U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vitamin A deficiency

MedGen UID:
22668
•Concept ID:
C0042842
•
Disease or Syndrome
Synonyms: Deficiencies, Vitamin A; Deficiency, Vitamin A; Vitamin A Deficiencies; Vitamin A Deficiency
SNOMED CT: Vitamin A deficiency (72000004); Hypovitaminosis A (72000004); Deficiency of vitamin A (72000004)
 
Monarch Initiative: MONDO:0007016

Definition

Deficiency of vitamin A due to malnutrition, malabsorption, or dietary lack. It is manifested with reduced night vision, night blindness, and xerophthalmia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin A deficiency

Professional guidelines

PubMed

National Vitamin A Supplementation Program in primary care: what is the reality in Minas Gerais, Brazil?
Miranda WD, Guimarães EAA, Campos DS, Luz ZMPD
Cien Saude Colet 2023 Aug;28(8):2323-2333. Epub 2023 Apr 28 doi: 10.1590/1413-81232023288.05922023. PMID: 37531540
Role of vitamin A supplementation in the treatment of tuberculosis.
Mathur ML
Natl Med J India 2007 Jan-Feb;20(1):16-21. PMID: 17557517
Vitamin A for the treatment of children with measles--a systematic review.
D'Souza RM, D'Souza R
J Trop Pediatr 2002 Dec;48(6):323-7. doi: 10.1093/tropej/48.6.323. PMID: 12521271

Recent clinical studies

Therapy

The Impact of Vitamin A Deficiency on Tuberculosis Progression.
Podell BK, Aibana O, Huang CC, DiLisio JE, Harris MC, Ackart DF, Armann K, Grover A, Severe P, Juste MAJ, Dupnik K, Basaraba RJ, Murray MB
Clin Infect Dis 2022 Dec 19;75(12):2178-2185. doi: 10.1093/cid/ciac326. PMID: 35486953Free PMC Article
Vitamin A distribution in danger.
The Lancet
Lancet 2018 May 12;391(10133):1866. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)31035-3. PMID: 29781430
Vitamin A Supplementation Programs and Country-Level Evidence of Vitamin A Deficiency.
Wirth JP, Petry N, Tanumihardjo SA, Rogers LM, McLean E, Greig A, Garrett GS, Klemm RD, Rohner F
Nutrients 2017 Feb 24;9(3) doi: 10.3390/nu9030190. PMID: 28245571Free PMC Article
Infections and vitamin A.
Bhaskaram P
Natl Med J India 1992 Mar-Apr;5(2):47-9. PMID: 1304261
Vitamin A deficiency and excess.
Moore T
Proc Nutr Soc 1965;24(2):129-35. doi: 10.1079/pns19650025. PMID: 5319194

Prognosis

Retinoids in Cutaneous Squamous Cell Carcinoma.
Everts HB, Akuailou EN
Nutrients 2021 Jan 5;13(1) doi: 10.3390/nu13010153. PMID: 33466372Free PMC Article
Vitamin A: its many roles-from vision and synaptic plasticity to infant mortality.
Dowling JE
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2020 May;206(3):389-399. Epub 2020 Feb 7 doi: 10.1007/s00359-020-01403-z. PMID: 32034476
Vitamin A supplementation during pregnancy for maternal and newborn outcomes.
McCauley ME, van den Broek N, Dou L, Othman M
Cochrane Database Syst Rev 2015 Oct 27;2015(10):CD008666. doi: 10.1002/14651858.CD008666.pub3. PMID: 26503498Free PMC Article
Maternal and child undernutrition: global and regional exposures and health consequences.
Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J; Maternal and Child Undernutrition Study Group
Lancet 2008 Jan 19;371(9608):243-60. doi: 10.1016/S0140-6736(07)61690-0. PMID: 18207566
Vitamin A deficiency and the eye.
Smith J, Steinemann TL
Int Ophthalmol Clin 2000 Fall;40(4):83-91. doi: 10.1097/00004397-200010000-00007. PMID: 11064859

Clinical prediction guides

Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA
Cochrane Database Syst Rev 2022 Mar 16;3(3):CD008524. doi: 10.1002/14651858.CD008524.pub4. PMID: 35294044Free PMC Article
A Life in Vision.
Dowling JE
Annu Rev Vis Sci 2018 Sep 15;4:1-23. doi: 10.1146/annurev-vision-091517-034222. PMID: 30222531
Inflammation and Vitamin A.
Thurnham DI
Food Nutr Bull 2015 Sep;36(3):290-8. Epub 2015 Aug 27 doi: 10.1177/0379572115597514. PMID: 26314733
Vitamin A and dendritic cell differentiation.
Beijer MR, Kraal G, den Haan JM
Immunology 2014 May;142(1):39-45. doi: 10.1111/imm.12228. PMID: 24843870Free PMC Article
Anophthalmia and microphthalmia.
Verma AS, Fitzpatrick DR
Orphanet J Rare Dis 2007 Nov 26;2:47. doi: 10.1186/1750-1172-2-47. PMID: 18039390Free PMC Article

Recent systematic reviews

Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age.
Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA
Cochrane Database Syst Rev 2022 Mar 16;3(3):CD008524. doi: 10.1002/14651858.CD008524.pub4. PMID: 35294044Free PMC Article
Micronutrient's deficiency in India: a systematic review and meta-analysis.
Venkatesh U, Sharma A, Ananthan VA, Subbiah P, Durga R; CSIR Summer Research training team
J Nutr Sci 2021;10:e110. Epub 2021 Dec 21 doi: 10.1017/jns.2021.102. PMID: 35059191Free PMC Article
Efect of vitamin A suplementation: a systematic review.
Soares MM, Silva MA, Garcia PPC, Silva LSD, Costa GDD, Araújo RMA, Cotta RMM
Cien Saude Colet 2019 Mar;24(3):827-838. doi: 10.1590/1413-81232018243.07112017. PMID: 30892504
Vitamin A supplementation in Brazilian pregnant and postpartum women: a systematic review.
Neves PA, Saunders C, Barros DC, Ramalho A
Rev Bras Epidemiol 2015 Oct-Dec;18(4):824-36. doi: 10.1590/1980-5497201500040012. PMID: 26982298
Vitamin A supplementation during pregnancy for maternal and newborn outcomes.
McCauley ME, van den Broek N, Dou L, Othman M
Cochrane Database Syst Rev 2015 Oct 27;2015(10):CD008666. doi: 10.1002/14651858.CD008666.pub3. PMID: 26503498Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...