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Abnormal left ventricular ejection fraction

MedGen UID:
1815067
•Concept ID:
C5706161
•
Finding
HPO: HP:0034314

Definition

Any abnormality of the left ventricular ejection fraction (LVEF), which is the fraction of chamber volume ejected in systole (stroke volume) in relation to the volume of the blood in the ventricle at the end of diastole (end-diastolic volume). Stroke volume (SV) is calculated as the difference between end-diastolic volume (EDV) and end-systolic volume (ESV). LVEF is calculated as [SV/EDV] in percent. [from HPO]

Professional guidelines

PubMed

Treatment of systolic and diastolic heart failure in the elderly.
Aronow WS
J Am Med Dir Assoc 2006 Jan;7(1):29-36. Epub 2005 Oct 24 doi: 10.1016/j.jamda.2005.07.008. PMID: 16413432
Drug treatment of systolic and of diastolic heart failure in elderly persons.
Aronow WS
J Gerontol A Biol Sci Med Sci 2005 Dec;60(12):1597-605. doi: 10.1093/gerona/60.12.1597. PMID: 16424295
Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure in elderly patients.
Aronow WS
Heart Dis 2003 Jul-Aug;5(4):279-94. doi: 10.1097/01.hdx.0000080714.87750.48. PMID: 12877761

Recent clinical studies

Etiology

Artificial intelligence electrocardiogram as a novel screening tool to detect a newly abnormal left ventricular ejection fraction after anthracycline-based cancer therapy.
Jacobs JEJ, Greason G, Mangold KE, Wildiers H, Willems R, Janssens S, Noseworthy P, Lopez-Jimenez F, Voigt JU, Friedman P, Van Aelst L, Vandenberk B, Attia ZI, Herrmann J
Eur J Prev Cardiol 2024 Mar 27;31(5):560-566. doi: 10.1093/eurjpc/zwad348. PMID: 37943680Free PMC Article
The primary cardiomyopathy of systemic sclerosis on cardiovascular magnetic resonance imaging.
Chhikara S, Kanda A, Ogugua FM, Rouf R, Nouraee C, Bawaskar P, Molitor JA, Shenoy C
Eur Heart J Cardiovasc Imaging 2023 Nov 23;24(12):1661-1671. doi: 10.1093/ehjci/jead147. PMID: 37364296
Longitudinal Assessment of Cardiac Function Following Multisystem Inflammatory Syndrome in Children Associated with COVID-19.
Das N, Hill R, Trivedi M, Kenkre TS, Alsaied T, Feingold B, Harris TH, Christopher AB
Pediatr Cardiol 2023 Mar;44(3):607-617. Epub 2022 Jul 21 doi: 10.1007/s00246-022-02972-3. PMID: 35864203Free PMC Article
Prognostic utility of echocardiographically derived left ventricular strain in assessing neonatal enteroviral myocarditis outcome.
Bigg HF, Kindel SJ, Kuhn E, Frommelt PC
Cardiol Young 2023 May;33(5):704-709. Epub 2022 May 18 doi: 10.1017/S1047951122001512. PMID: 35582979
Factors associated with abnormal left ventricular ejection fraction (decreased or increased) in patients with sepsis in the intensive care unit.
Shin DG, Kang MK, Seo YB, Choi J, Choi SY, Choi S, Cho JR, Lee N
PLoS One 2020;15(3):e0229563. Epub 2020 Mar 10 doi: 10.1371/journal.pone.0229563. PMID: 32155161Free PMC Article

Diagnosis

Artificial intelligence electrocardiogram as a novel screening tool to detect a newly abnormal left ventricular ejection fraction after anthracycline-based cancer therapy.
Jacobs JEJ, Greason G, Mangold KE, Wildiers H, Willems R, Janssens S, Noseworthy P, Lopez-Jimenez F, Voigt JU, Friedman P, Van Aelst L, Vandenberk B, Attia ZI, Herrmann J
Eur J Prev Cardiol 2024 Mar 27;31(5):560-566. doi: 10.1093/eurjpc/zwad348. PMID: 37943680Free PMC Article
Prognostic utility of echocardiographically derived left ventricular strain in assessing neonatal enteroviral myocarditis outcome.
Bigg HF, Kindel SJ, Kuhn E, Frommelt PC
Cardiol Young 2023 May;33(5):704-709. Epub 2022 May 18 doi: 10.1017/S1047951122001512. PMID: 35582979
Factors associated with abnormal left ventricular ejection fraction (decreased or increased) in patients with sepsis in the intensive care unit.
Shin DG, Kang MK, Seo YB, Choi J, Choi SY, Choi S, Cho JR, Lee N
PLoS One 2020;15(3):e0229563. Epub 2020 Mar 10 doi: 10.1371/journal.pone.0229563. PMID: 32155161Free PMC Article
Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.
Slieker MG, Fackoury C, Slorach C, Hui W, Friedberg MK, Fan CS, Manlhiot C, Dillenburg R, Kantor P, Mital S, Liu P, Nathan PC, Mertens L
Circ Cardiovasc Imaging 2019 Dec;12(12):e008869. Epub 2019 Dec 12 doi: 10.1161/CIRCIMAGING.119.008869. PMID: 31826678
Abnormal left ventricular ejection fraction response to mental stress and exercise in cardiomyopathy.
Wolz DE, Flores AR, Grandis DJ, Orie JE, Schulman DS
J Nucl Cardiol 1995 Mar-Apr;2(2 Pt 1):144-50. doi: 10.1016/s1071-3581(95)80025-5. PMID: 9420779

