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Adult Benign Brain Stem Neoplasm

MedGen UID:
272351
•Concept ID:
C1332467
•
Neoplastic Process
Synonyms: Adult Benign Brain Stem Neoplasms; Benign Adult Brain Stem Neoplasm; Benign Adult Brain Stem Tumor; Benign Adult Brain Stem Tumors; Benign Adult Brainstem Neoplasm; Benign Adult Brainstem Neoplasms; Benign Adult Brainstem Tumor; Benign Adult Brainstem Tumors; Benign Neoplasm of Adult Brain Stem; Benign Neoplasm of Adult Brainstem; Benign Neoplasm of the Adult Brain Stem; Benign Neoplasm of the Adult Brainstem; Benign Tumor of Adult Brain Stem; Benign Tumor of Adult Brainstem; Benign Tumor of the Adult Brain Stem; Benign Tumor of the Adult Brainstem

Definition

A benign neoplasm of the brain stem occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Benign Brain Stem Neoplasm

Professional guidelines

PubMed

Safety and efficacy of surgical treatment for brainstem hemangioblastoma: a meta-analysis.
Yin X, Li C, Li L, Duan H
Neurosurg Rev 2021 Apr;44(2):799-806. Epub 2020 Apr 30 doi: 10.1007/s10143-020-01305-3. PMID: 32356022Free PMC Article
The use of proton therapy in the treatment of benign or low-grade pediatric brain tumors.
Eaton BR, Yock T
Cancer J 2014 Nov-Dec;20(6):403-8. doi: 10.1097/PPO.0000000000000079. PMID: 25415686
Does conservative management for brain stem cavernomas have better long-term outcome?
Tarnaris A, Fernandes RP, Kitchen ND
Br J Neurosurg 2008 Dec;22(6):748-57. doi: 10.1080/02688690802354210. PMID: 19085358

Recent clinical studies

Etiology

CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
The integrated genomic and epigenomic landscape of brainstem glioma.
Chen LH, Pan C, Diplas BH, Xu C, Hansen LJ, Wu Y, Chen X, Geng Y, Sun T, Sun Y, Zhang P, Wu Z, Zhang J, Li D, Zhang Y, Wu W, Wang Y, Li G, Yang J, Wang X, Xu C, Wang S, Waitkus MS, He Y, McLendon RE, Ashley DM, Yan H, Zhang L
Nat Commun 2020 Jun 17;11(1):3077. doi: 10.1038/s41467-020-16682-y. PMID: 32555164Free PMC Article
Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course.
Delev D, Daka K, Heynckes S, Gaebelein A, Franco P, Pfeifer D, Prinz M, Schnell O, Urbach H, Mader I, Beck J, Grote A, Becker AJ, Heiland DH
Sci Rep 2020 Jan 9;10(1):96. doi: 10.1038/s41598-019-56146-y. PMID: 31919458Free PMC Article
Intracranial Subependymoma: A SEER Analysis 2004-2013.
Nguyen HS, Doan N, Gelsomino M, Shabani S
World Neurosurg 2017 May;101:599-605. Epub 2017 Feb 15 doi: 10.1016/j.wneu.2017.02.019. PMID: 28232153
Central nervous system.
Adamson DC, Rasheed BA, McLendon RE, Bigner DD
Cancer Biomark 2010;9(1-6):193-210. doi: 10.3233/CBM-2011-0177. PMID: 22112477

Diagnosis

CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course.
Delev D, Daka K, Heynckes S, Gaebelein A, Franco P, Pfeifer D, Prinz M, Schnell O, Urbach H, Mader I, Beck J, Grote A, Becker AJ, Heiland DH
Sci Rep 2020 Jan 9;10(1):96. doi: 10.1038/s41598-019-56146-y. PMID: 31919458Free PMC Article
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
Central nervous system.
Adamson DC, Rasheed BA, McLendon RE, Bigner DD
Cancer Biomark 2010;9(1-6):193-210. doi: 10.3233/CBM-2011-0177. PMID: 22112477
Malignant intracerebellar schwannoma.
Maiuri F, Colella G, D'Acunzi G, De Caro Mdel B
J Neurooncol 2004 Jan;66(1-2):191-5. doi: 10.1023/b:neon.0000013476.26986.7a. PMID: 15015786

