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Adult Brain Neoplasm

MedGen UID:
65076
•Concept ID:
C0220624
•
Neoplastic Process
Synonyms: Adult Brain Tumor; Brain Neoplasms, Adult; Neoplasm of Adult Brain; Neoplasm of the Adult Brain; Tumor of Adult Brain; Tumor of the Adult Brain

Definition

A benign or malignant, primary or metastatic neoplasm of the brain occurring in adults. [from NCI]

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society
J Clin Endocrinol Metab 2011 Feb;96(2):273-88. doi: 10.1210/jc.2010-1692. PMID: 21296991

Recent clinical studies

Etiology

Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Primary Brain Tumors in Adults: Diagnosis and Treatment.
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790
Anaplastic astrocytoma in adults.
Stupp R, Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):72-80. Epub 2007 May 2 doi: 10.1016/j.critrevonc.2007.03.003. PMID: 17478095
Pineoblastoma in adults.
Chang SM, Lillis-Hearne PK, Larson DA, Wara WM, Bollen AW, Prados MD
Neurosurgery 1995 Sep;37(3):383-90; discussion 390-1. doi: 10.1227/00006123-199509000-00003. PMID: 7501100

Diagnosis

Adolescents and young adults with brain tumors in the context of molecular advances in neuro-oncology.
Zapotocky M, Ramaswamy V, Lassaletta A, Bouffet E
Pediatr Blood Cancer 2018 Feb;65(2) Epub 2017 Oct 19 doi: 10.1002/pbc.26861. PMID: 29049858
Stereotactic Radiosurgery and Hypofractionated Radiotherapy for Glioblastoma.
Shah JL, Li G, Shaffer JL, Azoulay MI, Gibbs IC, Nagpal S, Soltys SG
Neurosurgery 2018 Jan 1;82(1):24-34. doi: 10.1093/neuros/nyx115. PMID: 28605463
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Angioleiomyoma of the falx.
Calle S, Louis D, Westmark R, Westmark K
J Radiol Case Rep 2016 Apr;10(4):8-15. Epub 2016 Apr 30 doi: 10.3941/jrcr.v10i4.2713. PMID: 27200167Free PMC Article
Primary Brain Tumors in Adults: Diagnosis and Treatment.
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614

Therapy

Contemporary RNA Therapeutics for Glioblastoma.
Melnick K, Dastmalchi F, Mitchell D, Rahman M, Sayour EJ
Neuromolecular Med 2022 Mar;24(1):8-12. Epub 2021 Jun 8 doi: 10.1007/s12017-021-08669-9. PMID: 34101090Free PMC Article
Molecularly Targeted Clinical Trials.
Smith-Cohn MA, Celiku O, Gilbert MR
Neurosurg Clin N Am 2021 Apr;32(2):191-210. Epub 2021 Feb 18 doi: 10.1016/j.nec.2020.12.002. PMID: 33781502
GammaTile(®): Surgically targeted radiation therapy for glioblastomas.
Gessler DJ, Ferreira C, Dusenbery K, Chen CC
Future Oncol 2020 Oct;16(30):2445-2455. Epub 2020 Jul 3 doi: 10.2217/fon-2020-0558. PMID: 32618209
Glioblastoma in older adults.
Holdhoff M, Rothenberger R, Browner IE
Aging (Albany NY) 2018 Feb 1;10(2):154-155. doi: 10.18632/aging.101377. PMID: 29394496Free PMC Article
Anaplastic astrocytoma in adults.
Stupp R, Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):72-80. Epub 2007 May 2 doi: 10.1016/j.critrevonc.2007.03.003. PMID: 17478095

Prognosis

Surveillance imaging in pediatric ependymoma.
Klawinski D, Indelicato DJ, Hossain J, Sandler E
Pediatr Blood Cancer 2020 Nov;67(11):e28622. Epub 2020 Aug 3 doi: 10.1002/pbc.28622. PMID: 32743915
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016.
Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150. PMID: 31675094Free PMC Article
Neuro-oncology dilemma: Tumour or tumefactive demyelinating lesion.
Abdoli M, Freedman MS
Mult Scler Relat Disord 2015 Nov;4(6):555-66. Epub 2015 Jul 29 doi: 10.1016/j.msard.2015.07.013. PMID: 26590662
Demographics of brain metastasis.
Johnson JD, Young B
Neurosurg Clin N Am 1996 Jul;7(3):337-44. PMID: 8823767
Pineoblastoma in adults.
Chang SM, Lillis-Hearne PK, Larson DA, Wara WM, Bollen AW, Prados MD
Neurosurgery 1995 Sep;37(3):383-90; discussion 390-1. doi: 10.1227/00006123-199509000-00003. PMID: 7501100

Clinical prediction guides

Extrachromosomal DNA: Redefining the pathogenesis of glioblastoma.
Shiras A, Mondal A
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188551. Epub 2021 Apr 20 doi: 10.1016/j.bbcan.2021.188551. PMID: 33892052
Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients.
Chen P, Zhang G, Zhou Q, Li Z
Biosci Rep 2020 Jul 31;40(7) doi: 10.1042/BSR20201449. PMID: 32639004Free PMC Article
Effect of MRI-based semiautomatic size-assessment in cerebral metastases on the RANO-BM classification.
Bauknecht HC, Klingebiel R, Hein P, Wolf C, Bornemann L, Siebert E, Bohner G
Clin Neuroradiol 2020 Jun;30(2):263-270. Epub 2019 Jun 13 doi: 10.1007/s00062-019-00785-1. PMID: 31197388
Epidemiology and Overview of Gliomas.
Davis ME
Semin Oncol Nurs 2018 Dec;34(5):420-429. Epub 2018 Nov 2 doi: 10.1016/j.soncn.2018.10.001. PMID: 30392758
The emerging role of advanced neuroimaging techniques for brain metastases.
Nowosielski M, Radbruch A
Chin Clin Oncol 2015 Jun;4(2):23. doi: 10.3978/j.issn.2304-3865.2015.05.04. PMID: 26112809

Recent systematic reviews

Telomerase inhibition in malignant gliomas: a systematic review.
D'Alessandris QG, Battistelli M, Pennisi G, Offi M, Martini M, Cenci T, Falchetti ML, Lauretti L, Olivi A, Pallini R, Montano N
Expert Rev Mol Med 2023 Mar 15;25:e10. doi: 10.1017/erm.2023.6. PMID: 36919343
Epstein-Barr Virus and Astrocytoma.
Freixo C, Hermouet S, Neves AM
Crit Rev Oncog 2019;24(4):339-347. doi: 10.1615/CritRevOncog.2020032954. PMID: 32421989
Mortality in adults with hypopituitarism: a systematic review and meta-analysis.
Jasim S, Alahdab F, Ahmed AT, Tamhane S, Prokop LJ, Nippoldt TB, Murad MH
Endocrine 2017 Apr;56(1):33-42. Epub 2016 Nov 5 doi: 10.1007/s12020-016-1159-3. PMID: 27817141
Subdural Hematoma Mimickers: A Systematic Review.
Catana D, Koziarz A, Cenic A, Nath S, Singh S, Almenawer SA, Kachur E
World Neurosurg 2016 Sep;93:73-80. Epub 2016 Jun 4 doi: 10.1016/j.wneu.2016.05.084. PMID: 27268313
Cerebral microbleeds: histopathological correlation of neuroimaging.
Shoamanesh A, Kwok CS, Benavente O
Cerebrovasc Dis 2011;32(6):528-34. Epub 2011 Nov 18 doi: 10.1159/000331466. PMID: 22104448

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