Therapy

Artificial intelligence electrocardiogram as a novel screening tool to detect a newly abnormal left ventricular ejection fraction after anthracycline-based cancer therapy.
Jacobs JEJ, Greason G, Mangold KE, Wildiers H, Willems R, Janssens S, Noseworthy P, Lopez-Jimenez F, Voigt JU, Friedman P, Van Aelst L, Vandenberk B, Attia ZI, Herrmann J
Eur J Prev Cardiol 2024 Mar 27;31(5):560-566. doi: 10.1093/eurjpc/zwad348. PMID: 37943680Free PMC Article
Long-term prognostic value of right ventricular dysfunction on cardiovascular magnetic resonance imaging in anthracycline-treated cancer survivors.
Chhikara S, Hooks M, Athwal PSS, Hughes A, Ismail MF, Joppa S, Velangi PS, Nijjar PS, Blaes AH, Shenoy C
Eur Heart J Cardiovasc Imaging 2022 Aug 22;23(9):1222-1230. doi: 10.1093/ehjci/jeab137. PMID: 34297807Free PMC Article
Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.
Slieker MG, Fackoury C, Slorach C, Hui W, Friedberg MK, Fan CS, Manlhiot C, Dillenburg R, Kantor P, Mital S, Liu P, Nathan PC, Mertens L
Circ Cardiovasc Imaging 2019 Dec;12(12):e008869. Epub 2019 Dec 12 doi: 10.1161/CIRCIMAGING.119.008869. PMID: 31826678
Treatment of systolic and diastolic heart failure in the elderly.
Aronow WS
J Am Med Dir Assoc 2006 Jan;7(1):29-36. Epub 2005 Oct 24 doi: 10.1016/j.jamda.2005.07.008. PMID: 16413432
The management of ventricular arrhythmias in older patients after CAST.
Aronow WS
Drugs Aging 1995 Feb;6(2):112-24. doi: 10.2165/00002512-199506020-00004. PMID: 7711358

Prognosis

The primary cardiomyopathy of systemic sclerosis on cardiovascular magnetic resonance imaging.
Chhikara S, Kanda A, Ogugua FM, Rouf R, Nouraee C, Bawaskar P, Molitor JA, Shenoy C
Eur Heart J Cardiovasc Imaging 2023 Nov 23;24(12):1661-1671. doi: 10.1093/ehjci/jead147. PMID: 37364296
Prognostic utility of echocardiographically derived left ventricular strain in assessing neonatal enteroviral myocarditis outcome.
Bigg HF, Kindel SJ, Kuhn E, Frommelt PC
Cardiol Young 2023 May;33(5):704-709. Epub 2022 May 18 doi: 10.1017/S1047951122001512. PMID: 35582979
Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.
Slieker MG, Fackoury C, Slorach C, Hui W, Friedberg MK, Fan CS, Manlhiot C, Dillenburg R, Kantor P, Mital S, Liu P, Nathan PC, Mertens L
Circ Cardiovasc Imaging 2019 Dec;12(12):e008869. Epub 2019 Dec 12 doi: 10.1161/CIRCIMAGING.119.008869. PMID: 31826678
Ventricular tachycardia storm: a case series and literature review.
Chia PL, Loh SY, Foo D
Med J Malaysia 2012 Dec;67(6):582-4. PMID: 23770949
Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure in elderly patients.
Aronow WS
Heart Dis 2003 Jul-Aug;5(4):279-94. doi: 10.1097/01.hdx.0000080714.87750.48. PMID: 12877761

Clinical prediction guides

Strain Echocardiography and Myocardial Dysfunction in Critically Ill Children With Multisystem Inflammatory Syndrome Unrecognized by Conventional Echocardiography: A Retrospective Cohort Analysis.
Basu S, Kim EJ, Sharron MP, Austin A, Pollack MM, Harahsheh AS, Dham N
Pediatr Crit Care Med 2022 Mar 1;23(3):e145-e152. doi: 10.1097/PCC.0000000000002850. PMID: 34636357Free PMC Article
Sex-dependent association between inflammation, neural stress responses, and impaired myocardial function.
Fiechter M, Haider A, Bengs S, Marędziak M, Burger IA, Roggo A, Portmann A, Schade K, Warnock GI, Treyer V, Messerli M, Fuchs TA, Pazhenkottil AP, Buechel RR, Kaufmann PA, Gebhard C
Eur J Nucl Med Mol Imaging 2020 Jul;47(8):2010-2015. Epub 2019 Nov 7 doi: 10.1007/s00259-019-04537-8. PMID: 31701187
Echocardiographic Assessment of Cardiac Function in Pediatric Survivors of Anthracycline-Treated Childhood Cancer.
Slieker MG, Fackoury C, Slorach C, Hui W, Friedberg MK, Fan CS, Manlhiot C, Dillenburg R, Kantor P, Mital S, Liu P, Nathan PC, Mertens L
Circ Cardiovasc Imaging 2019 Dec;12(12):e008869. Epub 2019 Dec 12 doi: 10.1161/CIRCIMAGING.119.008869. PMID: 31826678
Warranty periods for normal myocardial perfusion stress SPECT.
Romero-Farina G, Candell-Riera J, Aguadé-Bruix S, Ferreira-González I, Cuberas-Borrós G, Pizzi N, García-Dorado D
J Nucl Cardiol 2015 Feb;22(1):44-54. Epub 2014 Aug 13 doi: 10.1007/s12350-014-9957-6. PMID: 25116906
Depression and disease severity in patients with premature acute coronary syndrome.
Pelletier R, Lavoie KL, Bacon SL, Thanassoulis G, Khan NA, Pilote L; GENESIS-PRAXY Investigators
Am J Med 2014 Jan;127(1):87-93.e1-2. Epub 2013 Oct 16 doi: 10.1016/j.amjmed.2013.09.026. PMID: 24384103

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