Therapy

CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
Targeting BC200/miR218-5p Signaling Axis for Overcoming Temozolomide Resistance and Suppressing Glioma Stemness.
Su YK, Lin JW, Shih JW, Chuang HY, Fong IH, Yeh CT, Lin CM
Cells 2020 Aug 8;9(8) doi: 10.3390/cells9081859. PMID: 32784466Free PMC Article
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
Brain-stem hemangioblastomas: The seemingly innocuous lesion in a perilous location.
Joseph J, Behari S, Gupta S, Bhaisora KS, Gandhi A, Srivastava A, Jaiswal AK
Neurol India 2018 May-Jun;66(3):779-796. doi: 10.4103/0028-3886.232294. PMID: 29766943
The use of proton therapy in the treatment of benign or low-grade pediatric brain tumors.
Eaton BR, Yock T
Cancer J 2014 Nov-Dec;20(6):403-8. doi: 10.1097/PPO.0000000000000079. PMID: 25415686

Prognosis

The Present and Future of Optic Pathway Glioma Therapy.
Dal Bello S, Martinuzzi D, Tereshko Y, Veritti D, Sarao V, Gigli GL, Lanzetta P, Valente M
Cells 2023 Sep 29;12(19) doi: 10.3390/cells12192380. PMID: 37830595Free PMC Article
CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course.
Delev D, Daka K, Heynckes S, Gaebelein A, Franco P, Pfeifer D, Prinz M, Schnell O, Urbach H, Mader I, Beck J, Grote A, Becker AJ, Heiland DH
Sci Rep 2020 Jan 9;10(1):96. doi: 10.1038/s41598-019-56146-y. PMID: 31919458Free PMC Article
Intracranial Subependymoma: A SEER Analysis 2004-2013.
Nguyen HS, Doan N, Gelsomino M, Shabani S
World Neurosurg 2017 May;101:599-605. Epub 2017 Feb 15 doi: 10.1016/j.wneu.2017.02.019. PMID: 28232153
Central nervous system.
Adamson DC, Rasheed BA, McLendon RE, Bigner DD
Cancer Biomark 2010;9(1-6):193-210. doi: 10.3233/CBM-2011-0177. PMID: 22112477

Clinical prediction guides

CNS Tumors - clinical and radiological aspects.
Emmerová R, Engelová J, Vinakurau S, Ondrová B
Cesk Patol 2022 Fall;58(3):150-160. PMID: 36224037
Targeting BC200/miR218-5p Signaling Axis for Overcoming Temozolomide Resistance and Suppressing Glioma Stemness.
Su YK, Lin JW, Shih JW, Chuang HY, Fong IH, Yeh CT, Lin CM
Cells 2020 Aug 8;9(8) doi: 10.3390/cells9081859. PMID: 32784466Free PMC Article
Tectal plate tumours. Our experience with a paediatric surgical series.
Mottolese C, Szathmari A, Beuriat PA, Frappaz D, Jouvet A, Hermier M
Neurochirurgie 2015 Apr-Jun;61(2-3):193-200. Epub 2014 Oct 16 doi: 10.1016/j.neuchi.2013.12.007. PMID: 25441707
Long-term functional outcome of patients with cerebellar pilocytic astrocytoma surgically treated in childhood.
Ait Khelifa-Gallois N, Laroussinie F, Puget S, Sainte-Rose C, Dellatolas G
Brain Inj 2015;29(3):366-73. Epub 2014 Nov 10 doi: 10.3109/02699052.2014.975281. PMID: 25383654
Pediatric tectal plate gliomas: clinical and radiological progression, MR imaging characteristics, and management of hydrocephalus.
Griessenauer CJ, Rizk E, Miller JH, Hendrix P, Tubbs RS, Dias MS, Riemenschneider K, Chern JJ
J Neurosurg Pediatr 2014 Jan;13(1):13-20. Epub 2013 Nov 1 doi: 10.3171/2013.9.PEDS13347. PMID: 24180680

Recent systematic reviews

Safety and efficacy of surgical treatment for brainstem hemangioblastoma: a meta-analysis.
Yin X, Li C, Li L, Duan H
Neurosurg Rev 2021 Apr;44(2):799-806. Epub 2020 Apr 30 doi: 10.1007/s10143-020-01305-3. PMID: 32356022Free PMC Article

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