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Right Ventricular Dysfunction

MedGen UID:
116644
•Concept ID:
C0242707
•
Pathologic Function
Synonyms: Dysfunction, Right Ventricular; Dysfunctions, Right Ventricular; Right Ventricular Dysfunctions; Ventricular Dysfunction, Right; Ventricular Dysfunctions, Right

Definition

Impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRight Ventricular Dysfunction

Professional guidelines

PubMed

Eisenmenger syndrome: diagnosis, prognosis and clinical management.
Arvanitaki A, Giannakoulas G, Baumgartner H, Lammers AE
Heart 2020 Nov;106(21):1638-1645. Epub 2020 Jul 20 doi: 10.1136/heartjnl-2020-316665. PMID: 32690623
Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association.
Konstam MA, Kiernan MS, Bernstein D, Bozkurt B, Jacob M, Kapur NK, Kociol RD, Lewis EF, Mehra MR, Pagani FD, Raval AN, Ward C; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Cardiovascular Surgery and Anesthesia
Circulation 2018 May 15;137(20):e578-e622. Epub 2018 Apr 12 doi: 10.1161/CIR.0000000000000560. PMID: 29650544
Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology.
Harjola VP, Mebazaa A, Čelutkienė J, Bettex D, Bueno H, Chioncel O, Crespo-Leiro MG, Falk V, Filippatos G, Gibbs S, Leite-Moreira A, Lassus J, Masip J, Mueller C, Mullens W, Naeije R, Nordegraaf AV, Parissis J, Riley JP, Ristic A, Rosano G, Rudiger A, Ruschitzka F, Seferovic P, Sztrymf B, Vieillard-Baron A, Yilmaz MB, Konstantinides S
Eur J Heart Fail 2016 Mar;18(3):226-41. doi: 10.1002/ejhf.478. PMID: 26995592

Recent clinical studies

Etiology

What echocardiographic findings differentiate acute pulmonary embolism and chronic pulmonary hypertension?
Alerhand S, Adrian RJ
Am J Emerg Med 2023 Oct;72:72-84. Epub 2023 Jul 10 doi: 10.1016/j.ajem.2023.07.011. PMID: 37499553
Acute pulmonary embolism: a concise review of diagnosis and management.
Hepburn-Brown M, Darvall J, Hammerschlag G
Intern Med J 2019 Jan;49(1):15-27. doi: 10.1111/imj.14145. PMID: 30324770
Pulmonary embolism.
Huisman MV, Barco S, Cannegieter SC, Le Gal G, Konstantinides SV, Reitsma PH, Rodger M, Vonk Noordegraaf A, Klok FA
Nat Rev Dis Primers 2018 May 17;4:18028. doi: 10.1038/nrdp.2018.28. PMID: 29770793
Pulmonary Embolism.
Rali P, Gandhi V, Malik K
Crit Care Nurs Q 2016 Apr-Jun;39(2):131-8. doi: 10.1097/CNQ.0000000000000106. PMID: 26919674
Submassive pulmonary embolism.
Busse LW, Vourlekis JS
Crit Care Clin 2014 Jul;30(3):447-73. doi: 10.1016/j.ccc.2014.03.006. PMID: 24996605

Diagnosis

What echocardiographic findings differentiate acute pulmonary embolism and chronic pulmonary hypertension?
Alerhand S, Adrian RJ
Am J Emerg Med 2023 Oct;72:72-84. Epub 2023 Jul 10 doi: 10.1016/j.ajem.2023.07.011. PMID: 37499553
Right heart failure: A narrative review for emergency clinicians.
Kostura M, Smalley C, Koyfman A, Long B
Am J Emerg Med 2022 Aug;58:106-113. Epub 2022 May 25 doi: 10.1016/j.ajem.2022.05.030. PMID: 35660367
Current outcomes and treatment of tetralogy of Fallot.
van der Ven JPG, van den Bosch E, Bogers AJCC, Helbing WA
F1000Res 2019;8 Epub 2019 Aug 29 doi: 10.12688/f1000research.17174.1. PMID: 31508203Free PMC Article
Acute pulmonary embolism: a concise review of diagnosis and management.
Hepburn-Brown M, Darvall J, Hammerschlag G
Intern Med J 2019 Jan;49(1):15-27. doi: 10.1111/imj.14145. PMID: 30324770
Pulmonary embolism.
Huisman MV, Barco S, Cannegieter SC, Le Gal G, Konstantinides SV, Reitsma PH, Rodger M, Vonk Noordegraaf A, Klok FA
Nat Rev Dis Primers 2018 May 17;4:18028. doi: 10.1038/nrdp.2018.28. PMID: 29770793

