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Abnormality of digestive system physiology

MedGen UID:
927601
•Concept ID:
C4293692
•
Pathologic Function
HPO: HP:0025032

Definition

A functional anomaly of the digestive system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of digestive system physiology

Professional guidelines

PubMed

2023 update on the clinical management of gastroparesis.
El Halabi M, Parkman HP
Expert Rev Gastroenterol Hepatol 2023 May;17(5):431-441. Epub 2023 Mar 29 doi: 10.1080/17474124.2023.2196404. PMID: 36970885
Management of functional communication, swallowing, cough and related disorders: consensus recommendations for speech and language therapy.
Baker J, Barnett C, Cavalli L, Dietrich M, Dixon L, Duffy JR, Elias A, Fraser DE, Freeburn JL, Gregory C, McKenzie K, Miller N, Patterson J, Roth C, Roy N, Short J, Utianski R, van Mersbergen M, Vertigan A, Carson A, Stone J, McWhirter L
J Neurol Neurosurg Psychiatry 2021 Oct;92(10):1112-1125. Epub 2021 Jul 1 doi: 10.1136/jnnp-2021-326767. PMID: 34210802
Acute Malnutrition in Children: Pathophysiology, Clinical Effects and Treatment.
Dipasquale V, Cucinotta U, Romano C
Nutrients 2020 Aug 12;12(8) doi: 10.3390/nu12082413. PMID: 32806622Free PMC Article

Recent clinical studies

Etiology

Feeding and Swallowing Characteristics of Children With Esophageal Atresia and Tracheoesophageal Fistula.
Maybee J, Deck J, Jensen E, Ruiz A, Kinder S, DeBoer E
J Pediatr Gastroenterol Nutr 2023 Mar 1;76(3):288-294. Epub 2022 Dec 28 doi: 10.1097/MPG.0000000000003697. PMID: 36728731
Understanding gastroschisis and its clinical management: where are we?
Haddock C, Skarsgard ED
Expert Rev Gastroenterol Hepatol 2018 Apr;12(4):405-415. Epub 2018 Feb 16 doi: 10.1080/17474124.2018.1438890. PMID: 29419329
Neurogenic [corrected] and oropharyngeal dysphagia.
Rofes L, Clavé P, Ouyang A, Scharitzer M, Pokieser P, Vilardell N, Ortega O
Ann N Y Acad Sci 2013 Oct;1300:1-10. doi: 10.1111/nyas.12234. PMID: 24117630
Anorectal malformations.
Peña A
Semin Pediatr Surg 1995 Feb;4(1):35-47. PMID: 7728507
Pseudo-obstruction syndromes.
Stanghellini V, Corinaldesi R, Barbara L
Baillieres Clin Gastroenterol 1988 Jan;2(1):225-54. doi: 10.1016/0950-3528(88)90029-2. PMID: 3289641Free PMC Article

Diagnosis

Pediatric Dysphagia.
McClain W, Luttrell J, Lambert E
Otolaryngol Clin North Am 2024 Aug;57(4):531-540. Epub 2024 Mar 23 doi: 10.1016/j.otc.2024.02.010. PMID: 38521722
Review of the indications, methods, and clinical utility of anorectal manometry and the rectal balloon expulsion test.
Bharucha AE, Basilisco G, Malcolm A, Lee TH, Hoy MB, Scott SM, Rao SSC
Neurogastroenterol Motil 2022 Sep;34(9):e14335. Epub 2022 Feb 27 doi: 10.1111/nmo.14335. PMID: 35220645Free PMC Article
Joint hypermobility syndrome.
Fikree A, Aziz Q, Grahame R
Rheum Dis Clin North Am 2013 May;39(2):419-30. doi: 10.1016/j.rdc.2013.03.003. PMID: 23597972
The use of abdominal massage to treat chronic constipation.
Sinclair M
J Bodyw Mov Ther 2011 Oct;15(4):436-45. Epub 2010 Aug 25 doi: 10.1016/j.jbmt.2010.07.007. PMID: 21943617
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article

Therapy

Early Premature Infant Oral Motor Intervention Improved Oral Feeding and Prognosis by Promoting Neurodevelopment.
Li XL, Liu Y, Liu M, Yang CY, Yang QZ
Am J Perinatol 2020 May;37(6):626-632. Epub 2019 Apr 23 doi: 10.1055/s-0039-1685448. PMID: 31013539
Chronic constipation.
Camilleri M, Ford AC, Mawe GM, Dinning PG, Rao SS, Chey WD, Simrén M, Lembo A, Young-Fadok TM, Chang L
Nat Rev Dis Primers 2017 Dec 14;3:17095. doi: 10.1038/nrdp.2017.95. PMID: 29239347
Capsule endoscopy--transit abnormalities.
Lewis B
Gastrointest Endosc Clin N Am 2006 Apr;16(2):221-8, vii. doi: 10.1016/j.giec.2006.01.015. PMID: 16644452
Voriconazole.
Jeu L, Piacenti FJ, Lyakhovetskiy AG, Fung HB
Clin Ther 2003 May;25(5):1321-81. doi: 10.1016/s0149-2918(03)80126-1. PMID: 12867215
Managing cancer-related anorexia/cachexia.
Mantovani G, Macciò A, Massa E, Madeddu C
Drugs 2001;61(4):499-514. doi: 10.2165/00003495-200161040-00004. PMID: 11324680

