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Lung occult squamous cell carcinoma

MedGen UID:
235400
•Concept ID:
C1335100
•
Neoplastic Process
Synonyms: lung occult squamous cell carcinoma; Occult Lung Squamous Cell Carcinoma; Occult Squamous Cell Carcinoma of Lung; occult squamous cell carcinoma of lung; Occult Squamous Cell Carcinoma of the Lung; occult squamous cell carcinoma of the lung; Occult Squamous Cell Lung Carcinoma; occult squamous cell lung carcinoma
 
Monarch Initiative: MONDO:0003904

Definition

A squamous cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung occult squamous cell carcinoma

Professional guidelines

PubMed

Management of field change in actinic keratosis.
Vatve M, Ortonne JP, Birch-Machin MA, Gupta G
Br J Dermatol 2007 Dec;157 Suppl 2:21-4. doi: 10.1111/j.1365-2133.2007.08268.x. PMID: 18067627
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
Bronchoscopic localization and treatment of occult lung cancer.
Edell ES, Cortese DA
Chest 1989 Oct;96(4):919-21. doi: 10.1378/chest.96.4.919. PMID: 2529106

Recent clinical studies

Etiology

Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis.
Song Z, Zhu S, Chen T, Zhao W
J Cardiothorac Surg 2021 Nov 18;16(1):333. doi: 10.1186/s13019-021-01717-2. PMID: 34794482Free PMC Article
Detection of Occult Micrometastases in Patients With Clinical Stage I Non-Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance).
Martin LW, D'Cunha J, Wang X, Herzan D, Gu L, Abraham N, Demmy TL, Detterbeck FC, Groth SS, Harpole DH, Krasna MJ, Kernstine K, Kohman LJ, Patterson GA, Sugarbaker DJ, Vollmer RT, Maddaus MA, Kratzke RA
J Clin Oncol 2016 May 1;34(13):1484-91. Epub 2016 Feb 29 doi: 10.1200/JCO.2015.63.4543. PMID: 26926677Free PMC Article
Nomogram to Predict Occult N2 Lymph Nodes Metastases in Patients With Squamous Nonsmall Cell Lung Cancer.
Jiang L, Jiang S, Lin Y, Yang H, Xie Z, Lin Y, Long H
Medicine (Baltimore) 2015 Nov;94(46):e2054. doi: 10.1097/MD.0000000000002054. PMID: 26579815Free PMC Article
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
The influence of lung cancer mass screening on surgical results.
Koike T, Terashima M, Takizawa T, Haga M, Kurita Y, Yokoyama A, Misawa H
Lung Cancer 1999 May;24(2):75-80. doi: 10.1016/s0169-5002(99)00031-8. PMID: 10444057

Diagnosis

Detection of Occult Micrometastases in Patients With Clinical Stage I Non-Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance).
Martin LW, D'Cunha J, Wang X, Herzan D, Gu L, Abraham N, Demmy TL, Detterbeck FC, Groth SS, Harpole DH, Krasna MJ, Kernstine K, Kohman LJ, Patterson GA, Sugarbaker DJ, Vollmer RT, Maddaus MA, Kratzke RA
J Clin Oncol 2016 May 1;34(13):1484-91. Epub 2016 Feb 29 doi: 10.1200/JCO.2015.63.4543. PMID: 26926677Free PMC Article
Nomogram to Predict Occult N2 Lymph Nodes Metastases in Patients With Squamous Nonsmall Cell Lung Cancer.
Jiang L, Jiang S, Lin Y, Yang H, Xie Z, Lin Y, Long H
Medicine (Baltimore) 2015 Nov;94(46):e2054. doi: 10.1097/MD.0000000000002054. PMID: 26579815Free PMC Article
Gastrointestinal hemorrhage due to ileal metastasis from primary lung cancer.
Liu W, Zhou W, Qi WL, Ma YD, Xu YY
World J Gastroenterol 2015 Mar 21;21(11):3435-40. doi: 10.3748/wjg.v21.i11.3435. PMID: 25805957Free PMC Article
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
Squamous cell carcinoma of the lung: an update.
Carter D
Semin Diagn Pathol 1985 Nov;2(4):226-34. PMID: 3916556