Therapy

The Evolving Concept of Secondary Mitral Regurgitation Phenotypes: Lessons From the M-TEER Trials.
Stolz L, Doldi PM, Sannino A, Hausleiter J, Grayburn PA
JACC Cardiovasc Imaging 2024 Jun;17(6):659-668. Epub 2024 Mar 27 doi: 10.1016/j.jcmg.2024.01.012. PMID: 38551534
Acute pulmonary embolism: a concise review of diagnosis and management.
Hepburn-Brown M, Darvall J, Hammerschlag G
Intern Med J 2019 Jan;49(1):15-27. doi: 10.1111/imj.14145. PMID: 30324770
Pulmonary Embolism.
Rali P, Gandhi V, Malik K
Crit Care Nurs Q 2016 Apr-Jun;39(2):131-8. doi: 10.1097/CNQ.0000000000000106. PMID: 26919674
Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis.
Chatterjee S, Chakraborty A, Weinberg I, Kadakia M, Wilensky RL, Sardar P, Kumbhani DJ, Mukherjee D, Jaff MR, Giri J
JAMA 2014 Jun 18;311(23):2414-21. doi: 10.1001/jama.2014.5990. PMID: 24938564
Cardiogenic shock.
Cooper HA, Panza JA
Cardiol Clin 2013 Nov;31(4):567-80, viii. Epub 2013 Sep 20 doi: 10.1016/j.ccl.2013.07.009. PMID: 24188221

Prognosis

Right ventricular phenotyping in incident patients with idiopathic pulmonary arterial hypertension.
Ghio S, Badagliacca R, D'Alto M, Scelsi L, Argiento P, Brunetti ND, Casu G, Cedrone N, Confalonieri M, Corda M, Correale M, D'Agostino C, De Tommasi E, Filomena D, Galgano G, Greco A, Grimaldi M, Lombardi C, Madonna R, Manzi G, Mercurio V, Mihai A, Mulè M, Paciocco G, Papa S, Recchioni T, Romaniello A, Romeo E, Stolfo D, Vitulo P, Benza RL, Vizza CD; Italian Pulmonary Hpertension NETwork (iPHNET)
J Heart Lung Transplant 2024 Oct;43(10):1668-1676. Epub 2024 Jun 26 doi: 10.1016/j.healun.2024.06.003. PMID: 38942159
TRI-SCORE: a new risk score for in-hospital mortality prediction after isolated tricuspid valve surgery.
Dreyfus J, Audureau E, Bohbot Y, Coisne A, Lavie-Badie Y, Bouchery M, Flagiello M, Bazire B, Eggenspieler F, Viau F, Riant E, Mbaki Y, Eyharts D, Senage T, Modine T, Nicol M, Doguet F, Nguyen V, Le Tourneau T, Tribouilloy C, Donal E, Tomasi J, Habib G, Selton-Suty C, Raffoul R, Iung B, Obadia JF, Messika-Zeitoun D
Eur Heart J 2022 Feb 12;43(7):654-662. doi: 10.1093/eurheartj/ehab679. PMID: 34586392Free PMC Article
Right Heart Failure: Causes and Clinical Epidemiology.
Ashraf H, Rosenthal JL
Cardiol Clin 2020 May;38(2):175-183. doi: 10.1016/j.ccl.2020.01.008. PMID: 32284095
Current outcomes and treatment of tetralogy of Fallot.
van der Ven JPG, van den Bosch E, Bogers AJCC, Helbing WA
F1000Res 2019;8 Epub 2019 Aug 29 doi: 10.12688/f1000research.17174.1. PMID: 31508203Free PMC Article
Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and meta-analysis.
Gorter TM, Hoendermis ES, van Veldhuisen DJ, Voors AA, Lam CS, Geelhoed B, Willems TP, van Melle JP
Eur J Heart Fail 2016 Dec;18(12):1472-1487. Epub 2016 Sep 20 doi: 10.1002/ejhf.630. PMID: 27650220

