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Breast intraductal proliferative lesion

MedGen UID:
277343
•Concept ID:
C1334631
•
Neoplastic Process
Synonyms: Breast Intraductal Proliferative Lesion; breast intraductal proliferative lesion; DIN; Ductal Intraepithelial Neoplasia; ductal intraepithelial neoplasia; Intraductal Proliferative Lesion; intraductal proliferative lesion; Intraductal Proliferative Lesion of the Breast; intraductal proliferative lesion of the breast; Mammary Intraepithelial Neoplasia, Ductal Type; mammary intraepithelial neoplasia, ductal type
 
Monarch Initiative: MONDO:0004007

Definition

A group of non-invasive epithelial proliferations that occur in the ductal system of the breast. The vast majority of cases arise in the terminal ductal lobular units. This category includes atypical ductal hyperplasia, usual ductal hyperplasia, flat epithelial atypia, and ductal carcinoma in situ. There is an increased risk for subsequent development of invasive breast carcinoma. [from NCI]

Professional guidelines

PubMed

Expression-Based Diagnosis, Treatment Selection, and Drug Development for Breast Cancer.
Ye Q, Wang J, Ducatman B, Raese RA, Rogers JL, Wan YW, Dong C, Padden L, Pugacheva EN, Qian Y, Guo NL
Int J Mol Sci 2023 Jun 23;24(13) doi: 10.3390/ijms241310561. PMID: 37445737Free PMC Article
Core needle biopsy of benign, borderline and in-situ problematic lesions of the breast: Diagnosis, differential diagnosis and immunohistochemistry.
Rosa M, Agosto-Arroyo E
Ann Diagn Pathol 2019 Dec;43:151407. Epub 2019 Sep 3 doi: 10.1016/j.anndiagpath.2019.151407. PMID: 31634810
Management of atypical lobular hyperplasia, atypical ductal hyperplasia, and lobular carcinoma in situ.
Clauser P, Marino MA, Baltzer PA, Bazzocchi M, Zuiani C
Expert Rev Anticancer Ther 2016;16(3):335-46. Epub 2016 Feb 6 doi: 10.1586/14737140.2016.1143362. PMID: 26780850

Recent clinical studies

Etiology

Analysis of Incidentally Found Proliferative Lesions in Oncoplastic and Macromastia Breast Reductions.
Morrison KA, Choi M, Karp NS
Plast Reconstr Surg 2023 Oct 1;152(4):559e-565e. Epub 2023 Mar 3 doi: 10.1097/PRS.0000000000010341. PMID: 36862961
How Do We Approach Benign Proliferative Lesions?
Nakhlis F
Curr Oncol Rep 2018 Mar 23;20(4):34. doi: 10.1007/s11912-018-0682-1. PMID: 29572753
When Does Atypical Ductal Hyperplasia Require Surgical Excision?
Racz JM, Degnim AC
Surg Oncol Clin N Am 2018 Jan;27(1):23-32. doi: 10.1016/j.soc.2017.07.011. PMID: 29132563
Molecular profile of atypical hyperplasia of the breast.
Danforth DN
Breast Cancer Res Treat 2018 Jan;167(1):9-29. Epub 2017 Sep 14 doi: 10.1007/s10549-017-4488-x. PMID: 28913734
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436

Diagnosis

Expression-Based Diagnosis, Treatment Selection, and Drug Development for Breast Cancer.
Ye Q, Wang J, Ducatman B, Raese RA, Rogers JL, Wan YW, Dong C, Padden L, Pugacheva EN, Qian Y, Guo NL
Int J Mol Sci 2023 Jun 23;24(13) doi: 10.3390/ijms241310561. PMID: 37445737Free PMC Article
Atypia in breast pathology: what pathologists need to know.
Katayama A, Toss MS, Parkin M, Ellis IO, Quinn C, Rakha EA
Pathology 2022 Feb;54(1):20-31. Epub 2021 Dec 3 doi: 10.1016/j.pathol.2021.09.008. PMID: 34872753
How Do We Approach Benign Proliferative Lesions?
Nakhlis F
Curr Oncol Rep 2018 Mar 23;20(4):34. doi: 10.1007/s11912-018-0682-1. PMID: 29572753
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436
Current issues in breast cytopathology.
Stanley MW, Sidawy MK, Sanchez MA, Stahl RE, Goldfischer M
Am J Clin Pathol 2000 May;113(5 Suppl 1):S49-75. doi: 10.1309/29FP-0QAU-CMJY-BK3U. PMID: 11993710