Prognosis

Diagnostic Evaluation of Gastric Motor and Sensory Disorders.
Lacy BE, Crowell MD, Cangemi DJ, Lunsford TN, Simren M, Tack J
Am J Gastroenterol 2021 Dec 1;116(12):2345-2356. doi: 10.14309/ajg.0000000000001562. PMID: 35134012
Colonic dysmotility in constipation.
Dinning PG, Di Lorenzo C
Best Pract Res Clin Gastroenterol 2011 Feb;25(1):89-101. doi: 10.1016/j.bpg.2010.12.006. PMID: 21382581
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article
Anorectal malformations.
Peña A
Semin Pediatr Surg 1995 Feb;4(1):35-47. PMID: 7728507
Neuronal intestinal dysplasia.
Ryan DP
Semin Pediatr Surg 1995 Feb;4(1):22-5. PMID: 7728504

Clinical prediction guides

Gastroparesis.
Camilleri M, Sanders KM
Gastroenterology 2022 Jan;162(1):68-87.e1. Epub 2021 Oct 27 doi: 10.1053/j.gastro.2021.10.028. PMID: 34717924Free PMC Article
Refractory Constipation: What is the Clinician to Do?
Staller K
J Clin Gastroenterol 2018 Jul;52(6):490-501. doi: 10.1097/MCG.0000000000001049. PMID: 29794543
Microscopic enteritis: Bucharest consensus.
Rostami K, Aldulaimi D, Holmes G, Johnson MW, Robert M, Srivastava A, Fléjou JF, Sanders DS, Volta U, Derakhshan MH, Going JJ, Becheanu G, Catassi C, Danciu M, Materacki L, Ghafarzadegan K, Ishaq S, Rostami-Nejad M, Peña AS, Bassotti G, Marsh MN, Villanacci V
World J Gastroenterol 2015 Mar 7;21(9):2593-604. doi: 10.3748/wjg.v21.i9.2593. PMID: 25759526Free PMC Article
Colonic dysmotility in constipation.
Dinning PG, Di Lorenzo C
Best Pract Res Clin Gastroenterol 2011 Feb;25(1):89-101. doi: 10.1016/j.bpg.2010.12.006. PMID: 21382581
Anorectal malformations.
Levitt MA, Peña A
Orphanet J Rare Dis 2007 Jul 26;2:33. doi: 10.1186/1750-1172-2-33. PMID: 17651510Free PMC Article

Recent systematic reviews

The diagnosis of aspiration pneumonia in older persons: a systematic review.
Yoshimatsu Y, Melgaard D, Westergren A, Skrubbeltrang C, Smithard DG
Eur Geriatr Med 2022 Oct;13(5):1071-1080. Epub 2022 Aug 25 doi: 10.1007/s41999-022-00689-3. PMID: 36008745Free PMC Article
Psychopathological aspects of dysphagia: a systematic review on correlations with eating disorders and other psychiatric conditions.
Massa L, Fattori B, Nacci A, Santoro A, Palagini L, Abelli M, Forfori F, Pini S
Eat Weight Disord 2022 Apr;27(3):881-892. Epub 2021 Jul 2 doi: 10.1007/s40519-021-01227-z. PMID: 34213745
Obstructive sleep apnea and energy balance regulation: A systematic review.
Shechter A
Sleep Med Rev 2017 Aug;34:59-69. Epub 2016 Jul 15 doi: 10.1016/j.smrv.2016.07.001. PMID: 27818084Free PMC Article
Systematic Review: Non-Instrumental Swallowing and Feeding Assessments in Pediatrics.
Heckathorn DE, Speyer R, Taylor J, Cordier R
Dysphagia 2016 Feb;31(1):1-23. Epub 2015 Nov 25 doi: 10.1007/s00455-015-9667-5. PMID: 26607159
The processing of food stimuli in abnormal eating: a systematic review of electrophysiology.
Wolz I, Fagundo AB, Treasure J, Fernández-Aranda F
Eur Eat Disord Rev 2015 Jul;23(4):251-61. Epub 2015 May 15 doi: 10.1002/erv.2366. PMID: 25982390

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