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Vitamin A deficiency

MedGen UID:
22668
Concept ID:
C0042842
Disease or Syndrome
Synonyms: Deficiencies, Vitamin A; Deficiency, Vitamin A; Vitamin A Deficiencies; Vitamin A Deficiency
SNOMED CT: Vitamin A deficiency (72000004); Hypovitaminosis A (72000004); Deficiency of vitamin A (72000004)
 
Monarch Initiative: MONDO:0007016

Definition

Deficiency of vitamin A due to malnutrition, malabsorption, or dietary lack. It is manifested with reduced night vision, night blindness, and xerophthalmia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin A deficiency

Professional guidelines

PubMed

Miranda WD, Guimarães EAA, Campos DS, Luz ZMPD
Cien Saude Colet 2023 Aug;28(8):2323-2333. Epub 2023 Apr 28 doi: 10.1590/1413-81232023288.05922023. PMID: 37531540
Mathur ML
Natl Med J India 2007 Jan-Feb;20(1):16-21. PMID: 17557517
D'Souza RM, D'Souza R
J Trop Pediatr 2002 Dec;48(6):323-7. doi: 10.1093/tropej/48.6.323. PMID: 12521271

Recent clinical studies

Etiology

Song A, Mousa HM, Soifer M, Perez VL
Curr Opin Pediatr 2022 Apr 1;34(2):241-247. doi: 10.1097/MOP.0000000000001110. PMID: 35125379Free PMC Article
Wiseman EM, Bar-El Dadon S, Reifen R
Crit Rev Food Sci Nutr 2017 Nov 22;57(17):3703-3714. doi: 10.1080/10408398.2016.1160362. PMID: 27128154
Thurnham DI
Food Nutr Bull 2015 Sep;36(3):290-8. Epub 2015 Aug 27 doi: 10.1177/0379572115597514. PMID: 26314733
Lira LQ, Dimenstein R
Rev Assoc Med Bras (1992) 2010 May-Jun;56(3):355-9. doi: 10.1590/s0104-42302010000300023. PMID: 20676546
Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J; Maternal and Child Undernutrition Study Group
Lancet 2008 Jan 19;371(9608):243-60. doi: 10.1016/S0140-6736(07)61690-0. PMID: 18207566

Diagnosis

Patel R, Nair S, Choudhry H, Jaffry M, Dastjerdi M
Int Ophthalmol 2024 Apr 15;44(1):177. doi: 10.1007/s10792-024-03103-y. PMID: 38622271Free PMC Article
Sapkota J, Rana R
Nepal J Ophthalmol 2022 Jul;14(28):161-165. doi: 10.3126/nepjoph.v14i2.43679. PMID: 37609977
Gregory KE
J Perinat Neonatal Nurs 2014 Oct-Dec;28(4):253-5. doi: 10.1097/JPN.0000000000000072. PMID: 25347102
McLaren DS, Kraemer K
World Rev Nutr Diet 2012;103:52-64. Epub 2012 Aug 27 doi: 10.1159/000188073. PMID: 23008037
Lancet 1992 Jun 20;339(8808):1514-5. PMID: 1351193

Therapy

Huang D, Qian X, Chen J, Peng Y, Zhu Y
J Nutr Sci Vitaminol (Tokyo) 2023;69(3):157-163. doi: 10.3177/jnsv.69.157. PMID: 37394420
Eyeberu A, Getachew T, Tiruye G, Balis B, Tamiru D, Bekele H, Abdurke M, Alemu A, Dessie Y, Shiferaw K, Debela A
Int Health 2023 Nov 3;15(6):630-643. doi: 10.1093/inthealth/ihad038. PMID: 37264928Free PMC Article
Wirth JP, Petry N, Tanumihardjo SA, Rogers LM, McLean E, Greig A, Garrett GS, Klemm RD, Rohner F
Nutrients 2017 Feb 24;9(3) doi: 10.3390/nu9030190. PMID: 28245571Free PMC Article
Chaves GV, Peres WA, Gonçalves JC, Ramalho A
Nutrition 2015 May;31(5):664-8. Epub 2014 Nov 4 doi: 10.1016/j.nut.2014.10.016. PMID: 25837210
Bhaskaram P
Natl Med J India 1992 Mar-Apr;5(2):47-9. PMID: 1304261

Prognosis

Zhao T, Liu S, Zhang R, Zhao Z, Yu H, Pu L, Wang L, Han L
Nutrients 2022 Feb 23;14(5) doi: 10.3390/nu14050950. PMID: 35267925Free PMC Article
Everts HB, Akuailou EN
Nutrients 2021 Jan 5;13(1) doi: 10.3390/nu13010153. PMID: 33466372Free PMC Article
Dowling JE
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2020 May;206(3):389-399. Epub 2020 Feb 7 doi: 10.1007/s00359-020-01403-z. PMID: 32034476
Benn CS, Aaby P, Fisker AB
Nutrients 2019 Feb 21;11(2) doi: 10.3390/nu11020449. PMID: 30795563Free PMC Article
Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J; Maternal and Child Undernutrition Study Group
Lancet 2008 Jan 19;371(9608):243-60. doi: 10.1016/S0140-6736(07)61690-0. PMID: 18207566

Clinical prediction guides

Eyeberu A, Getachew T, Tiruye G, Balis B, Tamiru D, Bekele H, Abdurke M, Alemu A, Dessie Y, Shiferaw K, Debela A
Int Health 2023 Nov 3;15(6):630-643. doi: 10.1093/inthealth/ihad038. PMID: 37264928Free PMC Article
Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA
Cochrane Database Syst Rev 2022 Mar 16;3(3):CD008524. doi: 10.1002/14651858.CD008524.pub4. PMID: 35294044Free PMC Article
Dowling JE
Annu Rev Vis Sci 2018 Sep 15;4:1-23. doi: 10.1146/annurev-vision-091517-034222. PMID: 30222531
Li Z, Yu X, Shen J
Environ Sci Pollut Res Int 2015 Apr;22(8):5751-5. Epub 2015 Jan 29 doi: 10.1007/s11356-015-4144-0. PMID: 25628116
Weber D, Grune T
Mol Nutr Food Res 2012 Feb;56(2):251-8. Epub 2011 Sep 29 doi: 10.1002/mnfr.201100230. PMID: 21957049

Recent systematic reviews

Eyeberu A, Getachew T, Tiruye G, Balis B, Tamiru D, Bekele H, Abdurke M, Alemu A, Dessie Y, Shiferaw K, Debela A
Int Health 2023 Nov 3;15(6):630-643. doi: 10.1093/inthealth/ihad038. PMID: 37264928Free PMC Article
Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA
Cochrane Database Syst Rev 2022 Mar 16;3(3):CD008524. doi: 10.1002/14651858.CD008524.pub4. PMID: 35294044Free PMC Article
Venkatesh U, Sharma A, Ananthan VA, Subbiah P, Durga R; CSIR Summer Research training team
J Nutr Sci 2021;10:e110. Epub 2021 Dec 21 doi: 10.1017/jns.2021.102. PMID: 35059191Free PMC Article
Gannon BM, Rogers LM, Tanumihardjo SA
Adv Nutr 2021 Jun 1;12(3):942-958. doi: 10.1093/advances/nmaa137. PMID: 33216111Free PMC Article
Martínez-Moneo E, Stigliano S, Hedström A, Kaczka A, Malvik M, Waldthaler A, Maisonneuve P, Simon P, Capurso G
Pancreatology 2016 Nov-Dec;16(6):988-994. Epub 2016 Sep 20 doi: 10.1016/j.pan.2016.09.008. PMID: 27681502

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