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Deficiency Disease

MedGen UID:
4169
Concept ID:
C0011156
Disease or Syndrome
Synonyms: Deficiency Diseases; Disease, Deficiency; Diseases, Deficiency

Definition

A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed) [from MeSH]

Professional guidelines

PubMed

Sakane EN, Vieira MCC, Vieira GMM, Maeda SS
Arch Endocrinol Metab 2022 Nov 11;66(5):651-657. doi: 10.20945/2359-3997000000554. PMID: 36382754Free PMC Article
Carr AC, McCall C
J Transl Med 2017 Apr 14;15(1):77. doi: 10.1186/s12967-017-1179-7. PMID: 28410599Free PMC Article
Greulich T
COPD 2017 Mar 15;14(sup1):S8-S11. doi: 10.1080/15412555.2017.1286166. PMID: 28306355

Recent clinical studies

Etiology

Scharre S, Posset R, Garbade SF, Gleich F, Seidl MJ, Druck AC, Okun JG, Gropman AL, Nagamani SCS, Hoffmann GF, Kölker S, Zielonka M; Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD) Consortia Study Group
Ann Clin Transl Neurol 2022 Nov;9(11):1715-1726. Epub 2022 Oct 10 doi: 10.1002/acn3.51668. PMID: 36217298Free PMC Article
Goudouris ES, Segundo GRS, Poli C
J Pediatr (Rio J) 2019 Mar-Apr;95 Suppl 1:49-58. Epub 2018 Dec 26 doi: 10.1016/j.jped.2018.11.006. PMID: 30593791
Stern W
J Inherit Metab Dis 2016 Mar;39(2):321-4. doi: 10.1007/s10545-015-9908-7. PMID: 26743057
Wood TC, Harvey K, Beck M, Burin MG, Chien YH, Church HJ, D'Almeida V, van Diggelen OP, Fietz M, Giugliani R, Harmatz P, Hawley SM, Hwu WL, Ketteridge D, Lukacs Z, Miller N, Pasquali M, Schenone A, Thompson JN, Tylee K, Yu C, Hendriksz CJ
J Inherit Metab Dis 2013 Mar;36(2):293-307. Epub 2013 Feb 1 doi: 10.1007/s10545-013-9587-1. PMID: 23371450Free PMC Article
Robinson BH, Sherwood WG
J Inherit Metab Dis 1984;7 Suppl 1:69-73. doi: 10.1007/BF03047378. PMID: 6434848

Diagnosis

Lo RS, Cromie GA, Tang M, Teng K, Owens K, Sirr A, Kutz JN, Morizono H, Caldovic L, Ah Mew N, Gropman A, Dudley AM
Am J Hum Genet 2023 May 4;110(5):863-879. doi: 10.1016/j.ajhg.2023.03.019. PMID: 37146589Free PMC Article
Yoneda K
J Dermatol 2016 Mar;43(3):252-63. doi: 10.1111/1346-8138.13284. PMID: 26945533
Stern W
J Inherit Metab Dis 2016 Mar;39(2):321-4. doi: 10.1007/s10545-015-9908-7. PMID: 26743057
Häberle J, Shchelochkov OA, Wang J, Katsonis P, Hall L, Reiss S, Eeds A, Willis A, Yadav M, Summar S; Urea Cycle Disorders Consortium, Lichtarge O, Rubio V, Wong LJ, Summar M
Hum Mutat 2011 Jun;32(6):579-89. Epub 2011 May 5 doi: 10.1002/humu.21406. PMID: 21120950Free PMC Article
Wallace JC, Jitrapakdee S, Chapman-Smith A
Int J Biochem Cell Biol 1998 Jan;30(1):1-5. doi: 10.1016/s1357-2725(97)00147-7. PMID: 9597748

Therapy

Sakane EN, Vieira MCC, Vieira GMM, Maeda SS
Arch Endocrinol Metab 2022 Nov 11;66(5):651-657. doi: 10.20945/2359-3997000000554. PMID: 36382754Free PMC Article
Smirnikhina SA
Curr Gene Ther 2022;22(5):386-396. doi: 10.2174/1566523222666220720102556. PMID: 35864800
Klimant E, Wright H, Rubin D, Seely D, Markman M
Curr Oncol 2018 Apr;25(2):139-148. Epub 2018 Apr 30 doi: 10.3747/co.25.3790. PMID: 29719430Free PMC Article
Brunskill NJ
J Intern Med 2017 Jan;281(1):41-51. Epub 2016 Sep 19 doi: 10.1111/joim.12548. PMID: 27640884
Wilson JM
Mol Genet Metab 2009 Apr;96(4):151-7. Epub 2009 Feb 10 doi: 10.1016/j.ymgme.2008.12.016. PMID: 19211285