Therapy

Unclassifiable Infectious Complications after Lobectomy for Cancer: Etiology, Risks, and Outcomes.
Ueda K, Murakami J, Tanaka T, Hamano K
Thorac Cardiovasc Surg 2019 Jun;67(4):315-320. Epub 2018 Aug 28 doi: 10.1055/s-0038-1668600. PMID: 30153699
Detection of Occult Micrometastases in Patients With Clinical Stage I Non-Small-Cell Lung Cancer: A Prospective Analysis of Mature Results of CALGB 9761 (Alliance).
Martin LW, D'Cunha J, Wang X, Herzan D, Gu L, Abraham N, Demmy TL, Detterbeck FC, Groth SS, Harpole DH, Krasna MJ, Kernstine K, Kohman LJ, Patterson GA, Sugarbaker DJ, Vollmer RT, Maddaus MA, Kratzke RA
J Clin Oncol 2016 May 1;34(13):1484-91. Epub 2016 Feb 29 doi: 10.1200/JCO.2015.63.4543. PMID: 26926677Free PMC Article
Management of field change in actinic keratosis.
Vatve M, Ortonne JP, Birch-Machin MA, Gupta G
Br J Dermatol 2007 Dec;157 Suppl 2:21-4. doi: 10.1111/j.1365-2133.2007.08268.x. PMID: 18067627
Concurrent cisplatin, etoposide, and radiotherapy for unresectable stage III nonsmall cell lung cancer: a phase II study.
Reboul F, Brewer Y, Vincent P, Chauvet B, Faure CF, Taulelle M
Int J Radiat Oncol Biol Phys 1996 May 1;35(2):343-50. doi: 10.1016/0360-3016(96)00087-9. PMID: 8635942
Total (half-body) systemic irradiation for occult metastases in non-small cell lung cancer: an Eastern Cooperative Oncology Group pilot report.
Salazar OM, Scarantino CW, Rubin P, Feldstein ML, Keller BE
Cancer 1980 Nov 1;46(9):1932-44. doi: 10.1002/1097-0142(19801101)46:9<1932::aid-cncr2820460907>3.0.co;2-9. PMID: 7427899

Prognosis

EVI1 as a Marker for Lymph Node Metastasis in HNSCC.
Idel C, Ribbat-Idel J, Kuppler P, Krupar R, Offermann A, Vogel W, Rades D, Kirfel J, Wollenberg B, Perner S
Int J Mol Sci 2020 Jan 28;21(3) doi: 10.3390/ijms21030854. PMID: 32013033Free PMC Article
Nomogram to Predict Occult N2 Lymph Nodes Metastases in Patients With Squamous Nonsmall Cell Lung Cancer.
Jiang L, Jiang S, Lin Y, Yang H, Xie Z, Lin Y, Long H
Medicine (Baltimore) 2015 Nov;94(46):e2054. doi: 10.1097/MD.0000000000002054. PMID: 26579815Free PMC Article
Diagnosis and management of neck metastases from an unknown primary.
Calabrese L, Jereczek-Fossa BA, Jassem J, Rocca A, Bruschini R, Orecchia R, Chiesa F
Acta Otorhinolaryngol Ital 2005 Feb;25(1):2-12. PMID: 16080309Free PMC Article
Allelic loss on 17p13 (TP53) and allelic loss on 3p21 in early squamous cell carcinoma of the lung.
Endo C, Sato M, Fujimura S, Sakurada A, Aikawa H, Takahashi S, Usuda K, Saito Y, Sagawa M
Surg Today 2000;30(8):695-9. doi: 10.1007/s005950070079. PMID: 10955731
Prognosis and survival in resected lung carcinoma based on the new international staging system.
Naruke T, Goya T, Tsuchiya R, Suemasu K
J Thorac Cardiovasc Surg 1988 Sep;96(3):440-7. PMID: 2842549

Clinical prediction guides

Prevalence, molecular markers, and outcome of bronchial squamous carcinoma in situ in high-risk subjects.
Jonsson S, Franklin WA, Varella-Garcia M, Kennedy TC, Merrick D, Matney KD, Oskarsdottir GN, Saemundsson A, Keith RL, Bunn PA, Miller YE
APMIS 2023 Oct;131(10):513-527. Epub 2023 Aug 23 doi: 10.1111/apm.13345. PMID: 37608782
Nomogram to Predict Occult N2 Lymph Nodes Metastases in Patients With Squamous Nonsmall Cell Lung Cancer.
Jiang L, Jiang S, Lin Y, Yang H, Xie Z, Lin Y, Long H
Medicine (Baltimore) 2015 Nov;94(46):e2054. doi: 10.1097/MD.0000000000002054. PMID: 26579815Free PMC Article
A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.
Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones KD, Raz DJ, Xu Z, Jahan TM, Berryman D, He B, Mann MJ, Jablons DM
Lancet 2012 Mar 3;379(9818):823-32. Epub 2012 Jan 27 doi: 10.1016/S0140-6736(11)61941-7. PMID: 22285053Free PMC Article
Immunocytochemical detection of occult tumor cells in the bone marrow: prognostic impact on early stages of lung cancer.
Nosotti M, Tosi D, Palleschi A, Rosso L, Mendogni P, Santambrogio L
Eur Surg Res 2008;41(3):267-71. Epub 2008 Jul 1 doi: 10.1159/000141961. PMID: 18594145
Risk factors for occult nodal metastasis in clinical T1N0 lung cancer: a negative impact on survival.
Veeramachaneni NK, Battafarano RJ, Meyers BF, Zoole JB, Patterson GA
Eur J Cardiothorac Surg 2008 Mar;33(3):466-9. Epub 2008 Jan 31 doi: 10.1016/j.ejcts.2007.12.015. PMID: 18249130

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