Clinical prediction guides

The Evolving Concept of Secondary Mitral Regurgitation Phenotypes: Lessons From the M-TEER Trials.
Stolz L, Doldi PM, Sannino A, Hausleiter J, Grayburn PA
JACC Cardiovasc Imaging 2024 Jun;17(6):659-668. Epub 2024 Mar 27 doi: 10.1016/j.jcmg.2024.01.012. PMID: 38551534
Transcatheter Mitral Valve Repair in Patients With Atrial Functional Mitral Regurgitation.
Doldi P, Stolz L, Orban M, Karam N, Praz F, Kalbacher D, Lubos E, Braun D, Adamo M, Giannini C, Melica B, Näbauer M, Higuchi S, Wild M, Neuss M, Butter C, Kassar M, Petrescu A, Pfister R, Iliadis C, Unterhuber M, Thiele H, Baldus S, von Bardeleben RS, Schofer N, Hagl C, Petronio AS, Massberg S, Windecker S, Lurz P, Metra M, Hausleiter J
JACC Cardiovasc Imaging 2022 Nov;15(11):1843-1851. Epub 2022 Jul 13 doi: 10.1016/j.jcmg.2022.05.009. PMID: 35842361
Biomarkers and Right Ventricular Dysfunction.
Pradhan NM, Mullin C, Poor HD
Crit Care Clin 2020 Jan;36(1):141-153. Epub 2019 Oct 21 doi: 10.1016/j.ccc.2019.08.011. PMID: 31733676Free PMC Article
Imaging Challenges in Tricuspid Regurgitation and Right Ventricular Failure.
Grayburn PA, Chandrashekhar Y
JACC Cardiovasc Imaging 2019 Apr;12(4):768-770. doi: 10.1016/j.jcmg.2019.03.001. PMID: 30947910
Echocardiographic evaluation of right ventricular systolic function: The traditional and innovative approach.
Smolarek D, Gruchała M, Sobiczewski W
Cardiol J 2017;24(5):563-572. Epub 2017 May 12 doi: 10.5603/CJ.a2017.0051. PMID: 28497844

Recent systematic reviews

Right Ventricle and Epigenetics: A Systematic Review.
Toro V, Jutras-Beaudoin N, Boucherat O, Bonnet S, Provencher S, Potus F
Cells 2023 Nov 23;12(23) doi: 10.3390/cells12232693. PMID: 38067121Free PMC Article
Safety and efficacy of ProtekDuo right ventricular assist device: A systemic review.
Alam A, Baran DA, Doshi H, Van Zyl J, Patlolla S, Salem M, Afzal A, Al-Saffar F, Hall SA
Artif Organs 2023 Jul;47(7):1094-1103. Epub 2023 Apr 3 doi: 10.1111/aor.14525. PMID: 37012224
Right ventricular dysfunction and tricuspid regurgitation in functional mitral regurgitation.
Truong VT, Ngo TNM, Mazur J, Nguyen HTM, Pham TTM, Palmer C, Pham KNP, Phan HT, Lee KS, Bannehr M, Butter C, Gyoten T, Chung ES
ESC Heart Fail 2021 Dec;8(6):4988-4996. Epub 2021 Sep 22 doi: 10.1002/ehf2.13558. PMID: 34551208Free PMC Article
Right Ventricular Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis.
Paternoster G, Bertini P, Innelli P, Trambaiolo P, Landoni G, Franchi F, Scolletta S, Guarracino F
J Cardiothorac Vasc Anesth 2021 Nov;35(11):3319-3324. Epub 2021 Apr 11 doi: 10.1053/j.jvca.2021.04.008. PMID: 33980426Free PMC Article
Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery: a systematic review and expert consensus statement.
Price LC, Martinez G, Brame A, Pickworth T, Samaranayake C, Alexander D, Garfield B, Aw TC, McCabe C, Mukherjee B, Harries C, Kempny A, Gatzoulis M, Marino P, Kiely DG, Condliffe R, Howard L, Davies R, Coghlan G, Schreiber BE, Lordan J, Taboada D, Gaine S, Johnson M, Church C, Kemp SV, Wong D, Curry A, Levett D, Price S, Ledot S, Reed A, Dimopoulos K, Wort SJ
Br J Anaesth 2021 Apr;126(4):774-790. Epub 2021 Feb 19 doi: 10.1016/j.bja.2021.01.005. PMID: 33612249

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