jr, Nnacheta LC, Rao SV, Sellke FW, Sharma G, Yong CM, Zwischenberger BA
J Am Coll Cardiol 2022 Jan 18;79(2):e21-e129. Epub 2021 Dec 9 doi: 10.1016/j.jacc.2021.09.006. PMID: 34895950
Treatment for beta-blocker poisoning: a systematic review.
Rotella JA, Greene SL, Koutsogiannis Z, Graudins A, Hung Leang Y, Kuan K, Baxter H, Bourke E, Wong A
Clin Toxicol (Phila) 2020 Oct;58(10):943-983. Epub 2020 Apr 20 doi: 10.1080/15563650.2020.1752918. PMID: 32310006
Survival of patients with chronic heart failure in the community: a systematic review and meta-analysis.
Jones NR, Roalfe AK, Adoki I, Hobbs FDR, Taylor CJ
Eur J Heart Fail 2019 Nov;21(11):1306-1325. Epub 2019 Sep 16 doi: 10.1002/ejhf.1594. PMID: 31523902Free PMC Article
Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review.
van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH
Eur J Heart Fail 2016 Mar;18(3):242-52. Epub 2016 Jan 4 doi: 10.1002/ejhf.483. PMID: 26727047

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