U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lobular breast carcinoma in situ

MedGen UID:
79007
Concept ID:
C0279563
Neoplastic Process
Synonyms: Lobular carcinoma in situ; Lobular carcinoma in situ of breast
SNOMED CT: Lobular carcinoma in situ of breast (109888004); LCIS (lobular carcinoma in situ) of breast (109888004)
 
HPO: HP:0030076
Monarch Initiative: MONDO:0006270

Definition

A non-invasive adenocarcinoma of the breast characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma. [from NCI]

Professional guidelines

PubMed

Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Pleasant V
Best Pract Res Clin Obstet Gynaecol 2022 Sep;83:46-59. Epub 2022 Apr 4 doi: 10.1016/j.bpobgyn.2022.03.017. PMID: 35570155
Maughan KL, Lutterbie MA, Ham PS
Am Fam Physician 2010 Jun 1;81(11):1339-46. PMID: 20521754

Recent clinical studies

Etiology

Chapman JA, Costantino JP, Dong B, Margolese RG, Pritchard KI, Shepherd LE, Gelmon KA, Wolmark N, Pollak MN
Breast Cancer Res Treat 2015 Sep;153(2):353-60. Epub 2015 Aug 15 doi: 10.1007/s10549-015-3547-4. PMID: 26276354Free PMC Article
Claus EB, Stowe M, Carter D, Holford T
Breast 2003 Dec;12(6):451-6. doi: 10.1016/s0960-9776(03)00152-8. PMID: 14659121

Diagnosis

Zaloga AR, Card KR, Shields CL
JAMA Ophthalmol 2023 Feb 1;141(2):208-209. doi: 10.1001/jamaophthalmol.2022.5544. PMID: 36547944
Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article
Claus EB, Stowe M, Carter D, Holford T
Breast 2003 Dec;12(6):451-6. doi: 10.1016/s0960-9776(03)00152-8. PMID: 14659121

Therapy

Chapman JA, Costantino JP, Dong B, Margolese RG, Pritchard KI, Shepherd LE, Gelmon KA, Wolmark N, Pollak MN
Breast Cancer Res Treat 2015 Sep;153(2):353-60. Epub 2015 Aug 15 doi: 10.1007/s10549-015-3547-4. PMID: 26276354Free PMC Article
Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article

Prognosis

Chapman JA, Costantino JP, Dong B, Margolese RG, Pritchard KI, Shepherd LE, Gelmon KA, Wolmark N, Pollak MN
Breast Cancer Res Treat 2015 Sep;153(2):353-60. Epub 2015 Aug 15 doi: 10.1007/s10549-015-3547-4. PMID: 26276354Free PMC Article
Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article

Clinical prediction guides

Papantoniou V, Tsiouris S, Mainta E, Valotassiou V, Souvatzoglou M, Sotiropoulou M, Nakopoulou L, Lazaris D, Louvrou A, Melissinou M, Tzannetaki A, Pirmettis I, Koutsikos J, Zerva C
Breast Cancer Res 2005;7(1):R33-45. Epub 2004 Nov 8 doi: 10.1186/bcr948. PMID: 15642168Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...