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Abnormal blood ion concentration

MedGen UID:
312393
•Concept ID:
C1704431
•
Pathologic Function
Synonyms: Abnormality of ion homeostasis; Disorder of electrolytes; Electrolyte Disorder; Electrolyte disorders; Electrolyte disturbance
SNOMED CT: Disorder of electrolytes (237840007)
 
HPO: HP:0003111

Definition

Abnormality of the homeostasis (concentration) of a monoatomic ion. [from HPO]

Professional guidelines

PubMed

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Pathogenesis and treatment of primary aldosteronism.
Zennaro MC, Boulkroun S, Fernandes-Rosa FL
Nat Rev Endocrinol 2020 Oct;16(10):578-589. Epub 2020 Jul 28 doi: 10.1038/s41574-020-0382-4. PMID: 32724183
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Acid-base balance in hemodialysis patients in everyday practice.
Wieliczko M, Małyszko J
Ren Fail 2022 Dec;44(1):1090-1097. doi: 10.1080/0886022X.2022.2094805. PMID: 35793495Free PMC Article
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999
Potassium and anaesthesia.
Tetzlaff JE, O'Hara JF Jr, Walsh MT
Can J Anaesth 1993 Mar;40(3):227-46. doi: 10.1007/BF03037035. PMID: 8467545

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Pathogenesis and treatment of primary aldosteronism.
Zennaro MC, Boulkroun S, Fernandes-Rosa FL
Nat Rev Endocrinol 2020 Oct;16(10):578-589. Epub 2020 Jul 28 doi: 10.1038/s41574-020-0382-4. PMID: 32724183
Metabolic Alkalosis: A Brief Pathophysiologic Review.
Emmett M
Clin J Am Soc Nephrol 2020 Dec 7;15(12):1848-1856. Epub 2020 Jun 25 doi: 10.2215/CJN.16041219. PMID: 32586924Free PMC Article
The arterial blood gas algorithm: Proposal of a systematic approach to analysis of acid-base disorders.
Rodríguez-Villar S, Do Vale BM, Fletcher HM
Rev Esp Anestesiol Reanim (Engl Ed) 2020 Jan;67(1):20-34. Epub 2019 Dec 9 doi: 10.1016/j.redar.2019.04.001. PMID: 31826801
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999

Therapy

Recent advances in fibroblast growth factor 23-related hypophosphatemic disorders.
Takashi Y, Kawanami D, Fukumoto S
Curr Opin Endocrinol Diabetes Obes 2024 Aug 1;31(4):170-175. Epub 2024 Apr 30 doi: 10.1097/MED.0000000000000866. PMID: 38687287
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Metabolic acidosis: pathophysiology, diagnosis and management.
Kraut JA, Madias NE
Nat Rev Nephrol 2010 May;6(5):274-85. Epub 2010 Mar 23 doi: 10.1038/nrneph.2010.33. PMID: 20308999
Permissive hypercapnia.
Hickling KG
Respir Care Clin N Am 2002 Jun;8(2):155-69, v. doi: 10.1016/s1078-5337(02)00006-0. PMID: 12481813
Adult hypophosphatasia.
Sorensen E, Flodgaard H
Acta Med Scand 1975 May;197(5):357-60. doi: 10.1111/j.0954-6820.1975.tb04934.x. PMID: 167553

Prognosis

Hyperlactatemia in diabetic ketoacidosis.
Masharani U, Strycker LA, Lazar AA, Wu K, Brooks GA
Diabet Med 2022 Apr;39(4):e14723. Epub 2021 Oct 22 doi: 10.1111/dme.14723. PMID: 34655270
Metabolic Alkalosis: A Brief Pathophysiologic Review.
Emmett M
Clin J Am Soc Nephrol 2020 Dec 7;15(12):1848-1856. Epub 2020 Jun 25 doi: 10.2215/CJN.16041219. PMID: 32586924Free PMC Article
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
Magnesium and phosphorus.
Weisinger JR, Bellorín-Font E
Lancet 1998 Aug 1;352(9125):391-6. doi: 10.1016/S0140-6736(97)10535-9. PMID: 9717944
Organic acidemias.
Mahoney MJ
Clin Perinatol 1976 Mar;3(1):61-78. PMID: 8230

Clinical prediction guides

Recent advances in fibroblast growth factor 23-related hypophosphatemic disorders.
Takashi Y, Kawanami D, Fukumoto S
Curr Opin Endocrinol Diabetes Obes 2024 Aug 1;31(4):170-175. Epub 2024 Apr 30 doi: 10.1097/MED.0000000000000866. PMID: 38687287
Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Diet-induced metabolic acidosis.
Adeva MM, Souto G
Clin Nutr 2011 Aug;30(4):416-21. Epub 2011 Apr 9 doi: 10.1016/j.clnu.2011.03.008. PMID: 21481501
ACOG Committee Opinion No. 348, November 2006: Umbilical cord blood gas and acid-base analysis.
ACOG Committee on Obstetric Practice
Obstet Gynecol 2006 Nov;108(5):1319-22. doi: 10.1097/00006250-200611000-00058. PMID: 17077266
Magnesium and phosphorus.
Weisinger JR, Bellorín-Font E
Lancet 1998 Aug 1;352(9125):391-6. doi: 10.1016/S0140-6736(97)10535-9. PMID: 9717944

Recent systematic reviews

Exposure to drinking water pollutants and non-syndromic birth defects: a systematic review and meta-analysis synthesis.
Jauniaux E, Jeremiah L, Richardson B, Rogozińska E
BMJ Open 2024 Nov 11;14(11):e084122. doi: 10.1136/bmjopen-2024-084122. PMID: 39532365Free PMC Article
Elevated blood metal ion levels in patients undergoing instrumented spinal surgery: a systematic review and meta-analysis.
Burgos J, Hevia E, Sanpera I, García V, de Santos Moreno MT, Mariscal G, Barrios C
Spine J 2024 Jun;24(6):947-960. Epub 2024 Mar 2 doi: 10.1016/j.spinee.2024.02.019. PMID: 38437920
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB, Lau R
Cochrane Database Syst Rev 2015 May 1;2015(5):CD006174. doi: 10.1002/14651858.CD006174.pub3. PMID: 25929461Free PMC Article
The role of venous blood gas in the emergency department: a systematic review and meta-analysis.
Bloom BM, Grundlingh J, Bestwick JP, Harris T
Eur J Emerg Med 2014 Apr;21(2):81-8. doi: 10.1097/MEJ.0b013e32836437cf. PMID: 23903783
Intrapartum fetal scalp lactate sampling for fetal assessment in the presence of a non-reassuring fetal heart rate trace.
East CE, Leader LR, Sheehan P, Henshall NE, Colditz PB
Cochrane Database Syst Rev 2010 Mar 17;(3):CD006174. doi: 10.1002/14651858.CD006174.pub2. PMID: 20238343

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