Therapy

Analysis of Incidentally Found Proliferative Lesions in Oncoplastic and Macromastia Breast Reductions.
Morrison KA, Choi M, Karp NS
Plast Reconstr Surg 2023 Oct 1;152(4):559e-565e. Epub 2023 Mar 3 doi: 10.1097/PRS.0000000000010341. PMID: 36862961
Proliferative Lesions Found at Reduction Mammaplasty: Incidence and Implications in 995 Breast Reductions.
Mastroianni M, Lin A, Hughes K, Colwell AS
Plast Reconstr Surg 2019 Feb;143(2):271e-275e. doi: 10.1097/PRS.0000000000005192. PMID: 30489497
Predictors of recurrence for ductal carcinoma in situ after breast-conserving surgery.
Benson JR, Wishart GC
Lancet Oncol 2013 Aug;14(9):e348-57. doi: 10.1016/S1470-2045(13)70135-9. PMID: 23896274
Evolving concepts in the management of lobular neoplasia.
Anderson BO, Calhoun KE, Rosen EL
J Natl Compr Canc Netw 2006 May;4(5):511-22. doi: 10.6004/jnccn.2006.0041. PMID: 16687097
Pre-cancerous breast lesions: implications for breast cancer prevention trials.
Morrow M
Int J Radiat Oncol Biol Phys 1992;23(5):1071-8. doi: 10.1016/0360-3016(92)90915-5. PMID: 1322385

Prognosis

Proliferative Lesions Found at Reduction Mammaplasty: Incidence and Implications in 995 Breast Reductions.
Mastroianni M, Lin A, Hughes K, Colwell AS
Plast Reconstr Surg 2019 Feb;143(2):271e-275e. doi: 10.1097/PRS.0000000000005192. PMID: 30489497
Expression pattern and methylation of estrogen receptor α in breast intraductal proliferative lesions.
Mao X, Qiao Z, Fan C, Guo A, Yu X, Jin F
Oncol Rep 2016 Oct;36(4):1868-74. Epub 2016 Aug 1 doi: 10.3892/or.2016.4988. PMID: 27498697Free PMC Article
Expression and significance of Wnt signaling components and their target genes in breast carcinoma.
He Y, Liu Z, Qiao C, Xu M, Yu J, Li G
Mol Med Rep 2014 Jan;9(1):137-43. Epub 2013 Nov 4 doi: 10.3892/mmr.2013.1774. PMID: 24190141
Predictors of recurrence for ductal carcinoma in situ after breast-conserving surgery.
Benson JR, Wishart GC
Lancet Oncol 2013 Aug;14(9):e348-57. doi: 10.1016/S1470-2045(13)70135-9. PMID: 23896274
A useful immunohistochemical approach to evaluate intraductal proliferative lesions of the breast and to predict their prognosis.
Omi Y, Yamamoto T, Okamoto T, Obara T, Kobayashi M
Histol Histopathol 2011 Jan;26(1):79-86. doi: 10.14670/HH-26.79. PMID: 21117029

Clinical prediction guides

Breast Density Lacks Influence on Upgrade Rates to High Risk Lesions and Cancer Among Proliferative Breast Lesion Excisions.
Lueders A, Spivey T
Am Surg 2022 Sep;88(9):2119-2123. Epub 2022 Apr 27 doi: 10.1177/00031348221091949. PMID: 35477318
Whole-exome sequencing analysis of juvenile papillomatosis and coexisting breast carcinoma.
D'Alfonso TM, Pareja F, Da Cruz Paula A, Vahdatinia M, Gazzo A, Ferrando L, da Silva EM, Cheng E, Sclafani L, Chandarlapaty S, Zhang H, Hoda SA, Wen HY, Brogi E, Weigelt B, Reis-Filho JS
J Pathol Clin Res 2021 Mar;7(2):113-120. Epub 2020 Dec 2 doi: 10.1002/cjp2.190. PMID: 33263939Free PMC Article
Proliferative Lesions Found at Reduction Mammaplasty: Incidence and Implications in 995 Breast Reductions.
Mastroianni M, Lin A, Hughes K, Colwell AS
Plast Reconstr Surg 2019 Feb;143(2):271e-275e. doi: 10.1097/PRS.0000000000005192. PMID: 30489497
Expression pattern and methylation of estrogen receptor α in breast intraductal proliferative lesions.
Mao X, Qiao Z, Fan C, Guo A, Yu X, Jin F
Oncol Rep 2016 Oct;36(4):1868-74. Epub 2016 Aug 1 doi: 10.3892/or.2016.4988. PMID: 27498697Free PMC Article
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436

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