Prognosis

Zhang S, Hu Y, Wu Z, Zhou X, Wu T, Li P, Lian Q, Xu S, Gu J, Chen L, Wu G, Zhang T, Tang J, Xue J
Int J Radiat Oncol Biol Phys 2023 Apr 1;115(5):1244-1256. Epub 2022 Nov 22 doi: 10.1016/j.ijrobp.2022.11.022. PMID: 36423742
Scharre S, Posset R, Garbade SF, Gleich F, Seidl MJ, Druck AC, Okun JG, Gropman AL, Nagamani SCS, Hoffmann GF, Kölker S, Zielonka M; Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD) Consortia Study Group
Ann Clin Transl Neurol 2022 Nov;9(11):1715-1726. Epub 2022 Oct 10 doi: 10.1002/acn3.51668. PMID: 36217298Free PMC Article
Gleich GJ, Klion AD, Lee JJ, Weller PF
Allergy 2013 Jul;68(7):829-35. Epub 2013 Jun 6 doi: 10.1111/all.12169. PMID: 23742015Free PMC Article
Brusilow SW
Medicine (Baltimore) 2002 May;81(3):240-9. doi: 10.1097/00005792-200205000-00007. PMID: 11997720
Wraith JE
Arch Dis Child 2001 Jan;84(1):84-88. doi: 10.1136/adc.84.1.84. PMID: 11124797Free PMC Article

Clinical prediction guides

Lo RS, Cromie GA, Tang M, Teng K, Owens K, Sirr A, Kutz JN, Morizono H, Caldovic L, Ah Mew N, Gropman A, Dudley AM
Am J Hum Genet 2023 May 4;110(5):863-879. doi: 10.1016/j.ajhg.2023.03.019. PMID: 37146589Free PMC Article
Scharre S, Posset R, Garbade SF, Gleich F, Seidl MJ, Druck AC, Okun JG, Gropman AL, Nagamani SCS, Hoffmann GF, Kölker S, Zielonka M; Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD) Consortia Study Group
Ann Clin Transl Neurol 2022 Nov;9(11):1715-1726. Epub 2022 Oct 10 doi: 10.1002/acn3.51668. PMID: 36217298Free PMC Article
Segundo GRS
J Pediatr (Rio J) 2021 Mar-Apr;97 Suppl 1(Suppl 1):S3-S9. Epub 2020 Oct 26 doi: 10.1016/j.jped.2020.09.007. PMID: 33121930Free PMC Article
Firouzi M, Sherkatolabbasieh H, Shafizadeh S
Endocr Metab Immune Disord Drug Targets 2021;21(2):288-297. doi: 10.2174/1871530320666200704144912. PMID: 32621723
Gleich GJ, Klion AD, Lee JJ, Weller PF
Allergy 2013 Jul;68(7):829-35. Epub 2013 Jun 6 doi: 10.1111/all.12169. PMID: 23742015Free PMC Article

Recent systematic reviews

Molani-Gol R, Kheirouri S, Alizadeh M
J Health Popul Nutr 2023 Jan 6;42(1):2. doi: 10.1186/s41043-022-00337-3. PMID: 36609429Free PMC Article
Schlotawa L, Preiskorn J, Ahrens-Nicklas R, Schiller S, Adang LA, Gärtner J, Friede T
J Inherit Metab Dis 2020 Nov;43(6):1288-1297. Epub 2020 Jul 22 doi: 10.1002/jimd.12282. PMID: 32621519
Rosen MJ, Ireland B, Narasimhan M, French C, Irwin RS; CHEST Expert Cough Panel
Chest 2017 Nov;152(5):1038-1042. Epub 2017 Aug 19 doi: 10.1016/j.chest.2017.07.039. PMID: 28830820Free PMC Article
Similuk MN, Wang A, Lenardo MJ, Erby LH
J Clin Immunol 2016 Feb;36(2):123-33. Epub 2016 Feb 12 doi: 10.1007/s10875-016-0241-1. PMID: 26873708Free PMC Article
Brower KS, Del Vecchio MT, Aronoff SC
BMC Pediatr 2014 Dec 10;14:4. doi: 10.1186/s12887-014-0299-y. PMID: 25492164Free PMC Article

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